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Zeitschrift fur Gastroenterologie. Verhandlungsband最新文献

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[Value of nuclear medicine methods in hepato-gastroenterology--tumor detection]. [核医学方法在肝消化肿瘤检测中的价值]。
Zeitschrift fur Gastroenterologie. Verhandlungsband Pub Date : 1991-03-01
R P Baum, G Hör
{"title":"[Value of nuclear medicine methods in hepato-gastroenterology--tumor detection].","authors":"R P Baum, G Hör","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76844,"journal":{"name":"Zeitschrift fur Gastroenterologie. Verhandlungsband","volume":"26 ","pages":"134-6"},"PeriodicalIF":0.0,"publicationDate":"1991-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12877720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[New "diuretics" in therapy of ascites]. [新型“利尿剂”治疗腹水]。
Zeitschrift fur Gastroenterologie. Verhandlungsband Pub Date : 1991-03-01
J Schölmerich, T Andus, V Gross, H G Leser, W Gerok
{"title":"[New \"diuretics\" in therapy of ascites].","authors":"J Schölmerich, T Andus, V Gross, H G Leser, W Gerok","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76844,"journal":{"name":"Zeitschrift fur Gastroenterologie. Verhandlungsband","volume":"26 ","pages":"144-8"},"PeriodicalIF":0.0,"publicationDate":"1991-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12877725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Ulcerating, anal lesions--sexually transmissible diseases]. [溃疡、肛门病变——性传播疾病]。
Zeitschrift fur Gastroenterologie. Verhandlungsband Pub Date : 1991-03-01
D Geile, K Scheidter, F Staber
{"title":"[Ulcerating, anal lesions--sexually transmissible diseases].","authors":"D Geile, K Scheidter, F Staber","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76844,"journal":{"name":"Zeitschrift fur Gastroenterologie. Verhandlungsband","volume":"26 ","pages":"181-5"},"PeriodicalIF":0.0,"publicationDate":"1991-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12877737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Ethics in a Leonardo world]. [列奥纳多世界中的伦理学]。
Zeitschrift fur Gastroenterologie. Verhandlungsband Pub Date : 1991-03-01
J Mittelstrass
{"title":"[Ethics in a Leonardo world].","authors":"J Mittelstrass","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76844,"journal":{"name":"Zeitschrift fur Gastroenterologie. Verhandlungsband","volume":"26 ","pages":"3-6"},"PeriodicalIF":0.0,"publicationDate":"1991-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12878160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Emergency and critical care problems: acute intestinal ischemia]. [急危护理问题:急性肠缺血]。
Zeitschrift fur Gastroenterologie. Verhandlungsband Pub Date : 1991-03-01
A Encke
{"title":"[Emergency and critical care problems: acute intestinal ischemia].","authors":"A Encke","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76844,"journal":{"name":"Zeitschrift fur Gastroenterologie. Verhandlungsband","volume":"26 ","pages":"33-4"},"PeriodicalIF":0.0,"publicationDate":"1991-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12878177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Neurophysiology of the enteric nervous system]. [肠神经系统的神经生理学]
Zeitschrift fur Gastroenterologie. Verhandlungsband Pub Date : 1991-03-01
M Schemann
{"title":"[Neurophysiology of the enteric nervous system].","authors":"M Schemann","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76844,"journal":{"name":"Zeitschrift fur Gastroenterologie. Verhandlungsband","volume":"26 ","pages":"234-5"},"PeriodicalIF":0.0,"publicationDate":"1991-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12878296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular design of potent specific antagonists for the gastrin and cholecystokinin receptors. 胃泌素和胆囊收缩素受体强效特异性拮抗剂的分子设计。
Zeitschrift fur Gastroenterologie. Verhandlungsband Pub Date : 1991-03-01
B E Evans
