{"title":"Who cares?","authors":"D. Maclean","doi":"10.2307/j.ctv15wxnsd.6","DOIUrl":"https://doi.org/10.2307/j.ctv15wxnsd.6","url":null,"abstract":"Who Cares? Scotland welcomes the creation of a National Confidential Forum, which will hear the voices and acknowledge the experiences of adults placed in institutional care as children. Who Cares? Scotland works with children and young people up to the age of 25 years with experience of care. In preparation for formulating our response we have worked with a focus group of young people – all care leavers. Their experiences and perspectives have informed our organisational response.","PeriodicalId":75914,"journal":{"name":"Hospital progress","volume":"57 9 1","pages":"6,10"},"PeriodicalIF":0.0,"publicationDate":"2020-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42043404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hospital progressPub Date : 2016-06-01DOI: 10.53841/bpscpf.2016.1.282.46
L. R. Wauck
{"title":"The psychologist.","authors":"L. R. Wauck","doi":"10.53841/bpscpf.2016.1.282.46","DOIUrl":"https://doi.org/10.53841/bpscpf.2016.1.282.46","url":null,"abstract":"The science of psychology spans the three Research Councils of Canada. It includes the biological determinants of behaviour, such as the study of basic brain processes, memory, thought, perception (NSERC), the contribution of human behaviour across the continuum of health and health care (CIHR), and factors related to the workplace and society at large (SSHRC). Psychology is one of the few disciplines with such a broad scope of scientific interests, which allows it to act as a meeting ground and synthesizing agent for research from all three councils and from many other disciplines.","PeriodicalId":75914,"journal":{"name":"Hospital progress","volume":"43 1","pages":"86-9"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71057326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hospital progressPub Date : 2016-05-13Epub Date: 2016-03-16DOI: 10.1074/jbc.M116.722272
Dan Duc Pham, Hai Thi Do, Céline Bruelle, Jyrki P Kukkonen, Ove Eriksson, Isabel Mogollón, Laura T Korhonen, Urmas Arumäe, Dan Lindholm
{"title":"p75 Neurotrophin Receptor Signaling Activates Sterol Regulatory Element-binding Protein-2 in Hepatocyte Cells via p38 Mitogen-activated Protein Kinase and Caspase-3.","authors":"Dan Duc Pham, Hai Thi Do, Céline Bruelle, Jyrki P Kukkonen, Ove Eriksson, Isabel Mogollón, Laura T Korhonen, Urmas Arumäe, Dan Lindholm","doi":"10.1074/jbc.M116.722272","DOIUrl":"10.1074/jbc.M116.722272","url":null,"abstract":"<p><p>Nerve growth factor (NGF) influences the survival and differentiation of a specific population of neurons during development, but its role in non-neuronal cells has been less studied. We observed here that NGF and its pro-form, pro-NGF, are elevated in fatty livers from leptin-deficient mice compared with controls, concomitant with an increase in low density lipoprotein receptors (LDLRs). Stimulation of mouse primary hepatocytes with NGF or pro-NGF increased LDLR expression through the p75 neurotrophin receptor (p75NTR). Studies using Huh7 human hepatocyte cells showed that the neurotrophins activate the sterol regulatory element-binding protein-2 (SREBP2) that regulates genes involved in lipid metabolism. The mechanisms for this were related to stimulation of p38 mitogen-activated protein kinase (p38 MAPK) and activation of caspase-3 and SREBP2 cleavage following NGF and pro-NGF stimulations. Cell fractionation experiments showed that caspase-3 activity was increased particularly in the membrane fraction that harbors SREBP2 and caspase-2. Experiments showed further that caspase-2 interacts with pro-caspase-3 and that p38 MAPK reduced this interaction and caused caspase-3 activation. Because of the increased caspase-3 activity, the cells did not undergo cell death following p75NTR stimulation, possibly due to concomitant activation of nuclear factor-κB (NF-κB) pathway by the neurotrophins. These results identify a novel signaling pathway triggered by ligand-activated p75NTR that via p38 MAPK and caspase-3 mediate the activation of SREBP2. This pathway may regulate LDLRs and lipid uptake particularly after injury or during tissue inflammation accompanied by an increased production of growth factors, including NGF and pro-NGF. </p>","PeriodicalId":75914,"journal":{"name":"Hospital progress","volume":"39 4 1","pages":"10747-58"},"PeriodicalIF":0.0,"publicationDate":"2016-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1074/jbc.M116.722272","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90839626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A commentary on \"Securing Access to Health Care.\" Ethics Commission access report urges adequate care for all.","authors":"L J Weber","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Society has a moral obligation to provide adequate access to health care for all, concludes the President's Commission for te Study of Ethical Problems in Medicine and Biomedical and Behavorial Research in its report Securing Access to Health Care. Though the federal government's involvement is not necessary if private forces are able to achieve equity in health care delivery, the government bears the ultimate responsibility for ensuring that society fulfills its obligations. Meeting these objectives will require changes in the country's political and economic systems, which traditionally have not emphasized subordinating the individual good to the common good. The needs of the poor must take priority even at risk of burdening the advantaged. The commission recognizes that it is irresponsible to advocate equity without acknowledging the need to control costs. Greater equity can be attained only if changes in health care management practices are adopted and if decisions regarding resource use are based on social goals. Thus placing the needs of the poor first may mean a commitment to use less high-cost treatment. The report presents an opportunity to promote a more just health care policy. Catholic health care facilities, for example, can be made models of institutions that have met the needs of the poor, and they can become social justice advocates for government policies that benefit the poor and the disadvantaged.</p>","PeriodicalId":75914,"journal":{"name":"Hospital progress","volume":"65 7","pages":"62-5"},"PeriodicalIF":0.0,"publicationDate":"1984-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21134155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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