Advances in space biology and medicine最新文献

{"title":"miR-128在便秘发病中的作用及其机制","authors":"何彩, 周涛, 廖莉, H. Cai, Zhou Tao, Liao Li","doi":"10.36666/advbiomed.0002.2019","DOIUrl":"https://doi.org/10.36666/advbiomed.0002.2019","url":null,"abstract":"","PeriodicalId":76982,"journal":{"name":"Advances in space biology and medicine","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87597039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"高表达lncRNA FOXD2-AS1促进非小细胞肺癌的上皮-间充质转化","authors":"周瑜, 成都市第二人民医院 ICU急救中心； 中山大学附属第五医院神经外科； 成都市第二人民医院 呼吸与危重症医学二科, 王一平, 邓正旭, Zhou Yu, Wang Yiping, Deng Zhengxu","doi":"10.36666/advbiomed.0003.2019","DOIUrl":"https://doi.org/10.36666/advbiomed.0003.2019","url":null,"abstract":"","PeriodicalId":76982,"journal":{"name":"Advances in space biology and medicine","volume":"126 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87836639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"miR -183作为椎间盘退变的预后标志物及其在髓核增殖和凋亡中的作用","authors":"卿培东, 曹云, 徐剑峰, 邓海涛, 李明凡, Qing Peidong, Cao Yun, XU Jianfeng, Deng Haitao, LI Mingfan","doi":"10.36666/advbiomed.0004.2019","DOIUrl":"https://doi.org/10.36666/advbiomed.0004.2019","url":null,"abstract":"","PeriodicalId":76982,"journal":{"name":"Advances in space biology and medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85768031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Responses across the gravity continuum: hypergravity to microgravity.","authors":"Charles E Wade","doi":"10.1016/s1569-2574(05)10009-4","DOIUrl":"https://doi.org/10.1016/s1569-2574(05)10009-4","url":null,"abstract":"<p><p>In response to hypergravity, it appears that the larger the animal, the greater the response, if present. Therefore, the response of a rat exceeds that of a mouse in the same hypergravity environment. When investigated in the microgravity environment of space flight, this appears to hold true. The lack of definitive data obtained in space for either species makes the extrapolation of the continuum to levels below Earth-gravity problematic. However, in systems where responses are detected for both space flight and acceleration by centrifugation, a gravitational continuum is present supporting the \"principle of continuity\". For those and similar systems, it appears that the use of hypergravity could be used to predict responses to space flight.</p>","PeriodicalId":76982,"journal":{"name":"Advances in space biology and medicine","volume":"10 ","pages":"225-45"},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/s1569-2574(05)10009-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25248321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The hindlimb unloading rat model: literature overview, technique update and comparison with space flight data.","authors":"Emily Morey-Holton,&nbsp;Ruth K Globus,&nbsp;Alexander Kaplansky,&nbsp;Galina Durnova","doi":"10.1016/s1569-2574(05)10002-1","DOIUrl":"https://doi.org/10.1016/s1569-2574(05)10002-1","url":null,"abstract":"<p><p>The hindlimb unloading rodent model is used extensively to study the response of many physiological systems to certain aspects of space flight, as well as to disuse and recovery from disuse for Earth benefits. This chapter describes the evolution of hindlimb unloading, and is divided into three sections. The first section examines the characteristics of 1064 articles using or reviewing the hindlimb unloading model, published between 1976 and April 1, 2004. The characteristics include number of publications, journals, countries, major physiological systems, method modifications, species, gender, genetic strains and ages of rodents, experiment duration, and countermeasures. The second section provides a comparison of results between space flown and hindlimb unloading animals from the 14-day Cosmos 2044 mission. The final section describes modifications to hindlimb unloading required by different experimental paradigms and a method to protect the tail harness for long duration studies. Hindlimb unloading in rodents has enabled improved understanding of the responses of the musculoskeletal, cardiovascular, immune, renal, neural, metabolic, and reproductive systems to unloading and/or to reloading on Earth with implications for both long-duration human space flight and disuse on Earth.</p>","PeriodicalId":76982,"journal":{"name":"Advances in space biology and medicine","volume":"10 ","pages":"7-40"},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/s1569-2574(05)10002-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25248999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gravity effects on life processes in aquatic animals.","authors":"Eberhard R Horn","doi":"10.1016/s1569-2574(05)10010-0","DOIUrl":"https://doi.org/10.1016/s1569-2574(05)10010-0","url":null,"abstract":"","PeriodicalId":76982,"journal":{"name":"Advances in space biology and medicine","volume":"10 ","pages":"247-301"},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/s1569-2574(05)10010-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25248322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primates in space flight.","authors":"Tana M Hoban-Higgins,&nbsp;Edward