Ion channels最新文献

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Amino acid receptor-mediated synaptic currents in the CA1 region of the hippocampus. 海马CA1区氨基酸受体介导的突触电流。
Ion channels Pub Date : 1992-01-01 DOI: 10.1007/978-1-4615-3328-3_3
A D Randall, G L Collingridge
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引用次数: 7
Voltage-gated calcium channels in adult hippocampal neurons. 成人海马神经元的电压门控钙通道。
Ion channels Pub Date : 1992-01-01 DOI: 10.1007/978-1-4615-3328-3_2
D Johnston, R Fisher, R Gray
{"title":"Voltage-gated calcium channels in adult hippocampal neurons.","authors":"D Johnston, R Fisher, R Gray","doi":"10.1007/978-1-4615-3328-3_2","DOIUrl":"https://doi.org/10.1007/978-1-4615-3328-3_2","url":null,"abstract":"","PeriodicalId":77183,"journal":{"name":"Ion channels","volume":"3 ","pages":"39-62"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12531722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 18
Kinetic properties and regulation of GABAA receptor channels. GABAA受体通道的动力学性质及调控。
Ion channels Pub Date : 1992-01-01 DOI: 10.1007/978-1-4615-3328-3_10
R L MacDonald, R E Twyman
{"title":"Kinetic properties and regulation of GABAA receptor channels.","authors":"R L MacDonald,&nbsp;R E Twyman","doi":"10.1007/978-1-4615-3328-3_10","DOIUrl":"https://doi.org/10.1007/978-1-4615-3328-3_10","url":null,"abstract":"<p><p>Single-channel recordings of GABAA receptor single-channel currents have been obtained from mouse spinal cord neurons in cell culture. Detailed kinetic analysis of single-channel main-conductance level currents has allowed development of a preliminary kinetic scheme which describes the gating of the GABAA receptor channel. The essential features of this kinetic scheme are presented in scheme 1 (see above). In this scheme, the GABAA receptor channel is envisioned to exist in multiple open and closed states. Properties can be broken into three main categories. First, the receptor can exist in a closed and nondesensitized set of states. In the kinetic model it is envisioned that there is an unbound (C13), a singly bound (C12), and two doubly bound (C11 and C10) closed states. The singly bound and doubly bound closed states are thought to open to three open states (O1, O2, O3). However, each of the open states opens to two distal closed states whose kinetic properties are similar for all three open states (C4-C9). Only one desensitized state (D0) has been incorporated into the model. While this characterization of desensitization is certainly incomplete, it is an initial step toward including the desensitization process which is clearly evident in whole-cell and single-channel recordings. This kinetic scheme should be considered only an initial working model. A number of features appear to be correct. First, all analyses of open time frequency histograms for GABA- and GABA agonist-induced single-channel openings have demonstrated the presence of at least three distinct open time constants. Furthermore, the concentration-dependent change in the relative frequency of occurrence of the three open states suggests that the open states occur from singly and doubly bound forms of the receptor. Second, the presence of two brief closed states adjacent to the open states appears fairly secure. However, it should be noted that the kinetic analysis primarily suggests that each open state opens to two brief adjacent closed states in a concentration-independent manner. While we have indicated that these two closed states are distal to the three open states, the actual assignment of the location of these states is unclear. Another interpretation of these data is that there is only a single distal closed state and that the proximal, extraburst closed states have very brief durations that are similar to each other. What appears clear, however, is that the open states can close to either brief closed state.(ABSTRACT TRUNCATED AT 400 WORDS)</p>","PeriodicalId":77183,"journal":{"name":"Ion channels","volume":"3 ","pages":"315-43"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12556987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 64
