European journal of cancer. Part B, Oral oncology最新文献

{"title":"Oral verruca vulgaris in a bone marrow transplant patient: A case report and review of literature","authors":"A. Barasch ,&nbsp;E. Eisenberg ,&nbsp;J.A. D'Ambrosio ,&nbsp;K. Nuki ,&nbsp;D.E. Peterson","doi":"10.1016/0964-1955(95)00072-0","DOIUrl":"10.1016/0964-1955(95)00072-0","url":null,"abstract":"<div><p>Viral infections can cause severe morbidity in immunosuppressed cancer patients. A case of rapidly enlarging, biopsy-documented oral verruca vulgaris in a patient undergoing conditioning chemotherapy prior to bone marrow transplantation (BMT) is described. Human papillomavirus infections in immunosuppressed patients are discussed.</p></div>","PeriodicalId":77118,"journal":{"name":"European journal of cancer. Part B, Oral oncology","volume":"32 2","pages":"Pages 137-139"},"PeriodicalIF":0.0,"publicationDate":"1996-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0964-1955(95)00072-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19708476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nuclear morphometry in squamous cell carcinoma (SCC) of the tongue","authors":"C. Giardina ,&nbsp;D.M. Caniglia ,&nbsp;M. D'Aprile ,&nbsp;T. Lettini ,&nbsp;G. Serio ,&nbsp;T. Cipriani ,&nbsp;R. Ricco ,&nbsp;V.Pesce Delfino","doi":"10.1016/0964-1955(95)00062-3","DOIUrl":"10.1016/0964-1955(95)00062-3","url":null,"abstract":"<div><p>In the histological grading of oral squamous cell carcinoma (OSCC) nuclear features are very important. Nevertheless evaluation is usually performed in a subjective and not highly reproducible way. The aim of this work was to investigate the relationship between nuclear shape and survival in 30 cases of carcinoma of the tongue. All the patients were divided into two groups: short-term survival and long-term survival. Twenty nuclei for each tumour were submitted to a morphometrical study by the shape analytical morphometry (SAM) software system. It was thus possible to evaluate not only nuclear dimensions but also nuclear contour irregularities and nuclear shape asymmetries. Multivariate discriminant analysis (MDA) of the quantitative parameters obtained by the morphometrical study distinguished the patients of the two groups with only a 10% error; moreover successful cluster analysis was performed by using Fourier parameters. Both these sets of results were achieved mainly owing to the parameters for contour irregularities.</p></div>","PeriodicalId":77118,"journal":{"name":"European journal of cancer. Part B, Oral oncology","volume":"32 2","pages":"Pages 91-96"},"PeriodicalIF":0.0,"publicationDate":"1996-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0964-1955(95)00062-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19709202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum vitamins' status in oral leucoplakias—a preliminary study","authors":"G. Ramaswamy ,&nbsp;V.R. Rao ,&nbsp;S.V. Kumaraswamy ,&nbsp;N. Anantha","doi":"10.1016/0964-1955(95)00076-3","DOIUrl":"10.1016/0964-1955(95)00076-3","url":null,"abstract":"<div><p>Vitamins, such as A, β carotene, C, E, B₁₂ and folate, are the micronutrients with the strongest evidence of having a link to cancer prevention and control. Deficiency of these vitamins at the dietary, systemic or mucosal level will interact with tobacco use and increase the risk of oral precancerous lesions. The objective of this study was to (1) establish the baseline circulating levels of these vitamins in our normal population with and without tobacco use and (2) compare these levels with the values obtained in cases of oral leucoplakias. 50 normal controls with 25 each in chewers and non-chewers, matched for age and sex, were selected. 50 cases of oral leucoplakias (clinically detectable white patches) from the field constituted the study group. Simultaneous measurement of serum vitamin B₁₂ and folate were carried out by radioassay. The other serum vitamins were estimated spectrophotometrically. Except for serum vitamin E, all the other serum vitamin levels were significantly decreased in oral leucoplakias compared to the controls. Cancer chemopreventive agents acting as inhibitors of both initiation and promotion, as analysed in our population, is promising for further intervention trials.