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Psychopharmacology communications最新文献

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Studies on the metabolism of 5-hydroxytryptamine (serotonin). VII. Effects of haloindoles on cerebral 5-HT in various species. 5-羟色胺(血清素)代谢的研究。7氟吲哚对不同物种大脑5-羟色胺的影响。
Psychopharmacology communications Pub Date : 1976-01-01
A D Sherman, E M Gál
{"title":"Studies on the metabolism of 5-hydroxytryptamine (serotonin). VII. Effects of haloindoles on cerebral 5-HT in various species.","authors":"A D Sherman,&nbsp;E M Gál","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In a comparative study, the effective of intraventricularly or intraperitoneally injected p-chloroamphetamine (p-CA) and some chloroindoles on cerebral levels of serotonin was evaluated. 5-Chloroindole depressed 5-HT levels in the brainstem and telencephalon for three days, 6-chloro-2-methylindole (6-CMI) only during the first day. 5-Chloroindazole had no effect at all. p-CA was more toxic to guinea pigs than to rats. p-CA and 5-chloro-2-methylindole (5-CMI) had no effect on cerebral 5-HT in chicks. Apparently, none of these compounds represented or was converted to a metabolite possibly responsible for the neurotoxic effects of p-CA.</p>","PeriodicalId":76387,"journal":{"name":"Psychopharmacology communications","volume":"2 3","pages":"285-93"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12179354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of apomorphine plus 5-hydroxytryptophan on plasma prolactin levels in male rats. 阿波啡加5-羟色氨酸对雄性大鼠血浆催乳素水平的影响。
Psychopharmacology communications Pub Date : 1976-01-01
H Y Meltzer, V S Fang
{"title":"Effect of apomorphine plus 5-hydroxytryptophan on plasma prolactin levels in male rats.","authors":"H Y Meltzer,&nbsp;V S Fang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The relative potency of dopaminergic inhibition and serotonergic stimulation of prolactin secretion in male rats was compared. 5-Hydroxytryptophan (5-HTP), 100 mg/kg, i.p., the precursor of serotonin, produced a 6-11 fold increase in plasma prolactin. Apomorphine, a dopamine agonist, at doses of 1-10 mg/kg, i.p., had no significant effect on plasma prolactin. However, when apomorphine was given with or before 5-HTP, it nearly completely blocked the increase in prolactin produced by 5-htp. these results indicate that inhibition of prolactin secretion by dopaminergic stimulation can overcome the prolactin releasing effect of serotonin. The results are consistent with the hypothesis that prolactin secretion is ordinarily under a weak serotonergic stimulation and a profound dopaminergic inhibition. It is also possible that apomorphine affects plasma prolactin levels by increasing prolactin clearance.</p>","PeriodicalId":76387,"journal":{"name":"Psychopharmacology communications","volume":"2 3","pages":"189-98"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12267963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tardive dyskinesia and depressive illness. 迟发性运动障碍和抑郁症。
Psychopharmacology communications Pub Date : 1976-01-01
K L Davis, P A Berger, L E Hollister
{"title":"Tardive dyskinesia and depressive illness.","authors":"K L Davis,&nbsp;P A Berger,&nbsp;L E Hollister","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Tardive dyskinesia has been regarded as a long-term complication of neuroleptic administration to patients with the diagnosis of schizophrenia. However, nine of the first fourteen patients evaluated for an investigation of tardive dyskinesia met diagnostic criteria for depression. Neuroleptics produce blockade of post-synaptic dopaminergic receptors. Tardive dyskinesia occurs when neuroleptics are discontinued, and is regarded as a manifestation of super-sensitive post-synaptic dopaminergic receptors. Tardive dyskinesia occurs when neuroleptics are discontinued, and is regarded as a manifestation of super-sensitive post-synaptic dopaminergic receptors. Chronically decreased neurotransmission in the synapse of a patient with depression may contribute to the development of a super-sensitive receptor and could explain the high proportion of patients with depression seen in this sample of patients with tardive dyskinesia.</p>","PeriodicalId":76387,"journal":{"name":"Psychopharmacology communications","volume":"2 2","pages":"125-30"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11233668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Amine-responsive adenylate cyclase activity from brain: comparisons between rat and rhesus monkey and demonstration of dopamine-stimulated adenylate cyclase in monkey neocortex. 脑内胺反应性腺苷酸环化酶活性:大鼠与恒河猴的比较及猴新皮层多巴胺刺激腺苷酸环化酶的证明。
Psychopharmacology communications Pub Date : 1976-01-01
I Weinryb, I M Michel
{"title":"Amine-responsive adenylate cyclase activity from brain: comparisons between rat and rhesus monkey and demonstration of dopamine-stimulated adenylate cyclase in monkey neocortex.","authors":"I Weinryb,&nbsp;I M Michel","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effects of biogenic amines on adenylate cyclase from rhesus monkey brain have been surveyed. Dopamine-responsive cyclase activity was found throughout the subcortical limbic area and limbic cortex, as well as in the sensorimotor cortex, where stimulation by dopamine was blocked by fluphenazine. Cyclase activity from caudate nucleus in rat and rhesus monkey was very similar in relative responsiveness to stimulation by dopamine and norepinephrine. Some response of the enzyme from cingulate and sensorimotor cortex to isoproterenol was observed. The inhibition by fluphenazine of dopamine-responsive cyclase activity from sensorimotor cortex raises the possibility of a cerebrocortical locus of action for antipsychotic agents.</p>","PeriodicalId":76387,"journal":{"name":"Psychopharmacology communications","volume":"2 1","pages":"39-48"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12008355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute pharmacological activity of intravenous cocaine in the rhesus monkey. 恒河猴静脉注射可卡因的急性药理活性。
Psychopharmacology communications Pub Date : 1976-01-01
M C Wilson, J A Bedford, J Buelke, A H Kibbe
