Bulletin et memoires de l'Academie royale de medecine de Belgique最新文献_第9页

[Magnetic resonance imaging for quantifying hepatis steatosis and hepatic fibrosis]. [磁共振成像定量肝脂肪变性和肝纤维化]。

Bulletin et memoires de l'Academie royale de medecine de Belgique Pub Date : 2009-01-01

B Van Beers

引用次数: 0

[Embryonic development of the liver: basic biology and pediatric pathology]. [肝脏的胚胎发育:基础生物学和儿科病理学]。

Bulletin et memoires de l'Academie royale de medecine de Belgique Pub Date : 2009-01-01

F Lemaigre

引用次数: 0

[HLA-G: from feto-maternal tolerance to organ grafting]. [HLA-G:从胎母耐受到器官移植]。

Bulletin et memoires de l'Academie royale de medecine de Belgique Pub Date : 2009-01-01

E D Carosella

{"title":"[HLA-G: from feto-maternal tolerance to organ grafting].","authors":"E D Carosella","doi":"","DOIUrl":"","url":null,"abstract":"E.D. Carosella was the pioneer who demonstrated the protective role of the HLA-G molecule on trophoblasts, which form a shield protecting the fetus from the immune reaction of its mother and subsequent reject. This non-classical HLA class I molecule is first expressed on the fertilized ovocyte, thus enabling a uterine implantation and then on the surface of the placenta trophoblast where the classical class I and II antigens are absent. He brought the first demonstration ex vivo of the protector role of HLA-G molecule present on the surface of fetal cytotrophoblast cells versus the lysis carried out by maternal decidual uterine NK cells, in both semi-allogenic combinations (maternal uterine NK cells and their own fetal cytotropohoblast counterparts) and allogenic combinations (different maternal uterine NK cells and cytotrophoblasts from different fetuses). The blockage of this protein triggers off an important cytotoxicity towards the fetal cells. Furthermore, he showed that HLA-G molecules act as an inhibitor of the T-lymphocytes, NK cells and antigen presenting cells (APC). Through his discovery Carosella also shows for the first time the three major clinical consequences: I) HLA-G molecules are crucial, as an altered expression of these molecules would lead to abortion and failed pregnancies, i.e. recurrent spontaneous abortions and preeclamptic disease. The embryo expression of soluble HLA-G molecules is a mandatory prerequisite to implantation. II) In allogenic transplantation (heart, kidney and liver-kidney graft) the expression of HLA-G protein significantly reduces acute rejection and showed an absence of chronic rejections. III) Finally, this expression on the malignant cells has a negative functional impact in the anti-tumour response. So the expression of HLA-G molecule constitutes an escape mechanism from immunosurveillance, just as the fetal cells protect themselves from the aggression of maternal immune cells.","PeriodicalId":75641,"journal":{"name":"Bulletin et memoires de l'Academie royale de medecine de Belgique","volume":"164 3-4","pages":"87-99; discussion 99-101"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28682893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protein-protein interactions among ion channels regulate ion transport in the kidney. 离子通道之间的蛋白质-蛋白质相互作用调节肾脏中的离子运输。

Bulletin et memoires de l'Academie royale de medecine de Belgique Pub Date : 2009-01-01

E Boulpaep

{"title":"Protein-protein interactions among ion channels regulate ion transport in the kidney.","authors":"E Boulpaep","doi":"","DOIUrl":"","url":null,"abstract":"Epithelial ion transport in various organs has long been known to be controlled by extracellular agonists acting via membrane receptors or by intracellular messengers. Evidence is mounting for regulation of transport by direct interaction among membrane proteins or between a membrane transport protein and membrane-attached proteins. The membrane protein CFTR (Cystic Fibrosis Transmembrane Regulator) is widely expressed along the length of the nephron, but its role as a chloride channel does not appear to be critical for renal handling of salt and water. It is well established that the inward rectifying K channels (ROMK = Kir 1.1) in the thick ascending limb of Henle and in principal cells of the collecting duct are inhibited by millimolar concentrations of cytosolic Mg-ATP. However, the mechanism of this inhibition has been an enigma. We propose that the ATP-Binding Cassette (ABC) protein CFTR is a cofactor for Kir 1.1 regulation. Indeed, Mg-ATP sensitivity of Kir 1.1 is completely absent in two different mouse models of cystic fibrosis. In addition, the open-closed state of CFTR appears to provide a molecular gating switch that prevents or facilitates the ATP sensing of Kir 1.1. Does Mg-ATP sensing by the CFTR- Kir 1.1 complex play a role in coupling metabolism to ion transport? Physiological intracellular ATP concentrations in tubule cells are in the millimolar range, a saturating concentration for the gating of Kir 1.1 by Mg-ATP. Therefore, Kir 1.1 channels would be closed and unable to contribute to regulation of potassium secretion unless some other process modulated the CFTR-dependent ATP-sensitivity of Kir 1.1. The third component of the metabolic sensor-effector complex for Kir 1.1 regulation is most likely the AMP-regulated serine-threonine kinase, AMP kinase (AMPK). Changing levels in AMP rather than in ATP constitute the metabolic signal \"sensed\" by tubule cells. Because AMPK inhibits CFTR by modulating CFTR channel gating, we propose that renal K secretion is physiologically regulated by tri-molecular interactions between Kir 1.1, CFTR and AMPK.","PeriodicalId":75641,"journal":{"name":"Bulletin et memoires de l'Academie royale de medecine de Belgique","volume":"164 3-4","pages":"133-41; discussion 141-2"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28682895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Unravelling the mechanisms of the biogenesis of the outer membrane of Gram-negative bacteria: a step toward the development of new antibiotics]. [揭示革兰氏阴性菌外膜的生物发生机制:迈向新抗生素开发的一步]。

