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Current studies in hematology and blood transfusion最新文献

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New strategies in the development of thrombolytic agents. 溶栓药物发展的新策略。
Current studies in hematology and blood transfusion Pub Date : 1991-01-01 DOI: 10.1159/000419340
H R Lijnen, D Collen
{"title":"New strategies in the development of thrombolytic agents.","authors":"H R Lijnen, D Collen","doi":"10.1159/000419340","DOIUrl":"https://doi.org/10.1159/000419340","url":null,"abstract":"Recombinant DNA technology has allowed large-scale production of the physiological, fibrin-specific, plasminogen activators tissue-type plasminogen activator (t-PA) and single-chain urokinase-type plasminogen activator (scu-PA). The results of clinical trials with these agents, mainly for the treatment of acute myocardial infarction, have revealed a limited fibrin specificity at the large therapeutic doses required for efficient thrombolysis. Mutants and variants of t-PA and scu-PA have given important information on structure-function relationships in these proteins and have resulted in rt-PA variants with significantly prolonged half-lives in vivo. Construction of chimaeric plasminogen activators containing various portions of t-PA and scu-PA has produced functionally active enzymes, however with a lower fibrin-affinity than wild-type t-PA. The promise of antibody targeting and the use of synergistic combinations of thrombolytic agents remains to be further investigated. We anticipate that eventually these research lines will yield artificial plasminogen activators with improved efficacy, risk/benefit and cost/benefit ratios.","PeriodicalId":77091,"journal":{"name":"Current studies in hematology and blood transfusion","volume":" 58","pages":"69-72"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000419340","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13113122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
The molecular basis of von Willebrand disease. 血管性血友病的分子基础。
Current studies in hematology and blood transfusion Pub Date : 1991-01-01 DOI: 10.1159/000419342
T Vink, J J Sixma
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引用次数: 0
Therapeutic hemapheresis in the 1990s. 20世纪90年代的治疗性采血。
Current studies in hematology and blood transfusion Pub Date : 1990-01-01
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引用次数: 0
Viscosity as the symptom leading to plasma exchange. 黏度是导致血浆交换的症状。
Current studies in hematology and blood transfusion Pub Date : 1990-01-01 DOI: 10.1159/000418562
L Guillevin, A Bussel, F Schooneman, Z Amoura
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引用次数: 2
The risk/benefit equation for therapeutic plasma exchange. Analysis of the rationale for and the safety aspects of therapeutic plasma exchange. 治疗性血浆交换的风险/收益方程。分析治疗性血浆置换的基本原理和安全性。
Current studies in hematology and blood transfusion Pub Date : 1990-01-01 DOI: 10.1159/000418552
J P Isbister
{"title":"The risk/benefit equation for therapeutic plasma exchange. Analysis of the rationale for and the safety aspects of therapeutic plasma exchange.","authors":"J P Isbister","doi":"10.1159/000418552","DOIUrl":"https://doi.org/10.1159/000418552","url":null,"abstract":"","PeriodicalId":77091,"journal":{"name":"Current studies in hematology and blood transfusion","volume":" 57","pages":"10-30"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000418552","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13423595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Experience with low-density lipoprotein apheresis by polyclonal and monoclonal anti-apolipoprotein B antibodies and by dextran sulfate cellulose. 具有多克隆和单克隆抗载脂蛋白B抗体和葡聚糖硫酸盐纤维素低密度脂蛋白分离的经验。
Current studies in hematology and blood transfusion Pub Date : 1990-01-01 DOI: 10.1159/000418561
W F Riesen
{"title":"Experience with low-density lipoprotein apheresis by polyclonal and monoclonal anti-apolipoprotein B antibodies and by dextran sulfate cellulose.","authors":"W F Riesen","doi":"10.1159/000418561","DOIUrl":"https://doi.org/10.1159/000418561","url":null,"abstract":"","PeriodicalId":77091,"journal":{"name":"Current studies in hematology and blood transfusion","volume":" 57","pages":"208-19"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000418561","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13423600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Plasma exchange in nephrological diseases. 肾脏疾病的血浆交换。
Current studies in hematology and blood transfusion Pub Date : 1990-01-01 DOI: 10.1159/000418557
P D Mason, C D Pusey
{"title":"Plasma exchange in nephrological diseases.","authors":"P D Mason, C D Pusey","doi":"10.1159/000418557","DOIUrl":"https://doi.org/10.1159/000418557","url":null,"abstract":"","PeriodicalId":77091,"journal":{"name":"Current studies in hematology and blood transfusion","volume":" 57","pages":"152-66"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000418557","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13302310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Plasmapheresis to treat human T lymphotropic virus type I-associated myelopathy. 血浆置换治疗人类嗜T淋巴病毒i型相关脊髓病
Current studies in hematology and blood transfusion Pub Date : 1990-01-01 DOI: 10.1159/000418560
H Matsuo, T Nakamura, K Shibayama, M Motomura, K Nagasato, G Takeo, M Tsujihata, S Nagataki
{"title":"Plasmapheresis to treat human T lymphotropic virus type I-associated myelopathy.","authors":"H Matsuo, T Nakamura, K Shibayama, M Motomura, K Nagasato, G Takeo, M Tsujihata, S Nagataki","doi":"10.1159/000418560","DOIUrl":"https://doi.org/10.1159/000418560","url":null,"abstract":"","PeriodicalId":77091,"journal":{"name":"Current studies in hematology and blood transfusion","volume":" 57","pages":"198-207"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000418560","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13423599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Apheresis in transition. 过渡中的分离。
Current studies in hematology and blood transfusion Pub Date : 1990-01-01 DOI: 10.1159/000418550
H G Klein
{"title":"Apheresis in transition.","authors":"H G Klein","doi":"10.1159/000418550","DOIUrl":"https://doi.org/10.1159/000418550","url":null,"abstract":"","PeriodicalId":77091,"journal":{"name":"Current studies in hematology and blood transfusion","volume":" 57","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000418550","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13423594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Plasma exchange in thrombotic thrombocytopenic purpura. 血小板减少性紫癜的血浆置换。
Current studies in hematology and blood transfusion Pub Date : 1990-01-01 DOI: 10.1159/000418555
A Corvetta, R Centurioni, G Danieli
{"title":"Plasma exchange in thrombotic thrombocytopenic purpura.","authors":"A Corvetta, R Centurioni, G Danieli","doi":"10.1159/000418555","DOIUrl":"https://doi.org/10.1159/000418555","url":null,"abstract":"","PeriodicalId":77091,"journal":{"name":"Current studies in hematology and blood transfusion","volume":" 57","pages":"114-30"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000418555","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13423596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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