{"title":"The action of thalidomide on the peripheral nervous system of the embryo.","authors":"J McCredie","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The mode of teratogenic action of thalidomide is unknown. A new radiological interpretation of thalidomide-induced limb malformations suggested that pathological changes should be sought in the sensory ganglia. Newborn rabbits with thalidomide-induced limb defects were examined histologically, and failure of maturation of dorsal root ganglion cells was demonstrated. This neuronal immaturity supports the radiological hypothesis of embryonic neuropathy, which is proposed as the underlying pathology of the limb deformities due to thalidomide.</p>","PeriodicalId":76351,"journal":{"name":"Proceedings of the Australian Association of Neurologists","volume":"12 ","pages":"135-40"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12393002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B McCaughan, R A Ouvrier, K De Silva, A McLaughlin
{"title":"The value of the brain scan and cerebral arteriogram in the Sturge-Weber syndrome.","authors":"B McCaughan, R A Ouvrier, K De Silva, A McLaughlin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In a series of eight patients with the Sturge-Weber syndrome, the brain scan was shown to be the most accurate, non-invasive, diagnostic test, being abnormal in all eight patients. In four cases examined by cerebral arteriography, this study was also conspicuously abnormal. Some of the neurological disturbances occurring in these patients are more likely to be due to transient ischaemic attacks and cerebral infarctions than to epilepsy.</p>","PeriodicalId":76351,"journal":{"name":"Proceedings of the Australian Association of Neurologists","volume":"12 ","pages":"185-90"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12393012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A family with Charcot-Marie-Tooth disease and Leber's optic atrophy.","authors":"J G McLeod, P A Low, J A Morgan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A family has been studied in which members of 4 generations were affected by the hypertrophic type of Charcot-Marie-Tooth disease. The diagnosis was confirmed by electrophysiological studies and by sural nerve biopsy. 10 members of the family, 8 males and 2 females, developed optic atrophy of acute onset with progression over a period of two to six months. The history of visual failure, its maternal inheritance, and the neuro-ophthalmological findings of optic atrophy with bilateral central scotomata were typical of Leber's optic atrophy. 2 members of the family suffered from both Charcot-Marie-Tooth disease and Leber's optic atrophy. There have been a few previous reports of optic atrophy associated with Charcot-Marie-Tooth disease, and in the present family both conditions appeared to have been inherited independently.</p>","PeriodicalId":76351,"journal":{"name":"Proceedings of the Australian Association of Neurologists","volume":"12 ","pages":"23-5"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12393013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Periodic alternating nystagmus.","authors":"L DE Silva, B P Cooper, J G McLeod","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A typical case of periodic alternating nystagmus is described. Periodic alternating nystagmus is a form of horizontal or horizontal-rotary jerk nystagmus of which the most characteristic feature is an alternation in direction at regular intervals. The condition appears to be not as rare as has been believed previously and may indicate a lesion in the upper part of the medulla.</p>","PeriodicalId":76351,"journal":{"name":"Proceedings of the Australian Association of Neurologists","volume":"12 ","pages":"157-60"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12393007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Fibre function and perception during cutaneous nerve block.","authors":"R A Mackenzie, D Burke, N F Skuse, A K Lethlean","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In awake human subjects, neural responses in cutaneous nerves to electrical stimulation were recorded with intrafascicular tungsten micro-electrodes. Changes in the activity of individual fibre groups during blocking procedures were recorded and correlated with simultaneous alterations in the perception of standardized stimuli. Light touch sensibility in hairy skin was mediated by A-beta-gamma fibres, cold and pinprick by A-delta fibres and warmth and dull pain by C fibres.</p>","PeriodicalId":76351,"journal":{"name":"Proceedings of the Australian Association of Neurologists","volume":"12 ","pages":"65-73"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12391661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reversible corticospinal abnormality in the alcoholic.","authors":"C Y Huang, G A Broe, P G Procopis","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76351,"journal":{"name":"Proceedings of the Australian Association of Neurologists","volume":"12 ","pages":"107-10"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12391956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L M Cotter, G Smith, W D Hooper, J H Tyrer, M J Eadie
{"title":"The bioavailability of carbamazepine.","authors":"L M Cotter, G Smith, W D Hooper, J H Tyrer, M J Eadie","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Two aspects of the correlation of plasma carbamazepine level with drug dose in patients taking carbamazepine tablets indicated the possibility that the drug may be incompletely and variably absorbed from the alimentary tract of man. To investigate this possibility, pharmacokinetic studies were undertaken in six volunteers, who were given increasing single doses of carbamazepine in tablet form at appropriate intervals. These studies gave evidence of slow, and probably incomplete, absorption of carbamazepine. After administration of carbamazepine in a specially-prepared solution to 5 of the subjects, rapid absorption of the drug occurred, and in 4 subjects more drug was absorbed than when the same normal dose was given as tablets. It was concluded that the pharmaceutical formulation of carbamazepine tablets limits the bioavailability of the drug, and that problems may arise if the bioavailability of the drug is to be increased.</p>","PeriodicalId":76351,"journal":{"name":"Proceedings of the Australian Association of Neurologists","volume":"12 ","pages":"123-8"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12391958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Australian Association of Neurologists-a review of twenty-five years.","authors":"J Game","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76351,"journal":{"name":"Proceedings of the Australian Association of Neurologists","volume":"12 ","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11964448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Subacute sclerosing panencephalitis: a study of 25 patients.","authors":"P G Procopis","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76351,"journal":{"name":"Proceedings of the Australian Association of Neurologists","volume":"11 ","pages":"133-5"},"PeriodicalIF":0.0,"publicationDate":"1974-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15571811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A new myopathy with type II muscle fibre hypoplasia.","authors":"Y Matsuoka, S S Gubbay, B A Kakulas","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76351,"journal":{"name":"Proceedings of the Australian Association of Neurologists","volume":"11 ","pages":"155-9"},"PeriodicalIF":0.0,"publicationDate":"1974-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15571813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}