Revista do Hospital das Clinicas最新文献

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Endovascular techniques for placement of long-term chemotherapy catheters. 放置长期化疗导管的血管内技术。
Revista do Hospital das Clinicas Pub Date : 2003-07-01 Epub Date: 2003-09-30 DOI: 10.1590/s0041-87812003000400005
Guilherme Yazbek, Antonio Eduardo Zerati, Luiz Caetano Malavolta, Kenji Nishinari, Nelson Wolosker
{"title":"Endovascular techniques for placement of long-term chemotherapy catheters.","authors":"Guilherme Yazbek,&nbsp;Antonio Eduardo Zerati,&nbsp;Luiz Caetano Malavolta,&nbsp;Kenji Nishinari,&nbsp;Nelson Wolosker","doi":"10.1590/s0041-87812003000400005","DOIUrl":"https://doi.org/10.1590/s0041-87812003000400005","url":null,"abstract":"<p><strong>Purpose: </strong>To analyze the results from using endovascular techniques to place long-term chemotherapy catheters when advancing the catheter using the external jugular vein is difficult due to obstructions or kinking.</p><p><strong>Methods: </strong>Between July 1997 and August 2000, 320 long-term chemotherapy catheters were placed, and in 220 cases the external jugular vein was used as the primary venous approach. In 18 of these patients, correct positioning was not achieved and several endovascular techniques were then utilized to overcome these obstacles, including manipulation of a J-wire with a moveable core, venography, and the exchange wire technique.</p><p><strong>Results: </strong>In 94.5% of the patients with difficulties in obtaining the correct positioning, we were able to advance the long-term catheter to the desired position with the assistance of endovascular techniques.</p><p><strong>Conclusions: </strong>Venography and endovascular guidance techniques are useful for the placement of long-term catheters in the external jugular vein.</p>","PeriodicalId":76453,"journal":{"name":"Revista do Hospital das Clinicas","volume":"58 4","pages":"215-8"},"PeriodicalIF":0.0,"publicationDate":"2003-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1590/s0041-87812003000400005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24020302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Incisional hernia at the insertion site of the laparoscopic trocar: case report and review of the literature. 腹腔镜套管针插入部位切口疝:病例报告及文献复习。
Revista do Hospital das Clinicas Pub Date : 2003-07-01 Epub Date: 2003-09-30 DOI: 10.1590/s0041-87812003000400006
Frederico Teixeira, Hwan Yoo Jin, Aldo Junqueira Rodrigues Júnior
{"title":"Incisional hernia at the insertion site of the laparoscopic trocar: case report and review of the literature.","authors":"Frederico Teixeira,&nbsp;Hwan Yoo Jin,&nbsp;Aldo Junqueira Rodrigues Júnior","doi":"10.1590/s0041-87812003000400006","DOIUrl":"https://doi.org/10.1590/s0041-87812003000400006","url":null,"abstract":"<p><p>Laparoscopic operations offer a myriad of advantages resulting in a rapid postoperative recovery. Incisional hernia is an uncommon cause of morbidity in operative procedures performed by laparoscopic access, and the diagnosis may not be easily made. In our service we identified 2 patients with incisional hernia the site of trocar insertion. The records of these 2 cases were reviewed. We report on these 2 cases and present a review of the literature.</p>","PeriodicalId":76453,"journal":{"name":"Revista do Hospital das Clinicas","volume":"58 4","pages":"219-22"},"PeriodicalIF":0.0,"publicationDate":"2003-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24020206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Clinical and epidemiological features of AIDS/tuberculosis comorbidity. 艾滋病/结核病合并症的临床和流行病学特征。
Revista do Hospital das Clinicas Pub Date : 2003-07-01 Epub Date: 2003-09-30 DOI: 10.1590/s0041-87812003000400004
Alice Tung Wan Song, Denise Schout, Hillegonda Maria Dutilh Novaes, Moisés Goldbaum
