Current topics in radiation research quarterly最新文献_第3页

Therapeutic application of iodine-125 labeled iododeoxyuridine in an early ascites tumour model. 碘-125标记碘脱氧尿苷在早期腹水肿瘤模型中的治疗应用。

Current topics in radiation research quarterly Pub Date : 1978-01-01

W D Bloomer, S J Adelstein

{"title":"Therapeutic application of iodine-125 labeled iododeoxyuridine in an early ascites tumour model.","authors":"W D Bloomer, S J Adelstein","doi":"","DOIUrl":"","url":null,"abstract":"In its decay, iodine-125 emits cascades of Auger electrons with subcellular ranges and leaves a highly charged tellurium-125 product. When iodine-125 is incorporated into DNA as the thymidine analog 125I-UdR, the localized deposition of such energy has been shown to be extremely radiotoxic. This report presents the results of quantitative investigations into the therapeutic efficacy of 125I-UdR in an early ascites murine tumour model. An ovarian embryonal cell carcinoma has been maintained by serial intraperitoneal transplantation. Challenge doses of 10(4)-10(6) cells were used. Four divided doses of 125I-UdR were administered starting 24 h after tumour cell inoculation; the interval between doses was 4 or 12 h. Therapeutic efficacy was demonstrated by prolonged median and increased absolute survivals of treated animals. Divided doses were more effective than single doses, and antineoplastic activity was related to fractionation. The degree of cell killing with a given fractionation scheme was constant over the range of 10(4)-10(6) cells, and total doses of 50-100 muCi resulted in a 2-3 log killing of tumour cells (1-0.1% cell survival). Therapy with 125I-UdR affords a promising new approach to the treatment of cancer. The therapeutic potential of iodine-125 and other radionuclides whose decay results in a highly localized deposition of energy merits further investigation.","PeriodicalId":75768,"journal":{"name":"Current topics in radiation research quarterly","volume":"12 1-4","pages":"513-25"},"PeriodicalIF":0.0,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11841784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The form and interpretation of clearance curves for injected radioisotopes based on negative power laws, especially for 47Ca and estimating bone accretion rate. 基于负幂定律的注入放射性同位素间隙曲线的形式和解释，特别是47Ca和骨增生率的估计。

Current topics in radiation research quarterly Pub Date : 1978-01-01

M E Wise

{"title":"The form and interpretation of clearance curves for injected radioisotopes based on negative power laws, especially for 47Ca and estimating bone accretion rate.","authors":"M E Wise","doi":"","DOIUrl":"","url":null,"abstract":"Many hundreds of clearance curves for plasma and urine after a single injection of tracer are well fitted by y = sigmari = Ai exp(-Bit), r = 2 or 3, based on models with homogeneous compartments. Reanalyzing such sums as in a plot of log y versus log t shows that many of the original curves would fit y = At-alpha or At-alpha exp(-betat) over wide ranges of time and specific acitivity. Results of such reanalyses for a complete published series for serum albumin 131I are given, and an outline of those for various compounds in the human body labeled by 3H. For radiocalcium two such power laws can be fitted in one curve, with a transition between about 1 and 3 days, so that much of the log y versus log t plot consists of two straight lines. These lines are used for starting a numerical analysis that splits the curve into 2 non-linear components, plus a third one that is neglibible after 5 min from injection. An outline of the iteration method is given. The components are interpreted physiologically and used to predict total bone activities by (de)convolution, and these are compared with observed ankle activities and with excretion rates. The bone accretion rate is obtained mainly from the middle component and comes to 2 to 3 g Ca/day, while return of 47Ca from bone to plasma begins at about 1/2 day. These results seem imcompatible with any based on compartments. The concept of biological half-life then needs to be reconsidered.","PeriodicalId":75768,"journal":{"name":"Current topics in radiation research quarterly","volume":"12 1-4","pages":"63-82"},"PeriodicalIF":0.0,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11841785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microlocalization of artificial radionuclides in radiological protection of the environment. 人工放射性核素微定位在环境放射防护中的应用。

Current topics in radiation research quarterly Pub Date : 1978-01-01

R Bittel, R Magnaval

{"title":"Microlocalization of artificial radionuclides in radiological protection of the environment.","authors":"R Bittel, R Magnaval","doi":"","DOIUrl":"","url":null,"abstract":"Though environmental biological equilibrium seems to be safeguarded as long as the radiological protection of man is assumed, a number of problems raised by environmental protection are not fully solved. In particular, there occur both macroscopic processes of concentration at some levels of the biological chains, and microlocalization at the cellular, subcellular and molecular levels. The long-term consequences of the non-uniform distribution of the radionuclides should therefore be assessed even if the contamination levels of the physical environment are very low. These aspects are of particular significance with alpha-emitters (plutonium and transplutonium elements), beta-emitters (chiefly tritium) and activation products, some of which are radioisotopes of biologically significant elements. The incidence of these processes is discussed in the light of recent and future developments in nuclear energy. This approach might open new avenues for investigations in environmental radiological protection. The concept of a concentration factor between the environment and the total organism must be supplemented by the concept of a localization and concentration factor at the subcellular level. The significance of the physico-chemical forms of the radionuclides and the parameters likely to modify the characteristics of membranes should be emphasized. Finally, an indication is given on priority measures in the area of investigations of the long-term consequences of low doses on environmental organisms.","PeriodicalId":75768,"journal":{"name":"Current topics in radiation research quarterly","volume":"12 1-4","pages":"33-43"},"PeriodicalIF":0.0,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11843040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intracellular distribution of 57Co-bleomycin. 57co -博莱霉素的细胞内分布。

