{"title":"Merkel cell carcinoma.","authors":"Summer R Youker","doi":"10.1016/b978-0-323-39255-6.50255-6","DOIUrl":"https://doi.org/10.1016/b978-0-323-39255-6.50255-6","url":null,"abstract":"","PeriodicalId":76978,"journal":{"name":"Advances in dermatology","volume":"19 1","pages":"185-205"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53965240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Merkel cell carcinoma.","authors":"Summer R Youker","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Merkel cell carcinoma is an aggressive tumor that should be treated early and aggressively. Although there are 5 published cases of spontaneous regression of Merkel cell carcinoma, a patient's best chance for survival is early detection with either wide local excision or Mohs' micrographically controlled margins with a final 5- to 10-mm layer. This should be followed by sentinel lymph node biopsy with lymph node dissection of the draining basin if metastases are discovered. Adjuvant radiation to the primary site and the draining basin should follow. Although this aggressive approach to treatment is not appropriate for every case, the literature, although scanty, supports this. Chemotherapy with or without additional radiation therapy should be offered to patients with advanced disease, mostly for palliation. The need for prospective trials and longer follow-up for larger series of patients is obvious.</p>","PeriodicalId":76978,"journal":{"name":"Advances in dermatology","volume":"19 ","pages":"185-205"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24084381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"BP180 (type XVII collagen) and its role in cutaneous biology and disease.","authors":"Françoise Van den Bergh, George J Giudice","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>BP180 is a key component of the epidermal anchoring complex and functions to maintain adherence of the epidermis to the basement membrane. Structural studies have revealed that BP180 is a type II transmembrane protein with a long carboxy-terminal collagenous domain that projects into the extracellular region beneath the epidermal hemidesmosome. The collagenous domains have the characteristic tripeptide repeat, Gly-X-Y. A normal proteolytic processing event results in the shedding of the BP180 extracellular domain (LAD1) from the keratinocyte cell surface. The biologic relevance of this process is not yet known. The interactions of BP180 with other constituents of the anchoring complex have been extensively studied and underscore the importance of BP180 in the assembly and functioning of this cell-matrix adhesion structure. In addition to its role in maintaining the integrity of the dermal-epidermal junction, there is evidence that BP180 is involved in transmembrane signal transduction and in the regulation of keratinocyte differentiation. BP180 mutations are responsible for certain forms of JEB and a rare subform of epidermolysis bullosa simplex. In addition, 5 acquired blistering disorders (i.e. BP, HG, CP, LAD and LPP) are associated with an autoimmune response to BP180. In vivo and in vitro disease model systems have clearly established the pathogenic relevance of autoantibodies directed against specific sites on the BP180 extracellular domain. Molecular and cellular analyses of the autoimmune response in BP and HG have been unable to distinguish these 2 diseases, supporting the notion that HG can be considered a pregnancy-associated form of BP. In contrast, the anti-BP180 immune response of the other 3 disease--CP, LAD, and LPP--can be immunologically distinguished from BP and HG. The distinctions lie within the isotype and subclass of the autoantibodies, as well as in differences in their fine specificities or complement-fixing properties, or both. These differences are thought to account for the heterogeneous phenotypes observed in this family of autoimmune diseases.</p>","PeriodicalId":76978,"journal":{"name":"Advances in dermatology","volume":"19 ","pages":"37-71"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24084376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The cutaneous neurosensory system in skin disease.","authors":"Franz J Legat, Cheryl A Armstrong, John C Ansel","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The cutaneous neurosensory system appears to be involved in a number of skin diseases. Ongoing studies continue to uncover potential new roles for the components of the neurosensory system in skin homeostasis and disease states. There is new evidence that neuropeptides may play a role in melanogenesis with effects on vitiligo. An increase of intraepidermal nerve fibers with a possible pathophysiologic role in photodamaged facial skin has been proposed. As our understanding of the interactions between the cutaneous neurosensory system and the various components of the skin and the immune system in times of health and disease increases, specific treatments modulating the neurocutaneous system will find their way into the armamentarium of daily dermatologic therapy.</p>","PeriodicalId":76978,"journal":{"name":"Advances in dermatology","volume":"18 ","pages":"91-109"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22196940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Advances in wound closure materials.","authors":"Christie T Ammirati","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76978,"journal":{"name":"Advances in dermatology","volume":"18 ","pages":"313-38"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22196820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Actinic keratoses: new treatment options.","authors":"Christine E Correale","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76978,"journal":{"name":"Advances in dermatology","volume":"18 ","pages":"339-55"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22196821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alain H Rook, Jacqueline M Junkins-Hopkins, Karen S McGinnis, Maria Wysocka, Stephen K Richardson, Jeanne B Budgin, Suzanne Everitts, Carmela C Vittorio
{"title":"Cytokines and other biologic agents as immunotherapeutics for cutaneous T-cell lymphoma.","authors":"Alain H Rook, Jacqueline M Junkins-Hopkins, Karen S McGinnis, Maria Wysocka, Stephen K Richardson, Jeanne B Budgin, Suzanne Everitts, Carmela C Vittorio","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cutaneous T-cell lymphomas (CTCLs) are a group of skin-invasive malignancies of clonally derived T lymphocytes. Mycosis fungoides and Sézary syndrome, characterized by the proliferation of CD4+ T cells, are the most common forms of CTCL. Among these latter disorders, the host antitumor response appears to play an important role in disease control. Thus, systemic therapeutic agents are used in an effort to augment the host antitumor response while selectively targeting the malignant cells. Both new and old biologic response-modifying treatment options currently used to treat CTCL are reviewed.</p>","PeriodicalId":76978,"journal":{"name":"Advances in dermatology","volume":"18 ","pages":"29-43"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22196938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Treatment of inflammatory dermatoses with novel biologic agents: a primer.","authors":"Rachel Nussbaum, James G Krueger","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76978,"journal":{"name":"Advances in dermatology","volume":"18 ","pages":"45-89"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22196939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}