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[Kidney involvement in light-chain deposition disease]. [轻链沉积病累及肾脏]。
Sbornik lekarsky Pub Date : 2002-01-01
M Merta, R Rysavá, J Zabka, A Stejskalová, Z Vernerová, J Haber, I Spicka, V Tesar, P Klener
{"title":"[Kidney involvement in light-chain deposition disease].","authors":"M Merta,&nbsp;R Rysavá,&nbsp;J Zabka,&nbsp;A Stejskalová,&nbsp;Z Vernerová,&nbsp;J Haber,&nbsp;I Spicka,&nbsp;V Tesar,&nbsp;P Klener","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>An overview concerning different types of kidney involvement associated with monoclonal gammapathy (MG) is given, focused on light-chain deposition disease (LCDD). Pathophysiologic basis of LCDD remains in the light-chain tissue deposition (resp. in tissue deposition of immunoglobulin's stable domain). This mechanism is typical for monoclonal immunoglobulin's overproduction as found in MG. Clinical picture of LCDD reflects multiorgan character of disorder, while renal lesions rank among the most frequent, serious and best documented ones. Clinical data referring to a group of six patients, treated in our nephrologic department are presented. Diagnosis of LCDD was established on basis of the renal biopsy finding. Renal functions were decreased at the time of diagnosis in all patients, whereas haemodialysis treatment was started in one patient. On conclusion therapeutic possibilities of LCDD are discussed, in which number symptomatic therapy of renal failure is combined with corticosteroids therapy and cytostatic therapy; prognosis of most patients remains serious.</p>","PeriodicalId":76514,"journal":{"name":"Sbornik lekarsky","volume":"103 3","pages":"397-403"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22334621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Increased sP-selectin and other cardiovascular risk factors: fibrinogen, tissue plasminogen activator (t-PA Ag) and acute phase proteins after kidney transplantation]. [肾移植后sp -选择素及其他心血管危险因素:纤维蛋白原、组织纤溶酶原激活物(t-PA Ag)和急性期蛋白升高]。
Sbornik lekarsky Pub Date : 2002-01-01
J Kvasnicka, O Viklický, A Umlaufová, T Kvasnicka, E Teplá, H Homolková, I Malíkova, R Sauerová
{"title":"[Increased sP-selectin and other cardiovascular risk factors: fibrinogen, tissue plasminogen activator (t-PA Ag) and acute phase proteins after kidney transplantation].","authors":"J Kvasnicka,&nbsp;O Viklický,&nbsp;A Umlaufová,&nbsp;T Kvasnicka,&nbsp;E Teplá,&nbsp;H Homolková,&nbsp;I Malíkova,&nbsp;R Sauerová","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Our study was designed to monitor the presence of the \"coronary artery disease (CAD) risk factors\" after kidney transplantation.</p><p><strong>Methods: </strong>26 kidneys transplant recipients with well-functioning (creatinine clearance > 0.8 mL/s) renal allografts receiving cyclosporine A (CsA) as the basic component of immunosuppressive therapy and 60 healthy age-matched controls were included into the study. As \"CAD risk factors\" were determined the levels of fibrinogen, acute phase proteins orosomucoid and C-reactive protein, t-PA Ag, PAI-1 Ag and soluble adhesion molecules E-selectin, P-selectin and ICAM-1 in the peripheral blood serum or plasma.</p><p><strong>Results: </strong>Renal transplant recipients showed higher BMI (p < 0.001) and levels of fibrinogen (p < 0.001), t-PA Ag (p = 0.007) and PAI-1 Ag (p < 0.001), acute phase protein orosomucoid (p < 0.001) and higher level of soluble P-selectin (p = 0.038). The levels of sICAM-1 and sE-selectin did not differ statistically significantly from those in controls.</p><p><strong>Conclusion: </strong>Our study has demonstrated renal graft recipients with good kidney function already show significantly raised levels of \"CAD risk factors\" fibrinogen, acute phase reactant orosomucoid, t-PA Ag, PAI-1 Ag and sP-selectin.</p>","PeriodicalId":76514,"journal":{"name":"Sbornik lekarsky","volume":"103 3","pages":"411-7"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22334623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protooncogene bcl-2 in process of apoptosis. Review article. 原癌基因bcl-2在细胞凋亡过程中的作用。评论文章。
Sbornik lekarsky Pub Date : 2002-01-01
Z Humlová
