European journal of cancer. Part B, Oral oncology最新文献_第3页

Modifications of the microflora of the oral cavity arising during immunosuppressive chemotherapy 免疫抑制化疗引起的口腔微生物群的改变

European journal of cancer. Part B, Oral oncology Pub Date : 1996-09-01 DOI: 10.1016/0964-1955(96)00006-1

J.-L. Sixou , O. de Medeiros-Batista , M. Bonnaure-Mallet

引用次数: 40

Absence of Retinoblastoma gene product in human primary oral cavity carcinoma 人原发性口腔癌中视网膜母细胞瘤基因产物的缺失

European journal of cancer. Part B, Oral oncology Pub Date : 1996-09-01 DOI: 10.1016/0964-1955(96)00025-5

Z.P. Pavelic , M. Lasmar , LJ Pavelic , C. Sorensen , PJ Stambrook , N. Zimmermann , J.J Gluckman

{"title":"Absence of Retinoblastoma gene product in human primary oral cavity carcinoma","authors":"Z.P. Pavelic , M. Lasmar , LJ Pavelic , C. Sorensen , PJ Stambrook , N. Zimmermann , J.J Gluckman","doi":"10.1016/0964-1955(96)00025-5","DOIUrl":"https://doi.org/10.1016/0964-1955(96)00025-5","url":null,"abstract":"<div><p>Oral cavity cancer is a major health concern worldwide. Despite advances in surgery, radiotherapy and chemotherapy over the past 35 years, there has been no significant enhancement in the survival of oral cavity cancer patients. Improved survival will require identification of reliable prognostic markers that provide a rational basis for assessment of risk for progression. The altered retinoblastoma (RB) gene has been linked to the hereditary retinoblastoma. This gene is defective in several types of human malignancies. The intent of this study was to evaluate the role of the RB gene in oral cavity tumorigenesis and to explore whether or not there is a relationship between the loss of RB protein and each of several clinicopathological parameters in oral cavity carcinomas. We have analysed the expression of the RB gene in four cell Unes (J82, ML1, SaOS2 and WERI-RB-1), 182 oral cavity carcinomas (75 T1 and 107 T3 and T4 lesions) and 55 normal tissues adjacent to cancer by means of an immunohistochemical method and Western immunoblotting. The expression of RB protein was then correlated with clinical outcome in the patients with primary tumours. The significantly higher rate of altered RB expression was found in advanced oral cavity tumours (40 of 107; 37%) in comparison with low grade tumours (9 of 75; 7%). In T3 and T4 tumours, RB gene expression did not correlate with presence or absence of lymph node metastasis, degree of differentiation and patient survival. However, in the Tl cohort, poorer survival rate was seen for those patients who had a tumour with loss of RB protein. This study suggests that tumours in which the RB protein was altered were more aggressive than tumours in which the RB protein was present and that loss of RB protein in oral cavity cancer may be a prognostic variable of tumour progression.</p></div>","PeriodicalId":77118,"journal":{"name":"European journal of cancer. Part B, Oral oncology","volume":"32 5","pages":"Pages 347-351"},"PeriodicalIF":0.0,"publicationDate":"1996-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0964-1955(96)00025-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92010350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 38

Studies on promoting activity of Taiwan betel quid ingredients in hamster buccal pouch carcinogenesis 台湾槟榔液成分对仓鼠颊袋癌促进作用的研究

European journal of cancer. Part B, Oral oncology Pub Date : 1996-09-01 DOI: 10.1016/0964-1955(96)00018-8

Y.-T. Jin , S.-T. Tsai , T.-Y. Wong , F.-F. Chen , R.M.-Y. Chen

{"title":"Studies on promoting activity of Taiwan betel quid ingredients in hamster buccal pouch carcinogenesis","authors":"Y.-T. Jin , S.-T. Tsai , T.-Y. Wong , F.-F. Chen , R.M.-Y. Chen","doi":"10.1016/0964-1955(96)00018-8","DOIUrl":"10.1016/0964-1955(96)00018-8","url":null,"abstract":"<div><p>Previous studies indicated that Taiwan betel quid is a promoter rather than an initiator during the carcinogenesis of hamster buccal pouch carcinoma. The maximum promoting activity can be demonstrated 24 weeks after betel quid implantation, following an initial application of 0.5% DMBA (7,12-dimethyl benzanthracene) three times per week for 4 weeks. In the present study, components of Taiwan betel quid and its additives (dry betel nut fibre, piper betel, slaked lime, cold aqueous extract, and hot aqueous extract) were applied respectively or in various combinations to investigate their promoting activity. One hundred and thirty Syrian hamsters were divided into 13 groups based on different combinations of the betel quid ingredients applied. The incidence of tumours in the hamster buccal pouch was significantly higher in groups exposed to dry betel nut fibre (<em>P</em> < 0.01) and cold aqueous extract (<em>P</em> < 0.05). The results indicate that betel nut fibre and cold aqueous extract are the major components of betel quid that may promote carcinogenesis in the hamster buccal pouch.</p></div>","PeriodicalId":77118,"journal":{"name":"European journal of cancer. Part B, Oral oncology","volume":"32 5","pages":"Pages 343-346"},"PeriodicalIF":0.0,"publicationDate":"1996-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0964-1955(96)00018-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19908035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 37

