American Journal of Physiology - Gastrointestinal and Liver Physiology最新文献

筛选
英文 中文
Intestinal Perfusion of Unacylated Ghrelin Alleviated Metabolic Associated Fatty Liver Disease in Rat via a Central Glucagon-Like Peptide-1 Pathway 通过中枢胰高血糖素样肽-1 通路灌注未酰化胃泌素缓解大鼠代谢相关性脂肪肝
American Journal of Physiology - Gastrointestinal and Liver Physiology Pub Date : 2024-04-02 DOI: 10.1152/ajpgi.00217.2023
Pengfei Lv, Hongzeng Li, Xiangbo Li, Xueyuying Wang, Jiantong Yu, Yanling Gong
{"title":"Intestinal Perfusion of Unacylated Ghrelin Alleviated Metabolic Associated Fatty Liver Disease in Rat via a Central Glucagon-Like Peptide-1 Pathway","authors":"Pengfei Lv, Hongzeng Li, Xiangbo Li, Xueyuying Wang, Jiantong Yu, Yanling Gong","doi":"10.1152/ajpgi.00217.2023","DOIUrl":"https://doi.org/10.1152/ajpgi.00217.2023","url":null,"abstract":"Unacylated ghrelin (UAG), the unacylated form of ghrelin, accounts for 80-90% of circulation. Accumulated studies have pointed out that UAG may be used to treat metabolic disorders. This study aimed to investigate the effect of intestinal perfusion of UAG on metabolic associated fatty liver disease (MAFLD) induced by a high-fat diet and its possible mechanism. Neuronal retrograde tracking combined with immunofluorescence, central administration of GLP-1R antagonist, and hepatic vagotomy were performed to reveal its possible mechanism involving a central glucagon-like peptide-1 pathway. The results showed that intestinal perfusion of UAG significantly reduced serum lipids, aminotransferases, and food intake in MAFLD rats. Steatosis and lipid accumulation in the liver were significantly alleviated and lipid metabolism-related enzymes in the liver were regulated. UAG upregulated the expression of GLP-1 receptor (GLP-1R) in the paraventricular nucleus (PVN) and GLP-1 in the nucleus tractus solitarii (NTS), as well as activated GLP-1 neurons in the NTS. Furthermore, GLP-1 fibers projected from NTS to PVN were activated by intestinal perfusion of UAG. However, hepatic vagotomy and GLP-1R antagonist delivered into PVN before intestinal perfusion of UAG partially attenuated its alleviation on MAFLD. In conclusion, intestinal perfusion of UAG showed a therapeutic effect on MAFLD, which might be related to its activating on GLP-1 neuronal pathway from NTS to PVN. The present results provide a new strategy for the treatment of MAFLD.","PeriodicalId":7598,"journal":{"name":"American Journal of Physiology - Gastrointestinal and Liver Physiology","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140598479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lower uromodulin serum levels are associated with poorer prognosis in patients with cirrhosis and hepatorenal syndrome type 2 尿调节蛋白血清水平较低与肝硬化和 2 型肝肾综合征患者预后较差有关
American Journal of Physiology - Gastrointestinal and Liver Physiology Pub Date : 2024-03-19 DOI: 10.1152/ajpgi.00304.2023
Eva Maria Schleicher, Simon Johannes Gairing, Darko Castven, Charlotte Sophie Hock, Henrike Dobbermann, Sophia Heinrich, Myriam Meineck, Leonard Kaps, Peter Robert Galle, Julia Weinmann-Menke, Marc Nguyen-Tat, Jens Uwe Marquardt, Christian Labenz
{"title":"Lower uromodulin serum levels are associated with poorer prognosis in patients with cirrhosis and hepatorenal syndrome type 2","authors":"Eva Maria Schleicher, Simon Johannes Gairing, Darko Castven, Charlotte Sophie Hock, Henrike Dobbermann, Sophia Heinrich, Myriam Meineck, Leonard Kaps, Peter Robert Galle, Julia Weinmann-Menke, Marc Nguyen-Tat, Jens Uwe Marquardt, Christian Labenz","doi":"10.1152/ajpgi.00304.2023","DOIUrl":"https://doi.org/10.1152/ajpgi.00304.2023","url":null,"abstract":"American Journal of Physiology-Gastrointestinal and Liver Physiology, Ahead of Print. <br/>","PeriodicalId":7598,"journal":{"name":"American Journal of Physiology - Gastrointestinal and Liver Physiology","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140168075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interaction between fatty acid oxidation and ethanol metabolism in liver 肝脏中脂肪酸氧化与乙醇代谢之间的相互作用
