Monographs in human genetics最新文献

Genetic Basis of Male and Female Infertility 男性和女性不育的遗传基础

Monographs in human genetics Pub Date : 2017-01-01 DOI: 10.1159/000477275

Rathika Mallepaly, Peter R Butler, A. Herati, D. Lamb

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引用次数: 20

In vitro Spermatogenesis and Its Potential Clinical Implication for Patients 体外精子发生及其对患者的潜在临床意义

Monographs in human genetics Pub Date : 2017-01-01 DOI: 10.1159/000477285

J. Stukenborg, K. Jahnukainen

{"title":"In vitro Spermatogenesis and Its Potential Clinical Implication for Patients","authors":"J. Stukenborg, K. Jahnukainen","doi":"10.1159/000477285","DOIUrl":"https://doi.org/10.1159/000477285","url":null,"abstract":"The establishment of a robust and reliable culture system to study the differentiation of male germ cells in vitro has been a topic in developmental biology and reproductive medicine for over 100 years. Although successful approaches resulting in full mammalian spermatogenesis have been developed for mice, development of a system to elucidate details of the complex process of spermatogenesis in humans is still needed. A huge variety of strategies employing different types of cells, cultured in different conditions, have been investigated so far. However, mostly because of limited access to human gonadal material from healthy donors, crucial information necessary to establish a functioning system remains missing. To picture the current status of information on human spermatogenesis in vitro, this short review mainly focuses on articles published over the last decade. However, important articles published before 2006 have also been included in the absence of more recent studies. A literature search was conducted, including articles written in English and German, cited in PubMed, and references identified in articles, with the focus on in vitro spermatogenesis and its clinical implication for paediatric oncology and haematology patients subjected to gonadotoxic anticancer treatments.","PeriodicalId":76182,"journal":{"name":"Monographs in human genetics","volume":"21 1","pages":"162-172"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000477285","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65273361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

The Epigenetics of Sperm Chromatin 精子染色质的表观遗传学

Monographs in human genetics Pub Date : 2017-01-01 DOI: 10.1159/000477282

Monis B. Shamsi, L. Simon, D. Carrell

引用次数: 2

Clinical Challenges in Diagnosing the Genetic Etiology of Hearing Loss 听力损失遗传病因诊断的临床挑战

Monographs in human genetics Pub Date : 2016-04-21 DOI: 10.1159/000444564

A. Birkeland, M. Lesperance

引用次数: 1

The Importance of Genome Architecture in Mental Retardation 基因组结构在智力迟钝中的重要性

Monographs in human genetics Pub Date : 2010-02-15 DOI: 10.1159/000287595

H. Mefford