Pathobiology annual最新文献

Urinary bladder carcinogenesis. 膀胱癌变。

Pathobiology annual Pub Date : 1982-01-01

S M Cohen, R E Greenfield, G H Friedell

引用次数: 0

Urinary bladder carcinogenesis. 膀胱癌变。

Pathobiology annual Pub Date : 1982-01-01 DOI: 10.1097/00005392-199902000-00112

S. Cohen, R. E. Greenfield, G. Friedell

引用次数: 0

The use of experimental systems in the therapeutic research of small cell lung cancer. 实验系统在小细胞肺癌治疗研究中的应用。

Pathobiology annual Pub Date : 1982-01-01

D N Carney, A F Gazdar, J D Minna

引用次数: 0

Connective tissue, basement membrane, extracellular matrix. 结缔组织，基底膜，细胞外基质。

Pathobiology annual Pub Date : 1982-01-01

H R Catchpole

引用次数: 0

Pathogenetic analysis of congenital anomalies in humans. 人类先天性畸形的病理分析。

Pathobiology annual Pub Date : 1982-01-01

J M Opitz, E F Gilbert

引用次数: 0

Biology of cardiac overload. 心脏负荷生物学。

Pathobiology annual Pub Date : 1982-01-01

B Swynghedauw, C Delcayre

{"title":"Biology of cardiac overload.","authors":"B Swynghedauw, C Delcayre","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Mechanical overload in the heart induces two different types of adaptational mechanisms. (a) From a qualitative point of view, the maximum speed of shortening is depressed in relation to a myosin isoenzymic change responsible for decreased ATPase and, although the relaxation appears normal from a physiological point of view, the existence of an abnormality in Ca2+ uptake in the sarcoplasmic reticulum has been well documented. Both of these processes appear to improve efficiency by decreasing the heat produced per gram of tension. The existence of a large broadening of the action potential has now been well established, but it remains unexplained at the biochemical level. The functioning of mitochondria is rather controversial, and although it has been shown that they are both more abundant and smaller, the reason why their respiratory index changes remains unknown. (b) From a quantitative point of view, the adult heart adapts to overload by increasing its mass. This is mainly a consequence of a hypertrophy of the myocytes and a mitotic multiplication of nonmuscular cells. Data suggest that myocyte amitotic divisions may occur, at least in humans, and perhaps in very sizeable experimental hypertrophy. To this phenomenon has been added the development of polyploidy of myocyte nuclei, which seems to be specific to certain species. The stimulation of protein synthesis occurs very soon after pressure overload, and is delayed in volume overload; protein lysis also increases, although this is controversial. The process occurs whatever the proteins. This is accompanied by increased nuclear activity and a stimulation in RNA synthesis, which is especially precocious for messenger RNA. Among the very early events which could be potential signals for protein synthesis, attention has been focused on polyamine, RNA polymerase, and uridine kinase. The trigger mechanism, of course remains hypothetical. As a trigger for protein synthesis, several data suggest an increase in wall stress and stretch; a drop in efficiency is suggested as a trigger for qualitative changes.</p>","PeriodicalId":76307,"journal":{"name":"Pathobiology annual","volume":"12 ","pages":"137-83"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17281950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wilms' tumor: review of ultrastructure and histogenesis. 肾母细胞瘤:超微结构和组织发生的研究进展。

Pathobiology annual Pub Date : 1982-01-01

D Schmidt, G R Dickersin, G F Vawter, B Mackay, D Harms

引用次数: 0

Mechanisms of hypercalciuria. 高钙尿的机制。

Pathobiology annual Pub Date : 1982-01-01

J E Zerwekh, C Y Pak

引用次数: 0

Bone marrow transplantation: current status. 骨髓移植:现状。

Pathobiology annual Pub Date : 1982-01-01

R Dinsmore, R J O'Reilly