AGE最新文献_第9页

Multimorbidity, cognitive function, and physical activity 多发病、认知功能和身体活动

AGE Pub Date : 2016-01-14 DOI: 10.1007/s11357-016-9874-5

P. Loprinzi

引用次数: 38

The relationship of nitric oxide synthesis capacity, oxidative stress, and albumin-to-creatinine ratio in black and white men: the SABPA study 黑人和白人男性一氧化氮合成能力、氧化应激和白蛋白与肌酐比值的关系:SABPA研究

AGE Pub Date : 2016-01-14 DOI: 10.1007/s11357-016-9873-6

C. Mels, H. Huisman, Wayne Smith, R. Schutte, E. Schwedhelm, D. Atzler, R. Böger, L. Ware, A. Schutte

引用次数: 18

AGE Pub Date : 2015-12-30 DOI: 10.1007/s11357-015-9867-9

F. P. Fiuza, Kayo D. A. Silva, Renata A. Pessoa, André L. B. Pontes, Rodolfo L. P. Cavalcanti, R. S. Pires, J. G. Soares, Expedito S. Nascimento Júnior, M. Costa, R. C. Engelberth, J. S. Cavalcante

引用次数: 6

Functional MRI evidence for the decline of word retrieval and generation during normal aging 正常衰老过程中单词检索和生成能力下降的功能性MRI证据

AGE Pub Date : 2015-12-28 DOI: 10.1007/s11357-015-9857-y

M. Baciu, N. Boudiaf, E. Cousin, M. Perrone‐Bertolotti, C. Pichat, N. Fournet, H. Chainay, L. Lamalle, A. Krainik

引用次数: 76

Obesity is associated with insulin resistance but not skeletal muscle dysfunction or all-cause mortality 肥胖与胰岛素抵抗有关，但与骨骼肌功能障碍或全因死亡率无关

AGE Pub Date : 2015-12-24 DOI: 10.1007/s11357-015-9865-y

J. Loenneke, P. Loprinzi

引用次数: 9

Biomarkers of oxidative stress are associated with frailty: the Framingham Offspring Study 氧化应激的生物标志物与虚弱有关:弗雷明汉后代研究

AGE Pub Date : 2015-12-23 DOI: 10.1007/s11357-015-9864-z

Christine K. Liu, A. Lyass, M. Larson, J. Massaro, Na Wang, R. D'Agostino, E. Benjamin, J. Murabito

引用次数: 119

Prenatal and childhood growth and physical performance in old age--findings from the Helsinki Birth Cohort Study 1934-1944. 产前和儿童时期的成长和老年时的身体表现——来自1934-1944年赫尔辛基出生队列研究的发现。

AGE Pub Date : 2015-12-01 Epub Date: 2015-10-24 DOI: 10.1007/s11357-015-9846-1

Johan G Eriksson, Clive Osmond, Mia-Maria Perälä, Minna K Salonen, Mika Simonen, Pertti Pohjolainen, Eero Kajantie, Taina Rantanen, Mikaela B von Bonsdorff

{"title":"Prenatal and childhood growth and physical performance in old age--findings from the Helsinki Birth Cohort Study 1934-1944.","authors":"Johan G Eriksson, Clive Osmond, Mia-Maria Perälä, Minna K Salonen, Mika Simonen, Pertti Pohjolainen, Eero Kajantie, Taina Rantanen, Mikaela B von Bonsdorff","doi":"10.1007/s11357-015-9846-1","DOIUrl":"https://doi.org/10.1007/s11357-015-9846-1","url":null,"abstract":"Health in adulthood is in part a consequence of development and growth taking place during sensitive periods in early life. It has not been explored previously whether early growth is associated with physical performance in old age from a life course perspective taking into account health-related behavior, biological risk factors, and early life experiences. At a mean age of 71 years, physical performance was assessed using the Senior Fitness Test (SFT) in 1078 individuals belonging to the Helsinki Birth Cohort Study. We used multiple linear regression analysis to assess the association between the SFT physical fitness scores and individual life course measurements. Several adult characteristics were associated with physical performance including socioeconomic status, lifestyle factors, and adult anthropometry. Higher birth weight and length were associated with better physical performance, even after adjusting for potential confounders (all p values <0.05). The strongest individual association between life course measurements and physical performance in old age was found for adult body fat percentage. However, prenatal growth was independently associated with physical performance seven decades later. These findings suggest that physical performance in old age is at least partly programmed in early life.","PeriodicalId":7632,"journal":{"name":"AGE","volume":"37 6","pages":"108"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11357-015-9846-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34116528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 30

