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Plasma concentrations of chloroquinaldol (Sterosan) after administration of a vaginal tablet. 服用阴道片剂后氯喹那醇(甾体糖)的血浆浓度。
Gynecologic investigation Pub Date : 1978-01-01 DOI: 10.1159/000300981
O Meirik, K G Nygren, C Fagerlund, P Hartvig
{"title":"Plasma concentrations of chloroquinaldol (Sterosan) after administration of a vaginal tablet.","authors":"O Meirik,&nbsp;K G Nygren,&nbsp;C Fagerlund,&nbsp;P Hartvig","doi":"10.1159/000300981","DOIUrl":"https://doi.org/10.1159/000300981","url":null,"abstract":"<p><p>The systemic absorption and the plasma concentrations of chloroquinaldol have been determined after local application of one vaginal tablet of Sterosan. A peak plasma concentration of 33 ng/ml was determined 12 h after application. A mean absorption of 6.0% of the applied dose was estimated.</p>","PeriodicalId":75889,"journal":{"name":"Gynecologic investigation","volume":"9 4","pages":"166-9"},"PeriodicalIF":0.0,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000300981","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11949705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antihypertensive treatment with the adrenergic beta-receptor blocker metoprolol during pregnancy. 妊娠期肾上腺素能受体阻滞剂美托洛尔的降压治疗。
Gynecologic investigation Pub Date : 1978-01-01 DOI: 10.1159/000300984
B Sandström
{"title":"Antihypertensive treatment with the adrenergic beta-receptor blocker metoprolol during pregnancy.","authors":"B Sandström","doi":"10.1159/000300984","DOIUrl":"https://doi.org/10.1159/000300984","url":null,"abstract":"<p><p>In 101 hypertensive gravidae the selective beta-blocking agent metoprolol alone or in combination with hydralazine has been used. The effects of the mother and fetus have been compared with those of 97 hypertensive gravidae treated with hydralazine. In both groups a small dose of a thiazide was added. Perinatal mortality was lower in the metoprolol group (2.0%) than in the hydralazine group (8.0%). The rate of fetal growth retardations also was lower when using metoprolol (11.7 and 16.3% respectively). No abnormal effects of the beta-blocker was noticed on the fetus.</p>","PeriodicalId":75889,"journal":{"name":"Gynecologic investigation","volume":"9 4","pages":"195-204"},"PeriodicalIF":0.0,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000300984","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11949706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 105
Effectiveness of etamsylate in intrauterine-device menorrhagia. 乙胺酸治疗宫内节育器月经过多的疗效。
Gynecologic investigation Pub Date : 1978-01-01 DOI: 10.1159/000300980
L Kovács, J Annus
{"title":"Effectiveness of etamsylate in intrauterine-device menorrhagia.","authors":"L Kovács,&nbsp;J Annus","doi":"10.1159/000300980","DOIUrl":"https://doi.org/10.1159/000300980","url":null,"abstract":"<p><p>107 parous women wearing Szontágh-type IUDs were treated with either etamsylate or placebo tablets by a double-blind technique with random allocation. The length of the cycles, the duration of menstrual bleeding and the amount of bleeding were analyzed. Etamsylate treatment favourably influenced menstrual bleeding in IUD users. In the etamsylate group, the number of \"bleeding days' and the amount of menstrual flow were significantly less than in the placebo group.</p>","PeriodicalId":75889,"journal":{"name":"Gynecologic investigation","volume":"9 4","pages":"161-5"},"PeriodicalIF":0.0,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000300980","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11581638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Radioimmunoassay of LH-RH. Standard curves and specificity. rh - rh放射免疫测定。标准曲线和特异性。
Gynecologic investigation Pub Date : 1978-01-01 DOI: 10.1159/000300982
B Teuwissen, J P Fauconnier, K Thomas
{"title":"Radioimmunoassay of LH-RH. Standard curves and specificity.","authors":"B Teuwissen,&nbsp;J P Fauconnier,&nbsp;K Thomas","doi":"10.1159/000300982","DOIUrl":"https://doi.org/10.1159/000300982","url":null,"abstract":"<p><p>As important discrepancies in blood concentrations of LH-RH remain, the basic problem of the specificity of the radioimmunoassay was reinvestigated using an antiserum raised against a new conjugate (33). Cross-reactions with related and unrelated peptides were studied in both charcoal-dextran and second antibody methods of separation. The possible relation between the nature of the conjugate and the specificity is discussed.</p>","PeriodicalId":75889,"journal":{"name":"Gynecologic investigation","volume":"9 4","pages":"170-82"},"PeriodicalIF":0.0,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000300982","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11581639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Effect of human placental lactogen upon the human corpus luteum of late pregnancy. 人胎盘乳原对妊娠后期人黄体的影响。
