Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists最新文献_第9页

The fate of the terminally differentiated chondrocyte: evidence for microenvironmental regulation of chondrocyte apoptosis. 终分化软骨细胞的命运:微环境调节软骨细胞凋亡的证据。

Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists Pub Date : 2002-01-01 DOI: 10.1177/154411130201300604

Christopher S Adams, Irving M Shapiro

{"title":"The fate of the terminally differentiated chondrocyte: evidence for microenvironmental regulation of chondrocyte apoptosis.","authors":"Christopher S Adams, Irving M Shapiro","doi":"10.1177/154411130201300604","DOIUrl":"https://doi.org/10.1177/154411130201300604","url":null,"abstract":"Chondrocytes contained within the epiphyseal growth plate promote rapid bone growth. To achieve growth, cells activate a maturation program that results in an increase in chondrocyte number and volume and elaboration of a mineralized matrix; subsequently, the matrix is resorbed and the terminally differentiated cells are deleted from the bone. The major objective of this review is to examine the fate of the epiphyseal chondrocytes in the growing bone. Current studies strongly suggest that the terminally differentiated epiphyseal cells are deleted from the cartilage by apoptosis. Indeed, morphological, biochemical, and end-labeling techniques confirm that death is through the apoptotic pathway. Since the induction of apoptosis is spatially and temporally linked to the removal of the cartilage matrix, current studies have examined the apoptogenic activity of Ca(2+)-, Pi-, and RGD-containing peptides of extracellular matrix proteins. It is observed that all of these molecules are powerful apoptogens. With respect to the molecular mechanism of apoptosis, studies of cell death with Pi as an apoptogen indicate that the anion is transported into the cytosol via a Na(+/)Pi transporter. Subsequently, there is activation of caspases, generation of NO, and a decrease in the thiol reserve. Finally, we examine the notion that chondrocytes transdifferentiate into osteoblasts, and briefly review evidence for, and the rationale of, the transdifferentiation process. It is concluded that specific microenvironments exist in cartilage that can serve to direct chondrocyte apoptosis.","PeriodicalId":77086,"journal":{"name":"Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists","volume":"13 6","pages":"465-73"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/154411130201300604","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22170808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 106

Analysis of pulpal reactions to restorative procedures, materials, pulp capping, and future therapies. 分析牙髓对修复程序、材料、牙髓盖盖和未来治疗的反应。

Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists Pub Date : 2002-01-01 DOI: 10.1177/154411130201300607

Peter E Murray, L Jack Windsor, Thomas W Smyth, Abeer A Hafez, Charles F Cox

{"title":"Analysis of pulpal reactions to restorative procedures, materials, pulp capping, and future therapies.","authors":"Peter E Murray, L Jack Windsor, Thomas W Smyth, Abeer A Hafez, Charles F Cox","doi":"10.1177/154411130201300607","DOIUrl":"https://doi.org/10.1177/154411130201300607","url":null,"abstract":"Every year, despite the effectiveness of preventive dentistry and dental health care, 290 million fillings are placed each year in the United States; two-thirds of these involve the replacement of failed restorations. Improvements in the success of restorative treatments may be possible if caries management strategies, selection of restorative materials, and their proper use to avoid post-operative complications were investigated from a biological perspective. Consequently, this review will examine pulp injury and healing reactions to different restorative variables. The application of tissue engineering approaches to restorative dentistry will require the transplantation, replacement, or regeneration of cells, and/or stimulation of mineralized tissue formation. This might solve major dental problems, by remineralizing caries lesions, vaccinating against caries and oral diseases, and restoring injured or replacing lost teeth. However, until these therapies can be introduced clinically, the avoidance of post-operative complications with conventional therapies requires attention to numerous aspects of treatment highlighted in this review.","PeriodicalId":77086,"journal":{"name":"Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists","volume":"13 6","pages":"509-20"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/154411130201300607","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22171310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 159

Progress in understanding autoimmune exocrinopathy using the non-obese diabetic mouse: an update. 利用非肥胖糖尿病小鼠了解自身免疫性外源性病变的进展:最新进展

Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists Pub Date : 2002-01-01 DOI: 10.1177/154411130201300103

