L N Maslova, G T Shishkina, V V Bulygina, A L Markel', E V Naumenko
{"title":"[Brain catecholamines and the hypothalamo-hypophyseal-adrenocortical system in hereditary arterial hypertension].","authors":"L N Maslova, G T Shishkina, V V Bulygina, A L Markel', E V Naumenko","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Central catecholaminergic mechanisms regulating hypothalamic-pituitary-adrenocortical system (HPAS) and arterial blood pressure (ABP) are closely related. In adult rats with inherited stress-induced arterial hypertension (ISIAH rats), response of the HPAS to emotional stress is diminished. At the same time, the level and metabolic rate of noradrenaline (NA) in many brain regions taking part in the HPAS and ABP control are decreased, and the number of alpha 1-adrenoceptors in the medulla is elevated. Age-dependent changes and interstrain differences in basal and stress-induced plasma corticosterone levels and brain noradrenaline were studied at the age from 2 up to 18 weeks in ISIAH rats and normotensive Wistar rats. It was found that the 4th week of life in the ISIAH rats is a critical period in the development of inherited hypertension. At this time, fast forming of the hypertension is accompanied by an increase in adrenocortical stress responsivity and a fall in the medulla and hypothalamic NA contents. A short-term augmentation of the brain NA synthesis on the 4th week by L-DOPA and carbidopa treatment in the ISIAH rats was followed by a normalization of the arterial pressure and pituitary-adrenocortical function in adult animals accompanied by restoration of hypothalamic and medulla NA levels and medulla alpha 1-adrenoceptor number.</p>","PeriodicalId":77130,"journal":{"name":"Fiziologicheskii zhurnal imeni I.M. Sechenova","volume":"82 4","pages":"30-8"},"PeriodicalIF":0.0,"publicationDate":"1996-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19926107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[The effect of prenatal stress on the development of hypophyseal gonadotropic function in male rats].","authors":"L V Tarasenko, P V Sinitsyn, A G Reznikov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Significant changes of the aromatase and 5 alpha-reductase hypothalamic activity were found in juvenile prenatally stressed male Wistar rats. The blood plasma testosterone level increased following niftolide (NF) or 1, 4, 6-androstatine-3, 17-dione (ATD) administration. Prenatal stress seems to exert a modifying effect upon the regulating mechanisms of the pituitary gonadotropin function, lowering the functional reserves of the hypothalamo-hypophyseal-testicular axis in pre- and postpubertal male rats.</p>","PeriodicalId":77130,"journal":{"name":"Fiziologicheskii zhurnal imeni I.M. Sechenova","volume":"82 4","pages":"39-45"},"PeriodicalIF":0.0,"publicationDate":"1996-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19926109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[The serotoninergic neurosecretory system in the caudal neurosecretory complex of sturgeons].","authors":"I I Saenko","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77130,"journal":{"name":"Fiziologicheskii zhurnal imeni I.M. Sechenova","volume":"82 4","pages":"128-34"},"PeriodicalIF":0.0,"publicationDate":"1996-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19926101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Otto Loevi (on the 75th anniversary of the demonstration of the existence of the chemical transmission of a nerve impulse)].","authors":"A D Nozdrachev","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77130,"journal":{"name":"Fiziologicheskii zhurnal imeni I.M. Sechenova","volume":"82 4","pages":"153-8"},"PeriodicalIF":0.0,"publicationDate":"1996-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19926105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[The sexual dimorphism of the monoaminergic system of the brain: the effects of prenatal stress and neonatal androgenization in rats].","authors":"N D Nosenko","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Prenatal stress and neonatal androgenization manifest themselves by early postnatal changes in sexual differences of catecholamine and indoleamine contents and turnover in the preoptic area and mediobasal hypothalamus in 10-day-old rats. Neonatal androgenization did not prevent the formation of sexual dimorphism of noradrenaline content and turnover in the preoptic area but enhanced sexual differences of dopamine turnover in both these brain areas.