Gynecologic investigation Pub Date : 1978-01-01 DOI: 10.1159/000300986
L T Goldsmith, J A Hochman, G Weiss
{"title":"Effect of human placental lactogen upon the human corpus luteum of late pregnancy.","authors":"L T Goldsmith,&nbsp;J A Hochman,&nbsp;G Weiss","doi":"10.1159/000300986","DOIUrl":"https://doi.org/10.1159/000300986","url":null,"abstract":"<p><p>To acertain whether human placental lactogen (HPL) functions as a luteotropin during pregnancy in humans, studies were performed to determine if receptors for HPL are present in cells of the human corpus luteum of late pregnancy. Preparations of 125I-HPL which demonstrated specific binding to late pregnant rabbit mammary gland cell homogenates showed specific binding of less than 2.5% to homogenates of human corpora lutea of late pregnancy. These studies indicate that HPL is not luteotropic at this stage of pregnancy in humans. The action of HPL upon the corpus luteum appears to vary considerably according to species.</p>","PeriodicalId":75889,"journal":{"name":"Gynecologic investigation","volume":"9 4","pages":"210-8"},"PeriodicalIF":0.0,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000300986","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11258431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Influence of long-term beta-mimetic therapy on the lecithin content of amniotic fluid. 长期模拟β治疗对羊水卵磷脂含量的影响。
Gynecologic investigation Pub Date : 1978-01-01 DOI: 10.1159/000300985
J W Dudenhausen, G Kynast, A M Lange-Lindberg, E Saling
{"title":"Influence of long-term beta-mimetic therapy on the lecithin content of amniotic fluid.","authors":"J W Dudenhausen,&nbsp;G Kynast,&nbsp;A M Lange-Lindberg,&nbsp;E Saling","doi":"10.1159/000300985","DOIUrl":"https://doi.org/10.1159/000300985","url":null,"abstract":"<p><p>The lecithin content of 157 amniotic fluid samples taken from 60 patients who had been treated with Fenoterol over a long period of time (longer than 30 mg/daily per os for 14 days; intravenous infusion for longer than 7 days) was calculated thin-layer chromatographically according to Kynast and Saling. These lecithin levels were statistically compared with the levels in a control (Wilcoxon test). It emerged that the lecithin levels in the long-term beta-mimetic therapy group were significantly lower, i.e., from 33/0 to 39/6 (33/0-34/6, p less than 0.05; 35/0-39/6, p less than 0.01). The answer to the question how often levels occur in the long-term group which are below the as critical described level of 3 mg Lec/100 ml amniotic fluid appears to be clinically important. It is shown that values below the critical level from 33/0 to 39/6 are much more frequent in the long-term beta-mimetics therapy group than in the control group. There is no known explanation for this. It was concluded that the application of beta-mimetics in cases of long-term tocolysis should only be discontinued when the lecithin content of the amniotic fluid lies above the critical limit of 3 mg Lec/100 ml.</p>","PeriodicalId":75889,"journal":{"name":"Gynecologic investigation","volume":"9 4","pages":"205-9"},"PeriodicalIF":0.0,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000300985","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11949707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 19
Radioimmunoassay of LH-RH. Application to human plasma. rh - rh放射免疫测定。应用于人体血浆。
Gynecologic investigation Pub Date : 1978-01-01 DOI: 10.1159/000300983
B Teuwissen, J P Fauconnier, K Thomas
{"title":"Radioimmunoassay of LH-RH. Application to human plasma.","authors":"B Teuwissen,&nbsp;J P Fauconnier,&nbsp;K Thomas","doi":"10.1159/000300983","DOIUrl":"https://doi.org/10.1159/000300983","url":null,"abstract":"<p><p>Comparison of standard curves with different concentrations of human plasma in the medium of incubation is presented. It appears that Bo varies with the dilution although the ratio B/Bo is independent of the dilution. This last observation was used to research 'endogenous' LH-RH in four menstrual cycles, in postmenopausal women and in men. The validity of the dosage is discussed in a more general way in the light of the results published in the literature.</p>","PeriodicalId":75889,"journal":{"name":"Gynecologic investigation","volume":"9 4","pages":"183-94"},"PeriodicalIF":0.0,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000300983","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11581640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Abortifacient effect of intrauterine contraceptive devices? 宫内节育器的堕胎效果?
