发布求助
文献互助 智能选刊 最新文献

Bailliere's clinical neurology最新文献

筛选
英文 中文
Central nervous system trauma. 中枢神经系统损伤。
Bailliere's clinical neurology Pub Date : 1996-01-01 DOI: 10.1016/b978-1-4160-9979-6.00610-3
P. Statham, P. Andrews
{"title":"Central nervous system trauma.","authors":"P. Statham, P. Andrews","doi":"10.1016/b978-1-4160-9979-6.00610-3","DOIUrl":"https://doi.org/10.1016/b978-1-4160-9979-6.00610-3","url":null,"abstract":"","PeriodicalId":77030,"journal":{"name":"Bailliere's clinical neurology","volume":"4 1","pages":"497-514"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84996835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Paraneoplastic peripheral neuropathy. 副肿瘤周围神经病变。
Bailliere's clinical neurology Pub Date : 1995-11-01
P S Smitt, J B Posner
{"title":"Paraneoplastic peripheral neuropathy.","authors":"P S Smitt,&nbsp;J B Posner","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Paraneoplastic peripheral neuropathies are not common. They are out-numbered by the far more common peripheral neuropathies that occur either as a direct result of the cancer (metastases) or its treatment (usually chemotherapy). Nevertheless, paraneoplastic peripheral neuropathies are important because they may be the first sign of an otherwise occult cancer and/or because they may substantially disable the patient even when the cancer itself is asymptomatic. Paraneoplastic disorders are sometimes marked by the presence of autoantibodies that react with proteins both in the underlying cancer and in the nervous system. Their discovery may lead to an early diagnosis and potential cure of the underlying cancer.</p>","PeriodicalId":77030,"journal":{"name":"Bailliere's clinical neurology","volume":"4 3","pages":"443-68"},"PeriodicalIF":0.0,"publicationDate":"1995-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19579078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neurotrophic factors in the therapy of peripheral neuropathy. 神经营养因子在周围神经病变治疗中的作用。
Bailliere's clinical neurology Pub Date : 1995-11-01
S C Apfel, J A Kessler
{"title":"Neurotrophic factors in the therapy of peripheral neuropathy.","authors":"S C Apfel,&nbsp;J A Kessler","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Neurotrophic factors are proteins that promote the survival and differentiation of specific populations of neurones. With the successful cloning and large-scale production of many different neurotrophic factors, it has become practical to consider their application in the treatment of neurological disease. Several groups of neurotrophic factors hold particular promise for the therapy of peripheral nervous system disease in the near future. These include the neurotrophin gene family, cytokines such as CNTF and the IGF family. Evidence is accumulating that an abnormal availability of some of these factors may contribute towards the pathophysiology of some types of neuropathy, most notably diabetic neuropathy. Pre-clinical studies in animal models have demonstrated the likely efficacy of factors such as NGF for small-fibre sensory neuropathy, BDNF, CNTF and IGF-I for motor neurone disease, and NT-3 for large-fibre neuropathy. Clinical trials of several growth factors are currently underway for the treatment of peripheral nerve disease, and other clinical trials are currently being planned.</p>","PeriodicalId":77030,"journal":{"name":"Bailliere's clinical neurology","volume":"4 3","pages":"593-606"},"PeriodicalIF":0.0,"publicationDate":"1995-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19579084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Drug trials in neuropathy. 神经病变的药物试验。
Bailliere's clinical neurology Pub Date : 1995-11-01
R A Hughes, P Heywood, B Sharrack
{"title":"Drug trials in neuropathy.","authors":"R A Hughes,&nbsp;P Heywood,&nbsp;B Sharrack","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Drug trials in peripheral neuropathy have used different outcome measures, the choice of which has depended on the nature of the neuropathy and the hypothesis being tested. The majority of the published trials have relied on measuring impairment (reflecting the desirable sensitivity of these outcome measures), and only few have used measures of disability or handicap. Drug trials in inflammatory neuropathy (GBS and CIDP), diabetic, paraproteinaemic, and toxic neuropathies have been discussed in this chapter, to illustrate the different therapeutic approaches used in the literature. Future drug trials in peripheral neuropathy should pay more attention to disability and handicap measures.</p>","PeriodicalId":77030,"journal":{"name":"Bailliere's clinical neurology","volume":"4 3","pages":"607-27"},"PeriodicalIF":0.0,"publicationDate":"1995-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19579085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chronic motor neuropathies and lower motor neurone syndromes. 慢性运动神经病和下运动神经元综合征。
