Bulletin et memoires de l'Academie royale de medecine de Belgique最新文献_第2页

[Treatment of bone diseases with cell therapy]. [用细胞疗法治疗骨病]。

Bulletin et memoires de l'Academie royale de medecine de Belgique Pub Date : 2011-01-01

V Gangji

{"title":"[Treatment of bone diseases with cell therapy].","authors":"V Gangji","doi":"","DOIUrl":"","url":null,"abstract":"Osteonecrosis of the femoral head is a rare disease that affects young patients and is characterized by the occurrence of a necrotic lesion in the femoral head, loss of mechanical resistance of dead bone and collapse of the femoral head. Patients complain of hip pain and loss of function that could lead to total hip replacement. So far, osteonecrosis was considered as a vascular disease due to vascular section or compression leading to bone necrosis. We studied the physiopathology of the osteonecrosis considering it as a bone disease. We demonstrated as well as other teams that the number of mesenchymal stem cells, precursors of bone cells and osteoblastic cells, were reduced in patients with osteonecrosis. We initiated a controlled double blind trial to study the efficacy of stem cells implantation--obtained from concentrated bone marrow--in the osteonecrosis zone. This study showed that bone marrow implantation could delay disease progression to the fractural stage and improve hip pain and joint symptoms. We then tried to improve this treatment by developing a bone cell therapy product formed of osteoblastic cells. A novel cell therapy product formed ofosteoblastic cells, PREOB was developed. PREOB was tested in a randomized, controlled phase II trial in osteonecrosis of the femoral head and showed its superiority compared to concentrated bone marrow. Today, this cellular therapy product is developed by Bone Therapeutics, a spin-offcompany of the \"Université libre de Bruxelles\". Other bone diseases are characterized by reduced activities of stem cells that are unable to meet the need of bone remodelling due to a non-union fracture, for example. Clinical studies also showed that concentrated bone marrow could be implanted into the non-union. However, its efficacy was dependent on the number of implanted stem cells. The cellular therapy product is currently tested in a phase I trial with promising preliminary results. Cellular therapy for bone diseases is a novel therapeutic approach that evolves from stem cells to the use of the differentiated cells of interest.","PeriodicalId":75641,"journal":{"name":"Bulletin et memoires de l'Academie royale de medecine de Belgique","volume":"166 5-6","pages":"202-5; discussion 206-8"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30832927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[In search of the musical brain]. [寻找音乐大脑]。

Bulletin et memoires de l'Academie royale de medecine de Belgique Pub Date : 2011-01-01

S Samson

引用次数: 0

[Cancer stem cells]. [癌症干细胞]。

Bulletin et memoires de l'Academie royale de medecine de Belgique Pub Date : 2011-01-01

J Boniver, M Michaël Herfs

引用次数: 0

[Breast cancer: towards an evolution of minimalist locoregional therapy]. [乳腺癌:走向极简局部治疗的进化]。

Bulletin et memoires de l'Academie royale de medecine de Belgique Pub Date : 2011-01-01

J-M Nogaret

{"title":"[Breast cancer: towards an evolution of minimalist locoregional therapy].","authors":"J-M Nogaret","doi":"","DOIUrl":"","url":null,"abstract":"Breast cancer remains by far the most frequent cancer in women, for that matter it is the most frequent cancer in Belgium affecting both men and women. At the moment, more than 9000 cases are detected annually. The development of screening allows us, fortunately, to detect lesions and stages earlier, in that way locoregional treatmenthas considerably evolved. Since the seventies, radical mastectomy, which consists of the removal ofthe mammary gland, the axillary glands (lymph nodes) and sometimes the pectoral muscle, has been progressively replaced by conservatory treatment. This consists of a wide excision of the tumour with a safety resection margin, followed by a complete removal of the axillary glands (lymph nodes) then followed by a course of external radiotherapy testing treated six weeks daily on a five days week basis. During the nineties, in cases with certain precise indications, the complete axillary gland removal has been replaced by the removal of the first gland chain (lymph node chain) called \"sentinel nodes\". This technique avoids all morbidity associated to the complete lymph node removal. Finally, very recently, the classic external radiotherapy has been replaced by partial radiotherapy delivered exclusively in a few minutes during the surgical operation. Therefore, we can offer patients with early stage lesions a locoregional treatment carried out in one to two hours with an in-stay hospitalisation of two nights. This new technique manifestly offers a better locoregional control of the illness and very likely enhances (improves) their chances of recovery.","PeriodicalId":75641,"journal":{"name":"Bulletin et memoires de l'Academie royale de medecine de Belgique","volume":"166 5-6","pages":"229-32; discussion 233-4"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30832928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Globalization of Chagas disease (American trypanosomiasis): the situation in Europe and Belgium. 恰加斯病(美洲锥虫病)的全球化:欧洲和比利时的情况。

