Clinics in haematology最新文献_第9页

High dose chemotherapy in solid tumours in adults 成人实体瘤的高剂量化疗

Clinics in haematology Pub Date : 1986-02-01 DOI: 10.1016/S0308-2261(86)80013-3

Robert Souhami, William Peters

引用次数: 7

Autologous bone marrow transplantation. 自体骨髓移植。

Clinics in haematology Pub Date : 1986-02-01

引用次数: 0

Pregnancy in Sickle Cell Disease 镰状细胞病的妊娠

Clinics in haematology Pub Date : 1985-10-01 DOI: 10.1016/S0308-2261(21)00502-6

Samuel Charache, Jennifer R. Niebyl

引用次数: 0

Haematological disorders in pregnancy. 妊娠期血液病。

Clinics in haematology Pub Date : 1985-10-01

引用次数: 0

Iron metabolism and anaemia in pregnancy. 铁代谢与妊娠贫血。

Clinics in haematology Pub Date : 1985-10-01

D P Bentley

{"title":"Iron metabolism and anaemia in pregnancy.","authors":"D P Bentley","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The mechanism by which anaemia develops in pregnancy is well understood: haemodilution causes a fall in the haemoglobin concentration during the first and second trimesters of normal pregnancies. Negative iron balance throughout pregnancy, particularly in the latter half, may lead to iron deficiency anaemia during the third trimester. The increase in iron demand is required to meet the expansion in maternal haemoglobin mass and to meet the needs of fetal growth. Fetal demand for iron results in a unidirectional flow of iron to the fetus against a concentration gradient regulated by fetal requirements for iron; this iron transfer occurs almost entirely irrespective of maternal iron status. The development of maternal iron deficiency during pregnancy may be detected by monitoring the haemoglobin concentration frequently; values falling to less than 11 g/dl should be regarded as abnormal, but specific red cell changes, such as microcytosis, may be lacking. A diagnosis of iron deficiency can be most conveniently confirmed by the serum ferritin concentration falling to less than 12 micrograms/l. Women at risk from iron deficiency anaemia can therefore be readily identified and corrective treatment instituted prior to the development of severe anaemia. A serum ferritin concentration of less than 50 micrograms/l in early pregnancy is an indication for iron supplements. Women in whom the serum ferritin concentration is greater than 80 micrograms/l at booking are unlikely to require iron supplements during pregnancy. This approach would eliminate the need for routine prophylactic iron therapy, which, in populations enjoying a good nutritional status, can no longer be justified in early pregnancy. Furthermore, any risk to the fetus from severe maternal anaemia would be avoided by prophylaxis and prompt treatment.</p>","PeriodicalId":75718,"journal":{"name":"Clinics in haematology","volume":"14 3","pages":"613-28"},"PeriodicalIF":0.0,"publicationDate":"1985-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15022496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Obstetric haemorrhage: causes and management. 产科出血:原因和管理。

Clinics in haematology Pub Date : 1985-10-01

F E Boulton, E Letsky

引用次数: 0

Prenatal Diagnosis of Inherited Blood Diseases 遗传性血液病的产前诊断

Clinics in haematology Pub Date : 1985-10-01 DOI: 10.1016/S0308-2261(21)00503-8

D.J. Weatherall

引用次数: 0

Copyright Page 版权页

Clinics in haematology Pub Date : 1985-10-01 DOI: 10.1016/S0308-2261(21)00493-8