</p>","PeriodicalId":77130,"journal":{"name":"Fiziologicheskii zhurnal imeni I.M. Sechenova","volume":"82 4","pages":"46-53"},"PeriodicalIF":0.0,"publicationDate":"1996-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19926108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[The effect of thyroliberin on the nonapeptidergic hypothalamo-hypophyseal neurosecretory system in rats (in-vivo and in-vitro research)].","authors":"M V Glazova, I A Krasnovskaia","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A single i.p. injection of the thyrotropin-releasing hormone (TRH) decreased the plasma vasopressin in rats. A direct effect of the TRH involved a diminishing of the nucleoli size in oxytocin cells. The data obtained prove a direct effect of the TRH on the release and secretion processes in the nonapeptidergic cells in the paraventricular and supraoptic nuclei.</p>","PeriodicalId":77130,"journal":{"name":"Fiziologicheskii zhurnal imeni I.M. Sechenova","volume":"82 4","pages":"65-9"},"PeriodicalIF":0.0,"publicationDate":"1996-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19925298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[The anticonstrictor effect of endothelial sensitivity to shear stress].","authors":"A M Mel'kumiants, S A Balashov, S P Kartamyshev","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Responses of the femoral artery to drops in transmural pressure and to norepinephrine revealed the anticonstrictor effect of the endothelium sensitivity upon a stress action. The effect was less obvious at high flow rate. The data obtained suggests that the endothelium sensitivity to stress inhibits the arterial constrictor responses irrespective of the nature of the constrictor stimuli.</p>","PeriodicalId":77130,"journal":{"name":"Fiziologicheskii zhurnal imeni I.M. Sechenova","volume":"82 4","pages":"93-101"},"PeriodicalIF":0.0,"publicationDate":"1996-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19925304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Parathyroid hormone--an endogenous modulator of vascular functional activity].","authors":"D N Khudaverdian, Iu Ia Chursina","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Parathyroidin was found to exert a dose-dependent effect on the systemic arterial pressure irrespective of its hypercalcemic effect. The former effect seems to depend in vitro on the term of the parathyroidin incubation with a tissue under study. Endogenous parathyroid hormone seems to play a specific role in modulation of the vessels functional activity.</p>","PeriodicalId":77130,"journal":{"name":"Fiziologicheskii zhurnal imeni I.M. Sechenova","volume":"82 4","pages":"102-7"},"PeriodicalIF":0.0,"publicationDate":"1996-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19926096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[The organization of the afferent and efferent projections in the system of the subiculum-supraoptic area of the hypothalamus in rats].","authors":"E A Lutsik","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77130,"journal":{"name":"Fiziologicheskii zhurnal imeni I.M. Sechenova","volume":"82 4","pages":"123-6"},"PeriodicalIF":0.0,"publicationDate":"1996-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19926099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Genetic and ontogenetic variability in the noradrenergic regulation of adrenocortical function].","authors":"N N Dygalo, G T Shishkina","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Corticosterone levels in the blood under restriction positively correlated with the hormone response to i.c.v. norepinephrine injection in 7 genetic groups of rats. Reactions to stress and norepinephrine simultaneously decreased in adult rats after prenatal glucocorticoid treatment. Prenatal stress or corticosterone treatment have a lasting effect on typosine hydroxylase (TH) activity and adrenoligands binding in the mice brain. Prenatal treatment increased TH activity in the noradrenergic system of the brain and decreased binding of radiolabelled prazosin, clonidine and dihydroalprenolol in some brain regions as well as stress reaction in mice. Thus, individual variations in adrenocortical stress response may be related to the differences in the function of the brain noradrenergic system.</p>","PeriodicalId":77130,"journal":{"name":"Fiziologicheskii zhurnal imeni I.M. Sechenova","volume":"82 4","pages":"15-20"},"PeriodicalIF":0.0,"publicationDate":"1996-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19926104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}