Horizons in biochemistry and biophysics最新文献_第4页

Transport of proteins from the sites of genetic expression to their sites of functional expression: protein conformation and thermodynamic aspects. 蛋白质从基因表达位点到功能表达位点的运输:蛋白质构象和热力学方面。

Horizons in biochemistry and biophysics Pub Date : 1983-01-01

C Kempf, R D Klausner, R Blumenthal, J van Renswoude

引用次数: 0

The structure of nucleosomes and chromatin. 核小体和染色质的结构。

Horizons in biochemistry and biophysics Pub Date : 1983-01-01

A Klug, P J Butler

引用次数: 0

Structure and function of ribosomal RNA. 核糖体RNA的结构和功能。

Horizons in biochemistry and biophysics Pub Date : 1983-01-01

H F Noller, P H van Knippenberg

引用次数: 0

Structure and role of eubacterial ribosomal proteins. 真细菌核糖体蛋白的结构和作用。

Horizons in biochemistry and biophysics Pub Date : 1983-01-01

R A Garrett

引用次数: 0

Regulatory steps in the initiation of protein synthesis. 蛋白质合成起始的调控步骤。

Horizons in biochemistry and biophysics Pub Date : 1983-01-01

H O Voorma

{"title":"Regulatory steps in the initiation of protein synthesis.","authors":"H O Voorma","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Regulation of protein synthesis is being exerted at different levels with a different extent of attenuation. The major control module seems to work by the inactivation of the elF-2 recycling which enables the cell to shift down from a high rate of initiation to a low rate. Certain events in the cell cycle like mitosis do show such a drastic change in initiation rate. It is suggested that modifications of elF-2 by phosphorylation of the alpha-subunit by different protein-kinases is the basis for such a control mechanism. Already two protein kinases of this type have been described, the hemin-regulated inhibitor and the ds-RNA activated inhibitor from interferon-treated cells. On the other hand modifications of the beta-subunit by other metabolic events, for instance low NADH/NAD+ ratio, can as yet not be excluded. Other conditions like amino acid starvation, serum deprivation, heat-shock and virus-infection seem to evoke quite different strategies. In some cases it has been demonstrated that inactivation of mRNA binding factors as elF-4B and elF-4E, favour the translation of low-dependence, i.e. low secondary structure, messengers. It shall be worthwhile to establish whether the mRNA's with such low degree of secondary structure encoded proteins that are aimed at the survival of the cell under extreme metabolic or stress conditions. Much more work on the structure and nucleotide sequences of the leader sequence is needed to prove these hypothetical points.</p>","PeriodicalId":75908,"journal":{"name":"Horizons in biochemistry and biophysics","volume":"7 ","pages":"139-53"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17425750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Approaches to the study of hormonal regulation of gene expression. 激素调控基因表达的研究途径。

Horizons in biochemistry and biophysics Pub Date : 1983-01-01

A J Wynshaw-Boris, R W Hanson

引用次数: 0

Interplay between different genetic systems in eukaryotic cells: nucleocytoplasmic-mitochondrial interrelations. 真核细胞中不同遗传系统之间的相互作用:核细胞质-线粒体的相互关系。

Horizons in biochemistry and biophysics Pub Date : 1983-01-01

H de Vries, P van 't Sant

引用次数: 0

Genes: structure and expression. 基因:结构和表达。

Horizons in biochemistry and biophysics Pub Date : 1983-01-01

引用次数: 0