{"title":"Clinical and epidemiological features of AIDS/tuberculosis comorbidity.","authors":"Alice Tung Wan Song,&nbsp;Denise Schout,&nbsp;Hillegonda Maria Dutilh Novaes,&nbsp;Moisés Goldbaum","doi":"10.1590/s0041-87812003000400004","DOIUrl":"https://doi.org/10.1590/s0041-87812003000400004","url":null,"abstract":"<p><strong>Unlabelled: </strong>Considering the relevance of AIDS/tuberculosis comorbidity worldwide, especially in Brazil, this study was developed to describe the clinical and epidemiological features of the comorbid cases identified from 1989 to 1997 by the epidemiology service of the Hospital das Clínicas of the Universidade de São Paulo.</p><p><strong>Methods: </strong>Databases containing information on all identified AIDS/tuberculosis cases cared for at the hospital were used to gather information on comorbid cases.</p><p><strong>Results: </strong>During the period, 559 patients were identified as presenting with AIDS/tuberculosis comorbidity. Risk behavior for AIDS was primarily heterosexual contact (38.9%), followed by intravenous drug use (29.3%) and homosexual/bisexual contact (23.2%). Regarding clinical features, there were higher rates of extrapulmonary tuberculosis when compared to tuberculosis without comorbidity. There was an increase in reporting of AIDS by ambulatory units during the period. Epidemiologically, there was a decrease in the male/female ratio, a predominance in the 20 to 39 year-old age group, and a majority of individuals who had less than 8 years of schooling and had low professional qualifications.</p><p><strong>Conclusions: </strong>High rates of AIDS/tuberculosis cases at our hospital indicate the need for better attention towards early detection of tuberculosis, especially in its extrapulmonary form. Since the population that attends this hospital tends to be of a lower socioeconomic status, better management of AIDS and tuberculosis is required to increase the rates of treatment adherence and thus lower the social costs.</p>","PeriodicalId":76453,"journal":{"name":"Revista do Hospital das Clinicas","volume":"58 4","pages":"207-14"},"PeriodicalIF":0.0,"publicationDate":"2003-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24020301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 22
Bile duct-duodenal fistula caused by AIDS/HIV-associated tuberculosis. 艾滋病/ hiv相关结核引起的胆管-十二指肠瘘。
Revista do Hospital das Clinicas Pub Date : 2003-07-01 Epub Date: 2003-09-30 DOI: 10.1590/s0041-87812003000400007
Carlos Patino, Belchor Fontes, Renato Sergio Poggetti, Cornelius Mitteldorf, Conrado Alvarenga, Dario Birolini
{"title":"Bile duct-duodenal fistula caused by AIDS/HIV-associated tuberculosis.","authors":"Carlos Patino,&nbsp;Belchor Fontes,&nbsp;Renato Sergio Poggetti,&nbsp;Cornelius Mitteldorf,&nbsp;Conrado Alvarenga,&nbsp;Dario Birolini","doi":"10.1590/s0041-87812003000400007","DOIUrl":"https://doi.org/10.1590/s0041-87812003000400007","url":null,"abstract":"<p><p>Although infrequent, digestive fistulae in HIV/AIDS patients have been reported throughout the digestive tract from the esophagus to the anus, with predominance of esophageal fistulae. AIDS/HIV-associated opportunistic infections may invade the digestive system and lead to fistula formation. Tuberculosis is the most common infection associated with these esophageal fistulae. We report here one case of bile duct-duodenal fistula in a female AIDS patient with associated abdominal Mycobacterium tuberculosis infection compromising lymph nodes of the hepatic pedicle where the fistula was found. According to the reviewed literature, this is the third case of bile duct-duodenal fistula associated with abdominal tuberculosis in AIDS patient, and the first where both the fistula and the tuberculosis infection were diagnosed at laparotomy for acute abdomen. Whether the AIDS patient with abdominal pain needs or not a laparotomy to treat an infectious disease is often a difficult matter for the surgeon to decide, as most of the times appropriate medical treatment will bring more benefit.</p>","PeriodicalId":76453,"journal":{"name":"Revista do Hospital das Clinicas","volume":"58 4","pages":"223-6"},"PeriodicalIF":0.0,"publicationDate":"2003-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24020207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Use of licit and illicit drugs at the University of Alfenas. 在阿尔菲纳斯大学使用合法和非法药物。