</p></div>","PeriodicalId":77118,"journal":{"name":"European journal of cancer. Part B, Oral oncology","volume":"32 2","pages":"Pages 120-122"},"PeriodicalIF":0.0,"publicationDate":"1996-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0964-1955(95)00076-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19708472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic implications of sialosyl-Tn antigen expression in sinonasal intestinal-type adenocarcinoma","authors":"A. Franchi ,&nbsp;O. Gallo","doi":"10.1016/0964-1955(95)00075-5","DOIUrl":"10.1016/0964-1955(95)00075-5","url":null,"abstract":"<div><p>The expression of the mucin antigen sialosyl-Tn (S-Tn) was evaluated immunohistochemically in a series of 30 intestinal type adenocarcinomas of the nasal cavities and paranasal sinuses to assess the relationship between the histological features of the lesions and their clinical behaviour. In grades 1 and 2 adenocarcinomas, the staining localised at the apical pole or within the cytoplasm of neoplastic cells, and in the content of glandular structures. Grade 3 adenocarcinomas had a very scanty expression of the antigen. Mucinous adenocarcinomas showed an intense immunoreaction within the cell cytoplasm and in the extracellular mucous pools. Conversely, non-neoplastic sinonasal mucosa had a very focal distribution of the antigen. Immunostaining was scored according to the percentage of low power microscopic fields showing positivity. Twenty-one adenocarcinomas (70%) were considered positive. No significant relationship was found between S-Tn positivity and the histological degree of differentiation of the lesion. The 5-year survival rate and disease-free interval of patients with S-Tn positive adenocarcinomas were significantly lower than those with negative adenocarcinomas (17.8% versus 72%, <em>P</em> = 0.0001; 16.6% versus 40%, <em>P</em> = 0.0001, respectively). These results indicate that S-Tn immunostaining appears to be a significant prognostic factor in patients with sinonasal intestinal type adenocarcinoma.</p></div>","PeriodicalId":77118,"journal":{"name":"European journal of cancer. Part B, Oral oncology","volume":"32 2","pages":"Pages 123-127"},"PeriodicalIF":0.0,"publicationDate":"1996-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0964-1955(95)00075-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19708473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sweet's syndrome in a patient with oral cancer associated with radiotherapy","authors":"E.H. van der Meij ,&nbsp;J.B. Epstein ,&nbsp;J. Hay ,&nbsp;V. Ho ,&nbsp;K. Lerner","doi":"10.1016/0964-1955(95)00070-4","DOIUrl":"10.1016/0964-1955(95)00070-4","url":null,"abstract":"<div><p>Approximately 10–20% of the reported patients with acute febrile neutrophilic dermatosis (Sweet's syndrome) have an associated neoplasm. Oral findings of Sweet's syndrome are rarely reported, and no cases in patients with oral cancer have been reported to date. This report describes the clinico- and histopathological findings of Sweet's syndrome in a patient with oral cancer, treated with radiotherapy. After 10 fractions of external beam radiotherapy, treatment was interrupted because of severe oral mucositis which extended beyond the radiation fields. Two days later the patient developed multiple tender skin lesions and the diagnosis Sweet's syndrome was made. Skin and oral lesions resolved without additional treatment and did not recur upon resuming radiotherapy. As suggested in previous case reports, tumour antigens might play a role in the development of Sweet's syndrome. In this case, irradiation therapy may also have been a trigger for this syndrome.</p></div>","PeriodicalId":77118,"journal":{"name":"European journal of cancer. Part B, Oral oncology","volume":"32 2","pages":"Pages 133-136"},"PeriodicalIF":0.0,"publicationDate":"1996-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0964-1955(95)00070-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19708475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic factors of survival in a cohort of head and neck cancer patients in Oslo","authors":"H. Faye-Lund ,&nbsp;M. Abdelnoor","doi":"10.1016/0964-1955(95)00073-9","DOIUrl":"10.1016/0964-1955(95)00073-9","url":null,"abstract":"<div><p>A cohort of 433 Oslo patients with head and neck (H/N) carcinomas was analysed for prognostic factors of survival. Mean observation time was 635 days, the distribution of men and women was 2:1 and the mean age was 64.5 years. Tumour localisations were: oral cavity 32.1%, oro/hypopharynx 19.3%, larynx 22.6% and others 25.2%. Stage distribution was: stage I: 21.0%, stage II: 22.6%, stage III: 18.7% and stage IV: 37.4%. Pragmatic strategy showed independent prognostic factors of survival to be gender, age, tumour localisation and stage. A model of predicting 3 year survival was generated. An explanatory approach showed that female patients had a 38% lower risk of mortality compared to male patients after controlling for age, stage and tumour localisation. Comparing observed to expected mortality of the age and gender matched Norwegian population, showed excess risk of death among male compared to female patients when also adjusted for demographic confounders.