{"title":"Protooncogene bcl-2 in process of apoptosis. Review article.","authors":"Z Humlová","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The process of apoptosis is genetically regulated form of cell death, which is tightly connected, with maintaining of tissue homeostasis in multicellular organisms. Mitochondria play a key role in this process being involved in ATP synthesis, production of oxygen free radicals, control of Ca2+ ions, extrusion of apoptogenic molecules such as cytochrome c, apoptosis inducing factor, Smac/DIABLO protein and several procaspases. Changes in the flux of ions and water across the inner mitochondrial membrane characterize the early phase of apoptosis, during which an increase in matrix volume may precede a collapse of mitochondrial membrane potential (delta psi m). These changes are suppressed by Bcl-2/Bcl-XL facilitated by Bax, and mediated at least by so-called permeability transition pore complex which is one of possible mechanisms involved in mitochondrial membrane permeabilization (MMP).</p>","PeriodicalId":76514,"journal":{"name":"Sbornik lekarsky","volume":"103 4","pages":"419-25"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22334836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Acute phase reaction in severe injuries]. [严重损伤急性期反应]。
Sbornik lekarsky Pub Date : 2002-01-01
J Bríza, K Kudrna, J Kvasnicka, O Busta, T Trca
{"title":"[Acute phase reaction in severe injuries].","authors":"J Bríza,&nbsp;K Kudrna,&nbsp;J Kvasnicka,&nbsp;O Busta,&nbsp;T Trca","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Unlabelled: </strong>This study observes acute phase response in first time after injury.</p><p><strong>Hypothesis: </strong>Injured patients are already in first timepiece up severe injury in worse general state developed acute phase response than control group before planed surgery. Levels of indicators acute phase response and haemostasis from venous blood samples collected in an injury day and at patients control group before planned surgery were compared. We compare findings of traumatized in admission day and of patients at 6th-7th day after planned surgery, when is the biggest handicap. Plasma levels of orosomukoid, C reactive protein, prealbumin, transferin, alpha-2-macroglobulin, PAI-1, tPA, sE-Selectin, SICAM, sP-Selectin, antithrombin III, fibrinogen, haemoglobin, time of Quick test, TT, APTT, number of leukocytes, erythrocytes and thrombocytes were determined.</p><p><strong>Results: </strong>Tested group severe injured admitted in I. Surgical Department of First Medical School of Charles University and General Faculty Hospital in Prague in years 1995-1998 (n = 105) be characterized by average value ISS--19.182 +/- 3.315, PTS--28.284 +/- 2.362, AIS--6.739 +/- 0.829 and GCS--11.449 +/- 0.974 and average age 56.89 +/- 4.84 year. Average time hospitalization was 70 days. Between 7th-21st day of hospitalization 23 patients dead on multiorgan failure or sepsis. Control patient file before planned surgery (n = 50) and after planned surgery (n = 33) was comparable in age characteristics.</p><p><strong>Conclusions: </strong>Adaptation reserve of injured is already in first time-piece since injury significantly lower to patients without trauma. Starting position traumatized patients before acute surgery is comparable with state of patients at 6th-7th day after planned surgery, when culminates postoperative acute phase response.</p>","PeriodicalId":76514,"journal":{"name":"Sbornik lekarsky","volume":"103 2","pages":"193-202"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22334937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Analgesic effect of videothoracoscopic splanchnicectomy]. [胸腔镜下胰切除术的镇痛效果]。
Sbornik lekarsky Pub Date : 2002-01-01
R Demes, S Cermák, M Pesková, J Sváb, Z Krska, J Polívková, L Petruzelka, M Zemanová