S. Cha, A. Peck, M. Humphreys-Beher

{"title":"Progress in understanding autoimmune exocrinopathy using the non-obese diabetic mouse: an update.","authors":"S. Cha, A. Peck, M. Humphreys-Beher","doi":"10.1177/154411130201300103","DOIUrl":"https://doi.org/10.1177/154411130201300103","url":null,"abstract":"Sjögren's Syndrome (SS) is a chronic autoimmune disease characterized by histological and functional alterations of salivary and lacrimal glands that result in a severe dryness of the mouth and the eyes. The etiology of SS has remained undefined despite investigators' significant efforts to identify the mechanisms of initiation. Based on histopathology, several animal models are available--such as MRL/lpr, NZW/NZB, NFS/sld, graft vs. host, transgenic mouse expressing viral surface antigen, and the non-obese diabetic (NOD) mouse--for investigation of the etiology of SS. Biochemical and immunological similarities between human SS and autoimmune exocrinopathy (AEC) in the NOD mouse, including the loss of secretory function, establish the NOD mouse as an appropriate model to unravel the underlying pathophysiology of SS. Recently, several NOD congenic partner strains have been developed to investigate the roles of genetic intervals, cytokines, and autoantibodies in the disease pathogenesis. Studies on NOD-scid suggest that the pathogenesis of SS occurs in two phases: an asymptomatic phase, in which epithelial cells of exocrine tissues undergo dedifferentiation accompanied by elevated apoptosis; and a second phase in which autoaggression is mounted against target organ autoantigens, resulting in the activation of T- and B-cells, and the generation of autoantibodies. The presence of autoantibodies on the cell-surface signaling receptor, the muscarinic(3) receptor, in both SS patients and the NOD mice correlates with the hallmark clinical symptom of secretory dysfunction. Additionally, the NOD mouse model provides an important example of how both Th1 and Th2 cytokines, as well as non-immune genetic loci, are involved in the maintenance of and progression to the overt disease state. Ultimately, analysis of these data provides insight into potentially novel therapeutic interventions.","PeriodicalId":77086,"journal":{"name":"Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists","volume":"18 1","pages":"5-16"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72904179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 111

P21Waf1 control of epithelial cell cycle and cell fate. P21Waf1调控上皮细胞周期和细胞命运。

Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists Pub Date : 2002-01-01 DOI: 10.1177/154411130201300603

Wendy C Weinberg, Mitchell F Denning

引用次数: 160

Oral lichen planus and malignant transformation: is a recall of patients justified? 口腔扁平苔藓与恶性转化:患者召回是否合理?

Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists Pub Date : 2002-01-01 DOI: 10.1177/154411130201300503

Ulf Mattsson, Mats Jontell, Palle Holmstrup

引用次数: 156

Pemphigus vulgaris: update on etiopathogenesis, oral manifestations, and management. 寻常性天疱疮:最新的发病机制，口腔表现，和管理。

Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists Pub Date : 2002-01-01 DOI: 10.1177/154411130201300504

Crispian Scully, Stephen J Challacombe

{"title":"Pemphigus vulgaris: update on etiopathogenesis, oral manifestations, and management.","authors":"Crispian Scully, Stephen J Challacombe","doi":"10.1177/154411130201300504","DOIUrl":"https://doi.org/10.1177/154411130201300504","url":null,"abstract":"Pemphigus is a group of potentially life-threatening diseases characterized by cutaneous and mucosal blistering. There is a fairly strong genetic background to pemphigus with linkage to HLA class II alleles. Certain ethnic groups, such as Ashkenazi Jews and those of Mediterranean origin, are especially liable to pemphigus. Pemphigus vulgaris (PV), the most common and important variant, is an autoimmune blistering disease characterized by circulating pathogenic IgG antibodies against desmoglein 3 (Dsg3), about half the patients also having Dsg1 autoantibodies. Oral lesions are initially vesiculobullous but readily rupture, new bullae developing as the older ones rupture and ulcerate. Biopsy of perilesional tissue, with histological and immunostaining examinations, is essential to the diagnosis. Serum autoantibodies to either Dsg1 or Dsg3 are best detected by both normal human skin and monkey esophagus or by enzyme-linked immunosorbent assay (ELISA). Before the introduction of corticosteroids, pemphigus vulgaris was typically fatal mainly from dehydration or secondary systemic infections. Current treatment is largely based on systemic immunosuppression using systemic corticosteroids, with azathioprine, dapsone, methotrexate, cyclophosphamide, and gold as adjuvants or alternatives, but mycophenolate mofetil and intravenous immunoglobulins also appear promising.","PeriodicalId":77086,"journal":{"name":"Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists","volume":"13 5","pages":"397-408"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/154411130201300504","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22077966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 149