</p></div>","PeriodicalId":77118,"journal":{"name":"European journal of cancer. Part B, Oral oncology","volume":"32 2","pages":"Pages 83-90"},"PeriodicalIF":0.0,"publicationDate":"1996-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0964-1955(95)00073-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19709201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stage of disease confounds apparent relationship between levels of N-ras and duration of survival in head and neck tumours","authors":"K.M. Wilson ,&nbsp;R.L. Sonke ,&nbsp;J.S. McDonald ,&nbsp;P.J. Stambrook ,&nbsp;L.J. Pavelic ,&nbsp;P. Klusman ,&nbsp;E. Okum ,&nbsp;J. Neenan ,&nbsp;J.L. Gluckman ,&nbsp;Z.P. Pavelic","doi":"10.1016/0964-1955(95)00081-X","DOIUrl":"10.1016/0964-1955(95)00081-X","url":null,"abstract":"<div><p>The objective of this study was to determine whether elevated levels of N-ras correlated with clinicopathological data. Complete clinical data were available on 133 of 481 patients surgically treated for squamous cell carcinoma of the head and neck (SCCHN) who had immunohistochemical data for N-ras. Advanced stages of disease were strongly related to the staining for N-ras in tumour cells (<em>P</em> = 0.0031). The stage of disease was inversely related to duration of survival (<em>P</em> = 0.0017). Initial statistical evaluation revealed an apparent correlation between survival and N-ras staining. However, duration was found to be <em>independent</em> of the level of N-ras. The illusory relationship initially was a result of the confounding effect of the stage of disease.</p></div>","PeriodicalId":77118,"journal":{"name":"European journal of cancer. Part B, Oral oncology","volume":"32 2","pages":"Pages 73-75"},"PeriodicalIF":0.0,"publicationDate":"1996-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0964-1955(95)00081-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19709199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tenascin: Growth and adhesion modulation—Extracellular matrix degrading function: an in Vitro study","authors":"P. Shrestha ,&nbsp;S. Sumitomo ,&nbsp;C.H. Lee ,&nbsp;K. Nagahara ,&nbsp;A. Kamegai ,&nbsp;T. Yamanaka ,&nbsp;H. Takeuchi ,&nbsp;M. Kusakabe ,&nbsp;M. Mori","doi":"10.1016/0964-1955(95)00074-7","DOIUrl":"10.1016/0964-1955(95)00074-7","url":null,"abstract":"<div><p>Tenascin (TN), a recently characterised extracellular matrix protein, largely confined to the process with the development of embryo in areas of epithelial-mesenchymal interactions and in areas where there are morphogenetic movements and tissue patterning, has a highly restricted expression in adult tissues. The expression of TN is enhanced in a variety of human neoplastic lesions. However, function(s) and molecular mechanisms of enhanced expression in neoplastic lesions remain unclear. We employed human tongue carcinoma cells (SCCKN), human salivary gland adenocarcinoma cells (SGT-1), normal mouse embryonic fibroblasts (NIH3T3-3) and <em>K-ras</em>-2 transformed fibroblasts (Cle-H3) in an <em>in vitro</em> study to elucidate the biological roles of TN. In <em>in vitro</em> studies, all the cell lines examined had enhanced secretion of TN in the presence of transforming growth factor-beta in a dose-dependent manner and TN itself was found to possess a growth-enhancing activity. Moreover, studies on adhesion of the cell lines on coated substrates of fibronectin (FN), laminin (LN), tenascin (TN), TN/FN and TN/LN showed that all the cells adhere and spread well on FN and LN. However, on TN they attach poorly and remain rounded. The relative concentrations of TN and FN affected the cellular adhesion and morphology. In SCCKN and SGT-1, but not in NIH3T3 and Cle-He3 fibroblasts, a higher concentration of TN inhibited cellular adhesion on fibronectin, suggesting that cells attach poorly on TN, it may interfere with the action of fibronectin, and the relative concentrations of TN, FN or LN may affect cellular adhesion and morphology which may differ in different cell types. When TN was added in the growth medium of exponentially growing cells, the cells lost their cell to cell contact and were seen to be separating. The presence of these extracellular matrix proteins were further tested to determine whether they could modulate the secretion of proteolytic enzymes responsible for extracellular matrix degradation by tumour cells, when the neoplastic cells but not the non-neoplastic cells grown on FN/TN substrate showed positive immunofluorescence for collagenase. FN, LN or TN alone did not induce collagenase in the tumour cells. If the same is true <em>in vivo</em>, although a number of factors and interactions may implicate the ultimate outcome, the enhanced expression of TN in neoplastic lesions may have potential implications for tumour growth, differentiation, cellular adhesion, invasion and metastasis.