Verhandlungen der Deutschen Gesellschaft fur Pathologie最新文献

[The complement system]. 补体系统。

Verhandlungen der Deutschen Gesellschaft fur Pathologie Pub Date : 2021-01-07 DOI: 10.1201/9780824745097-9

H. Wellensiek

引用次数: 2

[Familial hemophagocytic lymphohistiocytosis]. [家族性噬血细胞淋巴组织细胞病]。

Verhandlungen der Deutschen Gesellschaft fur Pathologie Pub Date : 2020-02-10 DOI: 10.32388/j6j8qi

C. Hesse, M. Hansmann, G. Janka-Schaub, D. Rontogianni, H. Radzun, R. Fischer

引用次数: 0

[Drug-induced liver injury]. [药物性肝损伤]。

Verhandlungen der Deutschen Gesellschaft fur Pathologie Pub Date : 2020-02-07 DOI: 10.32388/nkaf0f

H. Denk

{"title":"[Drug-induced liver injury].","authors":"H. Denk","doi":"10.32388/nkaf0f","DOIUrl":"https://doi.org/10.32388/nkaf0f","url":null,"abstract":"Drugs may cause acute or chronic liver damage depending on their mode of action. Hepatotoxic drugs include anaesthetics, psychotropic and anticonvulsant drugs, antiinflammatory agents, steroids, antimicrobial agents and cardiovascular drugs as well as antineoplastic agents. Hepatotoxic agents, including drugs, fall into two categories: (i) intrinsic and obligatory liver toxins with dose-dependent and predictable adverse effects, and (ii) facultative (idiosyncratic) hepatotoxins with non-predictable and non-dose-dependent liver toxicity affecting only few exposed individuals. Intrinsic hepatotoxins may either injure hepatocytes directly, e.g. by direct physicochemical effects, or indirectly by interfering with specific metabolic processes. In the idiosyncratic type of liver injury immunologic hypersensitivity reactions or toxic metabolites may be involved. Clinical and morphologic consequences of adverse drug reactions are acute or chronic liver diseases, including parenchymal damage (finally leading to necrosis or apoptosis), steatosis, cholestasis, various types of vascular alterations, granuloma formation and also neoplastic transformation. Thus, drugs are important causes of liver diseases and may account for up to 40% of cases of hepatitis and up to 25% of fulminant hepatic failure. Moreover, drug-induced injury also plays a leading role as cause of acute cholestasis.","PeriodicalId":76792,"journal":{"name":"Verhandlungen der Deutschen Gesellschaft fur Pathologie","volume":"86 1","pages":"120-5"},"PeriodicalIF":0.0,"publicationDate":"2020-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47278386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 72

Molecular pathology of lung cancer 肺癌的分子病理学

Verhandlungen der Deutschen Gesellschaft fur Pathologie Pub Date : 2013-01-01 DOI: 10.1007/978-1-4419-0787-5_14

I. Wistuba, A. Gazdar

引用次数: 40

[Chronic myeloproliferative diseases]. 慢性骨髓增生性疾病。

Verhandlungen der Deutschen Gesellschaft fur Pathologie Pub Date : 2008-01-30 DOI: 10.1002/9780470344545.CH6

V. Valli

引用次数: 4

[GIPC: a new target for therapy in pancreatic adenocarcinoma?]. [GIPC:胰腺腺癌治疗的新靶点]。

Verhandlungen der Deutschen Gesellschaft fur Pathologie Pub Date : 2007-01-01

M H Muders, G B Baretton, D E Aust, S K Dutta, E Wang, Y Ikeda, M R Spaller, K Datta, D Mukhopadhyay

{"title":"[GIPC: a new target for therapy in pancreatic adenocarcinoma?].","authors":"M H Muders, G B Baretton, D E Aust, S K Dutta, E Wang, Y Ikeda, M R Spaller, K Datta, D Mukhopadhyay","doi":"","DOIUrl":"","url":null,"abstract":"GIPC is highly expressed in human pancreatic adenocarcinoma and is a central protein for the stability of IGF-1R in pancreatic adenocarcinoma cell lines (15). The goal of this study was to prove the importance of GIPC in vivo and to evaluate possible therapeutic strategies that target this protein and its PDZ domain. In vivo effects of GIPC knockout were studied after lentiviral transduction of luciferase-expressing MiaPaCa2 pancreatic cancer cells with shRNA against GIPC; growth characteristics were monitored with bioluminiscence. Knockdown of GIPC led to a significant inhibition of pancreatic tumor cell growth in vivo in different mouse models. To test a possible therapeutic approach, the PDZ domain of GIPC was targeted by a short peptide composed of the amino acid sequence PSQSSSEA. This octapeptide was designed based on the C-terminal binding motif of GAIP. Targeting GIPC with this peptide inhibited the association between IGF-1R and GIPC. The subsequent downregulation of IGF-1R decreased proliferation in vitro and in vivo. In conclusion, our findings suggest that targeting GIPC and its PDZ domain-mediated interaction with the tyrosine kinase receptor IGF-1R could be a promising new treatment option for pancreatic cancer.","PeriodicalId":76792,"journal":{"name":"Verhandlungen der Deutschen Gesellschaft fur Pathologie","volume":"91 ","pages":"286-93"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27298909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Mapping of a deletion interval on 8p21-22 in prostate cancer by gene dosage PCR]. [基因剂量PCR在前列腺癌中定位8p21-22缺失区间]。

