Clinical physiology (Oxford, England)最新文献_第3页

Correlation between fluorescein flowmetry, 133Xenon clearance and electromagnetic flow measurement: a study in the intestine of the pig. 荧光素流量法、133氙清除率与电磁流量法在猪肠道中的相关性研究。

Clinical physiology (Oxford, England) Pub Date : 1985-06-01

L Perbeck, D H Lewis, L Thulin, G Tydén

引用次数: 0

Skeletal muscle function in man: force, relaxation rate, endurance and contraction time-dependence on sex and age. 男性骨骼肌功能:力、松弛率、耐力和收缩时间——与性别和年龄的关系。

Clinical physiology (Oxford, England) Pub Date : 1985-06-01

C Lennmarken, T Bergman, J Larsson, L E Larsson

引用次数: 0

Regulation of muscle blood flow. 肌肉血流量的调节。

Clinical physiology (Oxford, England) Pub Date : 1985-06-01

O Hudlická

{"title":"Regulation of muscle blood flow.","authors":"O Hudlická","doi":"","DOIUrl":"","url":null,"abstract":"Nervous control of muscle blood flow, exerted mainly by the sympathetic adrenergic fibres, is important under resting conditions and also mainly during haemorrhage (when both alpha and beta receptors are involved), during fight and flight and in flow redistribution to muscles during exercise. The role of other fibres (cholinergic, histaminergic and peptidergic) is discussed. Myogenic control is responsible for the high basal tone and, consequently, the relatively low resting blood flow. The main regulatory mechanism is, however, the adaptation of blood flow to metabolic demands. Thus at rest, flow is higher in muscles with a high proportion of oxidative fibres. The regulation of flow in contracting muscles is exerted by metabolites, and various metabolites seem to play different roles to different extents in different types of contractions, with several factors probably involved at any one time. Potassium seems to be more important in mixed, predominantly glycolytic, muscles during tetanic or long-lasting isometric contractions; inorganic phosphate plays a role in short-lasting contractions and is probably more involved in highly oxidative muscles. Adenosine may play a role in long-lasting contractions in muscles with a high proportion of oxidative fibres. Dilatation of arterioles enables so-called capillary recruitment during muscle contractions, which seems to be mainly the result of changes in the velocity of red blood cells and a variable percentage of capillaries with intermittent flow (with very few cells with zero velocity and a more homogeneous flow in contracting muscles) rather than opening of unperfused capillaries.","PeriodicalId":77071,"journal":{"name":"Clinical physiology (Oxford, England)","volume":"5 3","pages":"201-29"},"PeriodicalIF":0.0,"publicationDate":"1985-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15038403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prospective evaluation of the accuracy of duplex scanning with spectral analysis in carotid artery disease. 颈动脉疾病双相扫描与光谱分析准确度的前瞻性评价。

Clinical physiology (Oxford, England) Pub Date : 1985-06-01

V Zbornikova, C Lassvik, I Johansson

引用次数: 0

Haemodynamic and metabolic responses to prolonged exercise after chronic beta 1-adrenoceptor blockade in hypertensive man. 高血压患者慢性- 1-肾上腺素受体阻断后长时间运动的血流动力学和代谢反应。

Clinical physiology (Oxford, England) Pub Date : 1985-06-01

M Frisk-Holmberg, A Juhlin-Dannfelt, H Aström

{"title":"Haemodynamic and metabolic responses to prolonged exercise after chronic beta 1-adrenoceptor blockade in hypertensive man.","authors":"M Frisk-Holmberg, A Juhlin-Dannfelt, H Aström","doi":"","DOIUrl":"","url":null,"abstract":"The influence of chronic beta 1-adrenoceptor blockade on haemodynamic and metabolic responses was examined in eight young hypertensive subjects during a 40 min submaximal bicycle test at 50% of maximal capacity. The patients were randomly allocated to one placebo and one treatment period of 6 weeks. During treatment atenolol (Tenormin, 100 mg) was given twice daily. Arterial pressure, cardiac output, leg blood flow, oxygen uptake and different metabolites in the blood were determined. The heart rate was reduced by beta 1-adrenoceptor blockade by 30% during exercise, and the decrease was related to plasma concentration of the drug. Cardiac output was decreased by approximately 10%, but the negative chronotropic effect was partly compensated for by a higher stroke volume. Blockade leg blood flow was reduced by 10%, but more oxygen was extracted, giving an unchanged oxygen uptake. Blood concentration and leg uptake of glucose were not influenced by the treatment, but plasma free fatty acids were reduced by 30-40%. Leg lactate release was decreased to half the value in the unblocked situation. Plasma renin activity did not increase at the beginning of exercise, but after 40 min an increase was seen, though only to half of the pretreatment value. It is concluded that beta 1-adrenoceptor blockade during submaximal exercise reduces blood flow to the working muscles and that this reduction is the result of a lower cardiac output. Aerobic metabolism is unchanged as a result of increased oxygen extraction, but less fat is used as lipolysis is inhibited. Glucose uptake by the working muscles is unchanged by beta 1-blockade, but there is evidence for an increased carbohydrate metabolism. As for non-selective blockade, atenolol decreases lactate release but this could be the result of non-specific action on the beta 1-receptor and/or increased carbohydrate oxidation. Furthermore, the beta 1-adrenoceptors seem to have a major influence on the renin release during exercise.","PeriodicalId":77071,"journal":{"name":"Clinical physiology (Oxford, England)","volume":"5 3","pages":"231-42"},"PeriodicalIF":0.0,"publicationDate":"1985-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13997600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Duplex scanning and periorbital pulsed Doppler in the diagnosis of external carotid artery disease: analysis of causes of error. 双工扫描与眶周脉冲多普勒诊断颈外动脉疾病:误差原因分析。