</p></div>","PeriodicalId":77118,"journal":{"name":"European journal of cancer. Part B, Oral oncology","volume":"32 2","pages":"Pages 106-113"},"PeriodicalIF":0.0,"publicationDate":"1996-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0964-1955(95)00074-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19708470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malignant salivary gland neoplasms: a cytogenetic study of 19 cases","authors":"C. Martins,&nbsp;I. Fonseca,&nbsp;L. Roque,&nbsp;A.E. Pinto,&nbsp;J. Soares","doi":"10.1016/0964-1955(95)00078-X","DOIUrl":"10.1016/0964-1955(95)00078-X","url":null,"abstract":"<div><p>A group of 19 malignant salivary gland neoplasms of various histological types (mucoepidermoid carcinoma, acinic cell carcinoma, adenoid cystic carcinoma, epithelial-myoepithelial carcinoma, myoepithelial carcinoma, basal cell adenocarcinoma, carcinoma ex-pleomorphic adenoma, ductal carcinoma, adenocarcinoma not otherwise specified and undifferentiated carcinoma) were cytogenetically investigated. Previous karyotypic information revealed deletion of the long arm of chromosome 6, loss of chromosome Y and the gain of chromosome 8 as the most recurrent deviations found in these neoplasms. Clonal chromosome aberrations were detected in 11 cases of this series. In 7 of them there were only numerical deviations (gain of chromosomes 2, 7, 8, 10 and X and loss of chromosomes 18, 21 and Y) without concomitant structural anomalies. Structural rearrangements such as t(2;7), t(6;16), t(6;9) and t(1;1) translocations were found in two mucoepidermoid carcinomas, one adenoid cystic carcinoma and one ductal carcinoma, respectively. The wide spectrum of changes found in this group of neoplasms may reflect the diversity in their histogenesis and differentiation phenotypes.</p></div>","PeriodicalId":77118,"journal":{"name":"European journal of cancer. Part B, Oral oncology","volume":"32 2","pages":"Pages 128-132"},"PeriodicalIF":0.0,"publicationDate":"1996-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0964-1955(95)00078-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19708474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of bFGF, KGF and FGF receptors on normal oral mucosa and SCC","authors":"M. Partridge ,&nbsp;S. Kiguwa ,&nbsp;Y. Luqmani ,&nbsp;J.D. Langdon","doi":"10.1016/0964-1955(95)00056-9","DOIUrl":"10.1016/0964-1955(95)00056-9","url":null,"abstract":"<div><p>Fibroblast growth factors (FGFs) are involved in the transmission of signals between the epithelia and connective tissue, and influence epidermal growth and differentiation. They are thought to be important in the restoration of normal tissues after injury and aberrant expression may also play a role in tumorigenesis. However, no information is available on the nature of cells within oral mucosa which synthesise and/or respond to FGFs. We have screened normal oral mucosa and oral squamous cell carcinoma (SCC) for expression of bFGF by immunohistology and northern analysis and used RT-PCR to look for transcripts for KGF and the high-affinity FGF receptors FGFR1 and FGFR2. Transcripts for bFGF were detected in normal and malignant oral mucosa and KGF within connective tissue elements. The predominant FGF receptor detected in the epidermis and oral mucosa was FGFR2 which binds KGF with greater affinity than bFGF. Production of KGF by connective tissue components and synthesis of the high-affinity KGF receptor, FGFR2, by oral keratinocytes provides circumstantial evidence for a paracrine growth control loop with KGF synthesised within the lamina propria or tumour stroma influencing the proliferation and maturation of both normal oral epithelium and SCC.</p></div>","PeriodicalId":77118,"journal":{"name":"European journal of cancer. Part B, Oral oncology","volume":"32 2","pages":"Pages 76-82"},"PeriodicalIF":0.0,"publicationDate":"1996-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0964-1955(95)00056-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19709200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}