American Journal of Medical Genetics Part B: Neuropsychiatric Genetics最新文献

{"title":"“It's Not Deterministic and It Will Never Be Deterministic”: A Qualitative Study on Stakeholder Perspectives of Polygenic Risk Score Testing for Post-Traumatic Stress Disorder","authors":"Brandy M. Fox","doi":"10.1002/ajmg.b.70018","DOIUrl":"10.1002/ajmg.b.70018","url":null,"abstract":"<p>Post-traumatic stress disorder (PTSD) causes significant mental and physical distress, yet only a small subset of individuals exposed to trauma develop the disorder. Scientists and clinicians are still unable to predict who will get the disorder or how it will manifest. Genetic factors contribute to PTSD risk, but integrating genetic findings into clinical practice has been challenging. Military veterans are especially impacted by PTSD and have different treatment outcomes when compared to civilians. Thus, genetic findings related to PTSD may be particularly valuable to this population. This qualitative study explored expectations and concerns regarding polygenic risk score (PRS) testing for PTSD risk among three stakeholder groups: military veterans diagnosed with PTSD, clinicians who treat veterans with PTSD, and researchers specializing in PTSD genetics. Through semi-structured interviews, I developed three themes that each convey a unique aspect of how research participants conceptualize some potential avenues for pre-empting and living with PTSD, should PRS become widely available: (1) Controlling what you can; (2) The complexity of PTSD; (3) Potential risks for an increased emphasis on the genetic component of PTSD. Understanding stakeholder perspectives is crucial for tailoring education efforts, anticipating ethical challenges, and facilitating the responsible, equitable integration of PRS into clinical settings in the future.</p>","PeriodicalId":7673,"journal":{"name":"American Journal of Medical Genetics Part B: Neuropsychiatric Genetics","volume":"201 7","pages":"441-450"},"PeriodicalIF":1.4,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ajmg.b.70018","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147694692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Risk and High Burden of Depression and Suicide in the Maya-Mestizo Population of Yucatán, México","authors":"Marta Menjivar,&nbsp;Erandi Bravo,&nbsp;Margarita Rivera-Balancan,&nbsp;Barbara Itzel Pena Espinoza","doi":"10.1002/ajmg.b.70017","DOIUrl":"10.1002/ajmg.b.70017","url":null,"abstract":"<p>Major depression and suicide are critical public health concerns, particularly in underrepresented populations with unique genetic and sociocultural contexts. The Maya-mestizo population presents the highest suicide rates in the country but remains understudied in psychiatric genetics. This study evaluated the association between three genetic variants, rs7305115 (<i>TPH2</i>), rs6265 (<i>BDNF</i>), and rs2428707 (<i>HTR2C</i>), and the presence of major depression, melancholic subtype, and suicide risk in Maya-mestizo adults. A total of 598 participants were recruited from urban and rural areas. Psychiatric evaluations were performed using the MINI 5.0 (DSM-IV), and functional status was assessed with the Karnofsky scale. Genotyping was performed with TaqMan assays, and ancestry was confirmed with ancestry-informative markers. Analyses included Hardy–Weinberg equilibrium testing and logistic regression models adjusted for sex and included age, body mass index, Karnofsky performance scale score, and sociodemographic variables as covariates. The prevalence of major depression was 38.9%, while suicide risk reached 24.7%. The rs2428707 variant of <i>HTR2C</i> was significantly associated with major depression (OR 2.31, 95% CI 1.03–5.18, <i>p</i> = 0.041). Variants in <i>TPH2</i> and <i>BDNF</i> were associated with the melancholic subtype. No statistically significant associations were found with suicide risk, though overlap with depressive phenotypes suggests shared vulnerability. This first report of psychiatric genetics in the Maya-mestizo population highlights the need for culturally and genetically tailored interventions.