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Acta paediatrica Hungarica最新文献

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The use of human recombinant erythropoietin in children on chronic dialysis. 人重组红细胞生成素在儿童慢性透析中的应用。
Acta paediatrica Hungarica Pub Date : 1992-01-01
P Sallay, G Reusz
{"title":"The use of human recombinant erythropoietin in children on chronic dialysis.","authors":"P Sallay,&nbsp;G Reusz","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Human recombinant erythropoietin (r-HuEPO, EprexR) was administered to 8 children with chronic renal failure and high transfusion requirement. The hormone was given i.v. 2-3 times per week at the end of the dialysis. The selected initial dose (160 U/kg/week) was gradually raised up to a maximum of 400 U/kg/week. Anaemia normalised by the tenth week. The aimed target haematocrit was 0.33, the average maintenance dose was 250-300 U/kg/week. The absolute reticulocyte count seemed to be a more sensitive indicator of the actual erythropoietin effect than the haematocrit level. No major adverse effects (convulsion, progressive hypertension, thrombosis) were observed during treatment with r-HuEPO. The need for transfusions decreased dramatically, no transfusion was needed following the second week of treatment. The general condition improved substantially. In one hyperimmunized child the cytotoxic antibody titer decreased by 75 per cent.</p>","PeriodicalId":76974,"journal":{"name":"Acta paediatrica Hungarica","volume":"32 4","pages":"333-45"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12478606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Severe hypoglycaemia and cardiovascular autonomic dysfunction in type I diabetic children treated with intensified conventional insulin therapy. 1型糖尿病儿童强化常规胰岛素治疗的严重低血糖和心血管自主神经功能障碍
Acta paediatrica Hungarica Pub Date : 1992-01-01
L Barkai, L Madácsy, I Vámosi
{"title":"Severe hypoglycaemia and cardiovascular autonomic dysfunction in type I diabetic children treated with intensified conventional insulin therapy.","authors":"L Barkai,&nbsp;L Madácsy,&nbsp;I Vámosi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>To assess the relationship between severe hypoglycaemias and autonomic dysfunction, five cardiovascular tests (resting heart rate, hyperventilatory arrhythmia, standing/lying heart rate ratio, orthostatic decrease in blood pressure, and increase in blood pressure during sustained handgrip) were performed in a 1-yr prospective study of 34 insulin-dependent diabetic children treated with intensified conventional insulin therapy (ICIT). There were twelve severe episodes in 7 diabetic children, and the remaining 27 patients had no severe hypoglycaemia. The hypoglycaemic group had a longer duration of diabetes than the nonhypoglycaemic group (5.4 SD 2.5 years vs. 2.8 SD 2.2 years, p less than 0.02). The hyperventilatory arrhythmia in the hypoglycaemic group in comparison with the nonhypoglycaemic group was significantly decreased (before ICIT: 16.1 SD 3/min vs. 24.4 SD 5/min, p less than 0.01; 1 yr thereafter: 17.3 SD 3/min vs. 26.0 SD 5/min, p less than 0.01). The hypoglycaemic group showed a pronounced orthostatic decrease in blood pressure compared to the nonhypoglycaemic group (before ICIT: 13.2 SD 4 mmHg vs. 6.0 SD 4 mmHg, p less than 0.01; 1 yr thereafter: 12.3 SD 4 mmHg vs. 5.6 SD 4 mmHg, p less than 0.01). Three or more abnormal cardiovascular test results were found in patients of the hypoglycaemic group who showed abnormal hyperventilatory arrhythmia and abnormal orthostatic decrease in blood pressure simultaneously, whereas such a coexistence was not found in the nonhypoglycaemic group. These observations may support the view that diabetic children and adolescents with autonomic dysfunction are susceptible to severe hypoglycaemia during ICIT.</p>","PeriodicalId":76974,"journal":{"name":"Acta paediatrica Hungarica","volume":"32 2","pages":"135-48"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12561784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
About DR beta-restriction fragment length polymorphism (RFLP) analysis in kidney transplantation in connection with a paediatric patient. 关于DR β -限制性片段长度多态性(RFLP)分析在肾移植与儿童患者。
Acta paediatrica Hungarica Pub Date : 1992-01-01
E Endreffy, I B Petri, E Csajbók, J Márton, G I Kaiser, I Raskó