L Robinson,&nbsp;Charles A Fuller","doi":"10.1016/s1569-2574(05)10011-2","DOIUrl":"https://doi.org/10.1016/s1569-2574(05)10011-2","url":null,"abstract":"","PeriodicalId":76982,"journal":{"name":"Advances in space biology and medicine","volume":"10 ","pages":"303-25"},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/s1569-2574(05)10011-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25248323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of space flight on circadian rhythms.","authors":"Gianluca Tosini,&nbsp;Jacopo Aguzzi","doi":"10.1016/s1569-2574(05)10006-9","DOIUrl":"https://doi.org/10.1016/s1569-2574(05)10006-9","url":null,"abstract":"","PeriodicalId":76982,"journal":{"name":"Advances in space biology and medicine","volume":"10 ","pages":"165-74"},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/s1569-2574(05)10006-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25248318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"International collaboration on Russian spacecraft and the case for free flyer biosatellites.","authors":"Richard E Grindeland,&nbsp;Eugene A Ilyin,&nbsp;Daniel C Holley,&nbsp;Michael G Skidmore","doi":"10.1016/s1569-2574(05)10003-3","DOIUrl":"https://doi.org/10.1016/s1569-2574(05)10003-3","url":null,"abstract":"<p><p>Animal research has been critical to the initiation and progress of space exploration. Animals were the original explorers of \"space\" two centuries ago and have played a crucial role by demonstrating that the space environment, with precautions, is compatible with human survival. Studies of mammals have yielded much of our knowledge of space physiology. As spaceflights to other planets are anticipated, animal research will continue to be essential to further reveal space physiology and to enable the longer missions. Much of the physiology data collected from space was obtained from the Cosmos (Bion) spaceflights, a series of Russian (Soviet)-International collaborative flights, over a 22 year period, which employed unmanned, free flyer biosatellites. Begun as a Soviet-only program, after the second flight the Russians invited American and other foreign scientists to participate. This program filled the 10 year hiatus between the last US biosatellite and the first animal experiments on the shuttles. Of the 11 flights in the Cosmos program nine of them were international; the flights continued over the years regardless of political differences between the Soviet Union and the Western world. The science evolved from sharing tissues to joint international planning and development, and from rat postmortem tissue analysis to in vivo measurements of a host of monkey physiological parameters during flight. Many types of biological specimens were carried on the modified Vostok spacecraft, but only the mammalian studies are discussed herein. The types of studies done encompass the full range of physiology and have begun to answer \"critical\" questions of space physiology posed by various ad hoc committees. The studies have not only yielded a prodigious and significant body of data, they have also introduced some new perspectives in physiology. A number of the physiological insights gained are relevant to physiology on Earth. The Cosmos flights also added significantly to flight-related technology, some of which also has application on our planet. In summary, the Cosmos biosatellite flights were extremely productive and of low cost. The Bion vehicles are versatile in that they can be placed into a variety of orbits and altitudes, and can carry radiation sources or other hazardous material which cannot be carried on manned vehicles. With recent advances in sensor, robotic, and data processing technology, future free flyers will be even more productive, and will largely preclude the need to fly animal experiments on manned vehicles. Currently, mammalian researchers do not have access to space for an unknown time, seriously impeding the advancement and understanding of space physiology during long duration missions. Initiation of a new, international program of free flyer biosatellites is critical to our further understanding of space physiology, and essential to continued human exploration of space.</p>","PeriodicalId":76982,"journal":{"name":"Advances in space biology and medicine","volume":"10 ","pages":"41-80"},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/s1569-2574(05)10003-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25249000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vestibular experiments in space.","authors":"Bernard Cohen,&nbsp;Sergei B Yakushin,&nbsp;Gay R Holstein,&nbsp;Mingjia Dai,&nbsp;David L Tomko,&nbsp;Anatole M Badakva,&nbsp;Inessa B Kozlovskaya","doi":"10.1016/s1569-2574(05)10005-7","DOIUrl":"https://doi.org/10.1016/s1569-2574(05)10005-7","url":null,"abstract":"","PeriodicalId":76982,"journal":{"name":"Advances in space biology and medicine","volume":"10 ","pages":"105-64"},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/s1569-2574(05)10005-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25248317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}