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Bulletin du Groupement international pour la recherche scientifique en stomatologie & odontologie最新文献

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ES cells-derived ectomesenchymal cells for tooth engineering. 胚胎干细胞衍生的外胚间充质细胞用于牙齿工程。
Bulletin du Groupement international pour la recherche scientifique en stomatologie & odontologie Pub Date : 2013-07-10
S Acuña-Mendoza, S Martin, S Ribes, L Keller, C Chaussain, L Lebrin, H Lesot, A Poliard
{"title":"ES cells-derived ectomesenchymal cells for tooth engineering.","authors":"S Acuña-Mendoza,&nbsp;S Martin,&nbsp;S Ribes,&nbsp;L Keller,&nbsp;C Chaussain,&nbsp;L Lebrin,&nbsp;H Lesot,&nbsp;A Poliard","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Recent progresses in stem cell biology and tissue engineering allow considering the possible development of new therapies for compensating the dental tissue losses associated with traumas, pathologies or ageing. The possibility of generating a tooth by mimicking development through reassociations between dental epithelial cells and ectomesenchymal cells derived from the neural crest (NC) has been demonstrated in the mouse. In the search of cell sources to be used for a human transfer, pluripotent stem cells could represent a good alternative. Our study thus focuses on obtaining, ectomesenchymal cells from pluripotent ES cells, capable of promoting tooth histomorphogenesis, when reassociated with a competent dental epithelium. To this end, two ES differentiation protocols, using cyclopamine or a combination of FGF2 and BMP4, have been developed and tested for their capacity to generate such cells. The differentiated ES cells were characterized by quantitative RT-PCR. Both protocols led the cells to acquire in 10 days a mesenchymal-like cell morphology. Rapidly after induction, the cells loose their expression of pluripotent genes while sequentially activating typical NC specifiers. However, the kinetics of gene activation differed between the 2 protocols. Interestingly, Twist, a gene whose expression in the NC is associated with a commitment towards an ectomesenchymal fate, is only activated under the influence of FGF2 and BMP4. Reassociation experiments with a competent epithelium will allow testing the odontogenic potential of the differentiated ES cells. These experiments performed in the mouse system should allow defining a strategy for obtaining odontogenic competent human cells.</p>","PeriodicalId":75640,"journal":{"name":"Bulletin du Groupement international pour la recherche scientifique en stomatologie & odontologie","volume":"52 1","pages":"e7-16"},"PeriodicalIF":0.0,"publicationDate":"2013-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32869909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Establishment of a model of murine odontoblasts underexpressing PKD1 using shRNA. 利用shRNA建立低表达PKD1的小鼠成牙细胞模型。
Bulletin du Groupement international pour la recherche scientifique en stomatologie & odontologie Pub Date : 2013-07-10
B Thivichon-Prince, N Labert, Ml Couble, F Bleicher
{"title":"Establishment of a model of murine odontoblasts underexpressing PKD1 using shRNA.","authors":"B Thivichon-Prince,&nbsp;N Labert,&nbsp;Ml Couble,&nbsp;F Bleicher","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We have previously shown that PKD1, the gene encoding Polycystin-1 (or TRPP1) is expressed in human odontoblasts and that this protein is localized at the primary cilium of the cell. Nevertheless, its function remain unclear in this cell even if studies on osteoblasts, osteocytes and chondrocytes give TRPP1 as a promising candidate for mechanotransduction in response to mechanical stress. Consequently, to evaluate the role of TRPP1 in this transduction process, we needed first to generate an in vitro murine model down expressing Pkd1. Using lentivirus-mediated shRNA technology, we obtained a 60% suppression of Pkd1 mRNA expression in transfected MO6-G3 cells associated with a decrease of cell proliferation. Thus, establishment of this murine odontoblast model underexpressing Pkd1 associated with applied mechanical forces (compression or shear stress) will allow us to go further in the determination of TRPP1 involvement in odontoblasts mechanotransduction.</p>","PeriodicalId":75640,"journal":{"name":"Bulletin du Groupement international pour la recherche scientifique en stomatologie & odontologie","volume":"52 1","pages":"e23-8"},"PeriodicalIF":0.0,"publicationDate":"2013-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32871127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
"In vivo" bone tibial response to the application of mineral trioxide aggregate (MTA). Study in New Zealand white rabbit. “体内”骨胫骨对三氧化矿物骨料(MTA)应用的反应。以新西兰白兔为研究对象。
Bulletin du Groupement international pour la recherche scientifique en stomatologie & odontologie Pub Date : 2013-06-03
O Torres Faria, P Carvalho Lobato, J M Ustrell Torrent, I Valdivia Gandur, M C Manzanares Céspedes