{"title":"[Analgesic effect of videothoracoscopic splanchnicectomy].","authors":"R Demes,&nbsp;S Cermák,&nbsp;M Pesková,&nbsp;J Sváb,&nbsp;Z Krska,&nbsp;J Polívková,&nbsp;L Petruzelka,&nbsp;M Zemanová","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The authors demonstrate analgetic effect on a group of 32 patients operated for pancreatic cancer pain after videothoracoscopic splanchnikectomy. The authors define adequate criteria for selection of splanchnikectomy.</p>","PeriodicalId":76514,"journal":{"name":"Sbornik lekarsky","volume":"103 2","pages":"227-32"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22334941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Surgery in breast carcinoma at the First Surgical Clinic of the First Medical Faculty of Charles University and at the General Faculty Hospital at the turn of the millennium]. [在世纪之交，查尔斯大学第一医学院第一外科诊所和综合学院医院的乳腺癌手术]。
Sbornik lekarsky Pub Date : 2002-01-01
J Suk
{"title":"[Surgery in breast carcinoma at the First Surgical Clinic of the First Medical Faculty of Charles University and at the General Faculty Hospital at the turn of the millennium].","authors":"J Suk","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The author explain the importance of the early diagnosis of breast cancer and introduce the surgery treatment of early stages of breast carcinoma, especially of DCIS (ductal carcinoma in situ) in the last years on the 1st Surgery Department of First Medical Faculty, Charles University and General Faculty Hospital in Prague.</p>","PeriodicalId":76514,"journal":{"name":"Sbornik lekarsky","volume":"103 2","pages":"233-6"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22334942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Regulation of respiration and its sleep-related disorders]. [呼吸及其睡眠相关疾病的调节]。
Sbornik lekarsky Pub Date : 2002-01-01
Z Tomori, V Donic, R Benacka, M Kuchta, S Koval, J Jakus
{"title":"[Regulation of respiration and its sleep-related disorders].","authors":"Z Tomori,&nbsp;V Donic,&nbsp;R Benacka,&nbsp;M Kuchta,&nbsp;S Koval,&nbsp;J Jakus","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Four basic control mechanisms of breathing (brainstem respiratory centre, peripheral and central chemoreceptors, intero- and exteroceptive reflexes and suprapontine influences), as well as their sleep-related disorders are analysed. A decrease in central chemoreceptor sensitivity to CO2 and an increase in upper airway resistance during sleep result in hypoventilation and mild hypoxaemia already in physiological conditions. Compensatory increase in ventilatory effort with synchronous inhibition of pharyngeal dilators during sleep reduces the upper airway lumen manifesting with snoring, upper airway resistance syndrome, and OSA. The resulting hypoxaemia may cause marked cardiovascular, neuro-psychic, endocrine-metabolic and behavioural disorders. The augmented ventilatory effort and hypoxaemia evoke reflex dilation of airways and arousal from sleep, stimulating the sympatho-adrenal system, which provokes autoresuscitation by gasping preventing fatal asphyxia. Failure of this autoresuscitation mechanism seems to cause SIDS. Elimination of voluntary breathing by sleep either in Ondine's curse induced by lesions of respiratory centre, or in congenital central hypoventilation syndrome caused by insufficient central chemoreceptors result in respiratory failure and death. Nocturnal attacks of bronchial and cardiac asthma, lung oedema and other consequences of pulmonary congestion are also discussed. The pathomechanism of extreme daytime sleepiness, chronic fatigue, and disorders of memory, cognitive and other brain functions, are also analysed. Severe cardiovascular consequences of SAS may manifest acutely as angina pectoris, myocardial infarction. dysrhythmias, transient ischaemic attacks and even stroke or sudden cardiac death. OSAS may result also in development of hypertension, central obesity, diabetes mellitus, erectile dysfunction, depression, and various behavioural disorders.</p>","PeriodicalId":76514,"journal":{"name":"Sbornik lekarsky","volume":"103 1","pages":"65-71"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22127336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Authenticity in psychology and psychotherapy]. [心理学和心理治疗中的真实性]。
Sbornik lekarsky Pub Date : 2002-01-01
Jan Vymĕtal
