The Cleft palate journal最新文献_第5页

Prenatal detection and fetal surgery of clefts and craniofacial abnormalities in humans: social and ethical issues. 人类腭裂和颅面畸形的产前检测和胎儿手术:社会和伦理问题。

The Cleft palate journal Pub Date : 1990-04-01 DOI: 10.1597/1545-1569(1990)027<0176:pdafso>2.3.co;2

R P Strauss, J U Davis

{"title":"Prenatal detection and fetal surgery of clefts and craniofacial abnormalities in humans: social and ethical issues.","authors":"R P Strauss, J U Davis","doi":"10.1597/1545-1569(1990)027<0176:pdafso>2.3.co;2","DOIUrl":"https://doi.org/10.1597/1545-1569(1990)027<0176:pdafso>2.3.co;2","url":null,"abstract":"Sophisticated prenatal diagnostic imaging has facilitated the progression of fetal surgery from the experimental possibility to a clinical therapy for several life-threatening congenital conditions. Guidelines for such fetal surgery include the expectation that the child will be reasonably healthy as a result and that the in utero approach will improve the outcome or is safer than postnatal intervention. Prenatal ultrasound detection of craniofacial anomalies is now common. Reports of experimental cleft repairs in animal fetuses suggest advantages including diminished scarring, improved health and nursing. While fetal craniofacial surgery has not been attempted in humans, speculations exist about the psychological and social benefits of being born with a repaired defect. Fetal surgery is an emerging technology that may alter experimentation, cleft treatment, and the allocation of scarce resources. This paper examines the social and ethical implications of prenatal diagnosis and fetal surgery, focusing on fetal/maternal rights, and clinical decision making.","PeriodicalId":76622,"journal":{"name":"The Cleft palate journal","volume":"27 2","pages":"176-82; discussion 182-3"},"PeriodicalIF":0.0,"publicationDate":"1990-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1597/1545-1569(1990)027<0176:pdafso>2.3.co;2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13490013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Experimental analyses of the migration and cell lineage of avian neural crest cells. 鸟类神经嵴细胞迁移及细胞谱系的实验分析。

The Cleft palate journal Pub Date : 1990-04-01 DOI: 10.1597/1545-1569(1990)027<0110:eaotma>2.3.co;2

M Bronner-Fraser

引用次数: 11

X chromosome genes involved in the regulation of facial clefting and spina bifida. 参与面部裂和脊柱裂调节的X染色体基因。

The Cleft palate journal Pub Date : 1990-04-01 DOI: 10.1597/1545-1569(1990)027<0131:xcgiit>2.3.co;2

G E Moore, A Ivens, R Newton, M A Balacs, D J Henderson, O Jensson

{"title":"X chromosome genes involved in the regulation of facial clefting and spina bifida.","authors":"G E Moore, A Ivens, R Newton, M A Balacs, D J Henderson, O Jensson","doi":"10.1597/1545-1569(1990)027<0131:xcgiit>2.3.co;2","DOIUrl":"https://doi.org/10.1597/1545-1569(1990)027<0131:xcgiit>2.3.co;2","url":null,"abstract":"Congenital malformations such as cleft palate and spina bifida may be multifactorial in etiology. They occur as a result of both environmental agents and defective genes. Consequently it is both practically and intellectually difficult to study their effects experimentally. The advent of molecular biology technology has enabled many genes on the human chromosome to be mapped and some to be cloned. Using these techniques and families that display common congenital malformations inherited in a purely genetic manner, the genetic defects can be separated from the environmental components. This report documents our studies of several families that have cleft palate or spina bifida as X-linked disorders. Their phenotype is similar to the more common multifactorial cases but segregates as a single gene in an X-linked fashion. Localization of these genes using different X chromosome DNA probes and linkage analysis is the first step towards our understanding of the genetic contribution to the etiology of congenital malformations.","PeriodicalId":76622,"journal":{"name":"The Cleft palate journal","volume":"27 2","pages":"131-5"},"PeriodicalIF":0.0,"publicationDate":"1990-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1597/1545-1569(1990)027<0131:xcgiit>2.3.co;2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13340702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

The otologic significance of cleft palate in a Sri Lankan population. 斯里兰卡人群腭裂的耳科学意义。

