Willian Abraham da Silveira, Esteban Vazquez-Hidalgo, Elesha Bartolotta, Ludivine Renaud, Paul Paolini, Gary Hardiman
{"title":"The effects of rosiglitazone on the neonatal rat cardiomyocyte transcriptome: a temporal analysis.","authors":"Willian Abraham da Silveira, Esteban Vazquez-Hidalgo, Elesha Bartolotta, Ludivine Renaud, Paul Paolini, Gary Hardiman","doi":"10.2217/pgs-2019-0077","DOIUrl":"10.2217/pgs-2019-0077","url":null,"abstract":"<p><p><b>Aim:</b> The objective was to determine via high-throughput RNA sequencing the temporal effects of rosiglitazone (Avandia<sup>®</sup>) on the neonatal rat ventricular myocyte transcriptome. <b>Materials & methods:</b> Neonatal rat ventricular myocytes (NRVMs) were exposed to rosiglitazone <i>in vitro</i>. Meta analyses utilized temporal comparisons of 0.5 h control versus 0.5 h treatment, 0.5 h treatment versus 24 h treatment and 24 h treatment versus 48 h treatment. <b>Results:</b> Time dependent responses were observed. At 0.5 h, the PI3K-AKT signaling pathway was impacted. At 24 h endoplasmic reticulum activity and protein degradation were altered. At 48 h, oxytocin signaling was perturbed. <b>Conclusion:</b> The effects of rosiglitazone occured early and increased in magnitude over time. A protective molecular response was triggered at 24 h and maintained until 48 h. In parallel, a response that can cause cardiac damage was activated. Our findings suggest that rosiglitazone has deleterious effects.</p>","PeriodicalId":77135,"journal":{"name":"Fortschritte der Kieferorthopadie","volume":"22 1","pages":"1125-1141"},"PeriodicalIF":1.9,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73220088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. U. Schendel, M. Lenhart, N. Fusenig, G. Komposch
{"title":"Testung der Toxizität von in der Kieferorthopädie verwendeten Kunststoffen","authors":"K. U. Schendel, M. Lenhart, N. Fusenig, G. Komposch","doi":"10.1007/BF02311853","DOIUrl":"https://doi.org/10.1007/BF02311853","url":null,"abstract":"","PeriodicalId":77135,"journal":{"name":"Fortschritte der Kieferorthopadie","volume":"53 1","pages":"354"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02311853","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52178124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Jost-Brinkmann, K. Tanne, M. Sakuda, R. Miethke
{"title":"FEM-Studie zum biomechanischen Vergleich von labialem und palatinalem Kraftangriff an oberen Inzisivi","authors":"P. Jost-Brinkmann, K. Tanne, M. Sakuda, R. Miethke","doi":"10.1007/BF02409024","DOIUrl":"https://doi.org/10.1007/BF02409024","url":null,"abstract":"","PeriodicalId":77135,"journal":{"name":"Fortschritte der Kieferorthopadie","volume":"54 1","pages":"142"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02409024","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52342948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Herbstsymposion der Deutschen Gesellschaft für Kieferorthopädie 10.–11. November 1989 in Bad Homburg","authors":"P. Schopf, I. Jonas, U. Tammoscheit","doi":"10.1007/BF02165213","DOIUrl":"https://doi.org/10.1007/BF02165213","url":null,"abstract":"","PeriodicalId":77135,"journal":{"name":"Fortschritte der Kieferorthopadie","volume":"51 1","pages":"57-59"},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02165213","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51581077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Deutsche Gesellschaft für Kieferorthopädie e. V.","authors":"Wiehtige Mitteilung","doi":"10.1007/BF02166607","DOIUrl":"https://doi.org/10.1007/BF02166607","url":null,"abstract":"","PeriodicalId":77135,"journal":{"name":"Fortschritte der Kieferorthopadie","volume":"30 1","pages":"240"},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02166607","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51602263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Preisausschreiben der Deutschen Gesellschaft für Kieferorthopädie","authors":"G. Korkhaus","doi":"10.1007/BF02167669","DOIUrl":"https://doi.org/10.1007/BF02167669","url":null,"abstract":"","PeriodicalId":77135,"journal":{"name":"Fortschritte der Kieferorthopadie","volume":"15 1","pages":"365"},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02167669","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51606237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Preisausschreiben der Deutschen Gesellschaft für Kieferorthopädie","authors":"G. Korkhaus","doi":"10.1007/BF02169354","DOIUrl":"https://doi.org/10.1007/BF02169354","url":null,"abstract":"","PeriodicalId":77135,"journal":{"name":"Fortschritte der Kieferorthopadie","volume":"699 1","pages":"188"},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02169354","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51615892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bericht über die Tagung des „Club international de morphologie faciale”","authors":"","doi":"10.1007/BF02169955","DOIUrl":"https://doi.org/10.1007/BF02169955","url":null,"abstract":"","PeriodicalId":77135,"journal":{"name":"Fortschritte der Kieferorthopadie","volume":"15 1","pages":"270-271"},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02169955","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51623056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}