{"title":"\"In vivo\" bone tibial response to the application of mineral trioxide aggregate (MTA). Study in New Zealand white rabbit.","authors":"O Torres Faria,&nbsp;P Carvalho Lobato,&nbsp;J M Ustrell Torrent,&nbsp;I Valdivia Gandur,&nbsp;M C Manzanares Céspedes","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Short Communication selected from the Oral Presentations of the 56th Congress of the Groupèment International pour la Recherche Scientifique en Stomatologie et Odontologie, Peñafiel (Portugal) May 2012. \";Prix du GIRSO\"; 2012. </p>","PeriodicalId":75640,"journal":{"name":"Bulletin du Groupement international pour la recherche scientifique en stomatologie & odontologie","volume":"51 2","pages":"e26"},"PeriodicalIF":0.0,"publicationDate":"2013-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32869756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of flexural resistance of three types of commercial zirconia. 三种商品氧化锆抗弯性能的比较。
Bulletin du Groupement international pour la recherche scientifique en stomatologie & odontologie Pub Date : 2013-06-03
G Silva, L Carvalho
{"title":"Comparison of flexural resistance of three types of commercial zirconia.","authors":"G Silva,&nbsp;L Carvalho","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Short Communication selected from the Oral Presentations of the 56th Congress of the Groupèment International pour la Recherche Scientifique en Stomatologie et Odontologie, Peñafiel (Portugal) May 2012. </p>","PeriodicalId":75640,"journal":{"name":"Bulletin du Groupement international pour la recherche scientifique en stomatologie & odontologie","volume":"51 2","pages":"e24"},"PeriodicalIF":0.0,"publicationDate":"2013-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32869755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Scott and the logs: design and data capture in a preparatory online package for children undergoing GA for dental procedures. 斯科特和日志:为接受牙科手术的儿童设计和数据采集预备在线包。
Bulletin du Groupement international pour la recherche scientifique en stomatologie & odontologie Pub Date : 2013-05-08
P A Reynolds, N Donaldson, C Huntington, C Liossi, T C Newton, M T Hosey
{"title":"Scott and the logs: design and data capture in a preparatory online package for children undergoing GA for dental procedures.","authors":"P A Reynolds,&nbsp;N Donaldson,&nbsp;C Huntington,&nbsp;C Liossi,&nbsp;T C Newton,&nbsp;M T Hosey","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75640,"journal":{"name":"Bulletin du Groupement international pour la recherche scientifique en stomatologie & odontologie","volume":"51 3","pages":"e23-4"},"PeriodicalIF":0.0,"publicationDate":"2013-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32868857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Technology enhanced learning (TEL) for training dental hygienists in ukraine: report of a round table discussion. 乌克兰培训牙科保健员的技术强化学习:圆桌讨论报告。
Bulletin du Groupement international pour la recherche scientifique en stomatologie & odontologie Pub Date : 2013-05-08
E Fabrikant, K Eaton
{"title":"Technology enhanced learning (TEL) for training dental hygienists in ukraine: report of a round table discussion.","authors":"E Fabrikant,&nbsp;K Eaton","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75640,"journal":{"name":"Bulletin du Groupement international pour la recherche scientifique en stomatologie & odontologie","volume":"51 3","pages":"e32-4"},"PeriodicalIF":0.0,"publicationDate":"2013-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32868861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Kinship--king's social harmonisation project. Pilot phase of a social network for use in higher education (HE). 亲属关系——金的社会和谐计划。用于高等教育(HE)的社会网络的试验阶段。
Bulletin du Groupement international pour la recherche scientifique en stomatologie & odontologie Pub Date : 2013-05-08
B A John
{"title":"Kinship--king's social harmonisation project. Pilot phase of a social network for use in higher education (HE).","authors":"B A John","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Students entering Higher Education are increasingly information and communications technology literate. Many students (graduates and undergraduates) arrive as \"digital residents\", who are adept with social media and technologically fluent. The informal use of social media for learning is becoming increasingly evident, along with the potentially detrimental effects of a poor digital profile on employment prospects. This paper describes the creation of Kinship (King's Social Harmonisation Project), a university hosted, members only social network, which is currently being piloted in the Medical School at King's College London. Along with a number of other teaching and learning resources, it is intended to use Kinship to establish an informal code of conduct by modelling and moderating appropriate professional online behaviour. Kinship was developed using an open source Elgg platform, thanks to funding of £20,000 from the College Teaching Fund under the mentorship of Brighton University (1). This educational research project, led by Medicine, was proposed to select, customise and evaluate a social networking platform in order to provide functionality that would enhance new and existing e-learning resources, support group interaction, participation and sharing and meet the diverse needs of three academic schools: Medicine, the Dental Institute and two separate Departments, the Modern Languages Centre and the Department of English from Arts & Humanities, as a pilot for wider College deployment. Student involvement is central to the project, from conducting the evaluation to moulding and customising the functionality and look of Kinship, in order to ensure that the site is authentic and evolves in response to their wishes and requirements. Formal evaluation of Kinship commences summer 2012.