{"title":"Similar Tuning of Distortion-Product Otoacoustic Emission Ratio Functions and Cochlear Vibrations in Mice.","authors":"James B Dewey, Christopher A Shera","doi":"10.1063/5.0195534","DOIUrl":"10.1063/5.0195534","url":null,"abstract":"<p><p>When elicited by two stimulus tones (at frequencies <i>f</i><sub>1</sub> and <i>f</i><sub>2</sub>, <i>f</i><sub>2</sub> > <i>f</i><sub>1</sub>), the amplitudes of specific distortion-product otoacoustic emission (DPOAE) components exhibit a characteristic bandpass shape as the ratio between <i>f</i><sub>2</sub> and <i>f</i><sub>1</sub> is varied. This bandpass shape has been attributed to various mechanisms including intracochlear resonance, suppression, and wave interference, and has been proposed to be related to cochlear frequency tuning. While human studies suggest modest correlations between psychophysical tuning and the tuning of DPOAE amplitude vs. <i>f</i><sub>2</sub>/<i>f</i><sub>1</sub> ratio functions, a relationship between the latter and the tuning of cochlear mechanical responses has yet to be established. This was addressed here through direct comparisons of DPOAEs and cochlear vibrations in wild-type CBA/CaJ mice. DPOAEs were elicited using a fixed-<i>f</i><sub>2</sub>, swept-<i>f</i><sub>1</sub> paradigm, and optical coherence tomography was used to measure displacements from cochlear locations with characteristic frequencies near <i>f</i><sub>2</sub>. The tuning sharpness of 2<i>f</i><sub>1</sub>-<i>f</i><sub>2</sub> DPOAE ratio functions was found to be remarkably similar to that of basilar membrane and/or tectorial membrane responses to single tones, with the tuning sharpness of all responses increasing similarly with decreasing stimulus level. This relationship was observed for <i>f</i><sub>2</sub> frequencies ranging from ~8 to 22 kHz. Intracochlear distortion products did not exhibit a bandpass shape as the <i>f</i><sub>2</sub>/<i>f</i><sub>1</sub> ratio was varied, indicating that interference between distortion products traveling to the stapes may be responsible for the tuning of the DPOAE ratio function. While these findings suggest that DPOAE ratio functions could be used to noninvasively infer cochlear tuning, it remains to be determined whether this relationship holds in other species and for lower frequency regions.</p>","PeriodicalId":7564,"journal":{"name":"AIP Conference Proceedings","volume":"3062 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10956552/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140183527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Advective mass transport along the cochlear coil.","authors":"Mohammad Shokrian, Douglas Kelley, Jong-Hoon Nam","doi":"10.1063/5.0189936","DOIUrl":"10.1063/5.0189936","url":null,"abstract":"<p><p>Mammalian auditory epithelium (the organ of Corti) stands out among different inner-ear epithelia in that it has large extracellular fluid spaces such as the tunnel of Corti, Nuel's space, outer tunnel, and spacing between outer hair cells. We tested the hypothesis that advective flow facilitates mass transport in the cochlear fluids, using computational simulations of cochlear fluid dynamics and <i>ex vivo</i> experiments to investigate mass transport in extracellular fluid spaces of the cochlea. Three model simulations were performed in series-cochlear mechanics, nonlinear fluid dynamics, and mass transport. In nonlinear fluid dynamics, we incorporated convection terms for more accurate computation of drift flow. For mass transport, both diffusion and advection were considered. For experiments, we measured vibrations of excised cochlear turns using optical coherence tomography. The excised OoC was subjected to acoustic and electrical stimulations.</p>","PeriodicalId":7564,"journal":{"name":"AIP Conference Proceedings","volume":"3062 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11584059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142708700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Preexcy B. Tupas, Juniel G. Lucidos, Marvin Rick G. Forcado, Catherine Bhel B. Aguila, John Joseph G. Aguila, Dayne N. Fradejas
{"title":"IBON: Image based ornithological identification mobile application - A mobile application development for image based classification of birds in Tablas","authors":"Preexcy B. Tupas, Juniel G. Lucidos, Marvin Rick G. Forcado, Catherine Bhel B. Aguila, John Joseph G. Aguila, Dayne N. Fradejas","doi":"10.1063/5.0235284","DOIUrl":"https://doi.org/10.1063/5.0235284","url":null,"abstract":"","PeriodicalId":7564,"journal":{"name":"AIP Conference Proceedings","volume":"3220 1","pages":"020002-020002"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147916153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Justification of technical and economic effectiveness of application of 20 kV voltage in overhead electric networks","authors":"Farrukh Rakhimov, Feruz Rakhimov, Shohrukh Samiev, Dilshodbek Abdukhalilov","doi":"10.1063/5.0218921","DOIUrl":"https://doi.org/10.1063/5.0218921","url":null,"abstract":"","PeriodicalId":7564,"journal":{"name":"AIP Conference Proceedings","volume":"3152 1","pages":"030023-030023"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147905382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nuralhuda Aladdin Jasim, Shahlaa Esmail Ebrahim, Saad H. Ammar