{"title":"About DR beta-restriction fragment length polymorphism (RFLP) analysis in kidney transplantation in connection with a paediatric patient.","authors":"E Endreffy,&nbsp;I B Petri,&nbsp;E Csajbók,&nbsp;J Márton,&nbsp;G I Kaiser,&nbsp;I Raskó","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A retrospective analysis of the HLA-DR antigens was performed at the DR beta DNA locus by the means of restriction fragment length polymorphism (RFLP) in the case of a two-times kidney transplanted paediatric patient and in 16 adult kidney donor recipient pairs in order to prove the importance of DNA molecular analysis in those cases where the serological identification is poor. The child and her grafts (first from her mother, the second from a cadaver donor) carried the DRw6 antigen which serologically can very poorly be defined. According to DR serotyping before transplantation both the child and the cadaver kidney proved to be DR5, 6, while the DNA analysis revealed mismatches; the child possessed the two subtypes: 13b1 and 14a of the DRw6 antigen only and none of the DR5, the cadaver kidney proved to belong to the DR4 antigen group instead of DR5, and furthermore to a different subtype of the DRw6 (13a3) than the recipient. The DNA analysis of other 16 adult donor-recipient pairs also underlined the importance of the DR beta RFLP analysis in cases where the transplantation antigens could be poorly defined.</p>","PeriodicalId":76974,"journal":{"name":"Acta paediatrica Hungarica","volume":"32 2","pages":"189-97"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12529283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Determination of hair trace elements in childhood celiac disease and in cystic fibrosis. 儿童乳糜泻和囊性纤维化患者头发微量元素的测定。
Acta paediatrica Hungarica Pub Date : 1992-01-01
A Várkonyi, M Boda, Z Szökefalvi-Nagy, B Nyilasi
{"title":"Determination of hair trace elements in childhood celiac disease and in cystic fibrosis.","authors":"A Várkonyi,&nbsp;M Boda,&nbsp;Z Szökefalvi-Nagy,&nbsp;B Nyilasi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Applying proton-induced X-ray emission authors investigated the hair trace element contents in 10 children with acute celiac disease after 3 to 6 and 12 months long gluten-free diet; in 9 children with cystic fibrosis and in a control group (6 children) of the same age. There was no difference in Cu, Fe, Ca, Cl values between the examined groups. The Zn contents of the hair are significantly low in the group with acute celiac disease after a short-term diet and also in the group with cystic fibrosis, the data approach the normal range only after a year's diet. The significant rise of hair potassium contents is well indicated in patients with acute celiac disease and this rise may be due to the destruction of cell cuticles. In case of cystic fibrosis there is no significant rise of hair potassium value.</p>","PeriodicalId":76974,"journal":{"name":"Acta paediatrica Hungarica","volume":"32 2","pages":"159-65"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12561786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Maternal weight gain and birth weight. 母亲体重增加和出生体重。
Acta paediatrica Hungarica Pub Date : 1992-01-01
A E Czeizel, I Dudás, M Dobó, M Pál
{"title":"Maternal weight gain and birth weight.","authors":"A E Czeizel,&nbsp;I Dudás,&nbsp;M Dobó,&nbsp;M Pál","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The data of first 1000 non-malformed, mature (greater than or equal to 2500 g) singletons of participants in the Hungarian Family Planning Programme were evaluated. The mean maternal weight gain during pregnancy was 13 kg which was modified by the body weight of women. Maternal weight gain exceeded 13 kg in 54% of pregnant women. There was a positive correlation between maternal weight gain and birth weight which was calculated as 26.6 g/kg.</p>","PeriodicalId":76974,"journal":{"name":"Acta paediatrica Hungarica","volume":"32 2","pages":"91-100"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12560350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
"Effects of prostaglandin E2 on the newborn respiratory system". 前列腺素E2对新生儿呼吸系统的影响。
Acta paediatrica Hungarica Pub Date : 1992-01-01
M Miltényi
{"title":"\"Effects of prostaglandin E2 on the newborn respiratory system\".","authors":"M Miltényi","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76974,"journal":{"name":"Acta paediatrica Hungarica","volume":"32 2","pages":"201-2"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12561788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bicarnesine-treated carnitine deficient myopathy: clinico-chemical investigations. 比卡尼斯治疗肉碱缺乏性肌病:临床化学研究。
Acta paediatrica Hungarica Pub Date : 1992-01-01
A László, L Klujber, A Svékus
{"title":"Bicarnesine-treated carnitine deficient myopathy: clinico-chemical investigations.","authors":"A László,&nbsp;L Klujber,&nbsp;A Svékus","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Authors report on a Bicarnesine replacement therapy in an infant girl patient suffering from carnitine deficient myopathy diagnosed at 1 year of age. The hypotonic patient's motoric functions improved and she became able to walk as a result of therapy applied, but the pathological process generalized to encephalomyopathy. Free and esterified carnitine were determined from the serum and muscle biopsymaterial. After the Bicarnesine-supplementation the serum carnitine fractions elevated.</p>","PeriodicalId":76974,"journal":{"name":"Acta paediatrica Hungarica","volume":"32 3","pages":"235-9"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12648120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prolactin and dopamine concentrations in the cerebrospinal fluid during the neonatal period. 新生儿期脑脊液中催乳素和多巴胺的浓度。
