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Gynecologic investigation最新文献

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Plasma concentrations of chloroquinaldol (Sterosan) after administration of a vaginal tablet. 服用阴道片剂后氯喹那醇(甾体糖)的血浆浓度。
Gynecologic investigation Pub Date : 1978-01-01 DOI: 10.1159/000300981
O Meirik, K G Nygren, C Fagerlund, P Hartvig
{"title":"Plasma concentrations of chloroquinaldol (Sterosan) after administration of a vaginal tablet.","authors":"O Meirik,&nbsp;K G Nygren,&nbsp;C Fagerlund,&nbsp;P Hartvig","doi":"10.1159/000300981","DOIUrl":"https://doi.org/10.1159/000300981","url":null,"abstract":"<p><p>The systemic absorption and the plasma concentrations of chloroquinaldol have been determined after local application of one vaginal tablet of Sterosan. A peak plasma concentration of 33 ng/ml was determined 12 h after application. A mean absorption of 6.0% of the applied dose was estimated.</p>","PeriodicalId":75889,"journal":{"name":"Gynecologic investigation","volume":"9 4","pages":"166-9"},"PeriodicalIF":0.0,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000300981","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11949705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antihypertensive treatment with the adrenergic beta-receptor blocker metoprolol during pregnancy. 妊娠期肾上腺素能受体阻滞剂美托洛尔的降压治疗。
Gynecologic investigation Pub Date : 1978-01-01 DOI: 10.1159/000300984
B Sandström
{"title":"Antihypertensive treatment with the adrenergic beta-receptor blocker metoprolol during pregnancy.","authors":"B Sandström","doi":"10.1159/000300984","DOIUrl":"https://doi.org/10.1159/000300984","url":null,"abstract":"<p><p>In 101 hypertensive gravidae the selective beta-blocking agent metoprolol alone or in combination with hydralazine has been used. The effects of the mother and fetus have been compared with those of 97 hypertensive gravidae treated with hydralazine. In both groups a small dose of a thiazide was added. Perinatal mortality was lower in the metoprolol group (2.0%) than in the hydralazine group (8.0%). The rate of fetal growth retardations also was lower when using metoprolol (11.7 and 16.3% respectively). No abnormal effects of the beta-blocker was noticed on the fetus.</p>","PeriodicalId":75889,"journal":{"name":"Gynecologic investigation","volume":"9 4","pages":"195-204"},"PeriodicalIF":0.0,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000300984","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11949706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 105
Radioimmunoassay of LH-RH. Application to human plasma. rh - rh放射免疫测定。应用于人体血浆。
Gynecologic investigation Pub Date : 1978-01-01 DOI: 10.1159/000300983
B Teuwissen, J P Fauconnier, K Thomas
{"title":"Radioimmunoassay of LH-RH. Application to human plasma.","authors":"B Teuwissen,&nbsp;J P Fauconnier,&nbsp;K Thomas","doi":"10.1159/000300983","DOIUrl":"https://doi.org/10.1159/000300983","url":null,"abstract":"<p><p>Comparison of standard curves with different concentrations of human plasma in the medium of incubation is presented. It appears that Bo varies with the dilution although the ratio B/Bo is independent of the dilution. This last observation was used to research 'endogenous' LH-RH in four menstrual cycles, in postmenopausal women and in men. The validity of the dosage is discussed in a more general way in the light of the results published in the literature.</p>","PeriodicalId":75889,"journal":{"name":"Gynecologic investigation","volume":"9 4","pages":"183-94"},"PeriodicalIF":0.0,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000300983","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11581640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
An analysis of the mechanisms of egg transport in the ampulla of the rabbit oviduct. 家兔输卵管壶腹内卵子转运机制的分析。
Gynecologic investigation Pub Date : 1977-08-01 DOI: 10.1097/00006254-197708000-00015
S. Halbert, P. Y. Tam, R. Adams, R. Blandau
{"title":"An analysis of the mechanisms of egg transport in the ampulla of the rabbit oviduct.","authors":"S. Halbert, P. Y. Tam, R. Adams, R. Blandau","doi":"10.1097/00006254-197708000-00015","DOIUrl":"https://doi.org/10.1097/00006254-197708000-00015","url":null,"abstract":"Ampullary transport of supravitally stained cumulus egg masses was studied in intact oviducts of anesthetized rabbits whose abdomens had been opened for observation. Following observations of normal transport, muscular activity of the ampulla was inhibited pharmacologically with Acepromazine, a preanesthetic tranquilizer. With muscle contractions blocked, egg transport continued but in a dramatically altered fashion; in the final two thirds of the ampulla the motion changed from rapid to-and-fro movements to a slow uniform prouterine movement which was attributed to ciliary activity. However, the net velocity of transport did not change when the smooth muscle was inhibited indicating that muscle contractions are at least unnecessary and perhaps ineffective for ampullary egg transport in the rabbit.","PeriodicalId":75889,"journal":{"name":"Gynecologic investigation","volume":"7 5 1","pages":"306-20"},"PeriodicalIF":0.0,"publicationDate":"1977-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/00006254-197708000-00015","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61917684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Molecular arrangement of cervical mucus: a reevaluation based on laser light-scattering spectroscopy. 宫颈黏液的分子排列:基于激光散射光谱的再评价。
