Adverse drug reactions and acute poisoning reviews最新文献

The complications of newer transplant antirejection drugs: treatment with cyclosporin A, OKT3, and FK506. 新型移植抗排斥药物的并发症:环孢素A、OKT3和FK506治疗。

Adverse drug reactions and acute poisoning reviews Pub Date : 1990-01-01

P K Li, M G Nicholls, K N Lai

引用次数: 0

Thyroid disorders induced by lithium and amiodarone: an overview. 锂和胺碘酮致甲状腺疾病综述。

Adverse drug reactions and acute poisoning reviews Pub Date : 1990-01-01

C C Chow, C S Cockram

引用次数: 0

Aspects of pesticide toxicology. 农药毒理学方面。

Adverse drug reactions and acute poisoning reviews Pub Date : 1990-01-01

P G Blain

{"title":"Aspects of pesticide toxicology.","authors":"P G Blain","doi":"","DOIUrl":"","url":null,"abstract":"Pesticides are currently perceived by the public as posing a major long-term threat to the health of the population. While the acute toxic effects of accidental or intentional ingestion of large doses are accepted, very little is known about the health risks associated with chronic occupational exposure or a life-long intake in food and drinking water. As in most cases of risk assessment, it is the relative risks that must be considered. Pesticides have made a vital contribution to the quality and quantity of food and overall to health both in developed and, most significantly, developing countries, so that their sudden withdrawal would present far more serious health problems than do their potential long-term toxic effects. Genetic engineering may develop seeds that are naturally resistant to many plant diseases, and biological methods of insect control are likely to be used more frequently, but the continued use of pesticides will be necessary for many more years. There is a pressing need for research into the chronic health effects in man of low-level exposure to pesticides, the mechanisms of the toxic effects, and the development of reliable methods for monitoring exposure. The responsibility for ensuring that this work is undertaken must be accepted by governments.","PeriodicalId":7693,"journal":{"name":"Adverse drug reactions and acute poisoning reviews","volume":"9 1","pages":"37-68"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13343497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Are pesticides immunotoxic? 农药有免疫毒性吗?

Adverse drug reactions and acute poisoning reviews Pub Date : 1990-01-01

P A Botham

{"title":"Are pesticides immunotoxic?","authors":"P A Botham","doi":"","DOIUrl":"","url":null,"abstract":"So far there is little evidence that occupational or environmental exposure to pesticides has led to clinically significant immunosuppression, and hence to an increased risk of developing infection or cancer. In addition, the incidence of hypersensitivity reactions to pesticides is generally low. Experiments have been conducted in experimental models that indicate that certain pesticides are immunosuppressive to animals. The majority of these experiments, however, have used high (frankly toxic) doses of pesticides and immunosuppression has been monitored using in vivo or in vitro immune function tests, the results of which are difficult to interpret in terms of effects on health. One exception is tributyltin oxide which, in the rat, causes immune dysfunction at doses below those that cause general toxicity, and which compromises the ability of the animals to resist bacterial and parasitic infection. Predictive assessment of possible immunotoxicity induced by exposure to a pesticide should be structured within the current framework of acute, subacute and chronic testing procedures used for regulatory purposes. With the exception of predicting some hypersensitivity reactions (respiratory allergy and autoimmunity), which would require the development of novel specialized methods, indications of potential immunotoxicity can be obtained from standard haematological investigations and by evaluation of lymphoid organs and tissues such as the spleen, thymus, lymph nodes, and bone marrow. Pathological and histopathological examination of the lymphoid system is a mandatory requirement of nearly all subchronic testing guidelines for pesticides worldwide. The incorporation of specialized, and in particular in vitro, immune function tests into the routine toxicological assessment of a pesticide is not only time-consuming and potentially wasteful of animals, but is also scientifically unacceptable; the significance of changes in such tests must await further research on the reserve capacity of the immune system.","PeriodicalId":7693,"journal":{"name":"Adverse drug reactions and acute poisoning reviews","volume":"9 2","pages":"91-101"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13372458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Button battery ingestion: a review. 纽扣电池摄入:回顾。

Adverse drug reactions and acute poisoning reviews Pub Date : 1990-01-01

N Thompson, F Lowe-Ponsford, T G Mant, G N Volans

引用次数: 0

The adverse effects of recombinant human erythropoietin therapy. 重组人促红细胞生成素治疗的不良反应。

Adverse drug reactions and acute poisoning reviews Pub Date : 1990-01-01

K C Wong, P K Li, S F Lui, M G Nicholls, K N Lai

引用次数: 0

Adverse drug reactions in neonatal intensive care units. 新生儿重症监护病房的药物不良反应。

Adverse drug reactions and acute poisoning reviews Pub Date : 1990-01-01

M Bonati, F Marchetti, M T Zullini, V Pistotti, G Tognoni