Expression of cytokeratins in Warthin's tumour (adenolymphoma) of parotid glands: Specific detection of individual cytokeratin types by monoclonal antibodies 细胞角蛋白在腮腺Warthin瘤(腺淋巴瘤)中的表达:单克隆抗体特异性检测单个细胞角蛋白类型

European journal of cancer. Part B, Oral oncology Pub Date : 1996-09-01 DOI: 10.1016/0964-1955(96)00023-1

C. Li, Y. Okamoto, H. Ohmura, K. Ogawa, P. Shrestha, M. Mori

{"title":"Expression of cytokeratins in Warthin's tumour (adenolymphoma) of parotid glands: Specific detection of individual cytokeratin types by monoclonal antibodies","authors":"C. Li, Y. Okamoto, H. Ohmura, K. Ogawa, P. Shrestha, M. Mori","doi":"10.1016/0964-1955(96)00023-1","DOIUrl":"10.1016/0964-1955(96)00023-1","url":null,"abstract":"<div><p>This study evaluated the distribution of cytokeratins detected by monoclonal antibodies directed against individual keratin proteins in normal human salivary glands and epithelial tumour cells of Warthin's tumour arising in parotid glands to determine a more precise mapping of their cellular distribution. The normal salivary ducts showed the presence of cytokeratins 7, 8, 18 and 19 in the intercalated, striated and excretory ducts, the primary keratins of stratified and simple epithelia with a profile very similar to the non-cornified epithelium of the oral mucosa. The basally located cells of salivary gland ducts other than myoepithelial cells were reactive for keratins 7 and 19 suggesting a close similarity in profile of keratin in the basal cells of the oral epithelium. In Warthin's tumour, keratins 7, 8, 18 and 19 were consistently detected in the epithelial cells of the tumour, a profile with a tendency to mimic the same in normal ductal epithelium. The distribution, however, was diverse and a heterogeneity was observed in the basal and luminal cells of Warthin's tumour which differed even in different areas of the same tumour specimen.</p></div>","PeriodicalId":77118,"journal":{"name":"European journal of cancer. Part B, Oral oncology","volume":"32 5","pages":"Pages 352-358"},"PeriodicalIF":0.0,"publicationDate":"1996-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0964-1955(96)00023-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19908037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Methodological variations for p53 detection by immunohistochemistry 免疫组织化学检测p53的方法学差异

European journal of cancer. Part B, Oral oncology Pub Date : 1996-09-01 DOI: 10.1016/0964-1955(96)83288-X

G.R. Ogden

引用次数: 3

Imaging and staging of head and neck cancer using a low pH in-111-bleomycin complex 使用低pH in-111-博莱霉素复合物对头颈癌的成像和分期

European journal of cancer. Part B, Oral oncology Pub Date : 1996-09-01 DOI: 10.1016/0964-1955(96)00005-X