Current topics in radiation research quarterly Pub Date : 1978-01-01

A W Konings, J J Rasker, G A Posthuma

{"title":"Intracellular distribution of 57Co-bleomycin.","authors":"A W Konings, J J Rasker, G A Posthuma","doi":"","DOIUrl":"","url":null,"abstract":"Since the first promising results of Nouel et al. 1972, additional positive experience has been obtained with 57Co-Bleomycin (57Co-BLM) as a tumour-localizing agent. In this preclinical study, mice with transplanted osteosarcoma and lymphosarcoma were used and rats with transplanted rhabdomyosarcoma. 57CoCl2 served as a control substance. 57Co-BLM had concentrated in the tumours with a factor 2 to 10 as compared to the (normal) liver of the animals. No preferential concentration in the tumours was found when 57CoCl2 was used. The highest specific activity of 57Co-BLM (cpm/mg protein) was found in a fraction containing mitochondria and lysosomes. Evidence for a lysosomal localization of this diagnostic compound was obtained from experiments in which the mitochondrial-lysosomal fraction was treated with hypertonic media of different osmolarities. Conditions could be found in which many lysosomes burst while almost all mitochondrial were intact. From these experiments it appeared that the radioactivity in the particles obtained from animals injected wtih 57Co-BLM was released very rapidly. It is concluded that 57Co-BLM is preferentially localized in the heavy lysosomes sedimenting together with most of the mitochondria of the cell and that these structures are more fragile than the light lysosomes.","PeriodicalId":75768,"journal":{"name":"Current topics in radiation research quarterly","volume":"12 1-4","pages":"497-512"},"PeriodicalIF":0.0,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11297456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cell survival and cytogenetic responses to 125I-UdR in cultured mammalian cells. 哺乳动物细胞对125I-UdR的细胞存活和细胞遗传学反应。

Current topics in radiation research quarterly Pub Date : 1978-01-01

P C Chan, E Lisco, H Lisco, S J Adelstein

引用次数: 0

Repair of the double-strand breaks produced by 125I disintegrations in the DNA of Micrococcus radiodurans. 耐辐射微球菌DNA中125I崩解产生的双链断裂的修复。

Current topics in radiation research quarterly Pub Date : 1978-01-01

D K Myers

引用次数: 0

The genetic and late somatic effects of chronic tritium ingestion in mice. 慢性摄入氚对小鼠的遗传和晚期躯体效应。

Current topics in radiation research quarterly Pub Date : 1978-01-01

A L Carsten, S L Commerford, E P Cronkite

引用次数: 0

DNA strand breakage and repair in human kidney cells after exposure to incorporated iodine-125 and cobalt-60 gamma-rays. 暴露于掺入的碘-125和钴-60伽马射线后人体肾细胞DNA链断裂和修复。

Current topics in radiation research quarterly Pub Date : 1978-01-01

L E Feinendegen, P Henneberg, G Tisljar-Lentulis

{"title":"DNA strand breakage and repair in human kidney cells after exposure to incorporated iodine-125 and cobalt-60 gamma-rays.","authors":"L E Feinendegen, P Henneberg, G Tisljar-Lentulis","doi":"","DOIUrl":"","url":null,"abstract":"Biological effects of 125I incorporated into DNA exceed those to be expected from the absorbed radiation dose by a factor 3--30. The reason for this discrepancy suggests special mechanisms introduced by 125I transmutation, decays by K-capture leading to the emission of an average of 6 low energy electrons including Auger electrons and to a highly positively charged daughter nuclide. The effect of 125I decay on DNA strand breakage and subsequent repair was studied. Human kidney cells T in the deep frozen state (-196 degrees C) were exposed to incorporated 125I and 60Co gamma-rays. The number of DNA single strand breaks (ssb) was determined by DNA centrifugation in alkaline sucrose gradients. DNA repair was studied by incubating the cells after thawing at 37 degrees C. For 125I decay in frozen cells which were kept with or without dimethyl-sulfoxide, 4 and 6 ssb were measured per decay. The gamma-rays produced 1ssb per 26 eV absorbed energy. Most of this damage was repaired 30 to 40 min after onset of incubation. No repair of the damage caused by 125I was observed. The high efficiency of 125I decays for the production of unreparable ssb provides evidence for the high radiotoxicity of this isotope. The observed lack of repair may in part be due to the high numbers of at least 2,000 125I decays per cell nucleus necessary for the assay system. Damage from many 125I decays may interfere with enzymatic repair processes.","PeriodicalId":75768,"journal":{"name":"Current topics in radiation research quarterly","volume":"12 1-4","pages":"436-52"},"PeriodicalIF":0.0,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11841781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tritium retention in rat after administration of various doses of tritiated water. 给药不同剂量的氚水后大鼠体内的氚潴留。

Current topics in radiation research quarterly Pub Date : 1978-01-01

I Radwan, Z Pietrzak-Flis, Z Jaworowski

引用次数: 0

Quantitative ESR-studies of decay-produced radicals in 5-iododeoxyuridine labeled with 125I, 131I or tritium: role of the Auger effect. 用125I、131I或氚标记的5-碘脱氧尿嘧啶衰变产生的自由基的定量esr研究:俄盖效应的作用。

Current topics in radiation research quarterly Pub Date : 1978-01-01

A Halpern, R Deutzmann, G Stöcklin

引用次数: 0