Bulletin et memoires de l'Academie royale de medecine de Belgique最新文献_第6页

[Cascade of gene activation in Landouzy Dejerine muscular dystrophy]. [Landouzy Dejerine肌营养不良症的基因激活级联]。

Bulletin et memoires de l'Academie royale de medecine de Belgique Pub Date : 2010-01-01

A Belayew

{"title":"[Cascade of gene activation in Landouzy Dejerine muscular dystrophy].","authors":"A Belayew","doi":"","DOIUrl":"","url":null,"abstract":"Our laboratory studies the Landouzy Dejerine muscular dystrophy or FSHD, a genetic disease which affects 7 in 100,000 individuals. The genetic defect is a deletion on chromosome 4 that decreases the copy number of a repeated DNA element, disturbs chromatin structure and activates the expression of neighbouring genes. The originality of our team has been to identify a gene within the repeated element itself and to show its activation in FSHD muscle cells. This gene expresses DUX4, a transcription factor that targets tens of genes, some of which express other transcription factors which target other genes, leading to a general deregulation. This DUX4-mediated cascade recapitulates by itself the major pathological features of FSHD: muscle atrophy, differentiation defect, oxidative stress... The homologous DUX4c gene located 42 kb from the repeat array expresses a protein that triggers myoblast proliferation. Its high expression level in severe cases of FSHD most probably contributes to the pathology by interfering with myoblast fusion with the muscle fibers at the last steps of muscle regeneration. We are performing global analyses of proteins and metabolites in healthy and FSHD myotubes (collaboration R Wattiez and JM Colet, UMONS) to identify abnormalities and their links with DUX4 or DUX4C.","PeriodicalId":75641,"journal":{"name":"Bulletin et memoires de l'Academie royale de medecine de Belgique","volume":"165 1-2","pages":"87-95; discussion 95-7"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29542485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Molecular classification of ganglionic T cell lymphomas. pathological and diagnostic implications]. 神经节T细胞淋巴瘤的分子分类。病理和诊断意义]。

Bulletin et memoires de l'Academie royale de medecine de Belgique Pub Date : 2010-01-01

L de Leval

引用次数: 0

[Cellular communication and regulation of insulin in the cell]. [细胞通讯和细胞内胰岛素的调节]。

Bulletin et memoires de l'Academie royale de medecine de Belgique Pub Date : 2010-01-01

P Meda

引用次数: 0

H2O2, signal, substrate, mutagen and chemorepellent from physiology to biochemistry and disease. 从生理到生物化学和疾病的H2O2、信号、底物、诱变剂和化学驱避剂。

Bulletin et memoires de l'Academie royale de medecine de Belgique Pub Date : 2010-01-01

J E Dumont, X De Deken, F Miot, V Corvilain, B Contempré, R Goyens, C Massart, J Van Sande, A Allaoui, A Botteaux

引用次数: 0

Cardiovascular effects of low-dose aspirin, traditional non-steroidal anti-inflammatory drugs and coxibs. 低剂量阿司匹林、传统非甾体抗炎药和coxibs对心血管的影响。

Bulletin et memoires de l'Academie royale de medecine de Belgique Pub Date : 2010-01-01

C Patrono

引用次数: 0

Belgium Royal Academy of Medicine membership list. 比利时皇家医学院会员名单。

Bulletin et memoires de l'Academie royale de medecine de Belgique Pub Date : 2010-01-01

引用次数: 0

[Viruses and bats: rabies and Lyssavirus]. [病毒和蝙蝠:狂犬病和溶血病毒]。

Bulletin et memoires de l'Academie royale de medecine de Belgique Pub Date : 2009-01-01

N Tordo, M Ph Marianneau

{"title":"[Viruses and bats: rabies and Lyssavirus].","authors":"N Tordo, M Ph Marianneau","doi":"","DOIUrl":"","url":null,"abstract":"Recent emerging zoonoses (hemorrhagic fevers due to Ebola or Marburg virus, encephalitis due to Nipah virus, severe acute respiratory syndrome due to SRAS virus...) outline the potential of bats as vectors for transmission of infectious disease to humans. Such a potential is already known for rabies encephalitis since seven out of the eight genotypes of Lyssavirus are transmitted by bats. In addition, phylogenetic reconstructions indicate that Lyssavirus have evolved in chiropters before their emergence in carnivores. Nevertheless, carnivores remain the most critical vectors for public health, in particular dogs that are originating 55.000 rabies deaths per year, essentially in developing countries. Rabies control in carnivores by parenteral (dog) or oral (wild carnivores) vaccination is efficacious and campaigns start to be more widely applied. On the other hand, rabies control in bat still remains non realistic, particularly as the pathogenicity of bat Lyssavirus for bats is still under debate, suggesting that a \"diplomatic relationship\" between partners would have arisen from a long term cohabitation. While comparing the interactions that humans and bats establish with Lyssavirus, scientists try to understand the molecular basis ofpathogenicity in man, a indispensable prerequisite to identify antiviral targets in a perspective of therapy.","PeriodicalId":75641,"journal":{"name":"Bulletin et memoires de l'Academie royale de medecine de Belgique","volume":"164 1-2","pages":"7-15; discussion 15-6"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28372422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Comprehensive cardiac imaging using multidetector CT and magnetic resonance imaging]. [多探头CT和磁共振综合心脏成像]。