Revista do Hospital das Clinicas Pub Date : 2003-07-01 Epub Date: 2003-09-30 DOI: 10.1590/s0041-87812003000400003
João Evangelista Fiorini, Adriana Luiza Alves, Luciano Resende Ferreira, Celso Maia Fiorini, Sandro Willian Durães, Ricardo Luiz Diniz Santos, Luiz Carlos do Nascimento, Andréa Mantelo Vicente Geraldini, Cássia de Fátima Ortiz
{"title":"Use of licit and illicit drugs at the University of Alfenas.","authors":"João Evangelista Fiorini,&nbsp;Adriana Luiza Alves,&nbsp;Luciano Resende Ferreira,&nbsp;Celso Maia Fiorini,&nbsp;Sandro Willian Durães,&nbsp;Ricardo Luiz Diniz Santos,&nbsp;Luiz Carlos do Nascimento,&nbsp;Andréa Mantelo Vicente Geraldini,&nbsp;Cássia de Fátima Ortiz","doi":"10.1590/s0041-87812003000400003","DOIUrl":"https://doi.org/10.1590/s0041-87812003000400003","url":null,"abstract":"<p><strong>Unlabelled: </strong>This paper reports the study of drug consumption carried out within the population of undergraduate students from 2 colleges of Alfenas, in the state of Minas Gerais state. Both licit and illicit drugs were studied, including alcohol, tobacco, marijuana, cocaine, heroin, crack, inhalants, glue, tranquilizers, stimulants, and others.</p><p><strong>Methodology: </strong>The research included a wide bibliographical search and the application of a questionnaire to approximately 23% of the students (total of 6500 students).</p><p><strong>Results: </strong>A total of 1500 students participated in this investigation. The results demonstrated that there was a significant consumption of both licit and illicit drugs. The pattern of drug consumption in the research sample was similar to other investigations conducted in Brazil and in other countries.</p><p><strong>Discussion: </strong>It was observed that 55% of the university students use drugs. However, the most surprising finding was that most of the students (88%) answered \"yes\" to the inquiry, \"Have you already tried any type of drug, including alcohol and cigarettes?\" The students revealed that they had taken drugs even prior to the admission to the university. The results suggest clearly that the university environment does not necessarily represent the starting point for student drug consumption.</p>","PeriodicalId":76453,"journal":{"name":"Revista do Hospital das Clinicas","volume":"58 4","pages":"199-206"},"PeriodicalIF":0.0,"publicationDate":"2003-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1590/s0041-87812003000400003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24020299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 25
Meningeal carcinomatosis as the initial manifestation of a gallbladder adenocarcinoma associated with a Krukenberg tumor. 脑膜癌是胆囊腺癌合并Krukenberg肿瘤的初始表现。
Revista do Hospital das Clinicas Pub Date : 2003-05-01 Epub Date: 2003-07-22 DOI: 10.1590/s0041-87812003000300007
Tizuko Miyagui, Luciana Luchemback, Graça Helena Maia do Canto Teixeira, Kátia Martins Lopes de Azevedo
