American Journal of Physiology - Renal Physiology最新文献

Spns1 is an iron transporter essential for megalin-dependent endocytosis. Spns1 是一种铁转运体，对巨球蛋白依赖性内吞作用至关重要。

American Journal of Physiology - Renal Physiology Pub Date : 2024-09-12 DOI: 10.1152/ajprenal.00172.2024

Andrew Beenken, Tian Shen, Guangchun Jin, Aryan Ghotra, Katherine Xu, Kivanc Nesanir, Rachel E. Sturley, Soundarapandian Vijayakumar, Atlas Kahn, Abraham Levitman, Jacob Stauber, Estefania Y. Chavez, Shelief Y. Robbins-Juarez, Luke Hao, Thomas B. Field, Hediye Erdjument-Bromage, Thomas A. Neubert, Lawrence Shapiro, Andong Qiu, Jonathan Barasch

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Glucagon receptor activation contributes to the development of kidney injury 胰高血糖素受体激活有助于肾损伤的发展

American Journal of Physiology - Renal Physiology Pub Date : 2024-09-12 DOI: 10.1152/ajprenal.00088.2024

Anna Billeschou Bomholt, Christian Dall Johansen, Katrine Douglas Galsgaard, Emilie Elmelund, Marie Winther-Sørensen, Jens Juul Holst, Nicolai J. Wewer Albrechtsen, Charlotte Mehlin Sorensen

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Role of Local Angiotensin II Signaling in Bladder Function 局部血管紧张素 II 信号在膀胱功能中的作用

American Journal of Physiology - Renal Physiology Pub Date : 2024-09-12 DOI: 10.1152/ajprenal.00204.2024

Hannah A. Anderson, Gabriella L. Robilotto, Aaron D. Mickle

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Establishment and characterization of a mouse model for studying kidney repair in diabetes 建立研究糖尿病肾脏修复的小鼠模型并确定其特征

American Journal of Physiology - Renal Physiology Pub Date : 2024-09-12 DOI: 10.1152/ajprenal.00143.2024

Shaoqun Shu, Hui Wang, Juan Cai, Anqun Chen, Zheng Dong

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MiR-199a-5p aggravates against renal ischemia-reperfusion and transplant injury by targeting AKAP1 to disrupt mitochondrial dynamics MiR-199a-5p 通过靶向 AKAP1 破坏线粒体动力学，加重肾缺血再灌注和移植损伤

American Journal of Physiology - Renal Physiology Pub Date : 2024-09-12 DOI: 10.1152/ajprenal.00409.2023

Lang Shi, Hongchu Zha, Hua Huang, Yao Xia, Huimin Li, Jing Huang, Ruchi Yue, Chenglong Li, Jiefu Zhu, Zhixia Song

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First Author Highlights 第一作者亮点

American Journal of Physiology - Renal Physiology Pub Date : 2024-09-10 DOI: 10.1152/ajprenal.2024.327.3.au

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Is there a role for uric acid in polycystic kidney disease progression? 尿酸在多囊肾进展过程中起作用吗？

American Journal of Physiology - Renal Physiology Pub Date : 2024-05-09 DOI: 10.1152/ajprenal.00121.2024

Lashodya V. Dissanayake, Oleg Palygin

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Early-life exposures and long-term health: adverse gestational environments and the programming of offspring renal and vascular disease 生命早期暴露与长期健康：不利的妊娠环境与后代肾脏和血管疾病的形成过程

American Journal of Physiology - Renal Physiology Pub Date : 2024-05-02 DOI: 10.1152/ajprenal.00383.2023

