Hospital formulary最新文献_第8页

Evaluation of i.v. ceftriaxone usage in a community-based hospital. 某社区医院静脉注射头孢曲松的评价

Hospital formulary Pub Date : 1993-02-01

G P Sesin, P Gannon

引用次数: 0

Clinical appropriateness, therapeutic equivalence, and cost of conversion of H2 antagonist therapy. H2拮抗剂治疗的临床适宜性、治疗等效性和转换成本。

Hospital formulary Pub Date : 1993-01-01

J G Kitrenos, D R Brown, D J Letting, D L Rotella

引用次数: 0

Economic challenges of gram-positive infection. Symposium held in Florence, Italy, Spring 1992. 革兰氏阳性感染带来的经济挑战。1992年春在意大利佛罗伦萨举行的专题讨论会。

Hospital formulary Pub Date : 1993-01-01

引用次数: 0

Roundtable discussion. Maximizing potential cost benefits of teicoplanin through appropriate usage. 圆桌会议讨论。通过适当使用，使替柯普兰的潜在成本效益最大化。

Hospital formulary Pub Date : 1993-01-01

M J Rybak, R Allen, P Arnow, P C Craven, R Freeman, R N Grüneberg, J Korin, C H Nightingale, E Rubinstein, G S Schaison

引用次数: 0

Health economics in the United States: cost implications. 美国的卫生经济学:成本影响。

Hospital formulary Pub Date : 1993-01-01

G N Whitelaw

引用次数: 0

Cost effectiveness of teicoplanin and ceftriaxone: a once-daily antibiotic regimen. 替柯planin和头孢曲松的成本效益:每日一次的抗生素方案。

Hospital formulary Pub Date : 1993-01-01

G S Schaison

{"title":"Cost effectiveness of teicoplanin and ceftriaxone: a once-daily antibiotic regimen.","authors":"G S Schaison","doi":"","DOIUrl":"","url":null,"abstract":"There is a high incidence of staphylococcal infection in febrile neutropenic children with a central venous line. These patients are usually initially treated with empiric antimicrobial therapy that provides broad spectrum coverage. In a study evaluating a conventional regimen of vancomycin 40 mg/kg/d plus ceftazidime 100 mg/kg/d given in three divided doses to 41 febrile children with leukemia or lymphoma, the response rate was 87% after a mean treatment duration of 16 days. A once-daily regimen of an investigational antibiotic, teicoplanin, 10 mg/kg/d and ceftriaxone 50 mg/kg/d evaluated in 47 febrile children with leukemia was found to produce an equivalent rate of success and require the same mean duration of therapy. A cost-effectiveness analysis comparing the economic impact of replacing the conventional regimen with once-daily teicoplanin-ceftriaxone revealed that a 16-day course of the latter treatment would produce cost savings in terms of the cost of the antibiotics and other nonreusable materials, as well as in nursing time. Using French drug pricing data, the savings calculated for drugs and materials were 478 FF ($80 US). The teicoplanin-ceftriaxone regimen saved approximately 14 hours in nursing time per patient. Extrapolations based on estimates of hospital occupancy and the ratio of days a patient receives antibiotic therapy to the total duration of hospital stay suggest that an average hospital ward could achieve monthly costsavings of 7,641 FF ($1,273 US) for antibiotics and materials.","PeriodicalId":76912,"journal":{"name":"Hospital formulary","volume":"28 Suppl 1 ","pages":"20-2"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20994642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cost implications of home care on serious infections. 家庭护理对严重感染的成本影响。