</p>","PeriodicalId":7673,"journal":{"name":"American Journal of Medical Genetics Part B: Neuropsychiatric Genetics","volume":"201 7","pages":"431-440"},"PeriodicalIF":1.4,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ajmg.b.70017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147680114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interaction of FXTAS Family History and College Degree Attainment Predicts Trajectories of Cognitive and Motor Symptoms in FMR1 Premutation Carrier Women","authors":"Jinkuk Hong,&nbsp;Leann Smith DaWalt,&nbsp;Jessica Klusek,&nbsp;Elizabeth M. Berry-Kravis,&nbsp;Marsha Mailick","doi":"10.1002/ajmg.b.70022","DOIUrl":"10.1002/ajmg.b.70022","url":null,"abstract":"<p>The present longitudinal study focuses on <i>FMR1</i> premutation carrier women during midlife and early old age (<i>n</i> = 115). Bringing together the genetic risk factor of a family history of FXTAS and the environmental protective factor of higher education, the goal of the study was to determine how these factors potentially interact to predict self-reported FXTAS-type symptoms in women carrying the <i>FMR1</i> premutation. We investigated age-related changes in symptoms, measured prospectively over a decade. Using an accelerated longitudinal design approach, we estimated trajectories of change extending from early midlife (starting at age 39) into older age (up to age 80) in a community-based cohort. Results indicated that women with the <i>FMR1</i> premutation who have a family history of FXTAS are at greater risk for experiencing symptoms during late midlife and older age than those who do not have such a family history. Consistent with research on other neurodegenerative diseases, this family history risk may be moderated by completing a college education, suggesting that cognitive enrichment during a period of neuroplasticity might provide protection from the neurodegenerative symptoms that are experienced by some women with the premutation as they age.</p>","PeriodicalId":7673,"journal":{"name":"American Journal of Medical Genetics Part B: Neuropsychiatric Genetics","volume":"201 7","pages":"451-463"},"PeriodicalIF":1.4,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ajmg.b.70022","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147990708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Genetic Correlations Between Tobacco or Alcohol Use and Neurodegenerative Diseases Using East Asian Genetic Ancestry Genome-Wide Association Study Results","authors":"Linda Wang,&nbsp;Wiame Belbellaj,&nbsp;Frida Lona-Durazo,&nbsp;Sarah A. Gagliano Taliun","doi":"10.1002/ajmg.b.70024","DOIUrl":"10.1002/ajmg.b.70024","url":null,"abstract":"<p>Alzheimer's disease (AD) and Parkinson's disease (PD) are the most prevalent late-onset neurodegenerative diseases worldwide. Both are influenced in part by genetic factors and are currently incurable. Tobacco and alcohol, the two most common substances used among the general adult population, are potential AD/PD risk factors and are also heritable. Although important progress has been made, most existing research on the genetics of AD and PD has been carried out in individuals of European genetic ancestry. Investigations in a broad range of groups are crucial to understand disease mechanisms. Given the current availability of ancestry-specific tobacco and alcohol use as well as AD and PD genome-wide association study summary statistics, we performed global and local genetic correlation analyses using East Asian datasets. Genes within the correlated genetic regions were subsequently used to identify potentially enriched biological pathways between substance use and neurodegenerative diseases. We identified a global genetic correlation between smoking cessation and PD, which we confirmed in complementary European genetic ancestry data. Gene set enrichment analyses highlighted potentially shared genetic mechanisms between breast cancer and AD, which warrants further exploration. This work aims to promote further analyses across genetic ancestry groups.