The Cleft palate journal Pub Date : 1990-04-01 DOI: 10.1597/1545-1569(1990)027<0155:tosocp>2.3.co;2

D M Albert, J Garrett, B Specker, M Ho

引用次数: 9

Regulatory issues during early craniofacial development: a summary. 颅面发育早期的调控问题:综述。

The Cleft palate journal Pub Date : 1990-04-01 DOI: 10.1597/1545-1569(1990)027<0101:ridecd>2.3.co;2

H C Slavkin

{"title":"Regulatory issues during early craniofacial development: a summary.","authors":"H C Slavkin","doi":"10.1597/1545-1569(1990)027<0101:ridecd>2.3.co;2","DOIUrl":"https://doi.org/10.1597/1545-1569(1990)027<0101:ridecd>2.3.co;2","url":null,"abstract":"During neurulation, craniofacial structures derived from the first branchial arch are determined to become maxillary, mandibular, and tongue formations. At least four interdependent developmental processes become integrated: (1) allocation of cells into specific lineages (perhaps during gastrulation); (2) regulation of time-dependent differential regulatory and structural gene expressions; (3) positional information resulting in pattern formations; and (4) morphogenesis, histogenesis, and cytodifferentiation. This review highlights progress toward understanding when, where, and how the one-dimensional genetic information encoded within DNA (deoxyribonucleic acid) is sequentially expressed into the embryonic craniofacial complex. Specifically, how might intrinsic autocrine and/or paracrine regulatory factors control the developmental program for early first branchial arch morphogenesis, histogenesis, and cytodifferentiation. Rules learned from normal development should be useful toward advancing the diagnosis, treatment, prognosis, and prevention of congenital craniofacial malformations.","PeriodicalId":76622,"journal":{"name":"The Cleft palate journal","volume":"27 2","pages":"101-9"},"PeriodicalIF":0.0,"publicationDate":"1990-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1597/1545-1569(1990)027<0101:ridecd>2.3.co;2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13340699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

The neurocristopathies: reinterpretation based upon the mechanism of abnormal morphogenesis. 神经病变:基于异常形态发生机制的重新解释。

The Cleft palate journal Pub Date : 1990-04-01 DOI: 10.1597/1545-1569(1990)027<0136:tnrbut>2.3.co;2

M C Jones

{"title":"The neurocristopathies: reinterpretation based upon the mechanism of abnormal morphogenesis.","authors":"M C Jones","doi":"10.1597/1545-1569(1990)027<0136:tnrbut>2.3.co;2","DOIUrl":"https://doi.org/10.1597/1545-1569(1990)027<0136:tnrbut>2.3.co;2","url":null,"abstract":"This review sets forth a broadened interpretation of the neurocristopathies based on the current understanding of the role of neural crest cells in normal development. Two general types of cristopathies are defined predicated on the abnormal mechanism involved in production of the defect or condition. Defects and disorders which constitute the originally defined neurocristopathies including pheochromocytoma, neurofibromatosis, and the multiple endocrine adenomatoses are best explained as dysplasias of neural crest derivatives. Affected individuals rarely exhibit true malformation of structure but do carry a lifetime risk for disordered growth of crest derived tissue. On the other hand, defects and disorders which derive from migrational abnormalities primarily of cranial neural crest cells such as frontonasal dysplasia, the DiGeorge sequence, and Waardenberg syndrome represent true malformations. The spectrum of involvement is usually definable at the time of diagnosis and disordered growth of crest derived tissue does not occur. The clinical implications of this distinction are discussed.","PeriodicalId":76622,"journal":{"name":"The Cleft palate journal","volume":"27 2","pages":"136-40"},"PeriodicalIF":0.0,"publicationDate":"1990-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1597/1545-1569(1990)027<0136:tnrbut>2.3.co;2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13340703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 42

Asymmetry of the maxilla in children with complete unilateral cleft lip and palate. 完全性单侧唇腭裂患儿上颌骨不对称。

The Cleft palate journal Pub Date : 1990-04-01 DOI: 10.1597/1545-1569(1990)027<0184:aotmic>2.3.co;2

K Mølsted, E Dahl

引用次数: 59

Incidence and prevalence of cleft lip and palate. 唇腭裂的发生率和患病率。

The Cleft palate journal Pub Date : 1990-04-01

R B Sayetta