Can consumption of antioxidant rich mushrooms extend longevity?: antioxidant activity of Pleurotus spp. and its effects on Mexican fruit flies' (Anastrepha ludens) longevity. 食用富含抗氧化剂的蘑菇能延长寿命吗?:侧耳菇的抗氧化活性及其对墨西哥果蝇寿命的影响。

AGE Pub Date : 2015-12-01 Epub Date: 2015-10-24 DOI: 10.1007/s11357-015-9847-0

José E Sánchez, Gabriela Jiménez-Pérez, Pablo Liedo

{"title":"Can consumption of antioxidant rich mushrooms extend longevity?: antioxidant activity of Pleurotus spp. and its effects on Mexican fruit flies' (Anastrepha ludens) longevity.","authors":"José E Sánchez, Gabriela Jiménez-Pérez, Pablo Liedo","doi":"10.1007/s11357-015-9847-0","DOIUrl":"https://doi.org/10.1007/s11357-015-9847-0","url":null,"abstract":"The variability of antioxidant capacity of 14 strains of the edible oyster mushroom Pleurotus spp. was determined, and the effect of selected mushroom supplements on the longevity of the Mexican fruit fly, Anastrepha ludens, was evaluated. The antioxidant capacity of the fruiting bodies was determined by three different methods, measuring the free radical scavenging activity of methanolic extracts, the OH radical scavenging capacity, and the total phenol content. The inhibition percentage of the DPPH radical varied between 32.6 and 85.7% and total phenols varied between 30.6 and 143.3 mg/g. The strains with the highest (Pleurotus djamor ECS-0142) and lowest (Pleurotus ostreatus ECS-1123) antioxidant capacity were selected to study their effect on the survival, life expectancy, and mortality of the Mexican fruit fly A. ludens. The results demonstrated differing responses between male and female flies. High concentrations of mushrooms (5 and 20%) in the diet resulted in a decrease in life expectancy. However, flies on the diet with 1% P. djamor ECS-0142 showed slightly but significantly greater survival than those on the control diet. The possible adverse effect of protein content in mushroom extracts is discussed.","PeriodicalId":7632,"journal":{"name":"AGE","volume":"37 6","pages":"107"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11357-015-9847-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34116527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Perceived age is associated with bone status in women aged 25-93 years. 在25-93岁的女性中，感知年龄与骨骼状况有关。

