Zeitschrift fur Morphologie und Anthropologie最新文献

{"title":"Relapse of tagraxofusp treated blastic plasmacytoid dendritic cell neoplasm with loss of CD123 expression.","authors":"Rohit Gulati, Asma Abu-Salah, Tareq Salous, Mehdi Nassiri","doi":"10.1007/s12308-021-00479-z","DOIUrl":"10.1007/s12308-021-00479-z","url":null,"abstract":"<p><p>Tagraxofusp, a CD123-based-targeted immunotherapy, was recently approved to treat blastic plasmacytoid dendritic cell neoplasm (BPDCN) with excellent response. Also, a subset of BPDCN shows resistance to tagraxofusp. These resistant cases continue to express CD123, which forms the basis of the continued utility of tagraxofusp in newer combination chemotherapies to overcome resistance in BPDCN. Herein, we report a case of an elderly male with BPDCN that achieved complete remission on initial primary treatment with tagraxofusp. However, BPDCN relapsed after 1.5 years while on treatment, with loss of CD123 expression. At relapse, the neoplasm was comprehensively immunophenotyped by flow cytometry (performed on both peripheral blood and bone marrow specimen) and by immunohistochemical evaluation of the bone marrow clot section. The neoplasm at relapse was diagnostic of BPDCN with a lack of CD123 expression. This case highlights a potential limitation of current and upcoming tagraxofusp-based multidrug therapies, at least in a subset of refractory BPDCN. We believe our report will serve as a sentinel to incite future investigations involving alternate resistance mechanisms in BDPCN.</p>","PeriodicalId":76854,"journal":{"name":"Zeitschrift fur Morphologie und Anthropologie","volume":"1 1","pages":"35-39"},"PeriodicalIF":0.6,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85770822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between genetic anomalies of different levels and deviations in dermatoglyphic traits. Part 7: Dermatoglyphic peculiarities of females with cervical and endometrial carcinoma.","authors":"M. Bejerano, K. Yakovenko, M. Katznelson, E. Kobyliansky","doi":"10.1127/ZMA/83/2001/75","DOIUrl":"https://doi.org/10.1127/ZMA/83/2001/75","url":null,"abstract":"This study was carried out to evaluate the effects of neoplastic diseases like carcinoma of the cervix and endometrial carcinoma, and was based on dermatoglyphic traits and their indices of intraindividual diversity (Div), fluctuating asymmetry (FIA) and directional asymmetry (DA). The results were compared with control groups of women and men, whose data have been detailed in our previous publications (Kobyliansky et al., 1999 a-d), and with analogous data of additional cancer groups available in the literature, like acute leukemia, bronchial cancer and breast cancer. The general aims of the study were as follows: (a) to obtain a dermatoglyphic characterization of discrete and quantitative traits and their Div, DA, FIA values in cancer patients, compared to healthy control groups, both female and male; (b) to test the hypothesis that in cancer patients there is an increased level of FIA as a result of an impaired developmental homeostasis; (c) to explore the possibility of using DT (dermatoglyphic traits) data of CW (women with cancer) to predict the probability of the appearance of cervical and endometrial carcinoma in apparently healthy females at a young age. The sample consisted of 94 Israeli-Jewish women of various groups, of which 54 had endometrial carcinoma and 40 had cervical carcinoma. The prints were collected in the Tel-Hashomer Hospital. The control group was a sample of 874 healthy subjects, half of them male and the other female, all from Jewish communities of European extractions (50%) as well as from Africa (50%). All controls were adults (over 18 years of age). Interpretation of prints was performed according to Cummins & Midlo (1961) and Penrose (1968) and included identification of patterns, ridge counts and the measurement of distances and angles in the palms, 79 DT for every individual were assessed. Significant differences were found for some of the studied traits between cancer patients and their healthy control groups. We encountered merely a low sexual dimorphism between the CW and the control males as compared to that between control males and females (with significant differences in 18% of the quantitative traits vs 64% in the control). The indices of diversity and asymmetry proved more suitable for discrimination, yielding the highest discrimination level between CW and control females. This finding suggested other data in the present study which points to a similarity between CW and control males.","PeriodicalId":76854,"journal":{"name":"Zeitschrift fur Morphologie und Anthropologie","volume":"47 1","pages":"75-108"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86028908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Schizodactylous Grasp of the Howling Monkey","authors":"D. Youlatos","doi":"10.1127/ZMA/82/1999/187","DOIUrl":"https://doi.org/10.1127/ZMA/82/1999/187","url":null,"abstract":"","PeriodicalId":76854,"journal":{"name":"Zeitschrift fur Morphologie und Anthropologie","volume":"8 1","pages":"187-198"},"PeriodicalIF":0.0,"publicationDate":"1999-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63726351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal analysis of adolescent growth of foot length and stature of children living in Ogi area of Japan: a 12 years data.","authors":"K. M. Liu, K. Shinoda, T. Akiyoshi, H. Watanabe","doi":"10.11501/3154861","DOIUrl":"https://doi.org/10.11501/3154861","url":null,"abstract":"Adolescent growth of foot length (FL) and stature were investigated in a sample of 586 children living in the Ogi area of Saga Prefecture Japan, who were traced longitudinally from 6.5 to 17.5 years of age. FL growth and its relationship to height were analyzed using the JPA2 model and the Optimal Kernel Method to fit the serial data of stature and FL. The results demonstrated that there was clear peak growth velocity (PGV) during the adolescent growth period of FL for most of the children; before 11.5 years of age there was no essential difference in mean foot length between girls and boys; the completion of FL growth was on average two years earlier than that of stature and two and a half years after the appearance of the peak height velocity (PHV); girls completed the FL growth two years earlier than boys; the longer the growth period for FL or the larger the value of FL at an early age the bigger the adult foot length; the foot grew in synchrony with the body as a whole.","PeriodicalId":76854,"journal":{"name":"Zeitschrift