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Diabetes Care and Research in Europe. 3rd European meeting for the Implementation of the St. Vincent Declaration. Athens, Greece, March 29-April 1, 1995. Abstracts. 欧洲糖尿病护理和研究。第三届欧洲执行圣文森特宣言会议。希腊雅典，1995年3月29日至4月1日。摘要。
Hormone and metabolic research. Supplement series Pub Date : 1995-01-01
{"title":"Diabetes Care and Research in Europe. 3rd European meeting for the Implementation of the St. Vincent Declaration. Athens, Greece, March 29-April 1, 1995. Abstracts.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75909,"journal":{"name":"Hormone and metabolic research. Supplement series","volume":"1 ","pages":"7-92"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20046970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Somatostatin receptor scintigraphy in brain tumors and pituitary tumors: first experiences. 脑肿瘤和垂体肿瘤的生长抑素受体闪烁成像:初步经验。
Hormone and metabolic research. Supplement series Pub Date : 1993-01-01
K Scheidhauer, G Hildebrandt, C Luyken, K Schomäcker, N Klug, H Schicha
{"title":"Somatostatin receptor scintigraphy in brain tumors and pituitary tumors: first experiences.","authors":"K Scheidhauer,&nbsp;G Hildebrandt,&nbsp;C Luyken,&nbsp;K Schomäcker,&nbsp;N Klug,&nbsp;H Schicha","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Somatostatin receptors have been demonstrated on various tumors of neuroendocrine and other origin. They have been detected in vitro by biochemical techniques as well as by autoradiography. The development of long-acting somatostatin analogs and the recent availability of radiolabeled octreotide have made the in vivo detection of somatostatin receptors possible. This preliminary study embraced 45 patients with meningiomas, brain tumors or pituitary tumors, which were imaged by planar and tomographic scintigraphy after intravenous injection of 111Indium-labeled octreotide. In all of the meningiomas studied (unifocal and multifocal tumors in various locations), a high density of somatostatin receptors was detected by scintigraphy. Pituitary tumors were slightly positive in 50% of cases only, independent of the endocrine activity. Gliomas with an intact blood-brain barrier showed no enhanced tracer uptake in vivo, while gliomas with disturbed blood-brain barrier had a high activity uptake. We conclude that in vivo somatostatin receptor scintigraphy, although not tumor-specific, may aid in the preoperative diagnosis and staging of intracranial tumors, especially skull base tumors.</p>","PeriodicalId":75909,"journal":{"name":"Hormone and metabolic research. Supplement series","volume":"27 ","pages":"59-62"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19318149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular mechanisms of somatostatin's inhibition of hormone release: participation of voltage-gated calcium channels and G-proteins. 生长抑素抑制激素释放的分子机制:电压门控钙通道和g蛋白的参与。
Hormone and metabolic research. Supplement series Pub Date : 1993-01-01
H Scherübl, J Hescheler, E O Riecken
{"title":"Molecular mechanisms of somatostatin's inhibition of hormone release: participation of voltage-gated calcium channels and G-proteins.","authors":"H Scherübl,&nbsp;J Hescheler,&nbsp;E O Riecken","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Somatostatin is known to inhibit hormone release from various neuroendocrine cells. In order to understand the mechanisms underlying somatostatin's action we performed patch-clamp experiments in GH3 pituitary, rMTC 44-2 thyroid and BON carcinoid cells. Calcium-mediated hormone release depended on the intracellular calcium concentration and thus on the calcium influx through voltage-gated calcium channels. In addition to inhibiting the cAMP-dependent secretory pathway, somatostatin reduced the calcium inward currents and thereby hormone release. The inhibition of voltage-gated calcium channels by somatostatin was mediated by \"signal transducing\" Go proteins. Thus, somatostatin's actions on hormone release involve both cAMP and intracellular calcium as second messengers. Patch-clamp experiments of voltage-gated calcium channels allow functional studies on the coupling of somatostatin receptors to cellular effector systems.</p>","PeriodicalId":75909,"journal":{"name":"Hormone and metabolic research. Supplement series","volume":"27 ","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19093246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of somatostatin analogs in the treatment of endocrine gastrointestinal tumors. 生长抑素类似物在胃肠道内分泌肿瘤治疗中的作用。
Hormone and metabolic research. Supplement series Pub Date : 1993-01-01
M E Trautmann, C Neuhaus, H Lenze, R Benning, M Benning, H J Dennler, C Bruns, K Joseph, R Arnold