Bulletin et memoires de l'Academie royale de medecine de Belgique Pub Date : 2009-01-01

J F Collet

{"title":"[Unravelling the mechanisms of the biogenesis of the outer membrane of Gram-negative bacteria: a step toward the development of new antibiotics].","authors":"J F Collet","doi":"","DOIUrl":"","url":null,"abstract":"The outer membrane of Gram negative bacteria such as Escherichia coli is a permeability barrier that is essential for the viability of Gram-negative bacteria and protects them against antimicrobial drugs, including hydrophobic antibiotics. Outer membrane components, including phospholipids, lipopolysaccharids and proteins are synthesized in the cytoplasm and the cytoplasmic membrane. The mechanisms by which unfolded proteins and lipids are then transported through the hydrophilic periplasm and are inserted in the outer membrane are essentially unknown. Our overall goal is to solve the fascinating problem of how such a complex macromolecular structure is assembled in a compartment devoid of obvious energy sources. Moreover, the proteins that are involved in OM biogenesis are also attractive targets for the design of new antibiotics and anti-inflammatory drugs. Developing new antibiotics active against E. coli and other Gram negative bacteria is criticial because the number of E. coli strains that are resistant to antibiotics is rapidly rising. We will describe results obtained recently in our laboratory that allowed us to characterize several periplasmic chaperones involved in the folding of envelope proteins.","PeriodicalId":75641,"journal":{"name":"Bulletin et memoires de l'Academie royale de medecine de Belgique","volume":"164 7-9","pages":"213-20; discussion 220"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28765937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Male and female fertility too late? Effect of parental age at conception on the health and mortality of children]. 【男性和女性生育太晚?】父母受孕年龄对儿童健康和死亡率的影响[j]。

Bulletin et memoires de l'Academie royale de medecine de Belgique Pub Date : 2009-01-01

G Wunsch, C Gourbin

引用次数: 0

[Regeneration of the liver: from hepatocyte cells to deficient hepatic cells]. [肝脏的再生:从肝细胞到缺陷肝细胞]。

Bulletin et memoires de l'Academie royale de medecine de Belgique Pub Date : 2009-01-01

E M Sokal

引用次数: 0

[Ethical reflections relating to management of a crisis like a pandemic of influenza]. [与流感大流行等危机管理有关的伦理思考]。

Bulletin et memoires de l'Academie royale de medecine de Belgique Pub Date : 2009-01-01

J-A Stiennon-Heuson

引用次数: 0

[General medicine in the 21st century]. [21世纪的全科医学]。

Bulletin et memoires de l'Academie royale de medecine de Belgique Pub Date : 2008-01-01

D Giet, D Pestiaux, M Schetgen

{"title":"[General medicine in the 21st century].","authors":"D Giet, D Pestiaux, M Schetgen","doi":"","DOIUrl":"","url":null,"abstract":"General medicine is the main pivot of our healthcare system. General practitioners' tasks are numerous: front line responsibility, networking coordination, long-term patient care, community medicine and also primary care research. In the framework of general medicine that has been undergoing profound change for many years, we have chosen to develop three of these facets: general practitioners' knowledge of family, psychological, social or environmental factors and their capacity to coordinate with other health workers will help them in their primary and secondary prevention and also quaternary work by sparing patients unnecessary treatment and examinations. General medicine will increasingly become a discipline, one of which specific expertise will be to manage bio-psycho-societal complexity. Multidisciplinary action will be the rule: general practitioners will no longer be able to claim they can deal with all the curative, preventive and health education tasks. And the research in general medicine is essential because general practitioners can deal with over 80% of the health problems identified by patients and because the symptoms leading to the treatment cannot only be studied by laboratory or hospital research.","PeriodicalId":75641,"journal":{"name":"Bulletin et memoires de l'Academie royale de medecine de Belgique","volume":"163 7-9","pages":"425-31"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28176405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Medical history of a Florentine dynasty: the Medici]. [佛罗伦萨王朝的医学史:美第奇王朝]。

Bulletin et memoires de l'Academie royale de medecine de Belgique Pub Date : 2008-01-01

I De Leeuw

{"title":"[Medical history of a Florentine dynasty: the Medici].","authors":"I De Leeuw","doi":"","DOIUrl":"","url":null,"abstract":"The family of the Medici has dominated the city of Florence from the 15th to the 18th century. With the fortune accumulated by their bank, their trade and industry, they made Florence the European capital of the Renaissance and one of the world centres of culture. However, the Medici got a lot of health problems that have often influenced the destiny of the city and its citizens. During the 15th century, the Medici of Cafaggiolo branch of the family were the uncrowned masters of the Florence republic. All got major \"rheumatic\" complaints, who often interfered with a normal professional activity. The tradition called their disease \"gout\" and one of the Medici even received the nickname \"the gouty\" (Piero il Gottoso). Radiological and pathological exploration of the bones, the study of documents from ocular witnesses and the icon pathological study of paintings of the family could however not confirm this diagnosis. On the contrary, 2 other osteo-articular syndromes could be disclosed in the family. During the 16th century, the Medici became Grandukes of Tuscany with absolute political power, abandoning their classical jobs as bankers and traders. Their luxurious life with feasts and lewdness induces their progressive fall that will be accelerated by illness. Malaria, the plague, venereal diseases, madness and cardiovascular disease decimate the family as well as murders, poisonings and other criminal acts. Moreover, the physical resistance of the family decreased due to some underlying, hereditary pathologies that were recently discovered. In 1737, the last Granduke died in a state of complete marasmus and Florence is taken over by the house of Lorraine.","PeriodicalId":75641,"journal":{"name":"Bulletin et memoires de l'Academie royale de medecine de Belgique","volume":"163 10-12","pages":"499-508"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28684007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0