Bailliere's clinical neurology Pub Date : 1995-11-01
A J Kornberg, A Pestronk
{"title":"Chronic motor neuropathies and lower motor neurone syndromes.","authors":"A J Kornberg,&nbsp;A Pestronk","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Immune-mediated motor neuropathies are most often disorders manifest clinically by slowly progressive, asymmetrical, distal weakness, starting in the hands more often than the legs. In some cases, electrophysiological findings show multifocal conduction block along the length of motor axons. Other patients have findings consistent with only axonal loss. Laboratory testing is unremarkable except for high-titre serum autoantibodies to GM1 and other neural antigens. Diagnosis of immune-mediated motor neuropathies provides an opportunity for effective immunomodulating therapy that can significantly improve quality of life in affected patients. The identification of antigenic targets of serum autoantibodies in patients with motor neuropathies lends hope that immunotherapies to specifically treat the autoimmune disorder can be developed.</p>","PeriodicalId":77030,"journal":{"name":"Bailliere's clinical neurology","volume":"4 3","pages":"427-41"},"PeriodicalIF":0.0,"publicationDate":"1995-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19579179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Drug-induced neuropathies. 药物引起的神经病变。
Bailliere's clinical neurology Pub Date : 1995-11-01
A J Windebank
{"title":"Drug-induced neuropathies.","authors":"A J Windebank","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Much progress has been made over the past 20 years in the description of the neurotoxic processes involved in drug-induced neuropathies. Essentially all of the clinical neuropathic syndromes resulting from these drugs have been extensively described. Current research centres not only on the delineation of the molecular mechanisms of these phenomena, but also on the possible therapeutic prevention of these neuropathies using novel neuroprotective agents. As more neurotoxic drugs (especially in chemotherapy) are developed, and with the future possibility of combination chemotherapy regimens with two or more neurotoxic agents, continued investigation in this area will remain vitally important. In addition, findings from this research may be applicable to other peripheral neurodegenerative processes that are not drug-induced.</p>","PeriodicalId":77030,"journal":{"name":"Bailliere's clinical neurology","volume":"4 3","pages":"529-73"},"PeriodicalIF":0.0,"publicationDate":"1995-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19579082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular biology of neurotrophic factors. 神经营养因子的分子生物学。
Bailliere's clinical neurology Pub Date : 1995-11-01
M Sendtner
{"title":"Molecular biology of neurotrophic factors.","authors":"M Sendtner","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The survival and functional maintenance of spinal motoneurones and of peripheral neurones, such as sensory, sympathetic and parasympathetic neurones, has been shown to depend on neurotrophic factors, both during the period of developmental cell death and in adulthood. A variety of such factors has been identified over recent years, among them factors of the NGF gene family, for example BDNF, NT-3, NT-4/5 and NT-6, and factors such as CNTF and LIF acting on neuronal target cells via receptor components shared with cytokines such as IL-6. In addition, pluripotent mitogens, such as IGF-I and IGF-II can support the survival of a variety of neuronal cell types, including spinal motoneurones both in cell culture and in vivo. The establishment of mice in which the genes for these factors and their receptors have been inactivated by homologous recombination has been a major step in the understanding of their physiological function. It is not clear so far whether or not similar gene defects in human are associated with any neurological disease. However, some of these factors have been demonstrated to be effective in animal models of neuropathy and motoneurone disorders, so that first clinical trials using these factors for symptomatic treatment of amyotrophic lateral sclerosis (ALS) and peripheral neuropathies have already been initiated.</p>","PeriodicalId":77030,"journal":{"name":"Bailliere's clinical neurology","volume":"4 3","pages":"575-91"},"PeriodicalIF":0.0,"publicationDate":"1995-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19579083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diabetic neuropathies. 糖尿病神经病变。
