{"title":"Acth regulation of the adrenal cortex","authors":"Gordon N. Gill","doi":"10.1016/S0306-039X(76)80011-6","DOIUrl":"10.1016/S0306-039X(76)80011-6","url":null,"abstract":"<div><p>Though significant advances in understanding ACTH regulation of the adrenal cortex have occurred, many questions concerning hormonal regulation of the adrenal cortical cell remain. Knowledge of the steroid biosynthetic pathway, the substrates, enzymes, co-factors, and subcellular compartmentalization involved provides a framework for understanding regulatory control of differentiated function in both health and disease. It is likely that precise regulatory control points and the mechanisms involved will shortly be forthcoming to complete many years of careful work by many investigators. Knowledge of regulation of growth and replication remains with a more incomplete framework. This aspect of hormonal regulation has assumed increasing importance in the broad area of growth control in normal and neoplastic cells. While it is clear that regulatory mechanisms involving cAMP are central to control of differentiated function and of growth, it is equally clear that ACTH regulation of growth is not directly correlated with activation of adenyl cyclase and elevated cAMP levels. Much additional work is needed to understand growth regulation and the ways in which this is deranged in the neoplastic state.</p></div>","PeriodicalId":76322,"journal":{"name":"Pharmacology & therapeutics. Part B: General & systematic pharmacology","volume":"2 2","pages":"Pages 313-338"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0306-039X(76)80011-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11400376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Molecular aspects of the biosynthesis of adrenal steroids","authors":"Evan R. Simpson , J. Ian Mason","doi":"10.1016/S0306-039X(76)80012-8","DOIUrl":"10.1016/S0306-039X(76)80012-8","url":null,"abstract":"","PeriodicalId":76322,"journal":{"name":"Pharmacology & therapeutics. Part B: General & systematic pharmacology","volume":"2 2","pages":"Pages 339-369"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0306-039X(76)80012-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11400377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Electrophysiology of the nigro-putamen dopamine pathway","authors":"D.H. York","doi":"10.1016/0306-039X(76)90012-X","DOIUrl":"10.1016/0306-039X(76)90012-X","url":null,"abstract":"","PeriodicalId":76322,"journal":{"name":"Pharmacology & therapeutics. Part B: General & systematic pharmacology","volume":"2 1","pages":"Pages 1-7"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0306-039X(76)90012-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11968483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pharmacology of pulmonary blood vessels","authors":"Che Su, John A. Bevan","doi":"10.1016/S0306-039X(76)80009-8","DOIUrl":"10.1016/S0306-039X(76)80009-8","url":null,"abstract":"","PeriodicalId":76322,"journal":{"name":"Pharmacology & therapeutics. Part B: General & systematic pharmacology","volume":"2 2","pages":"Pages 275-288"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0306-039X(76)80009-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11976389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Striatal dopamine and gamma-hydroxybutyrate","authors":"Robert H. Roth","doi":"10.1016/0306-039X(76)90020-9","DOIUrl":"10.1016/0306-039X(76)90020-9","url":null,"abstract":"","PeriodicalId":76322,"journal":{"name":"Pharmacology & therapeutics. Part B: General & systematic pharmacology","volume":"2 1","pages":"Pages 71-88"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0306-039X(76)90020-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12005937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Chemistry of the lipotropins","authors":"László Gráf","doi":"10.1016/0306-039X(76)90077-5","DOIUrl":"10.1016/0306-039X(76)90077-5","url":null,"abstract":"","PeriodicalId":76322,"journal":{"name":"Pharmacology & therapeutics. Part B: General & systematic pharmacology","volume":"2 4","pages":"Pages 753-769"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0306-039X(76)90077-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11405559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The mechanism of aldosterone function","authors":"James H. Ludens, Darrell D. Fanestil","doi":"10.1016/S0306-039X(76)80013-X","DOIUrl":"10.1016/S0306-039X(76)80013-X","url":null,"abstract":"","PeriodicalId":76322,"journal":{"name":"Pharmacology & therapeutics. Part B: General & systematic pharmacology","volume":"2 2","pages":"Pages 371-412"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0306-039X(76)80013-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11231969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The role of catecholamines in the action of drugs affecting behavior","authors":"Lewis S. Seiden","doi":"10.1016/0306-039X(76)90027-1","DOIUrl":"10.1016/0306-039X(76)90027-1","url":null,"abstract":"","PeriodicalId":76322,"journal":{"name":"Pharmacology & therapeutics. Part B: General & systematic pharmacology","volume":"2 1","pages":"Pages 155-165"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0306-039X(76)90027-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11968485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}