Clinics in haematology最新文献

{"title":"Bone marrow transplantation in acute leukaemia.","authors":"R P Gale,&nbsp;R E Champlin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Bone marrow transplantation is useful in AML. Results of chemotherapy and transplantation are compared in Table 4. Transplantation is the preferred treatment in individuals who fail chemotherapy. Transplantation is also likely to be superior or comparable to chemotherapy in individuals less than 30 years of age in first remission. Transplantation in older individuals in first remission is controversial, but it is unlikely that these results are inferior to results with chemotherapy. Transplants from donors other than HLA-identical siblings are less well investigated but may be a reasonable alternative in young individuals in first relapse or second remission, particularly if recipient and donor share most HLA antigens. Autotransplants are difficult to evaluate critically and should be considered investigational in individuals in second or later remission for whom a suitable donor is unavailable. Autotransplants in first remission should be restricted to controlled clinical trials, since their efficacy is otherwise inevaluable. It is uncertain whether in vitro treatment of the bone marrow is necessary in the context of autotransplantation; again, controlled trials are required. Bone marrow transplantation from an HLA-identical sibling is a useful therapy in individuals with ALL who relapse despite chemotherapy. Individuals undergoing transplantation in second or later remission or in relapse have a survival rate superior to those treated with chemotherapy; these data are summarized in Table 5. One important unresolved issue in ALL is whether children with high-risk ALL and adults should receive transplants in first remission. This answer will, to a considerable extent, depend on results achieved with chemotherapy alone. If intensive chemotherapy produces 50-70% disease-free survival in these individuals, it is unlikely that transplantation will be superior. If, however, alternative chemotherapy results are inferior, transplantation may be useful. Clearly, controlled clinical trials are needed. Results of transplants from donors other than HLA-identical siblings are less certain but this approach may be considered in selected young individuals who fail chemotherapy. Autotransplants should also be considered in this setting but not in individuals in first remission. It is likewise uncertain if in vitro treatment of the bone marrow is useful; this must be addressed in controlled trials. The data reviewed indicate an important role for bone marrow transplantation in the therapy of the acute leukaemias. We have attempted to precisely define its use in various disease states.(ABSTRACT TRUNCATED AT 400 WORDS)</p>","PeriodicalId":75718,"journal":{"name":"Clinics in haematology","volume":"15 3","pages":"851-72"},"PeriodicalIF":0.0,"publicationDate":"1986-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14658840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"9 Acute Lymphoblastic Leukaemia in Adults","authors":"H. Grant Prentice,&nbsp;J-P. Grob","doi":"10.1016/S0308-2261(18)30010-9","DOIUrl":"https://doi.org/10.1016/S0308-2261(18)30010-9","url":null,"abstract":"","PeriodicalId":75718,"journal":{"name":"Clinics in haematology","volume":"15 3","pages":"Pages 755-780"},"PeriodicalIF":0.0,"publicationDate":"1986-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138380704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"14 Infection and Transfusion Therapy in Acute Leukaemia","authors":"Winston G. Ho,&nbsp;Drew J. Winston","doi":"10.1016/S0308-2261(18)30015-8","DOIUrl":"https://doi.org/10.1016/S0308-2261(18)30015-8","url":null,"abstract":"","PeriodicalId":75718,"journal":{"name":"Clinics in haematology","volume":"15 3","pages":"Pages 873-904"},"PeriodicalIF":0.0,"publicationDate":"1986-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138380708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"13 Bone Marrow Transplantation in Acute Leukaemia","authors":"Robert Peter Gale,&nbsp;Richard E. Champlin","doi":"10.1016/S0308-2261(18)30014-6","DOIUrl":"https://doi.org/10.1016/S0308-2261(18)30014-6","url":null,"abstract":"","PeriodicalId":75718,"journal":{"name":"Clinics in haematology","volume":"15 3","pages":"Pages 851-872"},"PeriodicalIF":0.0,"publicationDate":"1986-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138380710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"7 Adult T Cell Leukaemla/Lymphoma","authors":"Paul R. Kuefler,&nbsp;Paul A. Bunn Jr","doi":"10.1016/S0308-2261(18)30008-0","DOIUrl":"https://doi.org/10.1016/S0308-2261(18)30008-0","url":null,"abstract":"","PeriodicalId":75718,"journal":{"name":"Clinics in haematology","volume":"15 3","pages":"Pages 695-726"},"PeriodicalIF":0.0,"publicationDate":"1986-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138381041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute lymphoblastic leukaemia in adults.","authors":"H G Prentice,&nbsp;J P Grob","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75718,"journal":{"name":"Clinics in haematology","volume":"15 3","pages":"755-80"},"PeriodicalIF":0.0,"publicationDate":"1986-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14658836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adult T cell leukaemia/lymphoma.","authors":"P R Kuefler,&nbsp;P A Bunn","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Adult T cell leukaemia/lymphoma was first identified by Japanese investigators in the mid 1970s. Distinctive characteristics include hypercalcaemia, metabolic bone disease, opportunistic infections and evidence of multiorgan involvement. The malignant cell has the surface phenotype of a T helper lymphocyte but functions as a T suppressor cell, and in leukaemic patients this cell usually has a unique multilobed appearance, which may aid in recognizing the disease. The overwhelming majority of patients with ATLL originate from the south-west Japanese archipelago, as well as the Caribbean basin and south-east USA. The geographic localization of this disease is the result of the endemic distribution of the human retrovirus (HTLV-I) which has been established as the cause of ATLL. Infection with this virus may result in no disease (asymptomatic carriers) or ATLL. While ATLL usually pursues an acute or subacute (prototypic) course, patients are also seen with 'chronic' or 'smouldering' disease. Over time, these more indolent variations may progress to the prototypic form. When aggressive, ATLL must be treated with intense combinations of cytotoxic drugs similar to those used to treat the more common B cell lymphoproliferative disorders. Even though half of the patients treated achieve a remission, the duration is usually brief and the overall actuarial median survival is only 11 months. In addition to recurrent disease, these patients frequently succumb to opportunistic infections.</p>","PeriodicalId":75718,"journal":{"name":"Clinics in haematology","volume":"15 3","pages":"695-726"},"PeriodicalIF":0.0,"publicationDate":"1986-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14015178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"1 Acute Leukaemias: Biology and Treatment","authors":"Robert Peter Gale,&nbsp;A. Victor Hoffbrand","doi":"10.1016/S0308-2261(18)30002-X","DOIUrl":"https://doi.org/10.1016/S0308-2261(18)30002-X","url":null,"abstract":"","PeriodicalId":75718,"journal":{"name":"Clinics in haematology","volume":"15 3","pages":"Pages 567-571"},"PeriodicalIF":0.0,"publicationDate":"1986-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138381043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Index","authors":"","doi":"10.1016/S0308-2261(18)30016-X","DOIUrl":"https://doi.org/10.1016/S0308-2261(18)30016-X","url":null,"abstract":"","PeriodicalId":75718,"journal":{"name":"Clinics in haematology","volume":"15 3","pages":"Pages 905-908"},"PeriodicalIF":0.0,"publicationDate":"1986-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0308-2261(18)30016-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138381058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biochemical aspects of acute leukaemia.","authors":"A V Hoffbrand,&nbsp;H G Drexler,&nbsp;K Ganeshaguru,&nbsp;A Piga,&nbsp;R G Wickremasinghe","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75718,"journal":{"name":"Clinics in haematology","volume":"15 3","pages":"669-94"},"PeriodicalIF":0.0,"publicationDate":"1986-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14228589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}