{"title":"Molecular design of potent specific antagonists for the gastrin and cholecystokinin receptors.","authors":"B E Evans","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Widespread distribution of receptors for the peptide hormones cholecystokinin (CCK) and gastrin in the gut and in the CNS suggests therapeutic potential for selective antagonists of these hormones. Discovery of the natural product Asperlicin provided a new class of non-peptidal CCK antagonists, but oral bioavailability in this class remained elusive. With Asperlicin as a guide, the new, selective, orally bioavailable, high affinity CCK-A antagonist, MK-329 (L-364,718; Devazepide) and CCK-B/gastrin antagonist, L-365,260 have been developed. Biological profiles of these compounds are presented and results of early clinical evaluation of MK-329 are described. The significance of these agents as models for development of non-peptidal ligands for other receptors are briefly summarized.</p>","PeriodicalId":76844,"journal":{"name":"Zeitschrift fur Gastroenterologie. Verhandlungsband","volume":"26 ","pages":"269-71"},"PeriodicalIF":0.0,"publicationDate":"1991-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12878307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Pathophysiology of lipoprotein metabolism]. [脂蛋白代谢病理生理学]。
Zeitschrift fur Gastroenterologie. Verhandlungsband Pub Date : 1991-03-01
E Windler, S Jäckle, F Rinninger, H Greten
{"title":"[Pathophysiology of lipoprotein metabolism].","authors":"E Windler,&nbsp;S Jäckle,&nbsp;F Rinninger,&nbsp;H Greten","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76844,"journal":{"name":"Zeitschrift fur Gastroenterologie. Verhandlungsband","volume":"26 ","pages":"98-9"},"PeriodicalIF":0.0,"publicationDate":"1991-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12878686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new role for the low density lipoprotein receptor. 低密度脂蛋白受体的新作用。
Zeitschrift fur Gastroenterologie. Verhandlungsband Pub Date : 1991-03-01
P B Salbach, U Janssen-Timmen, C Blattner, R Ziegler, A J Habenicht
{"title":"A new role for the low density lipoprotein receptor.","authors":"P B Salbach,&nbsp;U Janssen-Timmen,&nbsp;C Blattner,&nbsp;R Ziegler,&nbsp;A J Habenicht","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>It is well established that the low density lipoprotein (LDL) pathway functions to maintain a constant concentration of cellular cholesterol, but LDL effects that are unrelated to cholesterol metabolism have not been studied in great detail. In the present investigation we demonstrate that the LDL receptor pathway regulates cellular levels of free arachidonic acid (AA) and hence prostaglandin (PG) synthesis. We used platelet-derived growth factor (PDGF)-stimulated fibroblasts as a model system to investigate mechanism of LDL-dependent PG synthesis. PDGF-stimulated but not quiescent cells formed radiolabelled prostacyclin (PGI2) and PGE2 upon incubation with LDL that had been reconstituted with cholesteryl-(1-14C)-arachidonate (rec-LDL), while fibroblasts from patients that are afflicted with the LDL receptor negative phenotype of familial hypercholesterolaemia (FH) failed to synthesize significant amounts of PGs. Furthermore cells that had been preincubated with chloroquine or an anti LDL receptor antibody, that prevents binding of LDL to its receptor, did not produce significant amounts of PGs upon incubation with rec-LDL. Moreover incubation of PDGF-stimulated cells with LDL or AA led to a time and concentration-dependent inactivation of PGH synthase, the rate limiting enzyme of PG synthesis. When taken together our results establish a new role of the classical LDL receptor pathway of Brown and Goldstein by demonstrating that LDL provides AA to fibroblasts for eicosanoid formation and that LDL has a profound inhibitory effect on the key enzyme of PG synthesis, the PGH synthase.</p>","PeriodicalId":76844,"journal":{"name":"Zeitschrift fur Gastroenterologie. Verhandlungsband","volume":"26 ","pages":"107-9"},"PeriodicalIF":0.0,"publicationDate":"1991-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12877713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Prostaglandin analogs in ulcer therapy]. 前列腺素类似物在溃疡治疗中的应用。
Zeitschrift fur Gastroenterologie. Verhandlungsband Pub Date : 1991-03-01
J Hotz
{"title":"[Prostaglandin analogs in ulcer therapy].","authors":"J Hotz","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76844,"journal":{"name":"Zeitschrift fur Gastroenterologie. Verhandlungsband","volume":"26 ","pages":"162-5"},"PeriodicalIF":0.0,"publicationDate":"1991-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12877731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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