Dynamics of cell interactions and communications during melanoma development. 黑色素瘤发展过程中细胞相互作用和通讯的动力学。

Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists Pub Date : 2002-01-01 DOI: 10.1177/154411130201300107

G. Li, K. Satyamoorthy, M. Herlyn

{"title":"Dynamics of cell interactions and communications during melanoma development.","authors":"G. Li, K. Satyamoorthy, M. Herlyn","doi":"10.1177/154411130201300107","DOIUrl":"https://doi.org/10.1177/154411130201300107","url":null,"abstract":"Melanoma development not only involves genetic and epigenetic changes that take place within the cell, but also involves processes determined collectively by micro-environmental factors, including cell-cell interactions and communications. During the transition from normal cells to benign and malignant lesions, and subsequently to metastatic cancer, stepwise changes in intercellular communications provide tumor cells with the ability to overcome cell-cell adhesion and micro-environmental controls from the host and to invade surrounding tissues and disperse to distant locations. Cadherins are major cell-cell adhesion molecules involved in the development and maintenance of skin. E-cadherin expressed in normal melanocytes mediates growth and invasion control by keratinocytes. Progressive loss of E-cadherin and gain of N-cadherin during melanoma development not only free melanoma cells from control by keratinocytes, but also provide new adhesion properties, resulting in switched partnerships with fibroblasts and vascular endothelial cells. The cadherin subtype switching also dictates gap junctional specificity in melanocytic cells during tumor development. This selective intercellular communication may contribute to the regulation of cell growth, differentiation, apoptosis, and migration of melanocytic cells in both physiologic and pathologic conditions. Abnormal up-regulation of the immunoglobin repeat-containing cell adhesion molecules Mel-CAM and L1-CAM potentiates invasion and migration of melanoma. Thus, abnormal expression of intercellular adhesion receptors and dysregulated intercellular communication underlies melanoma development and progression.","PeriodicalId":77086,"journal":{"name":"Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists","volume":"11 1","pages":"62-70"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82623814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 90

Salivary (SD-type) cystatins: over one billion years in the making--but to what purpose? 唾液(sd型)胱抑素:超过10亿年的制造过程——但目的是什么?

Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists Pub Date : 2002-01-01 DOI: 10.1177/154411130201300606

D P Dickinson

{"title":"Salivary (SD-type) cystatins: over one billion years in the making--but to what purpose?","authors":"D P Dickinson","doi":"10.1177/154411130201300606","DOIUrl":"https://doi.org/10.1177/154411130201300606","url":null,"abstract":"Human saliva contains relatively abundant proteins that are related ancestrally in sequence to the cystatin superfamily. Most, although not all, members of this superfamily are potent inhibitors of cysteine peptidases. Four related genes have been identified, CST1, 2, 4 and 5, encoding cystatins SN, SA, S, and D, respectively. CST1, 4, and probably CST5 are now known to be expressed in a limited number of other tissues in the body, primarily in exocrine epithelia, and the term SD-type cystatin is more appropriate than 'salivary cystatin'. These genes are co-ordinately regulated in the submandibular gland during post-natal development. The organization of these tissue-specifically-expressed genes in the genome, and their phylogeny, indicate that they evolved from an ancestral housekeeping gene encoding the ubiquitously expressed cystatin C, and are members of a larger protein family. Their relationship to rat cystatin S, a developmentally regulated rodent submandibular gland protein, remains to be established. In this review, the evolution of the SD-type cystatins in the cystatin superfamily, their genomics, expression, and structure-function relationships are examined and compared with known cystatin functions, with the goal of providing clues to their biological roles.","PeriodicalId":77086,"journal":{"name":"Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists","volume":"13 6","pages":"485-508"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/154411130201300606","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22171309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 107

