H Schedel, A Schneller, T Vogl, H F Müller, J Mäurer, N Südkamp, A Eisenschenk, R Felix
{"title":"[Dynamic magnetic resonance tomography (MRI): a follow-up study after femur core decompression and instillation of recombinant human bone morphogenetic protein-2 (rhBMP-2) in avascular femur head necrosis].","authors":"H Schedel, A Schneller, T Vogl, H F Müller, J Mäurer, N Südkamp, A Eisenschenk, R Felix","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Object: </strong>The aim of the study was to test the use of dynamic magnetic resonance imaging study with Gd-DTPA-application and the dynamic changes of signal intensity at patients with avascular femoral head necrosis after having installed rhBMP-2 and/or decompressed the core.</p><p><strong>Material and methods: </strong>Six patients with avascular necrosis of the femoral head ARCO-stage I- or II-lesions were treated surgically by femoral head core decompression. Three of these patients were additionally treated with rhBMP-2-instillation. The progression or regression could be confirmed by T1- and T2-weighted spinecho-sequences (zero, four, ten, sixteen weeks and 24 months follow up).</p><p><strong>Results: </strong>Corresponding ARCO-classification with partly more sensitive measurement of vitality signs in comparison to the optical x-ray classification. The objective, quantitative measurement of signal intensity post contrast medium reduces the influence of experience and level of education. The dynamic sequences results are reproducible.</p><p><strong>Conclusion: </strong>The dynamic magnetic resonance imaging study after Gd-DTPA-application and the dynamic changes of signal intensity after Gd-DTPA enhancement in the necrotic areas of the femoral head were the important subject of our study and it seems, that these sequencies and the ascertainment of signal intensity changes will be an efficient method for judgement of vitality, vascularisation and perfusion after therapeutical intervention. Combination of femoral head core decompression and rhBMP-2-instillation for the purpose of osseous regeneration seems to stabilize the affection.</p>","PeriodicalId":76505,"journal":{"name":"Rontgenpraxis; Zeitschrift fur radiologische Technik","volume":"53 1","pages":"16-24"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21781551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Use of patient-related contrast media protocols in cardiovascular computerized tomography].","authors":"F D Knollmann, R Hetzer, R Felix","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To determine the temporal variability of the time to maximum aortic density after peripheral venous contrast injection in cardiovascular CT studies and to calculate potential contrast agent savings of selecting scan delay from test bolus kinetics.</p><p><strong>Methods: </strong>A peripheral contrast bolus was administered intravenously in 138 consecutive patients to determine the time to maximum density in a left ventricular or aortic region of interest by electron beam CT. 20 EKG-triggered scans were acquired within 70 heartbeats. The deviation of the time to maximum density from a standard, fixed scan delay was determined.</p><p><strong>Results: </strong>Mean time to maximum density was 22 s, and the average deviation from that mean was 5 s. At an injection rate of 4 cc/s, this deviation implies that determining the individual scan delay from a test bolus injection may potentially save 20 cc contrast per patient. This amount of contrast agent, in turn, is required for the test bolus.</p><p><strong>Conclusion: </strong>Deriving the individual scan delay from test bolus kinetics may improve image contrast in cardiovascular CT studies without additional contrast expense.</p>","PeriodicalId":76505,"journal":{"name":"Rontgenpraxis; Zeitschrift fur radiologische Technik","volume":"52 10-12","pages":"335-9"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21649700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Tumors of the anterior skull base. Effects of perioperative imaging on adjuvant radiotherapy planning].","authors":"J V Anton, J Schultze, W Gstöttner, C Matula","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>Treatment of anterior skull base tumours is still considered being a major challenge for all involved disciplines. Surgical management, complications, as well as the role of imaging for multimodality treatment options should be evaluated critically.</p><p><strong>Patients and methods: </strong>57 patients underwent interdisciplinary one step trans-basal approaches for resection of benign and malignant anterior fossa tumours. Beside assessment of surgical results and perioperative morbidity, in 13 patients with malignant tumours perioperative imaging was evaluated with regard to further possible radio-oncological treatment options.</p><p><strong>Results: </strong>Applying trans-basal approaches radical tumour resection could be achieved in all cases independent of tumor-size (diameter 12-114 mm). Permanent postoperative complications (until 6 months postoperatively) were found in 4 cases (7%), transient complications in 7 cases (12.3%). Evaluation of perioperative imaging showed a heterogen use of different imaging modalities and revealed lack of standardization, hampering further planning of radiation therapy.</p><p><strong>Conclusion: </strong>Treatment of anterior skull base tumours requires a maximum level of standardization of perioperative imaging, to grant a successful surgical and radio-oncological interdisciplinary patient management.</p>","PeriodicalId":76505,"journal":{"name":"Rontgenpraxis; Zeitschrift fur radiologische Technik","volume":"53 1","pages":"10-5"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21781550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E G Eising, V John-Mikolajewski, M Haritaworn, A Bockisch
