{"title":"Evaluation of valvular heart disease in patients older than age 65.","authors":"M N Kotler, L E Jacobs","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75674,"journal":{"name":"Cardiovascular clinics","volume":"22 2","pages":"75-96"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12753762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pulmonary vascular disease: primary pulmonary hypertension.","authors":"R G Tancredi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Clinical and pathologic features of primary pulmonary hypertension have been well characterized, but little is known regarding the underlying cause and pathogenesis. The disorder is usually discovered in its late stage, when pulmonary vascular resistance is already severely compromised and the pathologic changes already well developed. It is not surprising, then, that most attempts at defining effective pharmacologic interventions have been disappointing. Some new approaches are clearly needed. The past decade has witnessed the rapid growth of molecular techniques in areas applied to the study of the blood vessel wall, blood coagulation, and the platelet-endothelial cell interaction. Platelet-derived growth factors and other macrophage-derived factors may play important roles in the pathogenesis of the early proliferative lesions found in the small pulmonary arterioles. Other vascular-derived mediators may be important determinants in modulating the vasoconstrictor or vasodilator response in small vessels. A recent brief but pertinent review has highlighted some of the new directions being taken. It appears that the right questions are finally being asked, and we now may have the tools to answer them.</p>","PeriodicalId":75674,"journal":{"name":"Cardiovascular clinics","volume":"22 3","pages":"113-24"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12767151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Aneurysmal disease.","authors":"W M Morre, L H Hollier","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The frequency of the diagnosis of arterial aneurysms is increasing. Aneurysms in many locations remain asymptomatic and require careful evaluation of at-risk patient populations. Screening of first-degree relatives of patients with known AAA now appears to be indicated. A high index of suspicion of the possible presence or the existence of known aneurysms should prompt timely referral for evaluation by a vascular surgeon. Consideration of a patient's candidacy for surgical intervention should involve the evaluation of a myriad of factors, some of which have been elucidated in this overview. The safety of surgical intervention for aneurysm repair has continued to improve, and most patients can be surgically managed with an acceptably low rate of morbidity and mortality.</p>","PeriodicalId":75674,"journal":{"name":"Cardiovascular clinics","volume":"22 3","pages":"189-200"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12767156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Endothelium-derived factors and peripheral vascular disease.","authors":"J P Cooke","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The endothelium plays a major role in modulating vascular tone, vascular growth, and interactions of the vessel wall with blood constituents. Therefore, abnormalities in endothelial function may play a primary or contributory role to a variety of vasculopathies that are characterized by thrombosis, excessive vasoconstriction, or vascular smooth muscle proliferation. Our increasing understanding of the complexity of endothelial functions will permit us to understand the mechanisms of vascular disease and to design new therapies directed at these mechanisms of disease.</p>","PeriodicalId":75674,"journal":{"name":"Cardiovascular clinics","volume":"22 3","pages":"3-17"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12767161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Congestive heart failure in the elderly.","authors":"D Tighe, A N Brest","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Congestive heart failure is in large part a disease of patients with advancing age. As our population ages, the incidence and prevalence of this disorder will continue to rise. The etiology of CHF in the elderly is multifactorial and one must take into account normal changes associated with aging, the heterogeneity of the elderly population, and possible noncardiac as well as cardiac disorders. Therapy must be aimed at the primary pathophysiologic process affecting the heart. Despite a number of therapeutic advances with medical therapy, CHF usually signals a generally irreversible process with a high mortality, especially in those patients with advanced disease. Therefore preventive measures should assume a paramount role in this disorder. Modification of risk factors such as diabetes, smoking, obesity, sedentary life style, and hypercholesterolemia should be aggressively stressed and pursued in patients of all ages. These preventive measures may have a substantial impact on the incidence of CHF in the elderly.</p>","PeriodicalId":75674,"journal":{"name":"Cardiovascular clinics","volume":"22 2","pages":"127-38"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12753748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The relationship between socioeconomic status and coronary heart disease in older patients: implications for health care.","authors":"R T Coward, C Horne","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75674,"journal":{"name":"Cardiovascular clinics","volume":"22 2","pages":"231-41"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12753754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}