</p>","PeriodicalId":7673,"journal":{"name":"American Journal of Medical Genetics Part B: Neuropsychiatric Genetics","volume":"201 7","pages":"464-471"},"PeriodicalIF":1.4,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ajmg.b.70024","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148038401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genome-Wide Association Study of Symptom Change Following Cognitive Behavioral Therapy for Common Mental Disorders","authors":"Julia Bäckman,&nbsp;Olly Kravchenko,&nbsp;Matthew Halvorsen,&nbsp;Elles de Schipper,&nbsp;Ekaterina Ivanova,&nbsp;Viktor Kaldo,&nbsp;Nils Hentati Isacsson,&nbsp;Thorstein Olsen Eide,&nbsp;Kira D. Höffler,&nbsp;Manuel Mattheisen,&nbsp;Bjarne Hansen,&nbsp;Gerd Kvale,&nbsp;Kristen Hagen,&nbsp;Jan Haavik,&nbsp;David Mataix-Cols,&nbsp;James J. Crowley,&nbsp;John Wallert,&nbsp;Christian Rück,&nbsp;Nordic OCD and Related Disorders Consortium (NORDiC)","doi":"10.1002/ajmg.b.70015","DOIUrl":"10.1002/ajmg.b.70015","url":null,"abstract":"<p>Cognitive behavioral therapy (CBT) is a well-established, evidence-based treatment for common mental disorders such as depression, anxiety disorders, and obsessive-compulsive disorder (OCD). However, treatment outcomes vary widely, and a substantial proportion of patients do not achieve sufficient improvement. Robust predictors of individual differences in symptom change are currently lacking. Genetic differences have been suggested to play a role, but existing evidence is inconclusive. This study investigated the extent to which common genetic variants—single nucleotide polymorphisms (SNPs)—contribute to variability in symptom change. The sample was derived from the MULTI-PSYCH and NORDiC cohorts, comprising 3113 adults and children treated with CBT for depression, panic disorder, social anxiety disorder, or OCD. We performed a genome-wide association study (GWAS) of symptom change following CBT and estimated the proportion of variance attributed to SNPs. Secondary analyses included GWAS and SNP-based heritability estimation of additional clinically relevant outcomes: pre- and post-treatment symptom severity and remission status. No variants reached genome-wide significance. We estimated SNP-based heritability of symptom change at <span></span><math>\u0000 <semantics>\u0000 <mrow>\u0000 <msubsup>\u0000 <mi>h</mi>\u0000 <mi>SNP</mi>\u0000 <mn>2</mn>\u0000 </msubsup>\u0000 </mrow>\u0000 </semantics></math> = 0.221 (SE = 0.123). These results suggest that common genetic variation may contribute modestly to treatment outcomes. Much larger samples would be required to obtain more precise estimates and to detect genome-wide significant loci.</p>","PeriodicalId":7673,"journal":{"name":"American Journal of Medical Genetics Part B: Neuropsychiatric Genetics","volume":"201 6","pages":"396-405"},"PeriodicalIF":1.4,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ajmg.b.70015","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147392115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expanding the Phenotype of TLK2-Related Neurodevelopmental Disorder: Longitudinal Presentation in Two Young Adult Females","authors":"Alina Ivaniuk,&nbsp;Eva Kahn,&nbsp;Brendan Lanpher,&nbsp;Karthik Muthusamy","doi":"10.1002/ajmg.b.70016","DOIUrl":"10.1002/ajmg.b.70016","url":null,"abstract":"<div>\u0000 \u0000 <p><i>The TLK2</i> gene encodes a serine/threonine kinase essential for chromatin assembly. Loss-of-function heterozygous variants were recently identified as a cause of a rare neurodevelopmental disorder (<i>TLK2</i>-NDD) characterized by a variable spectrum of developmental delay, autism, behavioral issues, and severe constipation. We describe two unrelated young adult females presenting with neurodevelopmental delay, neurobehavioral abnormalities, and constipation since infancy secondary to truncating <i>TLK2</i> variants. Case 1 is a 26-year-old female who was referred to our clinic for extended assessment of new-onset psychosis and concern for seizures. She has been diagnosed with autism spectrum disorder and has a history of developmental delay, constipation, and aggressive outbursts since early childhood. At the age of 24 years, she developed an acute onset of persistent daily auditory hallucinations with threatening content that was refractory to medical and electroconvulsive therapy. Video-EEG assessment found no correlates for hallucinations. Trio whole genome sequencing revealed a heterozygous de novo pathogenic <i>TLK2</i> variant, NM_006852.6:c.367C&gt;T (p.Arg123Ter). Case 2 is a 19-year-old female who was evaluated for developmental delay and intellectual disability. Her phenotype was also notable for constipation since infancy and suggestive hypothalamic features with obesity, metrorrhagia, and hypersomnia. Trio whole genome sequencing revealed a likely pathogenic heterozygous <i>TLK2</i> variant NM_006852.6:c.587del(p.Ser196ThrfsTer19) inherited from an asymptomatic, mosaic father. We present the adult phenotype of two young females with truncating variants in <i>TLK2</i> and unusual phenotypic features of refractory hallucinations and possible hypothalamic syndrome. While both features may be independent of <i>TLK2</i>-NDD, evidence from schizophrenia genome-wide association studies and tissue expression data indicates that these features might be a part of longitudinal phenotype development. Long-term follow-up studies are required to unfold the phenotypic spectrum of <i>TLK2</i>-NDD and to better understand the implications of these findings for management and prognosis.