{"title":"Meningeal carcinomatosis as the initial manifestation of a gallbladder adenocarcinoma associated with a Krukenberg tumor.","authors":"Tizuko Miyagui,&nbsp;Luciana Luchemback,&nbsp;Graça Helena Maia do Canto Teixeira,&nbsp;Kátia Martins Lopes de Azevedo","doi":"10.1590/s0041-87812003000300007","DOIUrl":"https://doi.org/10.1590/s0041-87812003000300007","url":null,"abstract":"<p><p>A case of malignant neoplasm is described in which the initial manifestations were mental dysfunction and meningeal irritation, mimicking chronic or subacute meningitis. Physical examination showed cranial nerve involvement and a pelvic tumor. There was progressive deterioration, and death occurred in 2 weeks. The autopsy revealed a gallbladder adenocarcinoma, meningeal carcinomatosis, and ovarian metastasis presenting as a Krukenberg tumor. The authors emphasize the importance of including meningeal carcinomatosis as a possibility in the differential diagnosis of non-characteristic clinical pictures, as well as the importance of the cerebrospinal fluid cytologic examination, repeated as needed, in order to confirm this diagnosis.</p>","PeriodicalId":76453,"journal":{"name":"Revista do Hospital das Clinicas","volume":"58 3","pages":"169-72"},"PeriodicalIF":0.0,"publicationDate":"2003-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22510727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 18
Characterization of newborns with nonimmune hydrops fetalis admitted to a neonatal intensive care unit. 新生儿重症监护病房收治的非免疫性水肿胎儿新生儿的特征。
Revista do Hospital das Clinicas Pub Date : 2003-05-01 Epub Date: 2003-07-22 DOI: 10.1590/s0041-87812003000300001
Renata Suman Mascaretti, Mário Cícero Falcão, Andrea M Silva, Flávio Adolfo Costa Vaz, Cléa Rodrigues Leone
{"title":"Characterization of newborns with nonimmune hydrops fetalis admitted to a neonatal intensive care unit.","authors":"Renata Suman Mascaretti,&nbsp;Mário Cícero Falcão,&nbsp;Andrea M Silva,&nbsp;Flávio Adolfo Costa Vaz,&nbsp;Cléa Rodrigues Leone","doi":"10.1590/s0041-87812003000300001","DOIUrl":"https://doi.org/10.1590/s0041-87812003000300001","url":null,"abstract":"<p><strong>Purpose: </strong>To determine the incidence and characteristics of nonimmune hydrops fetalis in the newborn population.</p><p><strong>Method: </strong>A retrospective study of the period between 1996 and 2000, including all newborns with a prenatal or early neonatal diagnosis of nonimmune hydrops fetalis, based on clinical history, physical examination, and laboratory evaluation. The following were analyzed: prenatal follow-up, delivery type, gender, birth weight, gestational age, presence of perinatal asphyxia, nutritional classification, etiopathic diagnosis, length of hospital stay, mortality, and age at death.</p><p><strong>Results: </strong>A total of 47 newborns with hydrops fetalis (0.42% of live births), 18 (38.3%) with the immune form and 29 (61.7%) with the nonimmune form, were selected for study. The incidence of nonimmune hydrops fetalis was 1 per 414 neonates. Data was obtained from 21 newborns, with the following characteristics: 19 (90.5%) were suspected from prenatal diagnosis, 18 (85.7%) were born by cesarean delivery, 15 (71.4%) were female, and 10 (47.6%) were asphyxiated. The average weight was 2665.9 g, and the average gestational age was 35 3/7 weeks; 14 (66.6%) were preterm; 18 (85.0 %) appropriate delivery time; and 3 (14.3%) were large for gestational age. The etiopathic diagnosis was determined for 62%, which included cardiovascular (19.0%), infectious (9.5%), placental (4.8%), hematologic (4.7%), genitourinary (4.8%), and tumoral causes (4.8%), and there was a combination of causes in 9.5%. The etiology was classified as idiopathic in 38%. The length of hospital stay was 26.6 +/- 23.6 days, and the mortality rate was 52.4%.</p><p><strong>Conclusions: </strong>The establishment of a suitable etiopathic diagnosis associated with prenatal detection of nonimmune hydrops fetalis can be an important step in reducing the neonatal mortality rate from this condition.</p>","PeriodicalId":76453,"journal":{"name":"Revista do Hospital das Clinicas","volume":"58 3","pages":"125-32"},"PeriodicalIF":0.0,"publicationDate":"2003-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1590/s0041-87812003000300001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22510777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 34
