Monographs in pathology最新文献

{"title":"Pitfalls in the diagnosis of fine-needle aspiration of lymph nodes.","authors":"R L Katz","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76185,"journal":{"name":"Monographs in pathology","volume":" 39","pages":"118-33"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20192090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathology of the major peripheral nerve sheath neoplasms.","authors":"J M Woodruff","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76185,"journal":{"name":"Monographs in pathology","volume":"38 ","pages":"129-61"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19717560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An approach to the diagnosis of soft tissue tumors.","authors":"R L Kempson, M R Hendrickson","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76185,"journal":{"name":"Monographs in pathology","volume":"38 ","pages":"1-36"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19717557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fibrohistiocytic tumors.","authors":"C Fisher","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76185,"journal":{"name":"Monographs in pathology","volume":"38 ","pages":"162-80"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19717561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vascular tumors: an update with emphasis on the diagnosis of angiosarcoma and borderline vascular neoplasms.","authors":"C D Fletcher","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>It is clear from this selective review that the category of vascular tumors remains a great source of interest and diagnostic challenge because of its complex and heterogeneous constituents. Accurate diagnosis of the relatively infrequent angiosarcomas, with particular emphasis on avoiding overdiagnosis, remains crucial since the clinical outcome is generally very poor, especially when compared with the relatively innocent angiomatous lesions often mistaken for it. Equally, it is important to avoid confusing either spindle cell hemangioendothelioma or tufted angioma with Kaposi's sarcoma inasmuch as the connotations of the latter (especially in young patients) are considerable. Finally, the concept of borderline malignancy in vascular tumors is evolving and is still poorly defined. However, the number of tumors often placed in this category is expanding, and the indolent or unpredictable biologic behavior of these tumors will continue to pose problems and questions for pathologist and clinician alike.</p>","PeriodicalId":76185,"journal":{"name":"Monographs in pathology","volume":"38 ","pages":"181-206"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19717562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytogenetics and molecular biology of soft tissue tumors.","authors":"J A Fletcher","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Characteristic genetic aberrations have been identified in many soft tissue tumors, and it is likely that several of these aberrations, e.g., the translocation of chromosomes X and 18 in synovial sarcoma, will play an increasing diagnostic role. It is fascinating that most of the consistent soft tissue tumor translocations result in fusion genes, and these fusion genes encode proteins, which in turn regulate the expression of other genes. Thus, many soft tissue tumor translocations represent the first steps in complicated cascades of events contributing to deregulated tumor cell growth. Although a number of translocations appear to be useful in diagnosis, it should be emphasized that cytogenetic and molecular detection of chromosome translocations and gene fusions is not always straightforward. Cytogenetic and molecular analyses are perhaps best reserved for the subgroup of undifferentiated small round cell or spindle cell sarcomas, which remain unclassified after histological, immunohistochemical, and ultrastructural studies. Tumor specimens frozen at -70 degrees C can be used subsequently for FISH and PCR studies, although the opportunity to karyotype such specimens is lost upon freezing.</p>","PeriodicalId":76185,"journal":{"name":"Monographs in pathology","volume":"38 ","pages":"37-64"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19717558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipomatous tumors.","authors":"S. Weiss","doi":"10.1007/978-3-540-47648-1_3382","DOIUrl":"https://doi.org/10.1007/978-3-540-47648-1_3382","url":null,"abstract":"","PeriodicalId":76185,"journal":{"name":"Monographs in pathology","volume":"38 1","pages":"207-39"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51056302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunohistochemistry in the differential diagnosis of soft tissue tumors.","authors":"J S Brooks","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Immunohistochemical reagents have allowed us to analyze each and every soft tissue lesion over the past decade. What has been learned has been extraordinarily valuable and the fact that these reagents exist has undoubtedly led to more accurate diagnoses on the whole. We have learned to speak of \"differentiation\" rather than \"histogenesis.\" We have also learned that, as each marker has been held up to the test of time, there are very few perfect markers. Interpretation must always be made with (1) full knowledge of the phenotypic range of each marker, (2) knowledge of the range of marker reactivity of each tumor or lesion, and (3) the all-important clinico-morphologic setting, which must continue to weigh heavily in the diagnostic process.</p>","PeriodicalId":76185,"journal":{"name":"Monographs in pathology","volume":"38 ","pages":"65-128"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19717559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipomatous tumors.","authors":"S W Weiss","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Lipomatous tumors are a common group of mesenchymal lesions. Over the years the major changes in the classification of lipomatous tumors have included the addition of several new variants of lipoma, the use of the term atypical lipoma for well differentiated liposarcoma of the subcutaneous tissue, and recognition of the entity dedifferentiated liposarcoma. Lipomas, the most common lipomatous tumor, account for nearly one-half of all benign lesions. In their typical form they seldom present diagnostic problems for the pathologist. However, lipomas occurring in deep locations (e.g., intramuscular lipoma, perineural lipoma) or those having unusual features (e.g., chondroid lipoma, lipoma with hibernoma, cellular angiolipoma, spindle cell/pleomorphic lipoma) may be confused with liposarcoma. Recent cytogenetic studies have reaffirmed the separate nature of many of the variants of lipoma. Solitary lipomas commonly have rearrangements of chromosome 12, a finding not encountered in multiple lipomas or in spindle cell/ pleomorphic lipoma. Liposarcoma is the most common adult soft tissue sarcoma. It seldom arises from subcutaneous tissues or from preexisting lipomas, and is seldom found in children. The hallmark of liposarcoma is the immature fat cell or lipoblast. Diagnostic lipoblasts have an eccentric, hyperchromatic nucleus, which is indented or scalloped by the presence of one or more fat vacuoles. It is important that these cells occur in the appropriate histologic background because similar cells can be seen in a variety of nonlipomatous lesions (e.g., silicone reaction). Failure to apply strict criteria in identifying such cells and in noting the milieu in which they occur can lead to overdiagnosis of liposarcoma. Liposarcomas are divided into several subtypes: well differentiated, myxoid, round cell, pleomorphic, and dedifferentiated. Liposarcomas can be conceptualized as occurring in two broad groups, myxoid/round cell liposarcoma and well differentiated/dedifferentiated liposarcoma. Myxoid/round cell liposarcomas occur in middle-aged adults primarily as an extremity lesion. Tumors range from pure myxoid (low grade) to pure round cell (high-grade lesions) with some cases having transitional features. Behavior can be related to the amount of round cell areas. A consistent chromosome abnormality t(12;16) characterizes this spectrum of lesions. Well differentiated/dedifferentiated liposarcomas, in contrast, occur in late adult life as extremity or retroperitoneal lesions. They consist of mature fat interlaced with atypical hyperchromatic cells and rare lipoblasts. These lesions recur commonly, but they do not metastasize. Their behavior is strongly influenced by location, with retroperitoneal lesions having the worse prognosis. As a long-term complication of the disease, these lesions may progress histologically (dedifferentiate), a phenomenon that confers upon them metastatic potential. Dedifferentiation is largely a time-dependent phenomeno","PeriodicalId":76185,"journal":{"name":"Monographs in pathology","volume":"38 ","pages":"207-39"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19717563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sarcomas: the role of adjuvant chemotherapy and a proposed new staging system.","authors":"L H Baker,&nbsp;M Zalupski","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76185,"journal":{"name":"Monographs in pathology","volume":"38 ","pages":"240-51"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19717564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}