{"title":"The role of somatostatin analogs in the treatment of endocrine gastrointestinal tumors.","authors":"M E Trautmann,&nbsp;C Neuhaus,&nbsp;H Lenze,&nbsp;R Benning,&nbsp;M Benning,&nbsp;H J Dennler,&nbsp;C Bruns,&nbsp;K Joseph,&nbsp;R Arnold","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75909,"journal":{"name":"Hormone and metabolic research. Supplement series","volume":"27 ","pages":"24-7"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19377872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
OctreoScan 111 for imaging of a somatostatin receptor-positive islet cell tumor in rat. 生长抑素受体阳性大鼠胰岛细胞瘤的octrescan 111成像。
Hormone and metabolic research. Supplement series Pub Date : 1993-01-01
C Bruns, B Stolz, R Albert, P Marbach, J Pless
{"title":"OctreoScan 111 for imaging of a somatostatin receptor-positive islet cell tumor in rat.","authors":"C Bruns,&nbsp;B Stolz,&nbsp;R Albert,&nbsp;P Marbach,&nbsp;J Pless","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Somatostatin (SRIF) receptors are present in a variety of human tumors such as pituitary and endocrine pancreatic tumors, brain tumors, small cell lung cancers and malignant breast tumors. The 111In-labeled SRIF analog SDZ 215-811 (OctreoScan 111) binds with a high affinity to somatostatin receptors and exhibits SRIF-like biological properties, as demonstrated by the inhibition of growth hormone release from pituitary cells. We report here the in vitro characterization of SDZ 215-811 and the in vivo imaging of an islet cell tumor grown in rats using [111In]SDZ 215-811. In vitro autoradiographies revealed a high density of SRIF receptors on the pancreatic tumor tissue. As early as 5 min after intravenous injection of [111In]SDZ 215-811 into tumor-bearing rats, the tumors were clearly localized by gamma-camera scintigraphy. Even 24 h post injection, the islet cell tumor was still detectable. The radioligand was mainly cleared from the circulation via the kidneys, with a rapid alpha-phase (t1/2 = 5.6 min) and a slow elimination phase (t1/2 = 7.3 h). Biodistribution studies revealed a relatively high accumulation of radioactivity in the kidneys, but low uptake into the liver and the intestine. High uptake of [111In]SDZ 215-811 was observed for the tumor tissue (0.92 +/- 0.07% ID/g; 1 h post injection). Interestingly, a tumor load of 0.14 +/- 0.01% ID/g was still measured after 24 h. The tumor/blood ratio was 4.93 after 24 h, indicating specific accumulation of radioactivity in the islet cell tumor.(ABSTRACT TRUNCATED AT 250 WORDS)</p>","PeriodicalId":75909,"journal":{"name":"Hormone and metabolic research. Supplement series","volume":"27 ","pages":"5-11"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19377873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biodistribution of 111In-pentetreotide and dosimetric considerations with respect to somatostatin receptor expressing tumor burden. 111in -戊肽的生物分布和剂量学对生长抑素受体表达肿瘤负荷的影响。
Hormone and metabolic research. Supplement series Pub Date : 1993-01-01
H J Adrian, U Dörr, D Bach, H Bihl
{"title":"Biodistribution of 111In-pentetreotide and dosimetric considerations with respect to somatostatin receptor expressing tumor burden.","authors":"H J Adrian,&nbsp;U Dörr,&nbsp;D Bach,&nbsp;H Bihl","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The general features of the biodistribution of the labeled somatostatin analog 111In-pentetreotide are already known. We describe some details of 111In-pentetreotide accumulation in the thyroid gland, mammae, spleen and gastrointestinal tract with respect to endocrine parameters, kinetics and time of imaging. In addition, dose estimations were performed for liver, spleen and kidney in patients without neuroendocrine tumor load and in patients with large tumors positive for somatostatin receptors. The overall absorbed dose turned out to be within the range reported previously. However, in patients with extensive tumor burden the radiation dose in liver, spleen and kidney tended to be lower than in patients without such malignancy. The dependence of estimated organ doses on the presence of somatostatin receptor-expressing tumors will have to be considered if radiotherapy with suitable labeled somatostatin analogs becomes available.</p>","PeriodicalId":75909,"journal":{"name":"Hormone and metabolic research. Supplement series","volume":"27 ","pages":"18-23"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19316875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Receptor scintigraphy with 111In-pentetreotide for endocrine gastroenteropancreatic tumors. 111in -戊替肽受体显像治疗内分泌胃肠胰腺肿瘤。
Hormone and metabolic research. Supplement series Pub Date : 1993-01-01
K Joseph, J Stapp, J Reinecke, H J Skamel, H Höffken, C Neuhaus, H Lenze, M E Trautmann, R Arnold