Antiphospholipid antibodies in 57 children and adolescents with systemic lupus erythematosus. 57例系统性红斑狼疮儿童和青少年的抗磷脂抗体。
Revista do Hospital das Clinicas Pub Date : 2003-05-01 Epub Date: 2003-07-22 DOI: 10.1590/s0041-87812003000300005
Lúcia Maria de Arruda Campos, Maria Helena B Kiss, Elbio A D'Amico, Clóvis Artur Almeida Silva
{"title":"Antiphospholipid antibodies in 57 children and adolescents with systemic lupus erythematosus.","authors":"Lúcia Maria de Arruda Campos,&nbsp;Maria Helena B Kiss,&nbsp;Elbio A D'Amico,&nbsp;Clóvis Artur Almeida Silva","doi":"10.1590/s0041-87812003000300005","DOIUrl":"https://doi.org/10.1590/s0041-87812003000300005","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the frequencies and behavior of antiphospholipid antibodies in 57 children and adolescents with systemic lupus erythematosus.</p><p><strong>Methods: </strong>Anticardiolipin antibodies were investigated by ELISA and lupus anticoagulant antibodies by the international tests recommended. The antiphospholipid antibodies analyses were performed in frozen samples (mean of 5.3 samples per patient obtained during a mean follow-up period of 3 years and 7 months) and on blood samples collected between January 1997 and November 1998 (mean of 2.5 samples per patient during a 2-year follow-up period).</p><p><strong>Results: </strong>The frequencies of antiphospholipid antibodies (anticardiolipin and lupus anticoagulant) were similar in the samples collected prospectively and in the frozen samples (retrospective study): 63.2% and 75.4% respectively. Positivity for these antibodies fluctuated during the follow-up period and was not associated with any clinical or laboratory parameters of lupus erythematosus, including autoantibodies and also including disease activity and/or severity scores.</p><p><strong>Conclusions: </strong>The frequencies of antiphospholipid antibodies in children and adolescents with lupus erythematosus were similar to those observed in adults. The positivity fluctuated during the follow-up and was not correlated with clinical and/or laboratory disease parameters.</p>","PeriodicalId":76453,"journal":{"name":"Revista do Hospital das Clinicas","volume":"58 3","pages":"157-62"},"PeriodicalIF":0.0,"publicationDate":"2003-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1590/s0041-87812003000300005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22510723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Dura mater mitral and tricuspid bioprostheses: 30 years of follow-up. 硬脑膜二尖瓣和三尖瓣生物假体:30年随访。
Revista do Hospital das Clinicas Pub Date : 2003-05-01 Epub Date: 2003-07-22 DOI: 10.1590/s0041-87812003000300006
Luiz Boro Puig, Carlos Manuel de Almeida Brandão, Lauro Kawabe, Geraldo Verginelli, José Antonio Francchini Ramires, Sérgio Almeida de Oliveira
{"title":"Dura mater mitral and tricuspid bioprostheses: 30 years of follow-up.","authors":"Luiz Boro Puig,&nbsp;Carlos Manuel de Almeida Brandão,&nbsp;Lauro Kawabe,&nbsp;Geraldo Verginelli,&nbsp;José Antonio Francchini Ramires,&nbsp;Sérgio Almeida de Oliveira","doi":"10.1590/s0041-87812003000300006","DOIUrl":"https://doi.org/10.1590/s0041-87812003000300006","url":null,"abstract":"<p><strong>Purpose: </strong>The dura mater bioprosthesis was developed in the Department of Cardiopneumology of the Hospital das Clínicas of the University of São Paulo Medical School in 1971. Here, we present the clinical results of the dura mater bioprosthesis over 30 years of follow-up.</p><p><strong>Methods: </strong>We studied 70 consecutive patients who underwent mitral or tricuspid valve replacement with a dura mater bioprosthesis between January 1971 and August 1972.