AGE Pub Date : 2015-12-01 Epub Date: 2015-10-20 DOI: 10.1007/s11357-015-9842-5

Barbara Rubek Nielsen, Allan Linneberg, Kaare Christensen, Peter Schwarz

{"title":"Perceived age is associated with bone status in women aged 25-93 years.","authors":"Barbara Rubek Nielsen, Allan Linneberg, Kaare Christensen, Peter Schwarz","doi":"10.1007/s11357-015-9842-5","DOIUrl":"https://doi.org/10.1007/s11357-015-9842-5","url":null,"abstract":"Higher perceived age (PA) is reported to be associated with age-related diseases. Because osteoporosis is considered an age-related disease, we hypothesized that age perceived from photographs is associated with bone mineral density (BMD)/trabecular bone score (TBS) when controlled for chronological age. This is a cross-sectional study of 460 women aged 25-93 years. BMD/TBS was measured. Twenty physicians assessed age from facial and whole-body photographs. Residual PA (R(PACA)) was calculated from the regression of PA on chronological age. Participants were divided into \"looking old\" (LO) or \"looking young\" (LY). Linear mixed models and general linear models fitted with BMD/TBS as outcome and either R(PACA) or LO/LY as an independent variable, considering chronological age. Estimates of R(PACA) were all negative; i.e., an increase in R(PAC) is associated with lower BMD, consistent with the hypothesis (e.g., β -0.29%; 95% confidence interval (CI) 0.55, 0.03). Statistical significance of the association of age-adjusted facial R(PACA) with BMD was found. Adjusted for body mass index (BMI), menopause, and hormone replacement therapy, higher R(PACA) from all photographic presentations were significantly associated with lower BMD based on statistical significance. BMD/TBS was in all analyses higher in the group LY compared with LO, when adjusted for age and BMI (e.g., β 4.37%; 95 CI 0.62, 8.26), but statistical significance was obtained only from the BMD analyses. A higher PA was significantly associated with a lower BMD/TBD, and the size of association in older women indicates that it might have value as part of the clinical assessment of osteoporotic risk.","PeriodicalId":7632,"journal":{"name":"AGE","volume":"37 6","pages":"106"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11357-015-9842-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34105593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Elderly men with moderate and intense training lifestyle present sustained higher antibody responses to influenza vaccine. 以中等和高强度训练为生活方式的老年男性对流感疫苗的抗体反应持续较高。

AGE Pub Date : 2015-12-01 Epub Date: 2015-10-19 DOI: 10.1007/s11357-015-9843-4

Adriana Ladeira de Araújo, Léia Cristina Rodrigues Silva, Juliana Ruiz Fernandes, Manuella de Sousa Toledo Matias, Lucy Santos Boas, Clarisse Martins Machado, Luiz Eugênio Garcez-Leme, Gil Benard

{"title":"Elderly men with moderate and intense training lifestyle present sustained higher antibody responses to influenza vaccine.","authors":"Adriana Ladeira de Araújo, Léia Cristina Rodrigues Silva, Juliana Ruiz Fernandes, Manuella de Sousa Toledo Matias, Lucy Santos Boas, Clarisse Martins Machado, Luiz Eugênio Garcez-Leme, Gil Benard","doi":"10.1007/s11357-015-9843-4","DOIUrl":"https://doi.org/10.1007/s11357-015-9843-4","url":null,"abstract":"We aimed to verify whether different levels of training performed regularly and voluntarily for many years could have an impact on one of the main issues of immunosenescence: the poor response to vaccines. We recruited 61 healthy elderly men (65-85 years old), 23 with a moderate training (MT) lifestyle (for 17.0 ± 3.2 years), 22 with an intense training (IT) lifestyle (for 25.9 ± 3.4 years), and 16 without a training lifestyle (NT). Fitness was evaluated through the IPAQ and VO2max consumption. The participants were evaluated regarding cognitive aspects, nutritional status, depression, and quality of life. Antibody titers were determined by hemagglutination inhibition assay prior to influenza vaccination and at 6 weeks and 6 months post-vaccination. Strains used were B, H3N2, and H1N1. Our groups were matched for most characteristics, except for those directly influenced by their lifestyles, such as BMI, VO2max, and MET. In general, MT and IT elderly men showed significantly higher antibody titers to the three vaccine strains post-vaccination than NT elderly men. There were also higher titers against B and H1N1 strains in the trained groups before vaccination. Additionally, there were higher proportions of seroprotected (titers ≥1:40) individuals in the pooled trained groups both at 6 weeks (B and H3N2, p < 0.05) and 6 months (H1N1, p < 0.05; B, p = 0.07). There were no significant differences between the MT and IT groups. Either a moderate or an intense training is associated with stronger and longstanding antibody responses to the influenza vaccine, resulting in higher percentages of seroprotected individuals.","PeriodicalId":7632,"journal":{"name":"AGE","volume":"37 6","pages":"105"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11357-015-9843-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34166542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 49