</p>","PeriodicalId":75640,"journal":{"name":"Bulletin du Groupement international pour la recherche scientifique en stomatologie & odontologie","volume":"51 3","pages":"e19-22"},"PeriodicalIF":0.0,"publicationDate":"2013-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32868856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact on dental students' knowledge in three European countries through an online module on antibiotic prescribing: a preliminary study. 通过抗生素处方在线模块对三个欧洲国家牙科学生知识的影响:初步研究。
Bulletin du Groupement international pour la recherche scientifique en stomatologie & odontologie Pub Date : 2013-05-08
L Berr, N Donaldson, S Hatzipanagos, C Paganelli, P A Reynolds
{"title":"The impact on dental students' knowledge in three European countries through an online module on antibiotic prescribing: a preliminary study.","authors":"L Berr,&nbsp;N Donaldson,&nbsp;S Hatzipanagos,&nbsp;C Paganelli,&nbsp;P A Reynolds","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75640,"journal":{"name":"Bulletin du Groupement international pour la recherche scientifique en stomatologie & odontologie","volume":"51 3","pages":"e25-6"},"PeriodicalIF":0.0,"publicationDate":"2013-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32868858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Testing the theory of threshold concepts in a context of dental education. Preliminary analysis. 在牙科教育背景下检验阈值概念理论。初步分析。
Bulletin du Groupement international pour la recherche scientifique en stomatologie & odontologie Pub Date : 2013-05-08
M Kobus
{"title":"Testing the theory of threshold concepts in a context of dental education. Preliminary analysis.","authors":"M Kobus","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This paper reports on the pilot phase of a phenomenographic study which explores the relationship between teachers' and students' perceptions of the curriculum and theory of threshold concepts, which claims that there are concepts in all disciplines which must be understood, if learners are to progress to a more advanced level of understanding. It is suggested that threshold concepts may represent ways of thinking and practising within disciplines. In this study consideration is given to the troublesome aspects of knowledge as described by David Perkins (1999) and further developed by Meyer and Land (2003). Researcher's intention is to investigate if students experience any conceptual difficulties and what the nature of these might be. Students' and teachers' accounts of how they perceive the dental curriculum might help to verify if there is a relationship between the curriculum and the theory of threshold concepts. Analysis of the troublesome aspects of knowledge may lead to the identification of threshold concepts in the dental curriculum.</p>","PeriodicalId":75640,"journal":{"name":"Bulletin du Groupement international pour la recherche scientifique en stomatologie & odontologie","volume":"51 3","pages":"e27-9"},"PeriodicalIF":0.0,"publicationDate":"2013-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32868859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Revolutionising the dental curriculum--delivering better oral health. 革新牙科课程——提供更好的口腔健康。
Bulletin du Groupement international pour la recherche scientifique en stomatologie & odontologie Pub Date : 2013-05-08
J E Gallagher
{"title":"Revolutionising the dental curriculum--delivering better oral health.","authors":"J E Gallagher","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>There is a paradigm shift taking place in healthcare with the recognition that every consultation should count for health - not merely the treatment of disease - drawing on the principles of health promotion and underpinned by a strong evidence-base for clinical prevention. Institutions such as King's Health Partners [KHP], an academic health science centre in London, recognise that its responsibilities extend beyond the clinical environment to the local community and beyond and that there should be greater emphasis on promoting health. This paper outlines recent proposals by Dental Institute as a clinical academic group within KHP to promote health, the underlying philosophy, actions taken and the evidence-based resources available, as well as the challenges to be overcome.</p>","PeriodicalId":75640,"journal":{"name":"Bulletin du Groupement international pour la recherche scientifique en stomatologie & odontologie","volume":"51 3","pages":"e12-6"},"PeriodicalIF":0.0,"publicationDate":"2013-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32868854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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