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Investigative & cell pathology最新文献

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The structure and function of calcitonin. 降钙素的结构和功能。
Investigative & cell pathology Pub Date : 1980-04-01
J C Stevenson
{"title":"The structure and function of calcitonin.","authors":"J C Stevenson","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The structure of calcitonin in several species has been determined and its mode of action is now well established. The function of this hormone in man is still not completely understood but one role appears to be maintenance of the skeleton. It seems likely that future research in this field will be of great significance in understanding the mechanisms of disorders of skeletal metabolism.</p>","PeriodicalId":75950,"journal":{"name":"Investigative & cell pathology","volume":"3 2","pages":"187-93"},"PeriodicalIF":0.0,"publicationDate":"1980-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17221855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protein turnover in the whole animal. 整个动物的蛋白质周转。
Investigative & cell pathology Pub Date : 1980-04-01
J C Waterlow
{"title":"Protein turnover in the whole animal.","authors":"J C Waterlow","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Methods of measuring whole body protein turnover (WBPT) are discussed briefly. In a range of species from mouse to cow WBPT in the adult bears a fairly constant relationship to metabolic mass and to basal oxygen consumption. In young animals WBPT per unit metabolic mass is higher than in adults. During growth there appears to be an increase in the rate of protein breakdown as well as of synthesis. Of all tissues which have been studied, muscle shows the greatest developmental changes in the rate of protein synthesis. In the absence of food, for example during the night, the rate of protein turnover falls. Studies on the effects of different levels of protein and energy supply have not so far given a constant picture. Very few measurements of WBPT in disease states have been made. Preliminary results suggest that the loss of nitrogen after injury may be due to a block in synthesis rather than to an increase in body protein breakdown.</p>","PeriodicalId":75950,"journal":{"name":"Investigative & cell pathology","volume":"3 2","pages":"107-19"},"PeriodicalIF":0.0,"publicationDate":"1980-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18038957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Testicular germ cell tumours: should current classification be revised? 睾丸生殖细胞肿瘤:目前的分类是否应该修订?
Investigative & cell pathology Pub Date : 1980-04-01
C Parkinson, J O Beilby
{"title":"Testicular germ cell tumours: should current classification be revised?","authors":"C Parkinson,&nbsp;J O Beilby","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The potential inadequacies of current classifications of germ cell tumours are examined in the light of recent evidence high-lighting their high incidence of HCG and AFP production together with the responsible cell types.</p>","PeriodicalId":75950,"journal":{"name":"Investigative & cell pathology","volume":"3 2","pages":"135-40"},"PeriodicalIF":0.0,"publicationDate":"1980-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17221129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endocrine effects of tumours of the liver. 肝脏肿瘤对内分泌的影响。
Investigative & cell pathology Pub Date : 1980-04-01
N L Reeve, H Fox
{"title":"Endocrine effects of tumours of the liver.","authors":"N L Reeve,&nbsp;H Fox","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75950,"journal":{"name":"Investigative & cell pathology","volume":"3 2","pages":"151-8"},"PeriodicalIF":0.0,"publicationDate":"1980-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17310680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Radioimmunoelectrophoretic detection of alpha-fetoprotein in tumour specimens. 肿瘤标本中甲胎蛋白的放射免疫电泳检测。
Investigative & cell pathology Pub Date : 1980-04-01
B Nørgaard-Pedersen, K Toftager-Larsen, K Nørregaard Hansen, R Albrechtsen
{"title":"Radioimmunoelectrophoretic detection of alpha-fetoprotein in tumour specimens.","authors":"B Nørgaard-Pedersen,&nbsp;K Toftager-Larsen,&nbsp;K Nørregaard Hansen,&nbsp;R Albrechtsen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A radioimmunoelectrophoretic method to detect alphafetoprotein in tissue sections of various germ cell tumours is described and its application in the field of oncological pathology is outlined.</p>","PeriodicalId":75950,"journal":{"name":"Investigative & cell pathology","volume":"3 2","pages":"147-50"},"PeriodicalIF":0.0,"publicationDate":"1980-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17221853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Divergence of cortisol-induced involution of T and B cell areas in mouse lymph nodes and spleen. A histomorphometrical, enzyme-histochemical, and immunohistochemical study. 皮质醇诱导小鼠淋巴结和脾脏T和B细胞区内陷的分化。组织形态计量学、酶组织化学和免疫组织化学研究。
Investigative & cell pathology Pub Date : 1980-04-01
E M Meyer, G Meyer, B Niehaus, W Schlake, E Grundmann
{"title":"Divergence of cortisol-induced involution of T and B cell areas in mouse lymph nodes and spleen. A histomorphometrical, enzyme-histochemical, and immunohistochemical study.","authors":"E M Meyer,&nbsp;G Meyer,&nbsp;B Niehaus,&nbsp;W Schlake,&nbsp;E Grundmann","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The present functional and morphological studies strongly favour the concept that systemic immunosuppression with corticosteroids evokes differential, but not necessarily independent, lymph node and splenic responses.</p>","PeriodicalId":75950,"journal":{"name":"Investigative & cell pathology","volume":"3 2","pages":"175-85"},"PeriodicalIF":0.0,"publicationDate":"1980-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18015949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lung endocrine tumours. 肺内分泌肿瘤。