Zoé Oulerich, Amanda N. Sferruzzi-Perri

{"title":"Early-life exposures and long-term health: adverse gestational environments and the programming of offspring renal and vascular disease","authors":"Zoé Oulerich, Amanda N. Sferruzzi-Perri","doi":"10.1152/ajprenal.00383.2023","DOIUrl":"https://doi.org/10.1152/ajprenal.00383.2023","url":null,"abstract":"According to the Developmental Origins of Health and Disease (DOHaD) hypothesis, exposure to certain environmental influences during early life may be a key determinant of fetal development and short- and long-term offspring health. Indeed, adverse conditions encountered during the fetal, perinatal, and early childhood stages can alter normal development and growth, as well as put the offspring at elevated risk of developing long-term health conditions in adulthood, including chronic kidney disease (CKD) and cardiovascular diseases. Of relevance in understanding the mechanistic basis of these long-term health conditions, are previous findings showing low glomerular number in human intrauterine growth restriction and low birth weight - indicators of a sub-optimal intrauterine environment. In different animal models, the main sub-optimal intrauterine conditions studied relate to maternal dietary manipulations, poor micronutrient intake, prenatal ethanol exposure, maternal diabetes, glucocorticoid and chemical exposure, hypoxia, and placental insufficiency. These studies have demonstrated changes in kidney structure, glomerular endowment, and expression of key genes and signalling pathways controlling endocrine, excretion and filtration function of the offspring. This review aims to summarize those studies to uncover the effects and mechanisms by which adverse gestational environments impact offspring renal and vascular health in adulthood. This is important for identifying agents and interventions that can prevent and mitigate the long-term consequences of an adverse intrauterine environment on the subsequent generation.","PeriodicalId":7583,"journal":{"name":"American Journal of Physiology - Renal Physiology","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140829482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Preventive effects of vasohibin-2-targeting peptide vaccine for diabetic nephropathy 血管抑制素-2靶向多肽疫苗对糖尿病肾病的预防作用

American Journal of Physiology - Renal Physiology Pub Date : 2024-05-02 DOI: 10.1152/ajprenal.00341.2023

Yuri Nakashima, Katsuyuki Tanabe, Tomoyo Mifune, Takato Nakadoi, Hiroki Hayashi, Hironori Nakagami, Yasufumi Sato, Jun Wada

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Kidney collecting-duct-derived vasopressin is not essential for appropriate concentration or dilution of urine 肾脏集尿管产生的血管加压素对适当浓缩或稀释尿液并不重要

American Journal of Physiology - Renal Physiology Pub Date : 2024-05-02 DOI: 10.1152/ajprenal.00057.2024

Yvonne Zuchowski, Joshua Carty, Jonathan B. Trapani, Jason Watts, Fabian Bock, Mingzhi Zhang, Andrew Terker, Roy Zent, Eric Delpire, Raymond C. Harris, Juan Pablo Arroyo

{"title":"Kidney collecting-duct-derived vasopressin is not essential for appropriate concentration or dilution of urine","authors":"Yvonne Zuchowski, Joshua Carty, Jonathan B. Trapani, Jason Watts, Fabian Bock, Mingzhi Zhang, Andrew Terker, Roy Zent, Eric Delpire, Raymond C. Harris, Juan Pablo Arroyo","doi":"10.1152/ajprenal.00057.2024","DOIUrl":"https://doi.org/10.1152/ajprenal.00057.2024","url":null,"abstract":"We previously showed that kidney collecting ducts make vasopressin. However, the physiologic role of collecting-duct-derived vasopressin is uncertain. We hypothesized that collecting-duct-derived vasopressin was required for appropriate concentration of urine. We developed a vasopressin conditional knockout mouse model wherein Cre recombinase expression induces deletion of Avp exon 1 in the distal nephron. We then used age-matched 8 - 12 week old Avp fl/fl;Ksp-Cre(-) (WT) and Avp fl/fl;Ksp-Cre(+) mice for all experiments. We collected urine, serum, and kidney lysates at baseline. We then challenged both WT and KO mice with 24 hour water restriction, water loading, and administration of the vasopressin type 2 receptor (V2R) agonist desmopressin (dDAVP) 1 µg/kg/ip) followed by V2R antagonist OPC-31260 (10 mg/kg/ip). We performed immunofluorescence and immunoblot analysis at baseline and confirmed vasopressin knockout in the collecting duct. We found that urinary osmolality (UOsm), plasma Na+, K+, Cl-, BUN, and copeptin were similar in WT vs KO mice at baseline. Immunoblots of vasopressin regulated proteins Na:K:2Cl cotransporter (NKCC2), Na:Cl cotransporter (NCC) and water channel aquaporin-2 (AQP2) showed no difference in expression or phosphorylation at baseline. Following 24 hour water restriction, WT and KO mice had no differences in UOsm, plasma Na+, K+, Cl-, BUN or copeptin. Additionally, there were no differences in the rate of urinary concentration or dilution as WT and KO mice UOsm was nearly identical after dDAVP and OPC-31260 administration. We conclude that collecting-duct-derived vasopressin is not essential to appropriately concentrate or dilute urine.","PeriodicalId":7583,"journal":{"name":"American Journal of Physiology - Renal Physiology","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140829633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0