Experimental and clinical immunogenetics最新文献_第6页

The human T cell receptor alpha joining (TRAJ) genes. 人类T细胞受体α连接(TRAJ)基因。

Experimental and clinical immunogenetics Pub Date : 2000-01-01 DOI: 10.1159/000019129

D Scaviner, M P Lefranc

引用次数: 31

Childhood atopic asthma: positive association with a polymorphism of IL-4 receptor alpha gene but not with that of IL-4 promoter or Fc epsilon receptor I beta gene. 儿童特应性哮喘:与IL-4受体α基因多态性呈正相关，但与IL-4启动子或Fc epsilon受体I β基因多态性无关。

Experimental and clinical immunogenetics Pub Date : 2000-01-01 DOI: 10.1159/000019125

A Takabayashi, K Ihara, Y Sasaki, Y Suzuki, S Nishima, K Izuhara, N Hamasaki, T Hara

{"title":"Childhood atopic asthma: positive association with a polymorphism of IL-4 receptor alpha gene but not with that of IL-4 promoter or Fc epsilon receptor I beta gene.","authors":"A Takabayashi, K Ihara, Y Sasaki, Y Suzuki, S Nishima, K Izuhara, N Hamasaki, T Hara","doi":"10.1159/000019125","DOIUrl":"https://doi.org/10.1159/000019125","url":null,"abstract":"We examined the relative contributions of three representative candidate genes for atopy (Fc epsilon receptor I beta, IL-4, and IL-4 receptor alpha) to the development of atopic asthma. Four polymorphisms of the three candidate genes including Ile50Val and Gln551Arg of IL-4 receptor alpha, -590C/T of IL-4 promoter and Glu237Gly of Fc epsilon receptor I beta were studied in 100 patients with atopic asthma and 100 nonatopic controls in the northern Kyushu area in Japan. Among the four polymorphisms of the three candidate genes, the Ile50 allele of the IL-4 receptor alpha chain gene demonstrated an association with atopic asthma subjects (p = 0.044), especially in patients with onset at 2 years of age or earlier (p = 0.034) and in patients with moderate to severe atopic asthma (p = 0. 031). Gln551Arg of IL-4 receptor alpha, -590C/T of IL-4 promoter and Glu237Gly of Fc epsilon receptor I beta showed no association with atopic asthma. A slight linkage disequilibrium between Ile50Val and Gln551Arg polymorphisms of the IL-4 receptor alpha chain gene was observed in both patients and nonatopic controls. The identification of additional atopy genes in areas with a certain genetic background is essential for genetic diagnosis and to establish new therapeutic modalities for atopic asthma.","PeriodicalId":77124,"journal":{"name":"Experimental and clinical immunogenetics","volume":"17 2","pages":"63-70"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000019125","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21657632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 49

Characteristics of HLA class I and class II polymorphisms in Rwandan women. 卢旺达妇女HLAⅰ类和ⅱ类多态性特征

Experimental and clinical immunogenetics Pub Date : 2000-01-01 DOI: 10.1159/000019138

J Tang, E Naik, C Costello, E Karita, C Rivers, S Allen, R A Kaslow

{"title":"Characteristics of HLA class I and class II polymorphisms in Rwandan women.","authors":"J Tang, E Naik, C Costello, E Karita, C Rivers, S Allen, R A Kaslow","doi":"10.1159/000019138","DOIUrl":"https://doi.org/10.1159/000019138","url":null,"abstract":"Objective: To define HLA class I and class II polymorphisms in Rwandans.Methods: PCR-based HLA genotyping techniques were used to resolve variants of HLA-A, B, and C to their 2- or 4-digit allelic specificities, and those of DRB1 and DQB1 to their 4- or 5-digit alleles.Results: Frequencies of 14 A, 8 C, and 14 B specificities and of 13 DRB1 and 8 DQB1 alleles were >/=0.02 in a group of 280 Rwandan women. These major HLA factors produced 6 haplotypes extending across the class I and class II regions: A*01-Cw*04-B* 4501-DRB1*1503-DQB1*0602 (A1-Cw4-B12- DR15 - DQ6), A * 01 - Cw * 04 - B * 4901 -DRB1 * 1302-DQB1*0604 (A1-Cw4-B21-DR13-DQ6), A*30 - Cw*04 - B*15 - DRB1*1101 - DQB1*0301 (A19-Cw4-B15-DR11-DQ7), A*68-Cw*07-B* 4901-DRB1*1302-DQB1*0604(A28-Cw7-B21- DR13 - DQ6), A*30 - Cw*07 - B*5703 - DRB1* 1303-DQB1*0301(A19 - Cw7 - B17 - DR13 - DQ7), and A*74-Cw*07-B*4901-DRB1*1302-DQB1* 0604 (A19-Cw7-B21-DR13-DQ6), respectively. Collectively, these extended haplotypes accounted for about 19% of the total. Other apparent class I-class II haplotypes (e.g., Cw*17-B*42-DRB1*0302-DQB1*0402, Cw*06- B*58-DRB1*1102-DQB1*0301, and Cw*03- B*15-DRB1*03011-DQB1*0201) did not extend to the telomeric HLA-A locus, and other 3-locus class I haplotypes (e.g., A*68-Cw*04-B*15, A*74-Cw*04-B*15, and A*23-Cw*07-B*4901) completely or partially failed to link with any specific class II alleles.Discussion: Frequent recombinations appeared to occur between the three evolutionarily conserved HLA blocks carrying the class I and class II loci. The HLA class I profile seen in Rwandans was not directly comparable with those known in the literature, although the class II profile appeared to resemble those in several African populations. These data provide additional evidence for the extensive genetic diversity in Africans.","PeriodicalId":77124,"journal":{"name":"Experimental and clinical immunogenetics","volume":"17 4","pages":"185-98"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000019138","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21920517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 30