Acta paediatrica Hungarica Pub Date : 1992-01-01
V Thurzó, T Ertl, G Hartmann, E Gács
{"title":"Prolactin and dopamine concentrations in the cerebrospinal fluid during the neonatal period.","authors":"V Thurzó,&nbsp;T Ertl,&nbsp;G Hartmann,&nbsp;E Gács","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Unlabelled: </strong>Prolactin (PRL) has been detected in the cerebrospinal fluid (CSF) in humans and the absolute level appears to reflect the serum PRL concentration. Because PRL is thought to be involved in the regulation of brain water and electrolyte content attempt has been made to determine CSF and plasma PRL and dopamine (DA) concentrations, osmolality, and sodium level in 21 newborn infants undergoing lumbar punction because of apneic spells, fever, or perinatal asphyxia. The mean of gestational age was 36.5 weeks (range: 31-41) and birthweight was 2572 g (range: 1140-3550). The lumbar puncture was performed at the 8.3 postnatal day (range: 1-38). The plasma concentration of PRL was 106.52 +/- 14.43 ng/ml, significantly higher than the CSF PRL level (43.24 +/- 7.39 ng/ml, p < 0.01). This elevated level was observed in all individual cases. DA concentration in the plasma was much higher than the value detected in the CSF (64.75 +/- 13.83 vs 8.64 +/- 0.72 ng/ml, p < 0.01). No difference was observed between the sodium content of the CSF and plasma (138.94 +/- 1.28 vs 138.04 +/- 1.03 mmol/l), however, the osmolality of the plasma tended to be higher than the CSF osmolality (286.7 +/- 3.81 vs 276.76 +/- 2.19 mosm/kg, p < 0.05). In the CSF osmolality, PRL, DA, and sodium concentrations did not show any correlation.</p><p><strong>In conclusion: </strong>in the CSF PRL probably does not play a primary role in controlling the osmolality and sodium content. PRL in CSF seems to be independent from CSF DA concentration.</p>","PeriodicalId":76974,"journal":{"name":"Acta paediatrica Hungarica","volume":"32 4","pages":"299-307"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12478602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adolescent mothers: do they breast-feed less? 青春期母亲:她们母乳喂养少了吗?
Acta paediatrica Hungarica Pub Date : 1992-01-01
M Amador, M P Hermelo, J E Canetti, E Consuegra
{"title":"Adolescent mothers: do they breast-feed less?","authors":"M Amador,&nbsp;M P Hermelo,&nbsp;J E Canetti,&nbsp;E Consuegra","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Two groups of mothers with infants between sixty and eighty-nine days of age, from the same Health Area of the city of Havana were studied. The first group's age was nineteen years or less and members of the second one were twenty to twenty-five years old. The sociocultural level of the older group was significantly more favourable. The proportion of mothers exclusively breast-feeding was lower among the teenagers, and the frequency of complete weaning by the end of the third month was higher in their group. Duration of breast-feeding, either exclusive or combined with bottle-feeding was also shorter in the group of adolescent mothers, and frequency of diarrheal episodes was higher among their infants; body weight for age and body weight for length showed a shift towards lower percentile channels in these infants. Such differences were evident despite of that both groups of mothers had the same opportunity to receive information about the advantages of breast-feeding and there were no differences in the frequency and quality of prenatal care.</p>","PeriodicalId":76974,"journal":{"name":"Acta paediatrica Hungarica","volume":"32 3","pages":"269-85"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12648122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Simultaneous occurrence of selective ACTH insensitivity, achalasia and alacrimia accompanied by hyperlipoproteinaemia. 同时发生选择性ACTH不敏感、失弛缓症和血氧症伴高脂血症。
Acta paediatrica Hungarica Pub Date : 1992-01-01
A Várkonyi, J Julesz, P Szüts, I Tóth, I Faredin
{"title":"Simultaneous occurrence of selective ACTH insensitivity, achalasia and alacrimia accompanied by hyperlipoproteinaemia.","authors":"A Várkonyi,&nbsp;J Julesz,&nbsp;P Szüts,&nbsp;I Tóth,&nbsp;I Faredin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>An extremely rare clinical syndrome on a 7-year-old-girl is presented. Besides isolated glucocorticoid insufficiency, achalasia and alacrima disturbance of the lipid metabolism was also detected--being a special feature of this case. The details of the endocrine workup is discussed, providing clues for the possible pathomechanism. The correct diagnosis and specific therapy is of utmost importance in the everyday life of the patient.</p>","PeriodicalId":76974,"journal":{"name":"Acta paediatrica Hungarica","volume":"32 1","pages":"31-42"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12499360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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