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Journal of the Royal College of Physicians of London最新文献

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The emperor's new clothes. 皇帝的新衣。
Journal of the Royal College of Physicians of London Pub Date : 2000-09-01
W F Cunningham
{"title":"The emperor's new clothes.","authors":"W F Cunningham","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76057,"journal":{"name":"Journal of the Royal College of Physicians of London","volume":"34 5","pages":"501-2"},"PeriodicalIF":0.0,"publicationDate":"2000-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b8/e6/jrcollphyslond146954-0093b.PMC9665498.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21902973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Controversy in thyroid disease. 甲状腺疾病的争议。
Journal of the Royal College of Physicians of London Pub Date : 2000-09-01
A J Krentz
{"title":"Controversy in thyroid disease.","authors":"A J Krentz","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76057,"journal":{"name":"Journal of the Royal College of Physicians of London","volume":"34 5","pages":"502"},"PeriodicalIF":0.0,"publicationDate":"2000-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/50/36/jrcollphyslond146954-0094a.PMC9665504.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21902975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What is muscular dystrophy? Forty years of progressive ignorance. 什么是肌肉萎缩症?四十年的无知。
Journal of the Royal College of Physicians of London Pub Date : 2000-09-01
V Dubowitz
{"title":"What is muscular dystrophy? Forty years of progressive ignorance.","authors":"V Dubowitz","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This lecture traces recent advances in knowledge of the muscular dystrophies, as well as their increasing complexity. They are described through the eyes of the author from his first exposure to and complete ignorance of the disease in the late 1950s, through the advent of modern techniques, to the molecular genetic revolution, with the recognition of individual genes and proteins for disorders within the muscular dystrophy umbrella. There initially seemed to be a logical sequence of linked membrane proteins from dystrophin in Duchenne and Becker dystrophy, through the dystrophin-associated glycoproteins (sarcoglycans) in some of the limb girdle muscular dystrophies (LGMD), to the extracellular matrix protein merosin (alpha-2 laminin) in congenital muscular dystrophy (CMD). The first spoke in the wheel came with the discovery of a calcium activated protease enzyme, calpain 3, in one form of LGMD, and subsequently another novel non-membrane protein, dysferlin, in another. There are currently at least eight distinct genetic forms of LGMD alone, and another eight separate genetic entities in the CMD group. This has highlighted our ignorance of the pathogenesis of the muscular dystrophies in relation to a diverse array of protein deficiencies. To compound things further, the X-linked and dominant forms of Emery-Dreifuss muscular dystrophy have recently been linked to emerin and lamin A/C, respectively, two proteins of the nuclear membrane, opening up yet another new ballpark of discovery.</p>","PeriodicalId":76057,"journal":{"name":"Journal of the Royal College of Physicians of London","volume":"34 5","pages":"464-8"},"PeriodicalIF":0.0,"publicationDate":"2000-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0f/9e/jrcollphyslond146954-0056.PMC9665519.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21902963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bellmanism: the distortion of reason. 贝尔曼主义:理性的扭曲。
Journal of the Royal College of Physicians of London Pub Date : 2000-09-01
C L Berry
{"title":"Bellmanism: the distortion of reason.","authors":"C L Berry","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Single-issue compound or class related anxieties about chemical exposures are often the focus of concern for groups that seek to affect the regulatory process itself or the regulatory status of compounds that have passed through it. A characteristic of these groups is an imperfect understanding and use of science, in particular in the evaluation of data. Studies which have been discredited are cited repeatedly and the role of confounding factors is not generally acknowledged. The regulation of medicines, devices, pesticides and some household chemicals depends on the use of a methodology that follows strict protocols. This involves testing in many systems including mammals, other vertebrates, invertebrates, soil macrobiota or ground water, as examples, with often well-defined schemes of interpretation which facilitate extrapolation between species. A complex risk evaluation will then be made for different groups (by age, sex, or occupation, say) or targets (patients, farmers, consumers and vulnerable non-human species). Focusing on an effect in a single group may suggest interventions which will be damaging for others.</p>","PeriodicalId":76057,"journal":{"name":"Journal of the Royal College of Physicians of London","volume":"34 5","pages":"486-91"},"PeriodicalIF":0.0,"publicationDate":"2000-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/00/8f/jrcollphyslond146954-0078.PMC9665508.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21902969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The potential role of IT in supporting the work of junior doctors. 资讯科技在支援初级医生工作方面的潜在作用。
Journal of the Royal College of Physicians of London Pub Date : 2000-09-01
M Aitken
