Essays in neurochemistry and neuropharmacology最新文献_第3页

Cyclic nucleotides and postsynaptic events. 环核苷酸和突触后事件。

Essays in neurochemistry and neuropharmacology Pub Date : 1977-01-01

K G Walton

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Perspectives in behavioural neurochemistry. 行为神经化学的观点。

Essays in neurochemistry and neuropharmacology Pub Date : 1977-01-01

R B Holman, G R Elliott, J D Barchas

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Metabolism of aldehydes in brain. 脑内醛的代谢。

Essays in neurochemistry and neuropharmacology Pub Date : 1977-01-01

K F Tipton, M D Houslay, A J Turner

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Prospective neurotransmitters in vertebrate retina. 脊椎动物视网膜中的前瞻性神经递质。

Essays in neurochemistry and neuropharmacology Pub Date : 1977-01-01

M S Starr

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The mode of action of indolamine and other hallucinogens. 吲哚胺和其他致幻剂的作用方式。

Essays in neurochemistry and neuropharmacology Pub Date : 1977-01-01

M R Boarder

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The isolated perfused rat brain preparation--a critical assessment. 分离的灌注大鼠脑制剂——一项重要的评估。

Essays in neurochemistry and neuropharmacology Pub Date : 1977-01-01

H F Woods, M B Youdim

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The role of methylating enzymes in brain function. 甲基化酶在脑功能中的作用。

Essays in neurochemistry and neuropharmacology Pub Date : 1977-01-01

J M Saavedra

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Molecular events in trans-synaptic regulation of the synthesis of macromolecules. 跨突触调节大分子合成中的分子事件。

Essays in neurochemistry and neuropharmacology Pub Date : 1977-01-01

H Thoenen, U Otten

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Clinical approaches to the evaluation of brain amine function in mental illness: some conceptual issues. 精神疾病中脑胺功能评估的临床方法:一些概念问题。

Essays in neurochemistry and neuropharmacology Pub Date : 1977-01-01

F K Goodwin, R M Post, T Wehr

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Neurochemical findings in Huntington's chorea. 亨廷顿舞蹈病的神经化学发现。

Essays in neurochemistry and neuropharmacology Pub Date : 1977-01-01

E D Bird, L L Iversen

{"title":"Neurochemical findings in Huntington's chorea.","authors":"E D Bird, L L Iversen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Huntington's chorea is a dominantly inherited disorder that usually leads to involuntary movements in the third or fourth decade. On gross pathological examination of the post-mortem brain there is a marked atrophy of the caudate nucleus and putamen. Histological examination reveals cell loss in most regions of the brain, although the hippocampus is usually remarkably free of any abnormalities. Studies to detect a biochemical defect in patients with chorea have been largely unrewarding. Since chorea appears to be the clinical counterpart of Parkinson's disease a number of investigations on dopamine metabolism have been carried out by measuring dopamine in the post-mortem choreic brain, and HVA, a metabolite of dopamine, in the CSF of patients. Most studies have found the dopamine concentrations to be normal or sometimes decreased and the activity of the biosynthetic enzyme for dopamine, tyrosine hydroxylase, is normal. The discovery that the inhibitory neurotransmitter, GABA, and the biosynthetic enzyme GAD are greatly decreased in the post-mortem choreic brain provides some rational explanation for the uncontrolled movements in this disorder. The other significant abnormality found in many, but not all, choreic post-mortem brains has been a decrease in the biosynthetic enzyme for acetylcholine, choline acetyl transferase. The evidence that GABA receptors are intact in choreic brain provides an added stimulus for the development of useful GABA-mimetic drugs. For the ultimate eradication of this distressing disorder, however, a search must continue for the primary defect in order that this can be detected before the onset of symptoms, or hopefully in amniotic fluid.</p>","PeriodicalId":75830,"journal":{"name":"Essays in neurochemistry and neuropharmacology","volume":"1 ","pages":"177-95"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11369767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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