Clinical physiology (Oxford, England) Pub Date : 1985-06-01

V Zbornikova, C Lassvik, I Johansson

{"title":"Duplex scanning and periorbital pulsed Doppler in the diagnosis of external carotid artery disease: analysis of causes of error.","authors":"V Zbornikova, C Lassvik, I Johansson","doi":"","DOIUrl":"","url":null,"abstract":"The external carotid arteries (ECA) were examined by duplex scanning in 123 consecutive patients with transient ischaemic attacks (TIA) and minor stroke. Two occlusions and five out of six high grade stenosis were correctly classified, yielding a sensitivity of 88% defining disease as stenosis greater than 50. Specificity was 94% and accuracy was 93%. Nine low grade stenosis (less than 50%) and six normal vessels were judged as high grade stenosis. A possible cause of this overestimation was a compensatory flow increase in the ECA caused by an occlusion or high grade stenosis in the internal carotid arteries (ICA), either on the same side or bilaterally. This was supported by the finding of a significantly (P less than 0.05) higher retrograde flow velocity in the ipsilateral supratrochlear arteries (STA) in patients with high ECA flow velocity, as compared to those with normal ECA flow. Thus in the evaluation of a possible ECA stenosis, the condition of the ICA should be considered in order to avoid overestimation of ECA lesions. The additional examination of flow direction and velocity in STA gives an indication as to whether or not an ECA stenosis might be present.","PeriodicalId":77071,"journal":{"name":"Clinical physiology (Oxford, England)","volume":"5 3","pages":"271-9"},"PeriodicalIF":0.0,"publicationDate":"1985-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15007951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluorescein flowmetry: a method for measuring relative capillary blood flow in the intestine. 荧光素血流法:一种测量肠内相对毛细血管血流的方法。

Clinical physiology (Oxford, England) Pub Date : 1985-06-01

L Perbeck, F Lund, L Svensson, L Thulin

引用次数: 0

Effect of the contrast medium meglumine amidotrizoate on renal extraction of para-amino hippurate after injection into the renal vein. 造影剂氨基三酸甲氨胺对肾静脉注射后对氨基马尿酸提取的影响。

Clinical physiology (Oxford, England) Pub Date : 1985-06-01

B Tidgren

{"title":"Effect of the contrast medium meglumine amidotrizoate on renal extraction of para-amino hippurate after injection into the renal vein.","authors":"B Tidgren","doi":"","DOIUrl":"","url":null,"abstract":"The effect of the contrast medium meglumine amidotrizoate (AngiografinR) on the renal extraction of para-amino hippurate (EPAH) was studied in 24 patients with suspected or previous renin-dependent hypertension. A single injection technique for administration of PAH was used and in eight additional patients the relationship between the arterial concentration of PAH and EPAH was studied over a period of 30 min after the injection. No change in EPAH with decreasing arterial concentration of PAH was found. After injection of 26 g of contrast medium (40 ml) into the renal veins of 18 of the 24 patients, a small (6%) but significant decrease in EPAH was observed. There was no significant difference in the decrease in EPAH between kidneys with increased and normal renal vein plasma renin activity. In the remaining six patients, the contrast medium (20 ml) was injected into one renal vein only, and blood samples were repeatedly drawn from both kidneys over a period of 30 min after injection. A decrease in EPAH was observed in both the injected and contralateral kidney; the decrease lasted for at least 20 min, with a maximum 1 min after injection. It is concluded that meglumine amidotrizoate injected into the renal vein causes a reduction of EPAH. Therefore, a contrast medium such as meglumine amidotrizoate should be avoided before determining the renal extraction of PAH.","PeriodicalId":77071,"journal":{"name":"Clinical physiology (Oxford, England)","volume":"5 3","pages":"301-10"},"PeriodicalIF":0.0,"publicationDate":"1985-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15119087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Somatic neurophysiology in diabetes. Basic observations and the effect of treatment. 糖尿病的躯体神经生理学。基本观察及治疗效果。

Clinical physiology (Oxford, England) Pub Date : 1985-01-01

G Gregersen

引用次数: 0

Sympathetic defects in diabetic autonomic neuropathy. 糖尿病自主神经病变的交感神经缺损。

Clinical physiology (Oxford, England) Pub Date : 1985-01-01

P J Watkins

引用次数: 0