Bailliere's clinical neurology Pub Date : 1995-11-01
P A Low, G A Suarez
{"title":"Diabetic neuropathies.","authors":"P A Low,&nbsp;G A Suarez","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>There is a family of diabetic neuropathies that mimic the entire spectrum of peripheral neuropathies. Distal sensory neuropathy is the most common. In small-fibre neuropathy, autonomic failure and loss of sense of pain and temperature are prominent. Painfulness is seen in a number of diabetic neuropathies. The asymmetric neuropathies are distinctive and are probably caused by a combination of microvascular and immune-mediated mechanisms. The pathogenesis of diabetic neuropathy is probably multifactorial. Hyperglycaemia is central to any pathogenic scheme whereby nerve blood flow is reduced by an effect on microvessels mediated by perturbations such as oxidative stress, reduction of nitric oxide, prostaglandins and an increase in endothelin. It may also affect nerve fibres directly. Recent clinical trials have clearly demonstrated the importance of strict glycaemic control. There is also support for essential fatty acids, antioxidants and aldose reductase inhibitors. Treatment of diabetic neuropathy is focused on improving glycaemic control and treatment of symptoms. The precise role of other modalities of treatment of diabetic neuropathy remain to be firmly established.</p>","PeriodicalId":77030,"journal":{"name":"Bailliere's clinical neurology","volume":"4 3","pages":"401-25"},"PeriodicalIF":0.0,"publicationDate":"1995-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19579178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular genetics of peripheral neuropathies. 周围神经病变的分子遗传学。
Bailliere's clinical neurology Pub Date : 1995-11-01
A E Harding
{"title":"Molecular genetics of peripheral neuropathies.","authors":"A E Harding","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Molecular genetic techniques have identified the mutational basis of many inherited neuropathies due to metabolic disorders, including porphyrias, leukodystrophies and other storage diseases. Inherited amyloid neuropathies may be caused by mutations in three different genes: those for gelsolin, apolipoprotein A1 and, most frequently, transthyretin. The classification of hereditary motor and sensory neuropathies has been changed by the identification of underlying mutations encoding myelin proteins, P0 and peripheral myelin protein 22 and connexin 32. Peripheral myelin protein 22 gene defects are also seen in hereditary liability to pressure palsies. There is peripheral sensory nerve involvement in one of the diseases caused by an unstable trinucleotide repeat sequence: X-linked bulbospinal neuronopathy. These advances can be translated into clinical practice, leading to improved diagnosis and genetic counselling.</p>","PeriodicalId":77030,"journal":{"name":"Bailliere's clinical neurology","volume":"4 3","pages":"383-400"},"PeriodicalIF":0.0,"publicationDate":"1995-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19579177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vasculitic neuropathy. Vasculitic神经病变。
Bailliere's clinical neurology Pub Date : 1995-11-01
G Said
{"title":"Vasculitic neuropathy.","authors":"G Said","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Vasculitis is a common and treatable cause of neuropathy. In most cases, necrotizing arteritis of the type observed in polyarteritis nodosa is responsible for the lesions, but classification of vasculitis is still uncertain. The neuropathy often occurs in the context of a multisystem disorder, but in a substantial proportion of patients, especially among patients seen by neurologists, the neuropathy is the first and only manifestation of vasculitis. In such cases, the diagnosis can only be reached by performance of a nerve and muscle biopsy. Ischaemic nerve lesions can also result from secondary vasculitis in a number of inflammatory, infectious and immune-mediated disorders of the peripheral nervous system.</p>","PeriodicalId":77030,"journal":{"name":"Bailliere's clinical neurology","volume":"4 3","pages":"489-503"},"PeriodicalIF":0.0,"publicationDate":"1995-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19579080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信