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Pharmacology & therapeutics. Part B: General & systematic pharmacology最新文献

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Antiparkinsonian drugs and dopaminergic neostriatal mechanisms: Studies in rats with unilateral 6-hydroxydopamine (=6-OH-DA)-induced degeneration of the nigro-neostriatal da pathway and quantitative recording of rotational behaviour 抗帕金森药物和多巴胺能新纹状体机制:单侧6-羟多巴胺(=6-OH-DA)诱导大鼠黑质-新纹状体数据通路变性和旋转行为定量记录的研究
Pharmacology & therapeutics. Part B: General & systematic pharmacology Pub Date : 1976-01-01 DOI: 10.1016/0306-039X(76)90017-9
Kjell Fuxe, Urban Ungerstedt
{"title":"Antiparkinsonian drugs and dopaminergic neostriatal mechanisms: Studies in rats with unilateral 6-hydroxydopamine (=6-OH-DA)-induced degeneration of the nigro-neostriatal da pathway and quantitative recording of rotational behaviour","authors":"Kjell Fuxe,&nbsp;Urban Ungerstedt","doi":"10.1016/0306-039X(76)90017-9","DOIUrl":"10.1016/0306-039X(76)90017-9","url":null,"abstract":"<div><p>The results of the present study illustrate the importance of using rotational behavior in rats with a unilateral 6-OH-DA-induced degeneration of the nigro-neostriatal DA system as an index of neostriatal DA receptor activity, particularly when combined with turnover analysis of DA. In this way it has been possible to develop new drugs that can be useful in the treatment of parkinsonian patients such as piribedil, ergot alkaloid derivatives and to obtain evidence that not only <em>dopa</em> but also <em>m</em>-tyrosine can be a powerful antiparkinsonian agent.</p></div>","PeriodicalId":76322,"journal":{"name":"Pharmacology & therapeutics. Part B: General & systematic pharmacology","volume":"2 1","pages":"Pages 41-47"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0306-039X(76)90017-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12005936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
Structure activity relationships of thyroxine analogs 甲状腺素类似物的构效关系
Pharmacology & therapeutics. Part B: General & systematic pharmacology Pub Date : 1976-01-01 DOI: 10.1016/0306-039X(76)90073-8
Eugene C. Jorgensen
{"title":"Structure activity relationships of thyroxine analogs","authors":"Eugene C. Jorgensen","doi":"10.1016/0306-039X(76)90073-8","DOIUrl":"10.1016/0306-039X(76)90073-8","url":null,"abstract":"","PeriodicalId":76322,"journal":{"name":"Pharmacology & therapeutics. Part B: General & systematic pharmacology","volume":"2 4","pages":"Pages 661-682"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0306-039X(76)90073-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11405557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Centrally acting hormones and respiration 中枢作用的激素和呼吸
Pharmacology & therapeutics. Part B: General & systematic pharmacology Pub Date : 1976-01-01 DOI: 10.1016/0306-039X(76)90076-3
Harold A. Lyons
{"title":"Centrally acting hormones and respiration","authors":"Harold A. Lyons","doi":"10.1016/0306-039X(76)90076-3","DOIUrl":"10.1016/0306-039X(76)90076-3","url":null,"abstract":"","PeriodicalId":76322,"journal":{"name":"Pharmacology & therapeutics. Part B: General & systematic pharmacology","volume":"2 4","pages":"Pages 743-751"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0306-039X(76)90076-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11405558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 35
Mechanism of action of digitalis glycosides at the subcellular level 洋地黄苷在亚细胞水平的作用机制
Pharmacology & therapeutics. Part B: General & systematic pharmacology Pub Date : 1976-01-01 DOI: 10.1016/0306-039X(76)90081-7
George E. Lindenmayer
{"title":"Mechanism of action of digitalis glycosides at the subcellular level","authors":"George E. Lindenmayer","doi":"10.1016/0306-039X(76)90081-7","DOIUrl":"10.1016/0306-039X(76)90081-7","url":null,"abstract":"","PeriodicalId":76322,"journal":{"name":"Pharmacology & therapeutics. Part B: General & systematic pharmacology","volume":"2 4","pages":"Pages 843-861"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0306-039X(76)90081-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11356798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
Mucociliary function in the respiratory tract as influenced by physicochemical factors 呼吸道粘膜纤毛功能受理化因素的影响
Pharmacology & therapeutics. Part B: General & systematic pharmacology Pub Date : 1976-01-01 DOI: 10.1016/0306-039X(76)90003-9
Josef Iravani, G. Norris Melville
{"title":"Mucociliary function in the respiratory tract as influenced by physicochemical factors","authors":"Josef Iravani,&nbsp;G. Norris Melville","doi":"10.1016/0306-039X(76)90003-9","DOIUrl":"10.1016/0306-039X(76)90003-9","url":null,"abstract":"","PeriodicalId":76322,"journal":{"name":"Pharmacology & therapeutics. Part B: General & systematic pharmacology","volume":"2 3","pages":"Pages 471-492"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0306-039X(76)90003-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11234436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 51