Verhandlungen der Deutschen Gesellschaft fur Pathologie Pub Date : 2007-01-01

H Schmidt, A Semjonow, K Csiszar, E Korsching, B Brandt, E Eltze

{"title":"[Mapping of a deletion interval on 8p21-22 in prostate cancer by gene dosage PCR].","authors":"H Schmidt, A Semjonow, K Csiszar, E Korsching, B Brandt, E Eltze","doi":"","DOIUrl":"","url":null,"abstract":"Various microsatellite and CGH studies in prostate cancer identify deletions on the short arm of chromosome 8 especially at band 8p21-22 searching for unknown putative tumor suppressor genes. By means of microsatellite markers several candidate genes were detected which may play different roles in early prostate cancer progression. We established a quantitative gene dosage PCR based on the real time PCR method serving the purpose of genomic fine mapping. Therefore we used 10 Assays-on Demand (ABI) for the detection of deletions located between and nearby the microsatellite markers D8S258 and NEFL spanning a genomic region of approximate 7 mbp. Comparative immunohistochemical analysis from tissue micro arrays (TMA) of 1122 independent cases followed. We were able to detect three clearly separated deletion intervals on 8p21-22. One on LZTS1, second on NEFL and third a deletion hot spot on LOXL2, which was affected in 72% of all investigated cases. Our comparative immunohistochemical TMA based studies demonstrate that LOXL2 is nearly lost in most prostate cancer tissues. LOXL2 catalyze the crosslinking of collagen and elastin in the extracellular matrix and it has been assumed that it is involved in tumor suppression and cell adhesion. LOXL2 is frequently expressed in proliferating tissues and shows a high expression in benign prostate tissue too. In prostate cancer the expression is positive correlated with the MIB1-score.","PeriodicalId":76792,"journal":{"name":"Verhandlungen der Deutschen Gesellschaft fur Pathologie","volume":"91 ","pages":"302-7"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27299373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Loss of metastatic deposits in breast sentinel lymph nodes during intra-operative frozen section analysis]. 【术中冷冻切片分析中乳腺前哨淋巴结转移物的丢失】。

Verhandlungen der Deutschen Gesellschaft fur Pathologie Pub Date : 2007-01-01

Z Varga, C Rageth, E Saurenmann, C Honegger, S von Orelli, M Fehr, D Fink, B Seifert, H Moch, R Caduff

引用次数: 0

Standardized morphological phenotyping of mouse models of human diseases within the German Mouse Clinic. 德国小鼠诊所人类疾病小鼠模型的标准化形态学表型。

Verhandlungen der Deutschen Gesellschaft fur Pathologie Pub Date : 2007-01-01

I Mossbrugger, G Hoelzlwimmer, J Calzada-Wack, L Quintanilla-Martinez

{"title":"Standardized morphological phenotyping of mouse models of human diseases within the German Mouse Clinic.","authors":"I Mossbrugger, G Hoelzlwimmer, J Calzada-Wack, L Quintanilla-Martinez","doi":"","DOIUrl":"","url":null,"abstract":"Inbred strains are the raw material for the generation of Genetically Engineered Mice (GEM) that have become indispensable tools for cancer research, and for the identification of genes involved in human diseases. The \"German Mouse Clinic\" was designed to provide the scientific community with a systematic, standardized and comprehensive phenotyping of mouse models on various genetic backgrounds and generated by different methods (transgenic, knockouts, ENU mutagenesis screen and gene-trap approaches). The pathology screen within the German Mouse-Clinic was conceived to ensure a complete morphologic phenotype of mouse models, to support discovery of genes functions, and to understand how these genes influence the development of human diseases. The goal is to define disease entities that can be recognized by a pathologist and relate them to human disorders when possible. Knowing the inherent morphologic phenotype of the most frequent used mouse strains is of utmost importance for the correct interpretation of mouse models. The main challenges, which pathologist are confronted to validate mouse models for human diseases include (1) knowledge of mouse biology and of histological differences between mouse strains and humans, (2) the terminology that should be used for the classification of neoplastic lesions in GEM's, (3) to asses the usefulness of a particular GEM as model for a human disease.","PeriodicalId":76792,"journal":{"name":"Verhandlungen der Deutschen Gesellschaft fur Pathologie","volume":"91 ","pages":"98-103"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27298643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Bone tumors]. 骨肿瘤。

Verhandlungen der Deutschen Gesellschaft fur Pathologie Pub Date : 2007-01-01

A Roessner

引用次数: 0