{"title":"Correlation of radionuclide ventriculography with roentgenological findings in chemotherapy patients.","authors":"E G Eising, V John-Mikolajewski, M Haritaworn, A Bockisch","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Radionuclide ventriculography (RNV) is a common method to evaluate cardiotoxic effects of drugs applied during chemotherapeutic treatment, whereas thoracic radiographs are used to detect morphologic alterations. Aim of this study was to identify radiographic signs, which correlate with RNV parameters and with RNV image quality. For this study, RNV data of 116 patients receiving chemotherapy acquired during 205 RNV studies (some patients underwent up to 7 follow-up examinations) were correlated to roentgenologic findings assessed by 176 thoracic radiographs. Isolated thoracic radiographic signs of cardiac failure showed only slight correlations to left ventricular ejection fractions measured with radionuclide ventriculography, but the orientation of correlation (positive or negative) could be confirmed well by clinical data. This fact matches clinical experience, that radiographic signs of heart insufficiency can surely predict heart damage only when several of them coincide. By the help of this study it was possible to detect radiographic findings, which are of relevance in patients with suspicion of cardiotoxic damage as side effect of high-dose chemotherapy. The clinical value of several radiologic findings should be reassessed to diagnose cardiac failure in chemotherapy patients.</p>","PeriodicalId":76505,"journal":{"name":"Rontgenpraxis; Zeitschrift fur radiologische Technik","volume":"53 3","pages":"92-101"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21952996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H J Jäger, H M Gissler, S Hennigs, G Dittmar, K D Mathias
{"title":"[Hyperdense basilar artery in computerized tomography as an indication of basilar thrombosis].","authors":"H J Jäger, H M Gissler, S Hennigs, G Dittmar, K D Mathias","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76505,"journal":{"name":"Rontgenpraxis; Zeitschrift fur radiologische Technik","volume":"52 10-12","pages":"349-54"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21650908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[The biologically equivalent dose (BED): how solid is the calculation of this factor? A consideration of margins of error of biologically equivalent dose].","authors":"J M Jensen, J Zimmermann","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>To predict the effect on tumours in radiotherapy, especially relating to irreversible effects, but also to realize the retrospective assessment the so called L-Q-model is relied on at present. Internal specific organ parameters, such as alpha, beta, gamma, Tp, Tk, and rho, as well as external parameters, so as D, d, n, V, and Vref, were used for determination of the biologically equivalent dose BED. While the external parameters are determinable with small deviations, the internal parameters depend on biological varieties and dispersions: in some cases the lowest value is assumed to be delta = +/- 25%. This margin of error goes on to the biologically equivalent dose by means of the principle of superposition of errors. In some selected cases (lung, kidney, skin, rectum) these margins of error were calculated exemplarily. The input errors especially of the internal parameters cause a mean error delta on the biologically equivalent dose and a dispersion of the single fraction dose d dependent on the organ taking into consideration, of approximately 8-30%. Hence it follows only a very critical and cautious application of those L-Q-algorithms in expert proceedings, and in radiotherapy more experienced based decisions are recommended, instead of acting only upon simple two-dimensional mechanistic ideas.</p>","PeriodicalId":76505,"journal":{"name":"Rontgenpraxis; Zeitschrift fur radiologische Technik","volume":"52 10-12","pages":"355-60"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21650909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F A Siebert, J Schultze, N Czech, E Henze, B Kimmig
{"title":"[Software for landmark-assisted multimodality imaging and morphological detection of pathological PET findings].","authors":"F A Siebert, J Schultze, N Czech, E Henze, B Kimmig","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76505,"journal":{"name":"Rontgenpraxis; Zeitschrift fur radiologische Technik","volume":"53 3","pages":"120-2"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21952994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}