</p><p><strong>Results: </strong>The early mortality was 10% (7 patients). The follow-up was 87% complete (9 patients were lost to follow-up). Two patients were alive and asymptomatic 30 years after valve replacement; 33 patients underwent reoperations due to valve dysfunction, and 19 died during the follow-up period. At 30 years, the actuarial survival was 49.2 +/- 8.6%; freedom from rupture, 27.0 +/- 10.2%; freedom from calcification, 78.8 +/- 8.6%; and freedom from reoperation, 18.8 +/- 7.5%.</p><p><strong>Conclusions: </strong>The dura mater bioprosthesis played an important role in the treatment of patients with mitral and tricuspid valve disease. The low rate of thromboembolism and the long period of follow-up without evidence of valve dysfunction, which occurred for several of our patients, are important characteristics of these bioprosthesis.</p>","PeriodicalId":76453,"journal":{"name":"Revista do Hospital das Clinicas","volume":"58 3","pages":"163-8"},"PeriodicalIF":0.0,"publicationDate":"2003-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22510729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Histopathologic and biochemical liver test abnormalities in chronic asymptomatic or oligosymptomatic alcoholics: a review. 慢性无症状或少症状酒精中毒的组织病理学和生化肝脏检查异常:综述。
Revista do Hospital das Clinicas Pub Date : 2003-05-01 Epub Date: 2003-07-22 DOI: 10.1590/s0041-87812003000300004
Paulo Borini, Romeu Cardoso Guimarães, Sabrina Bicalho Borini
{"title":"Histopathologic and biochemical liver test abnormalities in chronic asymptomatic or oligosymptomatic alcoholics: a review.","authors":"Paulo Borini,&nbsp;Romeu Cardoso Guimarães,&nbsp;Sabrina Bicalho Borini","doi":"10.1590/s0041-87812003000300004","DOIUrl":"https://doi.org/10.1590/s0041-87812003000300004","url":null,"abstract":"<p><strong>Purpose: </strong>To review the medical literature regarding the histopathologic and biochemical liver test abnormalities in chronic asymptomatic or oligosymptomatic alcoholics.</p><p><strong>Methods: </strong>Review of articles in the MEDLINE and LILACS databases regarding serum levels and prevalence of alterations in aspartate-aminotransferase, alanine-aminotransferase, alkaline phosphatase, and total bilirubin, in relation to liver histopathology, with or without discrimination of types of histopathologic alteration.</p><p><strong>Results: </strong>Global mean prevalence rates of aspartate-aminotransferase and alanine-aminotransferase alterations were 86.3% and 51.1%; in cases with steatosis they were 79.1% and 38.5%; and in cases of hepatitis, 90.1% and 58%. In all studies, prevalence rates of aspartate-aminotransferase alterations were significantly higher with lower variability than those of alanine-aminotransferase. Mean aspartate-aminotransferase levels were higher than 2N (N is the upper normal limit of the method employed) in all cases with hepatitis histopathology, while those of alanine-aminotransferase were 1.48N, in the same cases. Prevalence of alkaline phosphatase and total bilirubin abnormalities were 74.5% and 74.9% globally; in cases of steatosis, they were 70.9% and 67.9%; and in cases of hepatitis, 75.9% and 77.7%. Mean alkaline phosphatase levels were above the upper normal limit in all cases, but those of total bilirubin were above normal in 4 of 7 hepatitis studies.</p><p><strong>Conclusions: </strong>Prevalence of aspartate-aminotransferase alteration was consistently related to presence of histopathologic abnormalities; an enzyme level higher than 2N suggests the diagnosis of alcoholic hepatitis.</p>","PeriodicalId":76453,"journal":{"name":"Revista do Hospital das Clinicas","volume":"58 3","pages":"147-56"},"PeriodicalIF":0.0,"publicationDate":"2003-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1590/s0041-87812003000300004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22510779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
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