fur Morphologie und Anthropologie","volume":"1 1","pages":"87-101"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79865664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body height, body mass and surface area of the Neanderthals.","authors":"H Helmuth","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Body size, expressed as height or stature, is an important determinant of many other biological variables. Thus, it is surprising that many textbooks portray a wrong picture of Neanderthal height as being \"very short\" or \"just over 5 feet\". Based on 45 long bones from maximally 14 males and 7 females, Neanderthals' height averages between 164 and 168 (males) resp. 152 to 156 cm (females). This height is indeed 12-14 cm lower than the height of post-WWII Europeans, but compared to Europeans some 20,000 or 100 years ago, it is practically identical or even slightly higher. Considering the body build of Neanderthals, new body weight estimates show that they are only slightly above the cm/weight or the Body Mass Index of modern Americans or Canadians. The calculation of the relative surface area (approximately 240-244 cm2/kg) is very low and supports earlier findings of a morphological and anatomical thermoregulatory adaptation to a cold climate in the Neanderthals.</p>","PeriodicalId":76854,"journal":{"name":"Zeitschrift fur Morphologie und Anthropologie","volume":"82 1","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20760326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facial reconstructions on the Vörs-Papkert B Cemetery series.","authors":"A Kustár","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Seven skulls from the Vörs-Papkert B Cemetery were analysed according to the facial reconstruction method of KOLLMANN and GERASIMOV. The degree of expression of sex, metric data of the skull, morphological characteristics of the skull and characteristics of the reconstructed face are presented for each of the skulls.</p>","PeriodicalId":76854,"journal":{"name":"Zeitschrift fur Morphologie und Anthropologie","volume":"82 1","pages":"13-45"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20760327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formation of morphological traits of the quadriceps femoris muscle (QFM) before and after birth. Part IV. Vastus intermedius muscle (VIM).","authors":"J Lewandowski","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76854,"journal":{"name":"Zeitschrift fur Morphologie und Anthropologie","volume":"82 1","pages":"75-86"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20760263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patterns of faciodental sexual dimorphism in Hispanopithecus.","authors":"D W Cameron","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This paper examines patterns of sexual dimorphism within the Spanish hominid Hispanopithecus. The inclusion of this genus within the Hominidae suggests that extant male and female great ape sexually specific characters are appropriate features for determining the sex of these fossil hominids. It is shown that Hispanopithecus has a distinct sexually dimorphic pattern from that observed in the extant great apes. It is also demonstrated that H. laietanus and H. crusafonti each have a distinct sex pattern from each other. This result further supports the dual species hypothesis.</p>","PeriodicalId":76854,"journal":{"name":"Zeitschrift fur Morphologie und Anthropologie","volume":"82 1","pages":"47-58"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20760328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal analysis of adolescent growth of foot length and stature of children living in Ogi area of Japan: a 12 years data.","authors":"K M Liu,&nbsp;K Shinoda,&nbsp;T Akiyoshi,&nbsp;H Watanabe","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Adolescent growth of foot length (FL) and stature were investigated in a sample of 586 children living in the Ogi area of Saga Prefecture Japan, who were traced longitudinally from 6.5 to 17.5 years of age. FL growth and its relationship to height were analyzed using the JPA2 model and the Optimal Kernel Method to fit the serial data of stature and FL. The results demonstrated that there was clear peak growth velocity (PGV) during the adolescent growth period of FL for most of the children; before 11.5 years of age there was no essential difference in mean foot length between girls and boys; the completion of FL growth was on average two years earlier than that of stature and two and a half years after the appearance of the peak height velocity (PHV); girls completed the FL growth two years earlier than boys; the longer the growth period for FL or the larger the value of FL at an early age the bigger the adult foot length; the foot grew in synchrony with the body as a whole.</p>","PeriodicalId":76854,"journal":{"name":"Zeitschrift fur Morphologie und Anthropologie","volume":"82 1","pages":"87-101"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20760264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Size comparison of the male and female human corpus callosum from autopsy samples.","authors":"S Matano,&nbsp;Y Nakano","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>161 cases of human-brain autopsies (93 Male, 68 Female) were collected from three samples in the Kinai district of Japan. From photographs of the midsagittal plane of each brain, surface areas of the corpus callosum (CC in mm2) and of the medial view of the cerebrum (H in mm2) were measured. The absolute H and CC values from each of the three samples were larger in males than in females, with full overlapping of the male and female ranges for both H and CC values. However, the relative values of CC corrected for H (CC/H) were almost equal between sexes. The relative values for the posterior one-fifth (splenium) of the CC, which were divided by CC or H, were slightly higher in females than in males in each of the three samples, but without statistical significance. This trend was also found in the relative values for the posterior one-third of the CC and in the relative values for region, meaning the posterior one-fifth of the CC subtracted from the posterior one-third of the CC (isthmus), but not in the relative values for the anterior one-fifth (genu) of the CC.</p>","PeriodicalId":76854,"journal":{"name":"Zeitschrift fur Morphologie und Anthropologie","volume":"82 1","pages":"67-73"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20760262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}