Rapid activation and desensitization of transmitter-liganded receptor channels by pulses of agonists. 激动剂脉冲对递质配体受体通道的快速激活和脱敏作用。
Ion channels Pub Date : 1992-01-01 DOI: 10.1007/978-1-4615-3328-3_8
J Dudel, C Franke, H Hatt
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引用次数: 43
Intracellular regulation of GABAA-receptor function. gabaa受体功能的细胞内调控。
Ion channels Pub Date : 1992-01-01 DOI: 10.1007/978-1-4615-3328-3_4
A Stelzer
{"title":"Intracellular regulation of GABAA-receptor function.","authors":"A Stelzer","doi":"10.1007/978-1-4615-3328-3_4","DOIUrl":"https://doi.org/10.1007/978-1-4615-3328-3_4","url":null,"abstract":"","PeriodicalId":77183,"journal":{"name":"Ion channels","volume":"3 ","pages":"83-136"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12556988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 32
Neurogenetic studies of ion channels in Drosophila. 果蝇离子通道的神经遗传学研究。
Ion channels Pub Date : 1992-01-01 DOI: 10.1007/978-1-4615-3328-3_9
C F Wu, B Ganetzky
{"title":"Neurogenetic studies of ion channels in Drosophila.","authors":"C F Wu,&nbsp;B Ganetzky","doi":"10.1007/978-1-4615-3328-3_9","DOIUrl":"https://doi.org/10.1007/978-1-4615-3328-3_9","url":null,"abstract":"","PeriodicalId":77183,"journal":{"name":"Ion channels","volume":"3 ","pages":"261-314"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/978-1-4615-3328-3_9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12503694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 88
Developmental regulation of potassium channels and the impact on neuronal differentiation. 钾离子通道的发育调控及其对神经元分化的影响。
Ion channels Pub Date : 1992-01-01 DOI: 10.1007/978-1-4615-3328-3_1
A B Ribera, N C Spitzer
{"title":"Developmental regulation of potassium channels and the impact on neuronal differentiation.","authors":"A B Ribera,&nbsp;N C Spitzer","doi":"10.1007/978-1-4615-3328-3_1","DOIUrl":"https://doi.org/10.1007/978-1-4615-3328-3_1","url":null,"abstract":"","PeriodicalId":77183,"journal":{"name":"Ion channels","volume":"3 ","pages":"1-38"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12592316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 67
Functional regulation of nicotinic acetylcholine receptor channels in muscle. 肌肉中烟碱乙酰胆碱受体通道的功能调节。
Ion channels Pub Date : 1992-01-01 DOI: 10.1007/978-1-4615-3328-3_7
C G Caratsch, F Grassi, F Eusebi
{"title":"Functional regulation of nicotinic acetylcholine receptor channels in muscle.","authors":"C G Caratsch,&nbsp;F Grassi,&nbsp;F Eusebi","doi":"10.1007/978-1-4615-3328-3_7","DOIUrl":"https://doi.org/10.1007/978-1-4615-3328-3_7","url":null,"abstract":"","PeriodicalId":77183,"journal":{"name":"Ion channels","volume":"3 ","pages":"177-206"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12556985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Neural correlates of memory storage. The role of ion channels. 记忆储存的神经关联。离子通道的作用。
Ion channels Pub Date : 1992-01-01 DOI: 10.1007/978-1-4615-3328-3_6
C Collin, D L Alkon
{"title":"Neural correlates of memory storage. The role of ion channels.","authors":"C Collin,&nbsp;D L Alkon","doi":"10.1007/978-1-4615-3328-3_6","DOIUrl":"https://doi.org/10.1007/978-1-4615-3328-3_6","url":null,"abstract":"","PeriodicalId":77183,"journal":{"name":"Ion channels","volume":"3 ","pages":"159-75"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/978-1-4615-3328-3_6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12556984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Axon terminal hyperexcitability seen in epileptogenesis in vitro. 体外癫痫发生中轴突末端高兴奋性的观察。
Ion channels Pub Date : 1992-01-01 DOI: 10.1007/978-1-4615-3328-3_5
S F Stasheff, W A Wilson
{"title":"Axon terminal hyperexcitability seen in epileptogenesis in vitro.","authors":"S F Stasheff,&nbsp;W A Wilson","doi":"10.1007/978-1-4615-3328-3_5","DOIUrl":"https://doi.org/10.1007/978-1-4615-3328-3_5","url":null,"abstract":"","PeriodicalId":77183,"journal":{"name":"Ion channels","volume":"3 ","pages":"137-57"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12592317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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