{"title":"The potential role of IT in supporting the work of junior doctors.","authors":"M Aitken","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76057,"journal":{"name":"Journal of the Royal College of Physicians of London","volume":"34 5","pages":"502"},"PeriodicalIF":0.0,"publicationDate":"2000-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8b/2d/jrcollphyslond146954-0094b.PMC9665513.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21904724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A single consultation cerebrovascular disease clinic is cost effective in the management of transient ischaemic attack and minor stroke. 脑血管病门诊一次会诊是治疗短暂性脑缺血发作和轻微中风的经济有效的方法。
Journal of the Royal College of Physicians of London Pub Date : 2000-09-01
A Blight, A C Pereira, M M Brown
{"title":"A single consultation cerebrovascular disease clinic is cost effective in the management of transient ischaemic attack and minor stroke.","authors":"A Blight,&nbsp;A C Pereira,&nbsp;M M Brown","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Aim: </strong>We examined the cost effectiveness of a single consultation strategy to manage patients referred with TIA or stroke to our cerebrovascular disease (CVD) clinic, where all relevant investigations (blood tests, CT brain scan and carotid Dopplers) were obtained prior to the clinic appointment.</p><p><strong>Design: </strong>Retrospective study of patients referred to the CVD clinic at St George's Hospital, London between October 1995 and 1996.</p><p><strong>Results: </strong>Of 211 new patients seen in the clinic, 73% had CVD; 146 (68%) patients had imaging studies prior to clinic attendance. Of these, 132 (90%) were managed with a single consultation. This strategy cost 5,700 Pounds less than if these patients had been followed up.</p><p><strong>Conclusion: </strong>Performing all relevant investigations prior to clinic attendance allowed a fully informed discussion with the patient at a single consultation and was cost effective.</p>","PeriodicalId":76057,"journal":{"name":"Journal of the Royal College of Physicians of London","volume":"34 5","pages":"452-5"},"PeriodicalIF":0.0,"publicationDate":"2000-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ef/a3/jrcollphyslond146954-0044.PMC9665520.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21903082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk management and substandard clinical care. 风险管理和不规范的临床护理。
Journal of the Royal College of Physicians of London Pub Date : 2000-09-01
J Ward
{"title":"Risk management and substandard clinical care.","authors":"J Ward","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Physicians must now openly demonstrate their competence and ability to perform their role as consultants. Measures have been developed which allow early identification of problems and provide procedures to examine in detail where and when problems arise. A number of organisations will be involved and efforts must be made to co-ordinate the various initiatives. One note of caution, however. Assuming that regular peer review is accepted, that CHI carry out a four-year cycle of visits to every trust in the land, that all visitors in such procedures have to be trained to do the job, that the visitors must be engaged in active clinical practice, that at home appraisal audit and assessment are in progress, the question inevitably arises as to where all the personnel will come from and what happens to clinical work in our under-doctored country? Change certainly stimulates excitement about the future.</p>","PeriodicalId":76057,"journal":{"name":"Journal of the Royal College of Physicians of London","volume":"34 5","pages":"478-80"},"PeriodicalIF":0.0,"publicationDate":"2000-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/92/4b/jrcollphyslond146954-0070.PMC9665503.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21902964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pathophysiology and management of meningococcal septicaemia. 脑膜炎球菌败血症的病理生理学和治疗。
Journal of the Royal College of Physicians of London Pub Date : 2000-09-01
N Pathan, S Nadel, M Levin
{"title":"Pathophysiology and management of meningococcal septicaemia.","authors":"N Pathan,&nbsp;S Nadel,&nbsp;M Levin","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76057,"journal":{"name":"Journal of the Royal College of Physicians of London","volume":"34 5","pages":"436-44"},"PeriodicalIF":0.0,"publicationDate":"2000-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4f/41/jrcollphyslond146954-0028.PMC9665499.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21903079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The research plans of specialist registrars: the RCP SpR questionnaire survey. 专业注册商的研究计划:RCP SpR问卷调查。
Journal of the Royal College of Physicians of London Pub Date : 2000-09-01
H M Mather
{"title":"The research plans of specialist registrars: the RCP SpR questionnaire survey.","authors":"H M Mather","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76057,"journal":{"name":"Journal of the Royal College of Physicians of London","volume":"34 5","pages":"456-7"},"PeriodicalIF":0.0,"publicationDate":"2000-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7e/c7/jrcollphyslond146954-0048.PMC9665514.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21902961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Update on revalidation. 关于重新验证的更新。
Journal of the Royal College of Physicians of London Pub Date : 2000-09-01
D Irvine
{"title":"Update on revalidation.","authors":"D Irvine","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76057,"journal":{"name":"Journal of the Royal College of Physicians of London","volume":"34 5","pages":"415-7"},"PeriodicalIF":0.0,"publicationDate":"2000-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7c/21/jrcollphyslond146954-0007.PMC9665509.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21903075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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