{"title":"Receptor scintigraphy with 111In-pentetreotide for endocrine gastroenteropancreatic tumors.","authors":"K Joseph,&nbsp;J Stapp,&nbsp;J Reinecke,&nbsp;H J Skamel,&nbsp;H Höffken,&nbsp;C Neuhaus,&nbsp;H Lenze,&nbsp;M E Trautmann,&nbsp;R Arnold","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Receptor scintigraphy with 111In-pentetreotide is a simple method with a sensitivity of 86% for the localization of the primary tumor and its metastases in patients presenting with the clinical and biochemical symptoms of an endocrine tumor of the gastrointestinal tract or the pancreas. As a whole-body scintigraphic technique it covers all body regions and is also able to reveal small tumors which either cannot be detected or can only be detected with difficulty by the usual imaging methods. In 85 patients with GEP tumors or after operative removal of such tumors, receptor scintigraphy proved to be superior to ultrasound and computed tomography in 34%, equal in 52%, and inferior in 14% of the cases.</p>","PeriodicalId":75909,"journal":{"name":"Hormone and metabolic research. Supplement series","volume":"27 ","pages":"28-35"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19316876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Somatostatin Receptor Imaging. 1st German meeting. Stuttgart, September 1992. 生长抑素受体成像。第一次德国会议。斯图加特，1992年9月。
Hormone and metabolic research. Supplement series Pub Date : 1993-01-01
{"title":"Somatostatin Receptor Imaging. 1st German meeting. Stuttgart, September 1992.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75909,"journal":{"name":"Hormone and metabolic research. Supplement series","volume":"27 ","pages":"1-62"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19316874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic reliability of somatostatin receptor scintigraphy during continuous treatment with different somatostatin analogs. 不同生长抑素类似物持续治疗期间生长抑素受体显像诊断的可靠性。
Hormone and metabolic research. Supplement series Pub Date : 1993-01-01
U Dörr, K Wurm, E Höring, G Guzman, U Räth, H Bihl
{"title":"Diagnostic reliability of somatostatin receptor scintigraphy during continuous treatment with different somatostatin analogs.","authors":"U Dörr,&nbsp;K Wurm,&nbsp;E Höring,&nbsp;G Guzman,&nbsp;U Räth,&nbsp;H Bihl","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In order to evaluate the diagnostic reliability of somatostatin receptor scintigraphy (SRS) in patients treated with somatostatin analogs, ten patients with metastatic neuroendocrine tumors were investigated before and during continuous treatment. Different somatostatin analogs were used for therapy: five patients received octreotide (Sandostatin, Sandoz, Switzerland) and five were treated with BIM 23014 (Lanreotide, Ipsen Biotech, France) within the scope of a clinical phase II study. The SRS findings were analyzed in terms of biodistribution of the labeled somatostatin analog and tumor visualization comparing the two studies in each patient. Whereas liver, spleen, and kidney uptake were decreased during octreotide treatment and increased on lanreotide therapy, tumor accumulation was intensified in all but one patient. Our results suggest that the diagnostic value of SRS is not necessarily restricted during treatment with somatostatin analogs. Indeed, tumor visualization may even be enhanced in this therapeutic setting.</p>","PeriodicalId":75909,"journal":{"name":"Hormone and metabolic research. Supplement series","volume":"27 ","pages":"36-43"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19316877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Somatostatin receptor scintigraphy in malignant lymphoma: first results and comparison with glucose metabolism measured by positron-emission tomography. 恶性淋巴瘤的生长抑素受体闪烁成像:初步结果和与正电子发射断层扫描测量的葡萄糖代谢的比较。
Hormone and metabolic research. Supplement series Pub Date : 1993-01-01
R Bares, P Galonska, W Dempke, S Handt, U Büll, R Osieka
{"title":"Somatostatin receptor scintigraphy in malignant lymphoma: first results and comparison with glucose metabolism measured by positron-emission tomography.","authors":"R Bares,&nbsp;P Galonska,&nbsp;W Dempke,&nbsp;S Handt,&nbsp;U Büll,&nbsp;R Osieka","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Somatostatin receptor scintigraphy with 111In-labeled octreotide was performed in 22 patients with suspected or known malignant lymphoma. The majority of extra-abdominal lesions (21/24 = 87.5%) were correctly localized, however, only one of nine intraabdominal lymphomas could be detected. No significant correlation was found between scintigraphic results and histological type of lymphoma. Metabolic imaging by positron-emission tomography with 18F-labeled deoxyglucose yielded a higher rate of detection of lymphoma manifestations (92% vs 64%) and better tumor contrast. Further prospective studies are needed to establish the clinical relevance of somatostatin receptor scintigraphy in malignant lymphoma.</p>","PeriodicalId":75909,"journal":{"name":"Hormone and metabolic research. Supplement series","volume":"27 ","pages":"56-8"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19318148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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