Monoaminergic drugs: General pharmacology 单胺能药物:一般药理学
Pharmacology & therapeutics. Part B: General & systematic pharmacology Pub Date : 1976-01-01 DOI: 10.1016/0306-039X(76)90030-1
W. Haefely, G. Bartholini, A. Pletscher
{"title":"Monoaminergic drugs: General pharmacology","authors":"W. Haefely,&nbsp;G. Bartholini,&nbsp;A. Pletscher","doi":"10.1016/0306-039X(76)90030-1","DOIUrl":"10.1016/0306-039X(76)90030-1","url":null,"abstract":"","PeriodicalId":76322,"journal":{"name":"Pharmacology & therapeutics. Part B: General & systematic pharmacology","volume":"2 1","pages":"Pages 185-218"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0306-039X(76)90030-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12005934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Compulsive gnawing 强迫性咬
Pharmacology & therapeutics. Part B: General & systematic pharmacology Pub Date : 1976-01-01 DOI: 10.1016/0306-039X(76)90029-5
A.M. Ernst
{"title":"Compulsive gnawing","authors":"A.M. Ernst","doi":"10.1016/0306-039X(76)90029-5","DOIUrl":"10.1016/0306-039X(76)90029-5","url":null,"abstract":"","PeriodicalId":76322,"journal":{"name":"Pharmacology & therapeutics. Part B: General & systematic pharmacology","volume":"2 1","pages":"Pages 173-184"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0306-039X(76)90029-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11968486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Chemistry of growth hormone 生长激素化学
Pharmacology & therapeutics. Part B: General & systematic pharmacology Pub Date : 1976-01-01 DOI: 10.1016/0306-039X(76)90008-8
J.A. Santomé, J.M. Dellacha, A.C. Paladini
{"title":"Chemistry of growth hormone","authors":"J.A. Santomé,&nbsp;J.M. Dellacha,&nbsp;A.C. Paladini","doi":"10.1016/0306-039X(76)90008-8","DOIUrl":"10.1016/0306-039X(76)90008-8","url":null,"abstract":"","PeriodicalId":76322,"journal":{"name":"Pharmacology & therapeutics. Part B: General & systematic pharmacology","volume":"2 3","pages":"Pages 571-590"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0306-039X(76)90008-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12163966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
Monkeys with nigrostriatal lesions: Tremor induced by harmaline and other drugs 黑质纹状体损伤的猴子:由盐碱和其他药物引起的震颤
Pharmacology & therapeutics. Part B: General & systematic pharmacology Pub Date : 1976-01-01 DOI: 10.1016/0306-039X(76)90023-4
L.J. Poirier, T.L. Sourkes
{"title":"Monkeys with nigrostriatal lesions: Tremor induced by harmaline and other drugs","authors":"L.J. Poirier,&nbsp;T.L. Sourkes","doi":"10.1016/0306-039X(76)90023-4","DOIUrl":"10.1016/0306-039X(76)90023-4","url":null,"abstract":"","PeriodicalId":76322,"journal":{"name":"Pharmacology & therapeutics. Part B: General & systematic pharmacology","volume":"2 1","pages":"Pages 105-112"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0306-039X(76)90023-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11228628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Studies on the cholinergic and dopaminergic innervation of the neostriatum with the help of intraneostriatal injections of drugs 纹状体内注射药物对新纹状体胆碱能和多巴胺能神经支配的研究
Pharmacology & therapeutics. Part B: General & systematic pharmacology Pub Date : 1976-01-01 DOI: 10.1016/0306-039X(76)90015-5
Kjell Fuxe, Urban Ungerstedt
{"title":"Studies on the cholinergic and dopaminergic innervation of the neostriatum with the help of intraneostriatal injections of drugs","authors":"Kjell Fuxe,&nbsp;Urban Ungerstedt","doi":"10.1016/0306-039X(76)90015-5","DOIUrl":"10.1016/0306-039X(76)90015-5","url":null,"abstract":"<div><p>The present study shows that direct chemical stimulation of the brain with relatively low doses (e.g. 100 ng) can be used to disclose the function of specific nerve terminal systems in the CNS. In this study the dopaminergic and cholinergic mechanisms in the neostriatum and their interaction has been evaluated. The results underline the important role the nigro-neostriatal DA neurons play in locomotor performance and in inducing stereotyped activity. The evidence suggest that the neostriatal cholinergic terminals can partly antagonize the behavioral effects of DA receptor stimulation in the neostriatum.</p></div>","PeriodicalId":76322,"journal":{"name":"Pharmacology & therapeutics. Part B: General & systematic pharmacology","volume":"2 1","pages":"Pages 29-36"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0306-039X(76)90015-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11968488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
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