The Teleostei immunoglobulin heavy IGH genes. 远骨免疫球蛋白重IGH基因。

Experimental and clinical immunogenetics Pub Date : 2000-01-01 DOI: 10.1159/000019134

S Artéro, M P Lefranc

引用次数: 18

The human T cell receptor beta variable (TRBV) genes. 人类T细胞受体β变量(TRBV)基因。

Experimental and clinical immunogenetics Pub Date : 2000-01-01 DOI: 10.1159/000019123

G Folch, M P Lefranc

引用次数: 102

Organizations and gene duplications of the human and mouse MHC complement gene clusters. 人和小鼠MHC互补基因簇的组织和基因复制。

Experimental and clinical immunogenetics Pub Date : 2000-01-01 DOI: 10.1159/000019119

Z Yang, C Y Yu

{"title":"Organizations and gene duplications of the human and mouse MHC complement gene clusters.","authors":"Z Yang, C Y Yu","doi":"10.1159/000019119","DOIUrl":"https://doi.org/10.1159/000019119","url":null,"abstract":"The MHC complement gene cluster (MCGC) in most people contains thirteen structural genes, pseudogenes and gene segments. Novel genes RD, SKI2W, DOM3Z and RP1 are organized as two head-to-head gene pairs between complement gene Bf and the first locus of C4. Southern blot analysis shows that single-copy genes for DOM3Z are detectable in primates and other mammals. Sequence analyses revealed that the exon- intron structures of human and mouse DOM3Z genes are identical. Both human and mouse DOM3Z transcripts exhibit splice variants at the 5' regions, although the open reading frames remain identical. Cloning and characterization of the mouse RP1 cDNA revealed a reading frame for 254 amino acids with a bipartite nuclear localization signal close to the amino terminus. The mouse RP1 gene consists of 7 exons and spans 12.9 kb. Located in intron 4 of mouse RP1 is an endogenous retrovirus that probably confers the androgen-responsive expression of the Slp protein in certain male mice. The availability of the complete human and mouse MCGC genomic and cDNA sequences allows further deliberate analyses of gene duplications and evolution. The intergenic region between mouse SLP and C4 genes is more than six times larger than the corresponding region in humans. It contains the functional gene steroid CYP21A, long stretches of repetitive DNA elements, and three partially duplicated gene segments TNXA, SKI2W2 and RP2. The modular duplications of human and mouse RP-C4-CYP21-TNX (RCCX) are sharply different as SKI2W2 is absent in the human MCGC, and TNXA and RP2 are smaller in size but higher in sequence conservation in humans.","PeriodicalId":77124,"journal":{"name":"Experimental and clinical immunogenetics","volume":"17 1","pages":"1-17"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000019119","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21539669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

The human T cell receptor alpha variable (TRAV) genes. 人类T细胞受体α变量(TRAV)基因。

Experimental and clinical immunogenetics Pub Date : 2000-01-01 DOI: 10.1159/000019128

D Scaviner, M P Lefranc

引用次数: 66

Subject Index Vol. 16, 1999 主题索引1999年第16卷

Experimental and clinical immunogenetics Pub Date : 1999-11-01 DOI: 10.1159/000019117

F. Fakhfakh, A. Maâlej, H. Makni, M. Abid, J. Jouida, M. Zouali, Hammadi Ayadi, M. Ruhwald, A. E. Pedersen, M. Claesson, S. Thulesen, A. Jørgensen, J. Gerwien, M. Dohlsten, M. Nissen, N. Ødum, C. Röpke, R. Binder, A. Kress, M. Kirschfink, M. Ruiz, M. Lefranc, P. Cucchi-Mouillot, S. Lai, C. Carcassi, P. Silicani-Amoros, L. Floris, J. Amoros, B. Genetet, D. Haras, L. Contu, Dominique Scaviner, V. Barbié

引用次数: 0

Contents Vol. 16, 1999 目录1999年第16卷

Experimental and clinical immunogenetics Pub Date : 1999-11-01 DOI: 10.1159/000019118

F. Fakhfakh, A. Maâlej, H. Makni, M. Abid, J. Jouida, M. Zouali, Hammadi Ayadi, M. Ruhwald, A. E. Pedersen, M. Claesson, S. Thulesen, A. Jørgensen, J. Gerwien, M. Dohlsten, M. Nissen, N. Ødum, C. Röpke, R. Binder, A. Kress, M. Kirschfink, M. Ruiz, M. Lefranc, P. Cucchi-Mouillot, S. Lai, C. Carcassi, P. Silicani-Amoros, L. Floris, J. Amoros, B. Genetet, D. Haras, L. Contu, Dominique Scaviner, V. Barbié

引用次数: 0

Author Index Vol. 16, 1999 作者索引1999年第16卷

Experimental and clinical immunogenetics Pub Date : 1999-11-01 DOI: 10.1159/000019116

引用次数: 0