Gynecologic investigation Pub Date : 1978-01-01 DOI: 10.1159/000300987
P J Keller, E Soyka
{"title":"Abortifacient effect of intrauterine contraceptive devices?","authors":"P J Keller,&nbsp;E Soyka","doi":"10.1159/000300987","DOIUrl":"https://doi.org/10.1159/000300987","url":null,"abstract":"","PeriodicalId":75889,"journal":{"name":"Gynecologic investigation","volume":"9 4","pages":"219-21"},"PeriodicalIF":0.0,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000300987","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11949708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
An analysis of the mechanisms of egg transport in the ampulla of the rabbit oviduct. 家兔输卵管壶腹内卵子转运机制的分析。
Gynecologic investigation Pub Date : 1977-08-01 DOI: 10.1097/00006254-197708000-00015
S. Halbert, P. Y. Tam, R. Adams, R. Blandau
{"title":"An analysis of the mechanisms of egg transport in the ampulla of the rabbit oviduct.","authors":"S. Halbert, P. Y. Tam, R. Adams, R. Blandau","doi":"10.1097/00006254-197708000-00015","DOIUrl":"https://doi.org/10.1097/00006254-197708000-00015","url":null,"abstract":"Ampullary transport of supravitally stained cumulus egg masses was studied in intact oviducts of anesthetized rabbits whose abdomens had been opened for observation. Following observations of normal transport, muscular activity of the ampulla was inhibited pharmacologically with Acepromazine, a preanesthetic tranquilizer. With muscle contractions blocked, egg transport continued but in a dramatically altered fashion; in the final two thirds of the ampulla the motion changed from rapid to-and-fro movements to a slow uniform prouterine movement which was attributed to ciliary activity. However, the net velocity of transport did not change when the smooth muscle was inhibited indicating that muscle contractions are at least unnecessary and perhaps ineffective for ampullary egg transport in the rabbit.","PeriodicalId":75889,"journal":{"name":"Gynecologic investigation","volume":"7 5 1","pages":"306-20"},"PeriodicalIF":0.0,"publicationDate":"1977-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/00006254-197708000-00015","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61917684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Bulk flows through human fetal membranes. 大流量通过人胎膜。
Gynecologic investigation Pub Date : 1977-04-01 DOI: 10.1097/00006254-197704000-00003
D. Abramovich, K. Page, L. Jandial
{"title":"Bulk flows through human fetal membranes.","authors":"D. Abramovich, K. Page, L. Jandial","doi":"10.1097/00006254-197704000-00003","DOIUrl":"https://doi.org/10.1097/00006254-197704000-00003","url":null,"abstract":"Bulk water flows across term human amnio-chorion are studied in vitro. The hydrodynamic permeability is found to vary with both hydrostatic and osmotic pressure. The coefficient characterizing flows generated by hydrostatic pressure is substantially larger than that characterizing osmotic flows. The measurements are utilised to predict in vivo bulk flows across the amnio-chorion. These lead to the prediction that at most a flux of 34-83 ml/day may occur across amnio-chorion directed outwards from the amniotic cavity, the principal contribution to this arising from the effects of hydrostatic pressure.","PeriodicalId":75889,"journal":{"name":"Gynecologic investigation","volume":"7 3 1","pages":"157-64"},"PeriodicalIF":0.0,"publicationDate":"1977-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/00006254-197704000-00003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61916011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
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