{"title":"Acute pharmacological activity of intravenous cocaine in the rhesus monkey.","authors":"M C Wilson,&nbsp;J A Bedford,&nbsp;J Buelke,&nbsp;A H Kibbe","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effects of the intravenous administration of cocaine (0.05-5.0 mg/kg) on body temperature, heart rate, respiration rate and several unconditioned behavioral categories were ascertained in unanesthetized male rhesus monkeys. Statistically significant increases in body temperature, respiration rate and heart rate occurred only after the largest dosage tested. Subjective increases in pupil size, activity, reactivity and vocalization as well as the occurrence of stereotyped behaviors, mydriasis and refusal to ingest fruit, were observed following injection with 0.2, 0.5 mg/kg and 5.0 mg/kg. A large degree of consistent intersubject variability in the magnitude of these responses was present. There was no consistent correlation across subjects between the magnitude of these responses and the plasma level of cocaine. However, within a given subject a direct correlation existed between these parameters.</p>","PeriodicalId":76387,"journal":{"name":"Psychopharmacology communications","volume":"2 3","pages":"251-61"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12011861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The occurrence of free vs. conjugated MHPG in non-human and human primate brain. 游离MHPG与结合MHPG在非人灵长类和人灵长类脑中的发生。
Psychopharmacology communications Pub Date : 1976-01-01
J W Maas, H Landis, H Dekirmenjian
{"title":"The occurrence of free vs. conjugated MHPG in non-human and human primate brain.","authors":"J W Maas,&nbsp;H Landis,&nbsp;H Dekirmenjian","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>It has been found that in the brain of the non-human primate (Macaca arctoides) MHPG occurs principally if not exclusively in the free rather than the conjugated form. It has also been found that in all areas of human brain examined MHPG is present in the free form rather than the conjugated form. The quantity of free MHPG present in various structures of human brain ranged from 46.4 to 69.8 microng/gm of tissue.</p>","PeriodicalId":76387,"journal":{"name":"Psychopharmacology communications","volume":"2 5-6","pages":"403-10"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12014618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prenatal reserpine administration: permanent changes in adrenal tyrosine hydroxylase and dopamine beta-hydroxylase. 产前利血平给药:肾上腺酪氨酸羟化酶和多巴胺-羟化酶的永久性改变。
Psychopharmacology communications Pub Date : 1975-01-01
J Bartolomé, T A Slotkin
{"title":"Prenatal reserpine administration: permanent changes in adrenal tyrosine hydroxylase and dopamine beta-hydroxylase.","authors":"J Bartolomé,&nbsp;T A Slotkin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Reserpine (1 mg/kg) was administered to pregnant rats on days 12, 13 and 14 of gestation. Although adrenal tyrosine hydroxylase and dopamine beta-hydroxylase activities were normal in the offspring at 4 days of postnatal age, both were elevated by 17 days and the elevations persisted into adulthood. The changes may result from permanently increased sympatho-adrenal stimulation.</p>","PeriodicalId":76387,"journal":{"name":"Psychopharmacology communications","volume":"1 5","pages":"465-72"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11231615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The search for the dopamine receptor: tribulations. 寻找多巴胺受体:磨难。
Psychopharmacology communications Pub Date : 1975-01-01
J Rotrosen, E Friedman, S Gershon
{"title":"The search for the dopamine receptor: tribulations.","authors":"J Rotrosen,&nbsp;E Friedman,&nbsp;S Gershon","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In an attempt to identify specific binding to dopamine receptors the binding of 3H-pimozide to preparations of brain and to an artificial cellulose membrane was examined. Binding occurred rapidly, was pH and temperature dependent, and was displaceable by other neuroleptics. Displaceable binding was saturable at 5 X 10(-8) M pimozide. A weak correlation between IC50's for displacement of binding by drugs and their clinical potencies was observed. Displaceable binding of 3H-pimozide in different brain areas did not correlate with dopamine levels. The similarity of binding properties to brain and to artificial membrane suggests that these effects are a function of the physical-chemical properties of these drugs, and that these properties may be related to their clinical effect.</p>","PeriodicalId":76387,"journal":{"name":"Psychopharmacology communications","volume":"1 2","pages":"229-37"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11229185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional heterogeneity within neurotransmitter systems. 神经递质系统的功能异质性。
Psychopharmacology communications Pub Date : 1975-01-01
M A Geyer
{"title":"Functional heterogeneity within neurotransmitter systems.","authors":"M A Geyer","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This paper reviews experiments that have revealed distinct differences between the dorsal and median raphe nuclei in the rat midbrain. The raphe nuclei appear to be hetrogeneous with respect to their anatomical projections to the forebrain, their relevance to specific behaviors, and their pharmacological responses. Startle response measures are useful indicators of the functional state of serotonergic system originating in the median raphe. As a way to study individual cells within the various raphe nuclei, microspectroflurimetric techniques are promising.</p>","PeriodicalId":76387,"journal":{"name":"Psychopharmacology communications","volume":"1 6","pages":"675-85"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11229186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The brain's dopamine receptor: labeling with (3H) dopamine and (3H) haloperidol. 大脑的多巴胺受体:标记(3H)多巴胺和(3H)氟哌啶醇。
Psychopharmacology communications Pub Date : 1975-01-01
S H Snyder, I Creese, D R Burt
{"title":"The brain's dopamine receptor: labeling with (3H) dopamine and (3H) haloperidol.","authors":"S H Snyder,&nbsp;I Creese,&nbsp;D R Burt","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76387,"journal":{"name":"Psychopharmacology communications","volume":"1 6","pages":"663-73"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12417252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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