Investigative & cell pathology Pub Date : 1980-04-01
B Corrin
{"title":"Lung endocrine tumours.","authors":"B Corrin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The structure of bronchial carcinoids, oat cell carcinomas and pulmonary 'tumourlets' is described and evidence presented that they are related histogenetically, all being derived from certain specialized cells of endocrine or chemoreceptor nature found within the lining epithelium of the airways. Chemoreceptors related to pulmonary blood vessels have also been identified and two different types of pulmonary tumour have both been termed chemodectoma in the belief that they arise from such structures: these are the so-called multiple minute chemodectoma and the larger solitary variety but the exact histogenesis of both these tumours must remain conjectural at present.</p>","PeriodicalId":75950,"journal":{"name":"Investigative & cell pathology","volume":"3 2","pages":"195-206"},"PeriodicalIF":0.0,"publicationDate":"1980-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17310681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tissue culture of normal rat glomeruli: contractile activity of the cultured mesangial cells. 正常大鼠肾小球组织培养:培养的肾小球系膜细胞的收缩活性。
Investigative & cell pathology Pub Date : 1980-04-01
P R Mahieu, J B Foidart, C H Dubois, C A Dechenne, J Deheneffe
{"title":"Tissue culture of normal rat glomeruli: contractile activity of the cultured mesangial cells.","authors":"P R Mahieu,&nbsp;J B Foidart,&nbsp;C H Dubois,&nbsp;C A Dechenne,&nbsp;J Deheneffe","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Rat glomerular epithelial and mesangial cells, and rat skin fibroblasts, were cultured in RPMI medium containing 15% decomplemented fetal bovine serum. They were incubated for 1 h at 37 degrees C with 2 mM [Ca2+]. At that time, their response to various concentrations of angiotensin II, norepinephrine and carbamylcholine was studied by phase contrast microscopy. Only the mesangial cells exhibited contractile activity in the presence of 10(-10) M angiotensin II and 10(-6) M norepinephrine, as demonstrated by the reduction of their length or, more frequently, by modification of their shape. No contractile activity was observed in the presence of 10(-5) M carbamylcholine. The percentage of contractile cells increased proportionally to the concentration of angiotensin II, reaching about 35% with 10(-6) M angiotensin II. The contractile activity was reversible. Specific inhibitors, i.e. Sar1-ala8-angiotensin II and phenoxybenzamine, when administered in concentrations 10 to 100-fold higher than that of the corresponding agonists, completely blocked the contractile response. This competitive effect was also reversible. The data, therefore, suggest that mesangial cells in culture display some functional properties of smooth muscle cells.</p>","PeriodicalId":75950,"journal":{"name":"Investigative & cell pathology","volume":"3 2","pages":"121-8"},"PeriodicalIF":0.0,"publicationDate":"1980-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18392603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of the nuclear antigen involved in mercury-induced glomerulopathy in the rat. 大鼠汞致肾小球病变核抗原的鉴定。
Investigative & cell pathology Pub Date : 1980-04-01
J J Weening, J Grond, D van der Top, P J Hoedemaeker
{"title":"Identification of the nuclear antigen involved in mercury-induced glomerulopathy in the rat.","authors":"J J Weening,&nbsp;J Grond,&nbsp;D van der Top,&nbsp;P J Hoedemaeker","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Low doses of inorganic mercury may cause an immune complex glomerulopathy in man and in experimental animals. In the PVG/C rat this mercury-induced glomerulopathy coincides with the occurrence of anti-nuclear antibodies in the serum. The same anti-nuclear activity can be demonstrated in the acid-eluted glomerular immune deposits. The characterization of the pathogenic nuclear antigen, to which these antibodies are induced, is the subject of this study. The effect of acid, fixatives, nucleases and proteases on indirect immunofluorescence of anti-nuclear antisera and IgG purified from these sera is studied, combined with absorption with several nuclear constituents and specific antigen blocking by Concanavalin A. The results show that the nuclear antigen involved is part of the nonhistone chromatin protein fraction.</p>","PeriodicalId":75950,"journal":{"name":"Investigative & cell pathology","volume":"3 2","pages":"129-34"},"PeriodicalIF":0.0,"publicationDate":"1980-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17504850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Large bowel biopsy in the differential diagnosis of inflammatory bowel disease. 大肠活检在炎性肠病的鉴别诊断中的应用。
Investigative & cell pathology Pub Date : 1980-04-01
T J Chambers, B C Morson
{"title":"Large bowel biopsy in the differential diagnosis of inflammatory bowel disease.","authors":"T J Chambers,&nbsp;B C Morson","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75950,"journal":{"name":"Investigative & cell pathology","volume":"3 2","pages":"159-73"},"PeriodicalIF":0.0,"publicationDate":"1980-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18392607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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