{"title":"[Authenticity in psychology and psychotherapy].","authors":"Jan Vymĕtal","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Authenticity, in psychological sense of the word, is connected with human identity and it belongs among the effective factors of psychotherapy. We can define it as a complex psychological variable and relatively constant characterization of a personality. Authenticity expresses the degree of a person's self-identity and, at the same time, it shows how much is his behaviour towards his surrounding connected with his self-concept. In the researches, for authenticity we can use the term congruence. In the psychotherapy therapist's authentic behaviour leads to release of the patient's spontaneity and to the increase of his own authentic behaviour. Mentally healthy person is authentic and independent, he leads a meaningful life and his decisions mainly depends on his own experience. Authenticity we can detect directly with the help of the clinical methods [interview] and indirectly through the self-concept and incongruences. One of the main instruments used to measure authenticity are rating scales.</p>","PeriodicalId":76514,"journal":{"name":"Sbornik lekarsky","volume":"103 3","pages":"313-21"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22334154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Renal infiltration in lymphoma--diagnosis in renal biopsy (case report)]. 【淋巴瘤肾浸润——肾活检诊断(病例报告)】。
Sbornik lekarsky Pub Date : 2002-01-01
M Merta, E Jelínková, J Zabka, A Stejskalová, Z Vernerová, J Karban, R Rysava, V Tesar, P Klener
{"title":"[Renal infiltration in lymphoma--diagnosis in renal biopsy (case report)].","authors":"M Merta,&nbsp;E Jelínková,&nbsp;J Zabka,&nbsp;A Stejskalová,&nbsp;Z Vernerová,&nbsp;J Karban,&nbsp;R Rysava,&nbsp;V Tesar,&nbsp;P Klener","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A case story of a patient with renal biopsy (RB) proven infiltration with lymphoma is given. RB in patient with known malignancy and onset of renal failure was indicated with regard to an atypical picture of kidney involvement (non-enlarged kidneys, without any structural changes typical for tumour mass presence). Though spread of the primary tumour to the kidney is not uncommon, involvement severe enough to impair renal function is unusual and occurs primarily with rapidly growing haematologic malignancies; diagnosis is being established by renal biopsy only rarely.</p>","PeriodicalId":76514,"journal":{"name":"Sbornik lekarsky","volume":"103 3","pages":"405-9"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22334622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Disseminated intravascular coagulation syndrome and protein C]. 弥散性血管内凝血综合征与蛋白C的关系[j]。
Sbornik lekarsky Pub Date : 2002-01-01
J Kvasnicka, Z Ehler, J Polívková, Z Krska, Z Hájek, I Malíková, P Horák
{"title":"[Disseminated intravascular coagulation syndrome and protein C].","authors":"J Kvasnicka,&nbsp;Z Ehler,&nbsp;J Polívková,&nbsp;Z Krska,&nbsp;Z Hájek,&nbsp;I Malíková,&nbsp;P Horák","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Disseminated intravascular coagulation (DIC) is characterized by systemic activation of the haemostasis. In many instances the release of inflammatory cytokines and tissue factor trigger the system in septic or traumatic conditions. Initially, the increased activation of haemostasis can be compensated by natural inhibitor systems. As release of the triggers persists, inhibitors (e.g. antithrombin and protein C) will be consumed leading to intravascular clotting. In this process many coagulation factors, most notably fibrinogen and platelets are consumed too, resulting in a failure of haemostasis system and in a diffuse bleeding (decompensated DIC). Fresh frozen plasma, blood transfusion, and fibrinogen concentrate correct the bleeding, if needed, in the case of traumatic (obstetric) DIC. Arrest of the activated haemostasis by heparin and natural anticoagulants (antithrombin or/and protein C) is recommended, mainly in septic conditions with systemic inflammatory reactions. A case of stercoral sepsis usefully treated by recombinant human activated protein C is reported.</p>","PeriodicalId":76514,"journal":{"name":"Sbornik lekarsky","volume":"103 2","pages":"257-64"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22334832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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