K.J.A. Kairemo , H.A. Ramsay , T. Paavonen , S. Bondestam

{"title":"Imaging and staging of head and neck cancer using a low pH in-111-bleomycin complex","authors":"K.J.A. Kairemo , H.A. Ramsay , T. Paavonen , S. Bondestam","doi":"10.1016/0964-1955(96)00005-X","DOIUrl":"10.1016/0964-1955(96)00005-X","url":null,"abstract":"<div><p>Bleomycin (BLM), a natural antibiotic toxic to dividing cells has been used for treatment of several forms of cancer. BLM has been labelled with various cations but most have turned out to be unstable <em>in vivo</em>. In-BLM has demonstrated high bone marrow uptake, but by using an In-111-bleomycin complex (BLMC) formed at low pH, the low <em>in vivo</em> stability and high bone marrow uptake can be avoided. Our premise is to combine radiotherapy and chemotherapy by using radionuclide-BLMC.</p><p>In this study we used In-111-A′2<sub><em>a</em>−<em>c</em></sub>-BLMC in 28 head and neck cancer patients. Scintigraphic findings were compared to those of surgery, pre-operative radiology and proliferation markers. The injected patient activity was approximately 85 MBq, 100 MBq/mg.</p><p>The half-life of In-111 activity in serum varied from 1.5 to 3.1 h, and in urine from 1.4 to 3.7 h. More than 95% of the urine activity was excreted within 24 h. From biopsies obtained from surgical specimens of 22 patients the absolute uptakes in tumour tissues varied between 0.10 and 0.95 × 10<sup>−3</sup>% ID/g. Uptakes in normal tissues varied from 0.01 to 0.32 × 10<sup>−3</sup>% ID/g, and were always lower than in malignant tissues of the same patients. All patients were examined on the injection day with ultrasonography of the neck. Using In-111-BLMC we missed small metastatic lymph nodes (< 1 cm) in 2 patients, but there were no false positive findings. The critical organ from the dosimetric point of view was the kidney. The absorbed radiation doses with these injected activities were 19 mGy in liver, 75 mGy in kidney and 1.0 mGy in whole body (5 h mean residence time). Our results indicate that In-111-BLMC targets head and neck cancer, and identifies metastatic spread. It could possibly be applied with higher activities for adjuvant Auger-electron therapy of head and neck cancer.</p></div>","PeriodicalId":77118,"journal":{"name":"European journal of cancer. Part B, Oral oncology","volume":"32 5","pages":"Pages 311-321"},"PeriodicalIF":0.0,"publicationDate":"1996-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0964-1955(96)00005-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19908715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Bilateral metastatic spread of testicular teratoma to mandibular condyles 双侧睾丸畸胎瘤向下颌髁转移扩散

European journal of cancer. Part B, Oral oncology Pub Date : 1996-09-01 DOI: 10.1016/0964-1955(96)00001-2

S.R. Porter , Z. Chaudhry , M.J. Griffiths , C. Scully , J. Kabala , E. Whipp

引用次数: 19

Oral manifestations of HIV infection HIV感染的口腔表现

European journal of cancer. Part B, Oral oncology Pub Date : 1996-09-01 DOI: 10.1016/0964-1955(96)83289-1

R.A. Cawson

引用次数: 0

Evaluation of inter-incisor distance as an objective criterion of the severity of oral submucous fibrosis in Karachi, Pakistan 评价切牙间距离作为判断巴基斯坦卡拉奇口腔黏膜下纤维化严重程度的客观标准

European journal of cancer. Part B, Oral oncology Pub Date : 1996-09-01 DOI: 10.1016/0964-1955(96)00009-7

R. Mäher , R. Sankaranarayanan , N.W. Johnson , K.A.A.S. Warnakulasuriya

引用次数: 16

Pathogenesis of oral Kaposi's sarcoma in HIV-infection: Relevance of endogenous glucocorticoid excess in blood and saliva 口腔卡波西肉瘤在hiv感染中的发病机制:血液和唾液中内源性糖皮质激素过量的相关性

European journal of cancer. Part B, Oral oncology Pub Date : 1996-07-01 DOI: 10.1016/0964-1955(95)00089-5

C.O. Enwonwu

{"title":"Pathogenesis of oral Kaposi's sarcoma in HIV-infection: Relevance of endogenous glucocorticoid excess in blood and saliva","authors":"C.O. Enwonwu","doi":"10.1016/0964-1955(95)00089-5","DOIUrl":"10.1016/0964-1955(95)00089-5","url":null,"abstract":"<div><p>Endogenous glucocorticoid excess with concomitant hypercortisolaemia and increased saliva level of the free active hormone, is a common feature of HIV-infected/AIDS patients. Exposure of the oral tissues to virtually uninterrupted high burden of glucocorticoids through saliva may contribute to the high frequency of oral Kaposi's sacoma (KS) in these patients. AIDS-KS cells contain unusually high levels of glucocorticoid receptor protein and recent studies indicate that growth of these cells in culture is significantly stimulated by glucocorticoids, particularly in the presence of growth factors, such as oncostatin-M. The suggestion that glucocorticoid excess may be important in the pathogenesis of KS in AIDS is not in conflict with the suspected aetiological role of newly reported KS-associated herpesviruses (KSHV), since steroid hormones may upregulate the expression of the viral gene. The latter is consistent with the observation that infection by specific oncogenic viruses does not necessarily result in cancers in the human, and does require the presence of other cellular factors or events.</p></div>","PeriodicalId":77118,"journal":{"name":"European journal of cancer. Part B, Oral oncology","volume":"32 4","pages":"Pages 271-274"},"PeriodicalIF":0.0,"publicationDate":"1996-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0964-1955(95)00089-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19747916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4