</p>\u0000 </div>","PeriodicalId":7673,"journal":{"name":"American Journal of Medical Genetics Part B: Neuropsychiatric Genetics","volume":"201 6","pages":"420-425"},"PeriodicalIF":1.4,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147611680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Global Prospective Harmonization Framework for Suicidality, Anhedonia, and Obsessive-Compulsive Symptoms in Psychiatric Genetic Studies: A Cross-Continental Study Within the Ancestral Population Network","authors":"Ana M. Diaz-Zuluaga,&nbsp;Jacey L. Anderberg,&nbsp;Ana M. Ramirez-Diaz,&nbsp;Andrea Horvath Marques,&nbsp;Catherine E. Rast,&nbsp;Daniel Bustamante,&nbsp;Deborah Jonker,&nbsp;Johanna Valencia-Echeverry,&nbsp;Joseph Kyebuzibwa,&nbsp;Josselyn S. Muñoz,&nbsp;Kristien van der Walt,&nbsp;Mauricio Castaño Ramirez,&nbsp;Olivia Wootton,&nbsp;Renee M. Frederick,&nbsp;Rocky E. Stroud II,&nbsp;Ruben Gur,&nbsp;Sang Jin Rhee,&nbsp;Shaili C. Jha,&nbsp;Stella Gichuru,&nbsp;Susan Service,&nbsp;Victor I. Reus,&nbsp;Akena Dickens,&nbsp;Carlos Lopez-Jaramillo,&nbsp;Carrie E. Bearden,&nbsp;Dan J. Stein,&nbsp;Ezra S. Susser,&nbsp;James J. Crowley,&nbsp;Jonathan Flint,&nbsp;Kenneth S. Kendler,&nbsp;Lukoye Atwoli,&nbsp;Michele T. Pato,&nbsp;Nelson B. Freimer,&nbsp;Roel A. Ophoff,&nbsp;Yong Min Ahn,&nbsp;Loes Olde Loohuis,&nbsp;Eric A. Storch,&nbsp;Bizu Gelaye","doi":"10.1002/ajmg.b.70019","DOIUrl":"10.1002/ajmg.b.70019","url":null,"abstract":"<p>This study aims to prospectively collect harmonized, quantitative, and dimensional psychiatric phenotypes (suicidality, anhedonia, and obsessive-compulsive symptoms) and information on discrimination, stigma, and unfair treatment in up to 27,500 individuals across diverse ancestries and clinical populations for genetic analysis within the NIMH Ancestral Population Network (APN). Five APN projects are participating in the current study (PUMAS-Paisa, PUMAS-NeuroGAP, KOMOGEN-D, LATINO, and SAX-II), spanning recruitment over 15 countries across the Americas, Africa, and Asia. Participants are being enrolled via the recruitment protocols specific to each participating project. The harmonized clinical battery includes the Columbia-Suicide Severity Scale, Snaith-Hamilton Pleasure Scale, and Florida Obsessive-Compulsive Inventory-II to assess suicidality, anhedonia, and obsessive-compulsive symptoms, respectively. Additionally, we use the Discrimination and Stigma Scale-Ultra Short to evaluate discrimination and stigma across cultures. This project is a pioneering effort to prospectively assess transdiagnostic phenotypes in large-scale, diverse ancestral and clinical populations (across different diagnoses) using a harmonized clinical battery, advancing genetic research in mental health in underrepresented populations.</p>","PeriodicalId":7673,"journal":{"name":"American Journal of Medical Genetics Part B: Neuropsychiatric Genetics","volume":"201 6","pages":"379-395"},"PeriodicalIF":1.4,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ajmg.b.70019","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147870493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychiatric and Cognitive Features in Italian Women With the FMR1 Premutation: A Comprehensive Assessment Using SCID-5 and Standardized Cognitive Measures","authors":"Federica Alice Maria Montanaro,&nbsp;Randi J. Hagerman,&nbsp;Giuseppina Spano,&nbsp;Flora Tassone,&nbsp;Giancarlo Logroscino,&nbsp;Andrea Bosco","doi":"10.1002/ajmg.b.70014","DOIUrl":"10.1002/ajmg.b.70014","url":null,"abstract":"<p>Women with the <i>FMR1</i> premutation (PM) are at increased risk for fragile X-associated conditions (FXPAC), including cognitive and psychiatric features collectively termed fragile X-associated neuropsychiatric disorders (FXAND). This study is the first to systematically investigate cognitive and psychiatric features in