{"title":"Photocatalytic degradation of rhodamine B utilizing core/shell structures (Zn0.3Mn0.7Fe2O4@AgVO3) under the irradiation of visible light: Synthesis, characterization, and its application","authors":"Nuralhuda Aladdin Jasim, Shahlaa Esmail Ebrahim, Saad H. Ammar","doi":"10.1063/5.0237320","DOIUrl":"https://doi.org/10.1063/5.0237320","url":null,"abstract":"","PeriodicalId":7564,"journal":{"name":"AIP Conference Proceedings","volume":"3219 1","pages":"020062-020062"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147883335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Slamet Wahyono, Sari Haryanti, Rohmat Mujahid, Wahyu Jokopriyambodo, Mery Budiarti
{"title":"Cytotoxic potential and phytochemical profiling of Scurrula atropurpurea (Bl.) dans extracts on T47D cell line","authors":"Slamet Wahyono, Sari Haryanti, Rohmat Mujahid, Wahyu Jokopriyambodo, Mery Budiarti","doi":"10.1063/5.0204936","DOIUrl":"https://doi.org/10.1063/5.0204936","url":null,"abstract":"The parasitic plant (Scurrula atropurpurea (Bl.) Dans) is well-known for treating diuretic, mitotic, and cancerous conditions. It grows on trees such as those bearing tea, mangoes, and avocados. This study evaluated the activity of ethyl acetate and ethanol extracts of S. atropurpurea (growing on avocado trees) using the MTT assay on the T47D breast cancer cell line. Soxhletation was performed with ethyl acetate and re-extraction of the residue with ethanol. The ethyl acetate extract of a phytochemical analysis using the TLC method exhibited four peaks, while the ethanol extract contained six peaks. According to the findings of the study, the IC50 of the ethyl acetate and ethanol extract was 17.93 and 44.64 µg/mL, respectively. Ethyl acetate has the highest potential as a cytotoxic agent than ethanol extract.","PeriodicalId":7564,"journal":{"name":"AIP Conference Proceedings","volume":"3109 1","pages":"020012-020012"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.aip.org/aip/acp/article-pdf/doi/10.1063/5.0204936/19874882/020012_1_5.0204936.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147884315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"On resonant vortex excitation of high-rise structures","authors":"A. Karakozova, V. Mondrus","doi":"10.1063/5.0103589","DOIUrl":"https://doi.org/10.1063/5.0103589","url":null,"abstract":"Subject of the research: Today, the design of flexible, extended in length and height structures of transport, industry, communication is one of the important directions of construction development. Such structures include continuous extended metal constructions such as chimneys, poles, billboards, monuments, bridges, pipelines. Besides ensuring the limit states for strength and deformability, there is another important condition for the durable operation of metal structures which is the absence of aerodynamic instability phenomena (mainly wind resonance) during the whole service life. Objectives: Review of the background, analysis of accidents that have occurred, proposals to avoid such situations at the design stage and in the occurrence of emergency conditions at existing facilities. Materials and methods: Review and analysis of existing data and proposals for further improvement of calculation and design methods. Results: The paper analyzes the mechanisms of the main types of aerodynamic instability (wind resonance, flutter, galloping, oscillations in the airfoil) on different types of structures, presents particular cases of the history of famous unique constructions and the authors' calculation practice, describes the ways to avoid this type of phenomena in the design of new buildings or in emergency situations on existing structures. Conclusions: The phenomena described in the article are applicable to an extremely narrow area of construction and are often ignored in calculation and design. This article is intended to draw special attention to these phenomena not only for designers, but also for research engineers in order to create new mechanisms for their analysis.","PeriodicalId":7564,"journal":{"name":"AIP Conference Proceedings","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87028933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}