Bulletin et memoires de l'Academie royale de medecine de Belgique Pub Date : 2009-01-01

B Gerber

{"title":"[Comprehensive cardiac imaging using multidetector CT and magnetic resonance imaging].","authors":"B Gerber","doi":"","DOIUrl":"","url":null,"abstract":"Recent technical improvements have allowed to non-invasive cardiac imaging by Multidetector CT. (MDCT). In initial work we compared the value of successive generations of MDCT (4, 16, and 64 slice) for non-invasive imaging of coronary arteries vs. non-invasive magnetic resonance coronary angiography using conventional coronary angiography as gold standard. Our work demonstrated progressive improvement of diagnostic accuracy from 4 to 64 slice MDCT technology. The most recent generation of 64 slice MDCT became more performing than MRI. Since cardiac function is the main predictor of outcome in patients with coronary artery disease, we evaluated whether MDCT can also access left ventricular volumes and ejection fraction, and observed excellent correlation of these parameters estimated by MDCT vs MRI. Subsequently we demonstrated that MDCT can also assess aortic stenosis by direct planimetry of the valve. We also found MDCT to be able of evaluating the severity and mechanism of aortic regurgitation and to evaluate function and mechanism of dysfunction of aortic bioprosthesis. We also demonstrated that MDCT can detect myocardial necrosis and fibrosis, and thus assess myocardial viability using similar mechanisms as MRI. Finally, we demonstrated that combined assessment of non-invasive coronary imaging and assessment of myocardial viability may allow assessing the etiology of ischemic vs non-ischemic heart failure, similarly well as the combination of mri and invasive coronary angiography. We also demonstrated that MDCT might allow avoiding performing systematic invasive coronary angiography in patients prior to valve surgery, by selecting only those patients with suspected coronary artery disease to undergo this test. Thus in summary, we performed work, demonstrating the value of MDCT not only for imaging of coronary arteries, but also for assessment of cardiac and valve function and evaluation of myocardial viability. Such comprehensive cardiac imaging by MDCT might be useful for assessment of patients with valve disease and to evaluate etiology of heart failure.","PeriodicalId":75641,"journal":{"name":"Bulletin et memoires de l'Academie royale de medecine de Belgique","volume":"164 3-4","pages":"103-7; discussion 107-8"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28682894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Study of the molecular mechanisms controlling activity of protein p53 in the development of new strategies in cancer therapeutics]. [控制p53蛋白活性的分子机制在癌症治疗新策略发展中的研究]。

Bulletin et memoires de l'Academie royale de medecine de Belgique Pub Date : 2009-01-01

Ch Marine

引用次数: 0

[Is it possible to correct the anergy of T lymphocytes that infiltrate tumors?]. [是否有可能纠正浸润肿瘤的T淋巴细胞的能量?]

Bulletin et memoires de l'Academie royale de medecine de Belgique Pub Date : 2009-01-01

P van der Bruggen

{"title":"[Is it possible to correct the anergy of T lymphocytes that infiltrate tumors?].","authors":"P van der Bruggen","doi":"","DOIUrl":"","url":null,"abstract":"Human tumor metastases are often infiltrated by T lymphocytes that are specific for tumor antigens, but these metastases progress anyway. The spontaneous anti-tumor immune response seems thus to become ineffective, probably because the effector T cells become anergic. This anergy could result from inhibitory mechanisms orchestrated by the tumor cells. We have observed that recently stimulated human cytolytic T cell clones lose transiently their capacity to secrete cytokines. This anergy is correlated with the absence of colocalization of the T cell receptors (TCR) and the CD8 co-receptors. Effector functions' and TCR/CD8 colocalization are recovered by treating cells with galectin-3 ligands, suggesting that exracellular galectin-3 forms glycoprotein-galectin lattices, which decrease the TCR mobility on the surface of anergic T lymphocytes. Galectin-3 is frequently released by tumor cells. This new mechanism of anergy could thus also explain the loss of functions of the tumor-infiltrating lymphocytes, because these lymphocytes recover their effector functions and TCR/CD8 colocalization after ex vivo treatment with galectin-3 ligands. These results could lead to new therapeutical strategies.","PeriodicalId":75641,"journal":{"name":"Bulletin et memoires de l'Academie royale de medecine de Belgique","volume":"164 5-6","pages":"183-91; discussion 192"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29150807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0