American Journal of Physiology - Gastrointestinal and Liver Physiology Pub Date : 2024-03-05 DOI: 10.1152/ajpgi.00281.2023
Yongke Lu, Joseph George
{"title":"Interaction between fatty acid oxidation and ethanol metabolism in liver","authors":"Yongke Lu, Joseph George","doi":"10.1152/ajpgi.00281.2023","DOIUrl":"https://doi.org/10.1152/ajpgi.00281.2023","url":null,"abstract":"American Journal of Physiology-Gastrointestinal and Liver Physiology, Ahead of Print. <br/>","PeriodicalId":7598,"journal":{"name":"American Journal of Physiology - Gastrointestinal and Liver Physiology","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140036741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alterations in descending brain-spinal pathways regulating colorectal motility in a rat model of Parkinson's disease 帕金森病大鼠模型中调节大肠蠕动的脑脊髓下降通路的改变
American Journal of Physiology - Gastrointestinal and Liver Physiology Pub Date : 2023-12-19 DOI: 10.1152/ajpgi.00181.2023
Tomoya Sawamura, Natsufu Yuki, Kanae Aoki, Kazuhiro Horii, Yuuki Horii, Kiyotada Naitou, Shumpei Tsukamoto, Takahiko Shiina, Yasutake Shimizu
{"title":"Alterations in descending brain-spinal pathways regulating colorectal motility in a rat model of Parkinson's disease","authors":"Tomoya Sawamura, Natsufu Yuki, Kanae Aoki, Kazuhiro Horii, Yuuki Horii, Kiyotada Naitou, Shumpei Tsukamoto, Takahiko Shiina, Yasutake Shimizu","doi":"10.1152/ajpgi.00181.2023","DOIUrl":"https://doi.org/10.1152/ajpgi.00181.2023","url":null,"abstract":"American Journal of Physiology-Gastrointestinal and Liver Physiology, Ahead of Print. <br/>","PeriodicalId":7598,"journal":{"name":"American Journal of Physiology - Gastrointestinal and Liver Physiology","volume":"233 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138742277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adiponectin affects ileal contractility of mouse preparations 脂肪素影响小鼠制备物的回肠收缩力
American Journal of Physiology - Gastrointestinal and Liver Physiology Pub Date : 2023-12-19 DOI: 10.1152/ajpgi.00203.2023
Eglantina Idrizaj, Silvia Nistri, Patrizia Nardini, Maria Caterina Baccari
{"title":"Adiponectin affects ileal contractility of mouse preparations","authors":"Eglantina Idrizaj, Silvia Nistri, Patrizia Nardini, Maria Caterina Baccari","doi":"10.1152/ajpgi.00203.2023","DOIUrl":"https://doi.org/10.1152/ajpgi.00203.2023","url":null,"abstract":"American Journal of Physiology-Gastrointestinal and Liver Physiology, Ahead of Print. <br/>","PeriodicalId":7598,"journal":{"name":"American Journal of Physiology - Gastrointestinal and Liver Physiology","volume":"66 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138742278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expression and function of transient receptor potential melastatin 3 in the spinal afferent innervation of the mouse colon 小鼠结肠脊髓传入神经支配中瞬时受体电位美拉塔素 3 的表达和功能
American Journal of Physiology - Gastrointestinal and Liver Physiology Pub Date : 2023-12-12 DOI: 10.1152/ajpgi.00230.2023
James W. King, Aidan S. W. Bennett, Hannah M. Wood, Corey C. Baker, Hanin Alsaadi, Max Topley, Stephen A. Vanner, David E. Reed, Alan E. Lomax
{"title":"Expression and function of transient receptor potential melastatin 3 in the spinal afferent innervation of the mouse colon","authors":"James W. King, Aidan S. W. Bennett, Hannah M. Wood, Corey C. Baker, Hanin Alsaadi, Max Topley, Stephen A. Vanner, David E. Reed, Alan E. Lomax","doi":"10.1152/ajpgi.00230.2023","DOIUrl":"https://doi.org/10.1152/ajpgi.00230.2023","url":null,"abstract":"American Journal of Physiology-Gastrointestinal and Liver Physiology, Ahead of Print. <br/>","PeriodicalId":7598,"journal":{"name":"American Journal of Physiology - Gastrointestinal and Liver Physiology","volume":"123 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138572800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信