Oral and pharyngeal reflexes in the mammalian nervous system: their diverse range in complexity and the pivotal role of the tongue. 哺乳动物神经系统的口腔和咽反射:它们的复杂程度和舌头的关键作用。

Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists Pub Date : 2002-01-01 DOI: 10.1177/154411130201300505

A J Miller

{"title":"Oral and pharyngeal reflexes in the mammalian nervous system: their diverse range in complexity and the pivotal role of the tongue.","authors":"A J Miller","doi":"10.1177/154411130201300505","DOIUrl":"https://doi.org/10.1177/154411130201300505","url":null,"abstract":"The oral cavity and pharynx are anatomically separate but functionally integrated regions of the head. The two regions are involved in complex motor responses that include feeding, chewing, swallowing, speech, and respiration. The multiple sensory receptors that innervate these two regions provide the first link in reflexes that control muscles of the entire head, upper gastrointestinal tract, and airway. Most of the reflexes affect the diversity of muscles that compose the tongue, which is vital to all stages of feeding and which continually affects the patency of the airway. Oral-pharyngeal reflexes are evident in the mammalian fetus and continually emerge as the animal or human matures. Some of the first reflexes in the oral region are geared toward nourishment. As the central nervous system matures and the oral and pharyngeal regions develop morphologically, new reflexes develop. Many of these reflexes are protective both of the tissue in the oral cavity, such as the tongue, and of the upper airway in preventing aspiration. While simple reflexes can be evoked in isolation, most reflexes combine with more complex oral and pharyngeal responses such as chewing and vocalization. Oral-pharyngeal reflexes demonstrate a range in complexity. Some sensory stimuli will evoke a series of responses, as is often evident in the infant, and other stimuli will evoke a complex multiple-level recruitment of muscles in a sequence, as in pharyngeal swallowing. Certain sensory inputs evoke an entire motor behavior pattern, such as taste avoidance or facial expression. The oral-pharyngeal reflexes are critical to maintaining life and ultimately serve functions that the oral and pharyngeal regions have in common, such as communication, feeding, and breathing.","PeriodicalId":77086,"journal":{"name":"Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists","volume":"13 5","pages":"409-25"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/154411130201300505","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22077967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 179

The biologic role for nuclear factor-kappaB in disease and its potential involvement in mucosal injury associated with anti-neoplastic therapy. 核因子- κ b在疾病中的生物学作用及其与抗肿瘤治疗相关的粘膜损伤的潜在参与

Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists Pub Date : 2002-01-01 DOI: 10.1177/154411130201300502

Stephen T Sonis

{"title":"The biologic role for nuclear factor-kappaB in disease and its potential involvement in mucosal injury associated with anti-neoplastic therapy.","authors":"Stephen T Sonis","doi":"10.1177/154411130201300502","DOIUrl":"https://doi.org/10.1177/154411130201300502","url":null,"abstract":"Oral mucosal barrier injury (mucositis) is a frequent, painful, serious, dose-limiting toxicity associated with many anti-neoplastic drugs and radiation to the head and neck. Results of recent studies suggest that mucositis is the result of a complex series of interactive biological events that take place in the submucosa and epithelium. The nuclear transcription factor NF-kappaB has been implicated in the control of a broad range of biological responses, the activation of a large number of specific cellular genes, and the determination of the fate of cells exposed to ionizing radiation and anti-neoplastic drugs. Of particular importance to mucositis is the fact that NF-kappaB regulates key elements in the apparent sequence that leads to normal tissue toxicity. Not the least of these is the effect that NF-kappaB activation has on apoptosis. In particular, a paradox exists between the potential pro-apoptotic effect NF-kappaB exerts on normal cells, and the anti-apoptotic and cytoprotective effect it causes in tumor cells. This paper provides a review of the structure and function of NF-kappaB and speculates how its apparent enigmatic effect on normal and tumor cells may occur.","PeriodicalId":77086,"journal":{"name":"Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists","volume":"13 5","pages":"380-9"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/154411130201300502","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22078688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 204