Hospital formulary Pub Date : 1993-01-01

E Rubinstein

{"title":"Cost implications of home care on serious infections.","authors":"E Rubinstein","doi":"","DOIUrl":"","url":null,"abstract":"More than 250,000 Americans will receive home IV drug therapy this year. Antibiotics will account for two-thirds of this care. Over 60% of infections treated at home are caused by gram-positive cocci, with staphylococci accounting for approximately 24% of the pathogens. Bone and joint infections represent the most common diagnoses among patients receiving parenteral antibiotics at home, and many of the infections treated at home were initially acquired in the hospital. The most common serious complications of coronary bypass surgery, the most frequently performed operation in many hospitals, are sternal wound infections are methicillin-resistant The major pathogenic causes of these infections are methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis. These complications are usually treated with prolonged inpatient IV therapy and surgery. In a study in which patients with sternal wound infections or mediastinitis secondary to coronary bypass surgery were treated with teicoplanin, preliminary results showed that the mean postoperative hospital stay was decreased by more than 7 days compared with patients receiving other types of antibiotic therapy. This was accomplished by changing from intravenous to intramuscular therapy as soon as the patient became stabilized and then discharging the patient after an additional 2 days to complete intramuscular therapy at home. In addition to enhancing the quality of life for the patient by allowing early hospital discharge and early ambulation, home therapy offers the additional benefits of decreasing the risk of cross infection to other patients, as well as to the already infected patient.","PeriodicalId":76912,"journal":{"name":"Hospital formulary","volume":"28 Suppl 1 ","pages":"46-50"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20995955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of nosocomial infections on hospital costs. 医院感染对医院成本的影响。

Hospital formulary Pub Date : 1993-01-01

C H Nightingale

引用次数: 0

Teicoplanin vs vancomycin: cost-effectiveness comparisons. 替可普兰与万古霉素:成本-效果比较。

Hospital formulary Pub Date : 1993-01-01

M J Rybak

{"title":"Teicoplanin vs vancomycin: cost-effectiveness comparisons.","authors":"M J Rybak","doi":"","DOIUrl":"","url":null,"abstract":"The rising incidence of methicillin-resistant staphylococci and resistant enterococci in recent years has led to increased use of vancomycin as an active combatant in the treatment of gram-positive infections. Teicoplanin is an investigational glycopeptide that shares a similar spectrum of activity with vancomycin and appears to have similar efficacy. Teicoplanin offers several theoretical advantages compared with vancomycin including once-daily dosing, fewer side effects, and the option for intramuscular administration. While these may be perceived as substantial advances in the glycopeptide class of antibiotics, teicoplanin will probably not replace the now generically available vancomycin on hospital formularies. If competitively priced as a once-daily dosing regimen, teicoplanin will likely gain initial acceptance as an alternative in patients with an intolerance to vancomycin infusion-related side effects or in patients placed on combination aminoglycoside therapy for extended periods of treatment, as an intramuscular antibiotic in patients with poor venous access, and for routine antibiotic prophylaxis where protection from resistant gram-positive pathogens is important. The use of teicoplanin in the hospital may become more widespread as its side effect profile and economic advantages of less frequent dosing compared with vancomycin become better understood.","PeriodicalId":76912,"journal":{"name":"Hospital formulary","volume":"28 Suppl 1 ","pages":"28-32"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20995951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cost control of therapy for i.v. catheter infections. 静脉置管感染治疗的成本控制。

Hospital formulary Pub Date : 1993-01-01

P Arnow

{"title":"Cost control of therapy for i.v. catheter infections.","authors":"P Arnow","doi":"","DOIUrl":"","url":null,"abstract":"Intravenous catheter sepsis is an important challenge for physicians because it is associated with a high incidence of complications, and treatment can be very costly. Significant complications occur in about 25% of cases and include septic shock, suppurative thrombophlebitis, metastatic infection, and endocarditis. The risk of such complications is increased when catheter removal or appropriate antibiotic therapy is delayed, when Staphylococcus aureus is the pathogen, and probably when a prosthetic heart valve or pulmonary artery catheter is present. The optimum duration of antibiotic therapy for intravenous catheter sepsis has not been established and depends on the pathogen and on the presence of other risk factors for complications. A treatment duration of 1 week may be adequate for pathogens, such as coagulase-negative staphylococci or Candida, that are unlikely to cause complications, while > or = 2 weeks of antibiotic therapy is warranted for S aureus. Recent approaches that may help to reduce costs include shortening the duration of parenteral antibiotic treatment either by giving oral agents for part of the treatment period or by using a synergistic combination of antibiotics. Also, for infections in subcutaneously tunneled catheters, intraluminal administration of small volumes of highly concentrated antibiotics often is an effective alternative to prolonged systemic antibiotic therapy.","PeriodicalId":76912,"journal":{"name":"Hospital formulary","volume":"28 Suppl 1 ","pages":"23-7"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20995950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0