Gynecologic investigation Pub Date : 1977-01-01
W I Lee, P Verdugo, R J Blandau, P Gaddum-Rosse
{"title":"Molecular arrangement of cervical mucus: a reevaluation based on laser light-scattering spectroscopy.","authors":"W I Lee,&nbsp;P Verdugo,&nbsp;R J Blandau,&nbsp;P Gaddum-Rosse","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Evidence obtained from laser light-scattering spectroscopy suggests that the molecular arrangement of cow estrous cervical mucus is an ensemble of entangled random-coiled macromolecules rather than a cross-linked macromolecular network, the model heretofore widely accepted. This new model can account for the following phenomena: (1) The viscoelastic properties of the estrous mucus and human mid-cycle cervical mucus are the result of the way in which the glycoproteins are entangled. Variations of these properties during the reproductive cycle may simply be due to changes in the water content of the cervical mucus. (2) Penetration of spermatozoa in mucus may be entirely mechanical without involving any kind of enzymatic lysis of cross-links (this is supported by changes in the pattern of spermatozoa flagellation during sperm penetration of cervical mucus as shown in motion picture films). (3) The orientation of spermatozoa in the cervical muscus need not be due to the presence of 'channels' between micelles but simply to an artifact, the stretching or flow of the mucus, which orients the entangled macromolecules and thus facilitates the penetration of spermatozoa in an axis parallel to them.</p>","PeriodicalId":75889,"journal":{"name":"Gynecologic investigation","volume":"8 5-6","pages":"154-66"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11783667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intrauterine pressure wave form characteristics of successful and failed first stage labor. 第一产程产程成功与失败的宫内压力波形特征。
Gynecologic investigation Pub Date : 1977-01-01 DOI: 10.1159/000301091
J Seitchik, M L Chatkoff
{"title":"Intrauterine pressure wave form characteristics of successful and failed first stage labor.","authors":"J Seitchik,&nbsp;M L Chatkoff","doi":"10.1159/000301091","DOIUrl":"https://doi.org/10.1159/000301091","url":null,"abstract":"<p><p>A retrospective study was designed to contrast the intrauterine pressure wave form characteristics of hypocontractile labor in patients with and without obstruction and before and after oxytocin therapy. No differences were observed between the patient groups (vaginal delivery vs. cesarean section), either before or after oxytocin. Problems in defining adequate contractility in patients with possible obstructed labors are discussed, and new parameters of potential value are identified.</p>","PeriodicalId":75889,"journal":{"name":"Gynecologic investigation","volume":"8 5-6","pages":"246-53"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000301091","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11814388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Galactosyltransferase activity of the microvillous surface of human placental syncytial trophoblast. 人胎盘合胞滋养细胞微绒毛表面半乳糖转移酶活性的研究。
Gynecologic investigation Pub Date : 1977-01-01 DOI: 10.1159/000301097
D M Nelson, A C Enders, B F King
{"title":"Galactosyltransferase activity of the microvillous surface of human placental syncytial trophoblast.","authors":"D M Nelson,&nbsp;A C Enders,&nbsp;B F King","doi":"10.1159/000301097","DOIUrl":"https://doi.org/10.1159/000301097","url":null,"abstract":"<p><p>The syncytial trophoblast has previously been shown to have minimal intrasyncytial galactosyltransferase activity at term. The biochemical and autoradiographic study reported here shows that the microvillous surface of term human placental syncytial trophoblast has a galactosyltransferase activity capable of transferring 3H-galactose from uridine diphosphate-D-galactose-1-3H to trichloroacetic-acid precipitable, endogenous acceptors. This capability of resynthesizing cleaved galactose moieties in the glycocalyx, without dependence on cytoplasmically located galactosyltransferases, would allow for reinstatement of the original surface molecular configuration without requiring synthesis and insertion of a completely new membrane molecule. It is suggested that the surface galactosyltransferase might function to repair damage to syncytial trophoblast glycocalyx induced by the enzymes in maternal blood.</p>","PeriodicalId":75889,"journal":{"name":"Gynecologic investigation","volume":"8 5-6","pages":"267-81"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000301097","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11817579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Vasodilating effect of estrogen on the human umbilical artery. 雌激素对人脐动脉血管的舒张作用。