Italian female premutation carriers (PCs). One hundred Italian women with the PM were stratified into four age-groups (≤ 40, 41–50, 51–64, and ≥ 65 years). Cognitive performance was assessed using Raven's Standard Progressive Matrices (RSPM) and the Telephone Montreal Cognitive Assessment (T-MoCA). Psychological symptoms were measured with standardized self-report questionnaires, and psychiatric diagnoses were determined through the Structured Clinical Interview for DSM-5 (SCID-5) disorders. Cognitive scores were generally within the normal range; however, participants aged ≥ 65 years performed significantly worse on both RSPM and T-MoCA. SCID-5 interviews showed that 51% met criteria for at least one current psychiatric disorder, most commonly generalized anxiety (37%) and major depression (18%). Early-life neurodevelopmental difficulties were frequently reported. Self-report measures often underestimated clinical severity relative to interview findings. These findings underline significant psychiatric vulnerability in female PCs and emphasize the need for prevention and timely intervention, including routine psychiatric assessment in clinical care.</p>","PeriodicalId":7673,"journal":{"name":"American Journal of Medical Genetics Part B: Neuropsychiatric Genetics","volume":"201 6","pages":"406-419"},"PeriodicalIF":1.4,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ajmg.b.70014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147477713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shared Blood Transcriptomic and Pathway Signatures in Major Depression, Generalized Anxiety, and Obsessive–Compulsive Disorder: A Systems-Level Study","authors":"Niloufar Salimian","doi":"10.1002/ajmg.b.70010","DOIUrl":"10.1002/ajmg.b.70010","url":null,"abstract":"<div>\u0000 \u0000 <p>Major depressive disorder (MDD), generalized anxiety disorder (GAD), and obsessive–compulsive disorder (OCD) frequently co-occur and share overlapping symptomatology. This in silico study systematically investigated shared transcriptomic signatures and biological pathways using peripheral blood expression data. Differential expression analysis revealed 13 genes commonly dysregulated in at least two disorders, including CNTNAP3, PROK2, S100P, HLA-DPB1, and IRAK3. Correlation patterns uncovered disorder-specific rewiring of gene–gene networks, with polarity shifts and strength alterations particularly involving EIF5A2 and CNTNAP3B in MDD and OCD. Functional enrichment revealed convergence in neurotransmission, synaptic regulation, immune signaling, and metabolic pathways. Five biological pathways, including “defense response to bacterium” (GO-BP), “cytokine signaling in the immune system,” “TCR signaling,” and “neutrophil degranulation” (Reactome), and “leishmaniasis” (KEGG), were enriched across all three disorders, alongside multiple overlaps in GO-MF and GO-CC domains. Protein–protein interaction mapping revealed ribosomal hub dominance in OCD and immune/inflammatory node centrality in MDD and GAD. A panel of 21 secreted dysregulated genes in MDD, validated for ELISA detection, demonstrated robust classification power (AUC &gt; 0.70). Drug-gene interaction analysis identified four downregulated compounds, carbamazepine, flupirtine, indomethacin, and doxorubicin hydrochloride, shared across all three disorders, suggesting therapeutic repurposing potential. These findings highlight shared immunometabolic dysregulation and nominate blood-based biomarkers and pharmacological targets applicable across psychiatric diagnostic categories.</p>\u0000 </div>","PeriodicalId":7673,"journal":{"name":"American Journal of Medical Genetics Part B: Neuropsychiatric Genetics","volume":"201 5","pages":"349-374"},"PeriodicalIF":1.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147319377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No Discrepancy in Combined Genotype Distribution Data Between Two Related Studies of 5-HTTLPR and Posttraumatic Stress Disorder Risk","authors":"Pingxing Xie,&nbsp;Joel Gelernter","doi":"10.1002/ajmg.b.70012","DOIUrl":"10.1002/ajmg.b.70012","url":null,"abstract":"","PeriodicalId":7673,"journal":{"name":"American Journal of Medical Genetics Part B: Neuropsychiatric Genetics","volume":"201 5","pages":"319-320"},"PeriodicalIF":1.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147392108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}