Bulletin et memoires de l'Academie royale de medecine de Belgique Pub Date : 2011-01-01

Y Carlier

引用次数: 0

New viral pathogens from wildlife. 来自野生动物的新型病毒病原体。

Bulletin et memoires de l'Academie royale de medecine de Belgique Pub Date : 2011-01-01

P A Barrow, A Abu-Median

引用次数: 0

Clinical evaluation of the safety and immunogenicity of H5N1 pandemic influenza vaccines. H5N1大流行性流感疫苗安全性和免疫原性的临床评价。

Bulletin et memoires de l'Academie royale de medecine de Belgique Pub Date : 2011-01-01

I Leroux-Roels

引用次数: 0

[Contributions of immunogenic cell death to the efficacy of anticancer chemotherapy]. 免疫原性细胞死亡对抗癌化疗疗效的贡献

Bulletin et memoires de l'Academie royale de medecine de Belgique Pub Date : 2011-01-01

G Kroemer, Sandy Adjemian, Mickaël Michaud, Isabelle Martins, Oliver Kepp, Abdul Qader Sukkurwala, Laurie Menger, Erika Vacchelli, Yuting Ma, Laurence Zitvogel

引用次数: 0

[Effects of electric and electromagnetic fields on cell differentiation and application in orthopedic and trauma surgery]. [电场和电磁场对细胞分化的影响及其在骨科和创伤外科中的应用]。

Bulletin et memoires de l'Academie royale de medecine de Belgique Pub Date : 2011-01-01

M Hinsenkamp

{"title":"[Effects of electric and electromagnetic fields on cell differentiation and application in orthopedic and trauma surgery].","authors":"M Hinsenkamp","doi":"","DOIUrl":"","url":null,"abstract":"The discovery of the dynamic electrical properties of bone is at the origin of the therapeutical application of the electromagnetic fields in Orthopaedics and Traumatology. The first empirical treatment of non-union, fresh fractures and osteonecroses allowed the observation of several effects which, without justifying a systematic clinical application, encouraged further fundamental research. The results of this work realized during 35 years are summarized in the present article. After exposure to specific electromagnetic fields, we observed a modification of the DNA activity and an increased production of RNA. During enchondral ossification, the amount of acid GAGS increased faster and the ossification of the primary ossification point is accelerated. On fresh fractures, the rigidity of the callus increased faster. Finally, the microarrays analyses show an upregulation of mRNA involved in cellular differentiation and proliferation. The mRNA responsible of the production of BMP-2 is significantly increased, explaining the main results observed after the expense of experimental models of the bond tissues. All the observed results are in favour of an acceleration of the cellular differentiation at the expense of the proliferation.","PeriodicalId":75641,"journal":{"name":"Bulletin et memoires de l'Academie royale de medecine de Belgique","volume":"166 7-9","pages":"307-15; discussion 316"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30832924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Role of immune alterations induced by papillomavirus in development of cervical cancer ]. 乳头瘤病毒诱导的免疫改变在宫颈癌发生中的作用

Bulletin et memoires de l'Academie royale de medecine de Belgique Pub Date : 2011-01-01

P Delvenne

引用次数: 0