Gynecologic investigation Pub Date : 1977-01-01 DOI: 10.1159/000301109
M F Silva de Sá, R S Meirelles
{"title":"Vasodilating effect of estrogen on the human umbilical artery.","authors":"M F Silva de Sá,&nbsp;R S Meirelles","doi":"10.1159/000301109","DOIUrl":"https://doi.org/10.1159/000301109","url":null,"abstract":"<p><p>The effects of estradiol, estrone and estriol on the tonus of the isolated vascular segments of human umbilical artery were studied by a perfusion technique. Estradiol (10 microgram/ml), estrone (10 microgram/ml) or estriol (2 and 10 microgram/ml) produce relaxation of the vascular bed which was reflected in a significant reduction in basal pressure of segments perfused at constant rate. A dose-dependent relationship was demonstrated for estriol. The time dependence and extent of relation were similar for all three natural estrogens.</p>","PeriodicalId":75889,"journal":{"name":"Gynecologic investigation","volume":"8 5-6","pages":"307-13"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000301109","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11817582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 25
24-hour rhythms in uterine and umbilical blood flows of conscious pregnant sheep. 有意识怀孕绵羊子宫和脐带血流的24小时节律。
Gynecologic investigation Pub Date : 1977-01-01 DOI: 10.1159/000301103
A M Walker, G K Oakes, M K McLaughlin, R A Ehrenkranz, D W Alling, R A Chez
{"title":"24-hour rhythms in uterine and umbilical blood flows of conscious pregnant sheep.","authors":"A M Walker,&nbsp;G K Oakes,&nbsp;M K McLaughlin,&nbsp;R A Ehrenkranz,&nbsp;D W Alling,&nbsp;R A Chez","doi":"10.1159/000301103","DOIUrl":"https://doi.org/10.1159/000301103","url":null,"abstract":"<p><p>The possibility that 24-hour rhythms exist in uterine blood flow (UtBF) and umbilical blood (UmBF) was investigated in 5 days postoperative chronically instrumented near-term pregnant sheep acclimated to a controlled environment. UtBF, UmBF and pressure measurements were made at 15-min intervals over 24 h beginning at 0800 h. Each data series was examined for the presence of significant rhythms of a 24-hour period using a method of Fourier analysis. UtBF 24-hour rhythms were found in all ewes; UmBF 24-hour rhythms were found in 4 of 5 lambs. A consistent reciprocal phase relationship between UtBF and UmBF was evident within animals. There were no associated rhythms in maternal arterial, fetal arterial, or amniotic fluid pressures. These results indicate that the presence of circadian rhythms must be considered as a possible variable when long-term uteroplacental hemodynamic studies are planned.</p>","PeriodicalId":75889,"journal":{"name":"Gynecologic investigation","volume":"8 5-6","pages":"288-98"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000301103","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11248882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 20
Molecular arrangement of cervical mucus: a reevaluation based on laser light-scattering spectroscopy. 宫颈黏液的分子排列:基于激光散射光谱的再评价。
Gynecologic investigation Pub Date : 1977-01-01 DOI: 10.1159/000301094
W. I. Lee, P. Verdugo, R. Blandau, P. Gaddum-Rosse
{"title":"Molecular arrangement of cervical mucus: a reevaluation based on laser light-scattering spectroscopy.","authors":"W. I. Lee, P. Verdugo, R. Blandau, P. Gaddum-Rosse","doi":"10.1159/000301094","DOIUrl":"https://doi.org/10.1159/000301094","url":null,"abstract":"Evidence obtained from laser light-scattering spectroscopy suggests that the molecular arrangement of cow estrous cervical mucus is an ensemble of entangled random-coiled macromolecules rather than a cross-linked macromolecular network, the model heretofore widely accepted. This new model can account for the following phenomena: (1) The viscoelastic properties of the estrous mucus and human mid-cycle cervical mucus are the result of the way in which the glycoproteins are entangled. Variations of these properties during the reproductive cycle may simply be due to changes in the water content of the cervical mucus. (2) Penetration of spermatozoa in mucus may be entirely mechanical without involving any kind of enzymatic lysis of cross-links (this is supported by changes in the pattern of spermatozoa flagellation during sperm penetration of cervical mucus as shown in motion picture films). (3) The orientation of spermatozoa in the cervical muscus need not be due to the presence of 'channels' between micelles but simply to an artifact, the stretching or flow of the mucus, which orients the entangled macromolecules and thus facilitates the penetration of spermatozoa in an axis parallel to them.","PeriodicalId":75889,"journal":{"name":"Gynecologic investigation","volume":"8 5-6 1","pages":"154-66"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000301094","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65431342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 63
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