{"title":"Clinical research: is the filling missing from the medical research sandwich?","authors":"P Dieppe, M Bachmann","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Clinical research is essential for patients to benefit from the advances of medical science. Particularly needed are thorough and imaginative investigations into applied physiology, clinical observation, and patients' experience. This can help clinicians and their patients to distinguish between pathology and healthy variation, interpret diagnostic information, understand what patients want and gain from health care, and apply study results to individuals' problems. Clinical research has not grown as much as other forms of medical research, and is sometimes regarded as unscientific. Young academic clinicians are often persuaded that the only road to science leads through the laboratory. Clinical research, however, offers equal opportunities for original enquiry, rigour and excellence. The medical research sandwich will continue to provide an unbalanced diet unless research leaders and funders take the clinical setting more seriously.</p>","PeriodicalId":76057,"journal":{"name":"Journal of the Royal College of Physicians of London","volume":"34 3","pages":"282-4"},"PeriodicalIF":0.0,"publicationDate":"2000-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d0/0b/jrcollphyslond146952-0062.PMC9665552.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21745412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Measuring the quality of care for older people: preparing for the National Service Framework.","authors":"P H Millard","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76057,"journal":{"name":"Journal of the Royal College of Physicians of London","volume":"34 3","pages":"306-7"},"PeriodicalIF":0.0,"publicationDate":"2000-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b4/c0/jrcollphyslond146952-0086.PMC9665537.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21746695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The 'learning curve' for temporary pacing: evidence that current training guidelines are unrealistic.","authors":"M Connaughton, P Forsey, R Smith, M Gammage","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76057,"journal":{"name":"Journal of the Royal College of Physicians of London","volume":"34 3","pages":"315"},"PeriodicalIF":0.0,"publicationDate":"2000-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5c/23/jrcollphyslond146952-0095b.PMC9665539.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21746697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Stereotactic intracranial radiotherapy/radiosurgery has come of age.","authors":"P N Plowman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The current, highly sophisticated, brain imaging techniques and three dimensional (stereotactic) mapping of intracranial targets, combined with recent developments in concentration of radiation therapy (x- or gamma-ray) onto these targets, have allowed obliterative treatment for many intracranial diseases previously the preserve of the neurosurgeon alone. Vascular malformations, acoustic neuroma, complex meningioma, pituitary adenoma and craniopharyngioma all fall into this category, as well as base of skull tumours. There are occasional indications for single (a few) cerebral metastases and possibly a highly selected role in primary malignant brain tumours. The subject of so-called 'radiosurgery' is an important and developing one and is complementary to modern neurosurgery.</p>","PeriodicalId":76057,"journal":{"name":"Journal of the Royal College of Physicians of London","volume":"34 3","pages":"273-81"},"PeriodicalIF":0.0,"publicationDate":"2000-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ba/15/jrcollphyslond146952-0053.PMC9665558.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21746691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"NTNs and all that! Will specialist registrars get a consultant post a will consultants have a registrar?","authors":"W R Burnham","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76057,"journal":{"name":"Journal of the Royal College of Physicians of London","volume":"34 3","pages":"285-8"},"PeriodicalIF":0.0,"publicationDate":"2000-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/44/e4/jrcollphyslond146952-0065.PMC9665535.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21746692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Recent advances in autoimmune diseases.","authors":"D E Jones","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76057,"journal":{"name":"Journal of the Royal College of Physicians of London","volume":"34 3","pages":"302-5"},"PeriodicalIF":0.0,"publicationDate":"2000-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0e/72/jrcollphyslond146952-0082.PMC9665538.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21746701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Acute medicine: the physician's future role.","authors":"C M Black","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76057,"journal":{"name":"Journal of the Royal College of Physicians of London","volume":"34 3","pages":"235-8"},"PeriodicalIF":0.0,"publicationDate":"2000-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/44/3c/jrcollphyslond146952-0015.PMC9665529.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21745405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hypoglycaemia unawareness: causes, consequences and treatment.","authors":"K M MacLeod","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76057,"journal":{"name":"Journal of the Royal College of Physicians of London","volume":"34 3","pages":"245-50"},"PeriodicalIF":0.0,"publicationDate":"2000-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9f/d4/jrcollphyslond146952-0025.PMC9665553.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21745408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"New hypoglycaemic therapies.","authors":"E A Gale","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76057,"journal":{"name":"Journal of the Royal College of Physicians of London","volume":"34 3","pages":"250-3"},"PeriodicalIF":0.0,"publicationDate":"2000-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/da/51/jrcollphyslond146952-0030.PMC9665550.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21745409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The National Service Framework for coronary heart disease: the emperor's new clothes.","authors":"J R Hampton","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76057,"journal":{"name":"Journal of the Royal College of Physicians of London","volume":"34 3","pages":"226-9; discussion 229-30"},"PeriodicalIF":0.0,"publicationDate":"2000-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cb/4d/jrcollphyslond146952-0006.PMC9665548.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21745402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}